Kogo R, Manako T, Iwaya T, Nishizuka S, Hiraki H, Sasaki Y, Idogawa M, Tokino T, Koide A, Komune N, Yasumatsu R, Nakagawa T. Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma. Cancer Med. in press.
Iwaya T, Endo F, Takahashi F, Tokino T, Sasaki Y, Nishizuka SS, Collaborators. Frequent tumor burden monitoring of esophageal squamous cell carcinoma with circulating tumor DNA using individually designed digital PCR. Gastroenterology. 160: 463-465, 2021.
Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nature communications 12: 3390, 2021.
Fujisawa R, Iwaya T, Endo F, Idogawa M, Sasaki N, Hiraki H, Tange S, Hirano T, Koizumi Y, Abe M, Takahashi T, Yaegashi M, Akiyama Y, Masuda M, Sasaki A, Takahashi F, Sasaki Y, Tokino T, Nishizuka SS. Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer. Carcinogenesis. 42: 1239-49, 2021.
Hatanaka Y, Niinuma T, Kitajima H, Nishiyama K, Maruyama R, Ishiguro K, Toyota M, Yamamoto E, Kai M, Yorozu A, Sekiguchi S, Ogi K, Dehari H, Idogawa M, Sasaki Y, Tokino T, Miyazaki A, Suzuki H. DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes. Sci Rep. 11: 20438, 2021.
Oike T, Sekiguchi Y, Yoshimoto Y, Oike T, Ando K, Gu W, Sasaki Y, Tokino T, Iwase A, Ohno T. Mutation Analysis of Radioresistant Early-Stage Cervical Cancer. Int J Mol Sci. 23: 2021.
Saito T, Tsukahara T, Suzuki T, Nojima I, Tadano H, Kawai N, Kubo T, Hirohashi Y, Kanaseki T, Torigoe T, Li L. Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma. Cancer Sci. 112:550-562, 2021.
Nakakura T, Suzuki T, Horiguchi K, Tanaka H, Arisawa K, Miyashita T, Nekooki-Machida Y, Hagiwara H. Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization. Cell Tissue Res. 384:449-463, 2021.
Nakakura T, Suzuki T, Tanaka H, Arisawa K, Miyashita T, Nekooki-Machida Y, Kurosawa T, Tega Y, Deguchi Y, Hagiwara H. Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary. Cell Tissue Res. 383:823-833, 2021.
Hida T, Idogawa M, Okura M, Sugita S, Sugawara T, Sasaki Y, Tokino T, Yamashita T, Uhara H. Genetic analyses of mosaic neurofibromatosis type 1 with giant cafe-au-lait macule, plexiform neurofibroma and multiple melanocytic nevi. J Dermatol. 47: 658-62, 2020.
Yokose T, Kitago M, Matsuda S, Sasaki Y, Masugi Y, Nakamura Y, Shinoda M, Yagi H, Abe Y, Oshima G, Hori S, Fujita Y, Nakano Y, Endo Y, Abe K, Tokino T, Kitagawa Y. Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer. Cancer Sci. 111: 2174-82, 2020.
12. Ota R, Sawada T, Tsuyama S, Sasaki Y, Suzuki H, Kaizaki Y, Hasatani K, Yamamoto E, Nakanishi H, Inagaki S, Tsuji S, Yoshida N, Doyama H, Minato H, Nakamura K, Kasashima S, Kubota E, Kataoka H, Tokino T, Yao T, Minamoto T. Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas. J Pathol. 252: 330-42, 2020.
Yoshimoto Y, Sasaki Y, Murata K, Noda S, Miyasaka Y, Hamamoto J, Furuya M, Hirato J, Suzuki Y, Ohno T, Tokino T, Oike T, Nakano T. Mutation profiling of uterine cervical cancer patients treated with definitive radiotherapy. Gynecol Oncol. 159: 546-553, 2020.
Udagawa C, Sasaki Y, Tanizawa Y, Suemizu H, Ohnishi Y, Nakamura Y, Tokino T, Zembutsu H. Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs. PLoS One. 15: e0239614, 2020.
