臨床外科学（前期・後期）

教育研究領域紹介

博士課程前期

科学に基づいた実践的研究によって疾病の病態、治療の質、疫学的分析による症例集積を基本として、看護上の問題点を明らかにし解決法を提案します。

博士課程後期

自律した研究者としてクリニカルクエスチョンに対する臨床的エビデンスを獲得し、ガイドラインへの導出を実践する。情報看護学として新たな学問分野を探求します。

教員紹介

研究テーマ

  1. 生活習慣病の疫学と予防循環器
  2. インスリン抵抗性の病態解明
  3. 看護外科学・重症看護学（安全安心な術後管理と患者家族の幸福を追求する看護サポート）
  4. 情報看護学（モバイル生体情報の社会的普及）

研究業績

研究論文

  1. Harada K, Ishinuki T, Ohashi Y, Tanaka T, Chiba A, Numasawa K, Imai T, Hayasaka S, Tsugiki T, Miyanishi K, Nagayama M, Takemasa I, Kato J, Mizuguchi T. Nature of the liver volume depending on the gender and age assessing volumetry from a reconstruction of the computed tomography. PLoS ONE 2021; 16(12): e0261094. https://doi.org/10.1371/journal.pone.0261094.
  2. Kutomi G, Shima H, Maeda H, Kuga Y, Satomi F, Wada A, Sato K, Mizuguchi T, Takemasa I. Surgical advantage of ultrasonically activated devices during axillary lymph node dissection for breast cancer. Int Surg 2021;105:623–627.
  3. Ichinohe N, Ishii M, Tanimizu N, Mizuguchi T, Yoshioka Y, Ochiya T, Suzuki H, Mitaka T. Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers. Stem Cell Res Ther. 2021 May 29;12(1):312. doi: 10.1186/s13287-021-02387-6. PMID: 34051870
  4. Ueda T, Takesue Y, Matsumoto T, Tateda K, Kusachi S, Mikamo H, Sato J, Hanaki H, Mizuguchi T, Morikane K, Kobayashi M, Harihara Y, Seki S, Ishida Y, Fukushima R, Hada M, Matsuo Y, Kubo S, Kimura Y, Hata H, Nakajima K, Ohge H, Akagi S, Takeda S, Fukui Y, Suzuki K, Okamoto K, Yanagihara K, Kawamura H. Change in antimicrobial susceptibility of pathogens isolated from surgical site infections over the past decade in Japanese nation-wide surveillance study. J Infect Chemother. 2021 Jul;27(7):931-939. doi: 10.1016/j.jiac.2021.03.010. Epub 2021 Mar 29. PMID: 33795192
  5. Shima H, Kutomi G, Sato K, Kuga Y, Wada A, Satomi F, Uno S, Nisikawa N, Kameshima H, Ohmura T, Mizuguchi T, Takemasa I. An Optimal Timing for Removing a Drain After Breast Surgery: A Systematic Review and Meta-Analysis. J Surg Res. 2021;267:267-273. doi: 10.1016/j.jss.2021.05.031.
  6. Ishinuki T, Ota S, Harada K, Tatsumi H, Harada K, Miyanishi K, Nagayama M, Takemasa I, Ohyanagi T, Hui T, Mizuguchi T. Health-related quality of life in patients that have undergone liver resection: A systematic review and meta-analysis. World J Meta-Anal, 2021; 9: 88-100.
  7. Ohge H, Mayumi T, Haji S, Kitagawa Y, Kobayashi M, Kobayashi M, Mizuguchi T, Mohri Y, Sakamoto F, Shimizu J, Suzuki K, Uchino M, Yamashita C, Yoshida M, Hirata K, Sumiyama Y, Kusachi S; Committee for Gastroenterological Surgical Site Infection Guidelines, the Japan Society for Surgical Infection. The Japan Society for Surgical Infection: guidelines for the prevention, detection, and management of gastroenterological surgical site infection, 2018. Surg Today. 2021 Jan;51(1):1-31.
  8. Uchino M, Ikeuchi H, Shimizu J, Ohge H, Haji S, Mizuguchi T, Mohri Y, Yamashita C, Kitagawa Y, Suzuki K, Kobayashi M, Kobayashi M, Sakamoto F, Yoshida M, Mayumi T, Hirata K, Takesue Y.　Association between preoperative tumor necrosis factor alpha inhibitor and surgical site infection after surgery for inflammatory bowel disease: a systematic review and meta-analysis. Surg Today. 2021 Jan;51(1):32-43. doi: 10.1007/s00595-020-02003-9.