Ishiguro K, Sasaki Y, Takagi Y, Niinuma T, Suzuki H, Tokino T, Hayashi T, Takahashi T, Igarashi T, Matsuno Y. Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy: A case report. Medicine (Baltimore). 99: e21938, 2020.
Fujita Y, Matsuda S, Sasaki Y, Masugi Y, Kitago M, Yagi H, Abe Y, Shinoda M, Tokino T, Sakamoto M, Kitagawa Y. Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis. Cancer Sci. 111: 739-48, 2020.
Ogi K, Kobayashi J, Nakagaki T, Okamoto J, Koike K, Hirokawa N, Someya M, Sakamoto H, Takada K, Tokino T, Sasaki Y, Hiratsuka H, Miyazaki A. Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients. Oral Oncol. 102: 104509, 2020.
Nakanishi H, Sawada T, Kaizaki Y, Ota R, Suzuki H, Yamamoto E, Aoki H, Eizuka M, Hasatani K, Takahashi N, Inagaki S, Ebi M, Kato H, Kubota E, Kataoka H, Takahashi S, Tokino T, Minamoto T, Sugai T, Sasaki Y. Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum. PLoS One. 15: e0229262, 2020.
Idogawa M, Hida T, Tanaka T, Ohira N, Tange S, Sasaki Y, Uhara H, Masumori N, Tokino T, Natori H. Renal angiomyolipoma (AML) harboring a missense mutation of TSC2 with copy-neutral loss of heterozygosity (CN-LOH). Cancer Biol Ther. 21: 315-319, 2020.
Suzuki N, Idogawa M, Tange S, Ohashi T, Sasaki Y, Nakase H, Tokino T. p53-induced ARVCF modulates the splicing landscape and supports the tumor suppressive function of p53. Oncogene. 39: 2202-2211, 2020.
Ishiguro K, Kitajima H, Niinuma T, Ishida T, Maruyama R, Ikeda H, Hayashi T, Sasaki H, Wakasugi H, Nishiyama K, Shindo T, Yamamoto E, Kai M, Sasaki Y, Tokino T, Nakase H, Suzuki H. DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling. Haematologica 104: 155-65, 2019.
Adachi Y, Mita H, Sasaki Y, Himori R, Onodera K, Nakamura M, Kikuchi T, Yamashita K, Yoshida Y, Ishii Y, Endo T. Malignant paraganglioma of posterior mediastinum – a case report with genetic analysis. Mol Clin Oncol. 10: 10-16, 2019.
Fukamachi H, Kim SK, Koh J, Lee HS, Sasaki Y, Yamashita K, Nishikawaji T, Shimada S, Akiyama Y, Byeon SJ, Bae DH, Okuno K, Nakagawa M, Tanioka T, Inokuchi M, Kawachi H, Tsuchiya K, Kojima K, Tokino T, Eishi Y, Kim YS, Kim WH, Yuasa Y, Tanaka S: A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors. Exp Clin Cancer Res. 38: 127, 2019.
Idogawa M, Nakase H, Sasaki Y, Tokino T. Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer. J Oncol. 2: 4368068, 2019.
Darwis NDM, Nachankar A, Sasaki Y (Contributed equally), Matsui T, Noda S, Murata K, Tamaki T, Ando K, Okonogi N, Shiba S, Irie D, Kaminuma T , Kumazawa T, Anakura M, Yamashita S, Hirakawa T, Kakoti S, Hirota Y, Tokino T, Iwase A, Ohno T, Shibata A, Oike T, Nakano T. FGFR Signaling as Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy. Int. J. Mol. Sci. 20: 4563, 2019.
Shindo T, Hirobe M, Adachi Y, Sasaki Y, Tokino T, Masumori N. Genomic characterization for familial cases with urothelial carcinoma. Int Cancer Conf J. 8: 185-89, 2019.
Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H. Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs. Exp Ther Med 15: 1339-59, 2018
Takahashi Y, Saito A, Chiba H, Kuronuma K. Ikeda K. Kobayashi T, Ariki S, Takahashi M, Sasaki Y, Takahashi H. Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis. Respir Res 19: 34, 2018.