  9. Hazawa Y, Kutomi G, Shima H, Honma T, Ohmura T, Wada A, Mikami T, Hotta M, Narumi M, Ishinuki T, Kuno Y, Meguro M, Takemasa I, Okazaki M, Masuoka H, Asaishi K, Ohyanagi T, T. Hui T, Mizuguchi T. The Unique Mental Impacts of Breast-Conserving Surgery and Mastectomy According to a Multi-Centered Cross Sectional Survey Conducted in Japan. Arch Breast Cancer. 2020; 7: 119-26.
  10. Yamaguchi H, Kimura Y, Imamura M, Nagayama M, Ito T, Kyuno D, Kono T, Kimura A, Akizuki E, Nishidate T, Okita K, Nobuoka T, Mizuguchi T, Hirata K, Takemasa I. Effect of Rikkunshito, a Traditional Japanese Herbal Medicine, on Delayed Gastric Emptying and Oral Dietary Intake After Pancreaticoduodenectomy: A Prospective, Randomized, Single-Center, Open-Labeled Study. Clin Exp Gastroenterol. 2020 Dec 9;13:577-587.
  11. Uchino M, Ikeuchi H, Shimizu J, Ohge H, Haji S, Mizuguchi T, Mohri Y, Yamashita C, Kitagawa Y, Suzuki K, Kobayashi M, Kobayashi M, Sakamoto F, Yoshida M, Mayumi T, Hirata K, Takesue Y.　Association between preoperative tumor necrosis factor alpha inhibitor and surgical site infection after surgery for inflammatory bowel disease: a systematic review and meta-analysis. Surg Today. 2020 Apr 10. doi: 10.1007/s00595-020-02003-9.
  12. Kikuchi A, Koide R, Iwasaki M, Teramoto M, Satohisa S, Tamate M, Sawada I, Shudo E, Niwa N, Saito T, Mizuguchi T.　Quality assessment using Brief Cancer-Related Worry Inventory before and after gynecologic surgery for women. World J Obstet Gynecol. 8: 1-7, 2019.
  13. Harada K, Nagayama M, Ohashi Y, Chiba A, Numazawa K, Meguro M, Kimura Y, Yamaguchi H, Kobayashi M, Miyanishi K, Kato J, Mizuguchi T. Scoring criteria for determining the safety of liver resection for malignant liver tumors. World J Meta-Anal. 7: 234-248, 2019.
  14. Koide R, Kikuchi A, Miyajima M, Mishina T, Takahashi Y, Okawa M, Sawada I, Nakajima J, Watanabe A, Mizuguchi T. Quality assessment using EQ-5D-5L after lung surgery for non-small cell lung cancer (NSCLC) patients. Gen Thorac Cardiovasc Surg. 67: 1056-1061, 2019.
  15. Kino J, Ichinohe N, Ishii M, Suzuki H, Mizuguchi T, Tanimizu N, Mitaka T. Self-Renewal Capability of Hepatocytic Parental Progenitor Cells Derived From Adult Rat Liver Is Maintained Long Term When Cultured on Laminin 111 in Serum-Free Medium. Hepatol Commun. 2019 Nov 2;4(1):21-37.
  16. Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T.　Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma. Cancer Sci. 110(8):2378-2385, 2019. doi: 10.1111/cas.14106. Epub 2019 Jul 23.
  17. Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T. Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series. Cancer Sci. 2019 Aug;110(8):2386-2395. doi: 10.1111/cas.14099. Epub 2019 Jul 11.
  18. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Nakajima K, Ueda T, Uchino M, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K.　Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan. J Infect Chemother. 2018 May;24(5):330-340.
  19. Shima H, Kutomi G, Satomi F, Imamura M, Kimura Y, Mizuguchi T, Watanabe K, Takahashi A, Murai A, Tsukahara T, Kanaseki T, Hirohashi Y, Iwayama Y, Tsuruma T, Kameshima H, Sato N, Torigoe T, Takemasa I.　Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine.　Cancer Immunol Immunother. 2018;67(10):1603-1609. doi: 10.1007/s00262-018-2217-x. Epub 2018 Aug 1.
  20. Uchino M, Mizuguchi T, Ohge H, Haji S, Shimizu J, Mohri Y, Yamashita C, Kitagawa Y, Suzuki K, Kobayashi M, Kobayashi M, Sakamoto F, Yoshida M, Mayumi T, Hirata K; SSI Prevention Guideline Committee of the Japan Society for Surgical Infection. The Efficacy of Antimicrobial-Coated Sutures for Preventing Incisional Surgical Site Infections in Digestive Surgery: a Systematic Review and Meta-analysis. J Gastrointest Surg. 22(10):1832-1841, 2018. doi: 10.1007/s11605-018-3832-8.
  21. Imamura M, Hirata K, Unno M, Kamiya K, Gotoh M, Konno H, Shibata A, Sugihara K, Takahashi A, Nishiyama M, Hakamada K, Fukui T, Furukawa T, Mizushima T, Mizuma M, Miyata H, Mori M, Takemasa I, Mizuguchi T, Fujiwara T.　Current status of projects for developing cancer-related clinical practice guidelines in Japan and recommendations for the future.　Int J Clin Oncol. 2019 Feb;24(2):189-195. doi: 10.1007/s10147-018-1340-1. Epub 2018 Aug 24.
  22. Ichinohe N, Ishii M, Tanimizu N, Kon J, Yoshioka Y, Ochiya T, Mizuguchi T, Hirata K, Mitaka T.: Transplantation of Thy1+ Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-like Progenitor Cells via IL17RB Signaling. Stem Cells. 35:920-931, 2017
  23. Kutomi G, Mizuguchi T, Satomi F, Maeda H, Shima H, Kimura Y, Hirata K. Current status of the prognostic molecular biomarkers in breast cancer: A systematic review. Oncol Lett. 13:1491-1498, 2017.
  24. Ishii M, Kon J, Ichinohe N, Tanimizu N, Ninomiya T, Suzuki H, Mizuguchi T, Hirata K, Mitaka T.: Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture. Sci. Rep. 7, 46177, 2017.
  25. Yamaguchi H, Kimura Y, Imamura M, Nagayama M, Ito T, Nobuoka T, Mizuguchi T, Takemasa I. Oncological features and outcomes of curatively resected non-functional pancreatic neuroendocrine tumor: single institute experiences. JOP. 18:380-386, 2017
  26. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K.　Corrigendum to 'Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014-2015. J Infect Chemother. 2017 Jun;23(6):339-348.
  27. Asayama K, Ohkubo T, Satoh A, Tanaka S, Higashiyama, A, Murakami, Y, Yamada M, Saitoh S, Okayama A, Miura K, Ueshima H, Miyamoto Y, Okamura T on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group. Cardiovascular risk and blood pressure lowering treatment among elderly individuals: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan. Journal of Hypertension 2018, 36( 2) ; 410–418
  28. Furuhashi M, Yuda S, Muranaka A, Kawamukai M, Matsumoto M, Tanaka M, Moniwa N, Ohnishi H, MD, Saitoh S, Shimamoto K, Miura T. Circulating Fatty Acid-Binding Protein 4 Concentration Predicts the Progression of Carotid Atherosclerosis in a General Population Without Medication. Circ J 2018; 82: 1121 – 1129
  29. Hirakawa Y, Ninomiya T, Kiyohara Y, Murakami Y, Saitoh S, Nakagawa H, Okayama A, Tamakoshi A, Sakata K, Miura K, Ueshima H, Okamura T, Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN). Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN). Journal of epidemiology. 2017;27:123-129
  30. Koyama T, Yoshita K, Okuda N, Saitoh S, Sakata K, Okayama A, Nakagawa H, Miyagawa N, Miura K, Chan Q, Elliott P, Stamler J, Ueshima H. Overall nutrient and total fat intake among Japanese people: The INTERLIPID Study Japan. Asia Pacific Cournal of clinical nutrition;2017; 26(5)837-848
  31. Ogawa T, Hirohashi Y, Murai A, Nishidate T, Okita K, Wang L, Ikehara Y, Satoyoshi T, Usui A, Kubo T, Nakastugawa M, Kanaseki T, Tsukahara T, Kutomi G, Furuhata T, Hirata K, Sato N, Mizuguchi T, Takemasa I, Torigoe T. ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway. Oncotarget. 2017 Nov 8;8(68):112550-112564.