Takashima Y, Sasaki Y, Hayano A, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Tokino T, Yamanaka R. Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma. Oncotarget 9: 27471-86, 2018.
Adachi Y, Akino K, Nojima M, Himori R, Kikuchi T, Mita H, Nakamura M, Tsukuda H, Yamano HO, Sasaki Y, Yoshida Y, Kato Y, Nakase H, Endo, T. Prognostic nutritional index and early mortality with percutaneous endoscopic gastrostomy. QJM. 111: 635-41, 2018.
Nakagaki T, Tamura M, Kobashi K, Omori A, Koyama R, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y. Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma. Tumor Biol. 40: 1010428318800180, 2018.
Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y, Suzuki M, Okuse C, Iwabuchi S, Nakano M, Akutsu N, Kang JH, Matsui T, Yamada N, Sasaki H, Yamamoto E, Kai M, Sasaki Y, Sasaki S, Tanaka Y, Yotsuyanagi H, Tsutsumi T, Yamamoto H, Tokino T, Nakase H, Suzuki H, Itoh F. Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment. Cancer Lett. 434: 91-100, 2018.
Nishiyama K, Maruyama R, Niinuma T, Kai M, Kitajima H, Toyota M, Hatanaka Y, Igarashi T, Kobayashi JI, Ogi K, Dehari H, Miyazaki A, Yorozu A, Yamamoto E, Idogawa M, Sasaki Y, Sugai T, Tokino T, Hiratsuka H, Suzuki H. Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1. Cell Death Dis. 9: 826, 2018.
Nuryadi E, Sasaki Y (Contributed equally), Hagiwara Y, Bunga Mayang Permata T, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda S, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, Nakano T. Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy. Oncotarget 9: 32642-52, 2018.
Harada T, Yamamoto E, Yamano HO, Aoki H, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Eizuka M, Yorozu A, Sudo G, Kitajima, H, Niinuma, T, Kai, M, Sasaki, Y, Tokino, T, Sugai, T, Nakase, H, Suzuki, H. Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors. J Gastroenterol. 53: 1241-52, 2018.
Horibe R, Hirohashi R, Asano T, Mariya T, Suzuki T, Takaya A, Saijo H, Shionoya Y, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Watanabe K, Torigoe T. Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy. PLoS ONE. 12(3): e0171460, 2017.
Nakakura T, Suzuki T, Horiguchi K, Fujiwara K, Tsukada T, Asano-Hoshino A, Tanaka H, Arisawa K, Nishijima Y, Nekooki-Machida Y, Kiuchi Y, Haruo Hagiwara. Expression and localization of forkhead box protein FOXJ1 in S100beta-positive multiciliated cells of the rat pituitary. Med Mol Morphol. 50:59-67, 2017.
Nakakura T, Suzuki T, Torii S, Asano-Hoshino A, Nekooki-Machida Y, Tanaka H, Arisawa K, Nishijima Y, Susa T, Okazaki T, Kiuchi Y, Hagiwara H. ATAT1 is essential to regulate the homeostasis-retaining cellular responses in corticotrophs along the hypothalamic-pituitary-adrenal axis. Cell Tissue and Res. 370:169-178, 2017.
Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y. Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. Oncotarget, 8: 59113-22, 2017.
Tokino T, Idogawa M, Sasaki Y. Fledglings in p53 signaling network. Oncotarget. 8: 55768-69, 2017.
Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y. Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53. Cancer Sci. 108: 2413-21, 2017.
Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Arimura Y, Tokino T, Carbone DP, Imai K, Shinomura Y. The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy. Mol Carcinog 56: 515-526, 2017.
Ohashi T, Idogawa M, Sasaki Y, Tokino T. p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN. Cancer Lett. 390: 58-66, 2017.
Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaki Y, Tokino T, Esumi M. Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation. PLoS One. 12: e0176280, 2017.
Idogawa M, Ohashi T, Sasaki Y, Nakase H, Tokino T. Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. Int J Cancer. 140: 2785-91, 2017.