総説

  1. 斎藤重幸．糖尿病．腎と透析．2018、85：228-233．
  2. 斎藤重幸．糖尿病と高血圧．血圧．2018、25：818-822．
  3. 斎藤重幸．わが国の糖尿病のトレンド．日本循環器予防学会．2018、53：211-219.
  4. 斎藤重幸．認知症合併の降圧療法．Current Thrapy．2019、37：586-591．
  5. 大西浩文，斎藤重幸．端野・壮瞥町研究．循環器内科．2019，85：855-861.
  6. 斎藤重幸．他疾患を合併する高血圧の治療．Heart View．2019、23：1064-1069．
  7. 斎藤重幸．高血圧治療ガイドライン2019改訂のポイント．調剤と情報．2019、16：2522-2527．
  8. 斎藤重幸．ほかの疾患を合併する高血圧（糖尿病・メタボリックシンドローム・脂質異常症・高尿酸血症）．医学のあゆみ．2019、270：319-323．
  9. 斎藤重幸．日本人に適した高血圧治療．大津医師会雑誌．2019、42：23-26．
  10. 斎藤重幸．メタボリックシンドロームと高血圧．臨床検査．2020、64：140-145．
  11. 斎藤重幸．糖尿病合併する高血圧．日本臨床．2020、78：297-303．
  12. 斎藤重幸．収縮期血圧140mmHg，薬剤を追加して下げるべきか？ 循環器ジャーナル 2018，66：48-57．
  13. 斎藤重幸．高血圧とその管理．日本冠動脈学会雑誌 2017，23：103-107．

競争的資金

  • 高齢者のがん治療をサポートするヘルスプラットフォームを開発する研究 (リレーフォーライフジャパン：日本対がん協会) R2 (水口 徹)
  • 高齢がん患者の外科治療を支援する健康デジタルプラットフォームの構築（安田記念医学財団）R2 (石貫智裕)
  • B型肝炎による肝硬変・肝がん治療後のQOL調査による医療経済研究 (北海道B型肝炎訴訟オレンジ基金) R2 (水口 徹)
  • 患者幸福を実現するオンライン医療管理システムの開発 (ファイザーヘルスリサーチ振興財団) R2 代表 (水口 徹)
  • 外科治療後の健康科学評価と患者意志決定に新基準を創造する研究 (テルモ生命科学振興財団) R2 代表 (水口 徹)
  • クラウド管理によるウイルス肝炎・肝がんのQOL情報のアクティブ化とAIによる費用対効果の透明化 (ウイルス肝炎研究財団) R3 代表 (水口 徹)
  • 外科術後のQOL値を明らかにするPROとフィードバックシステムの構築と実装研究 R2～R4 科学研究費助成金 （基盤研究C） 代表（水口 徹）
  • 重症患者とその家族に対するWEBシステムの精神的サポート効果と予後予測モデル開発 R3～R5 科学研究費助成金 （基盤研究C） 代表（石貫智裕） 分担（水口 徹）
  • 循環器疾患における集団間格差のじっつたいと把握とその対策を目的とした大規模コホート研究：厚生労働科学研究費補助金 研究期間 :2011年 - 2015年 代表者 : 岡村智教 分担者：斎藤重幸

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