大学院研究科

基礎臨床医療科学

教育研究分野紹介

博士課程前期

 看護学との関連より疾病の病態・病理、診断、治療、疫学を概説し、症例検討を通じ、看護・診療上の問題点について探求します。

博士課程後期

 臨床病態内科学では、臨床医学の基本である内科学を看護学研究の立場から検討します。特に生活習慣病の疫学、病態、内科管理治療、予防を俯瞰し、普遍的な看護理論や生活習慣病特有の管理理論を考察します。

教員紹介

教授 齋藤 重幸
教授 水口 徹

研究テーマ

  1. 生活習慣病の疫学と予防循環器
  2. インスリン抵抗性の病態解明

研究業績

研究論文
  1. Asayama K, Ohkubo T, Satoh A, Tanaka S, Higashiyama, A, Murakami, Y, Yamada M, Saitoh S, Okayama A, Miura K, Ueshima H, Miyamoto Y, Okamura T on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group. Cardiovascular risk and blood pressure lowering treatment among elderly individuals: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan. Journal of Hypertension 2018,  36( 2) ; 410–418
  2. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Nakajima K, Ueda T, Uchino M, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan.  J Infect Chemother. 2018 May;24(5):330-340.
  3. Hirakawa Y, Ninomiya T, Kiyohara Y, Murakami Y, Saitoh S, Nakagawa H, Okayama A, Tamakoshi A, Sakata K, Miura K, Ueshima H, Okamura T, Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN). Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN). Journal of epidemiology. 2017;27:123-129
  4. Koyama T, Yoshita K, Okuda N, Saitoh S, Sakata K, Okayama A, Nakagawa H, Miyagawa N, Miura K, Chan Q, Elliott P, Stamler J, Ueshima H. Overall nutrient and total fat intake among Japanese people: The INTERLIPID Study Japan. Asia Pacific journal of clinical nutrition  2017; 26(5) 837-848
  5. Hirata T, Sugiyama D, Nagasawa SY, Murakami Y, Saitoh S, Okayama A, Iso H, Irie F, Sairenchi T, Miyamoto Y, Yamada M, Ishikawa S, Miura K, Ueshima H, Okamura T, Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group. A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan. European journal of epidemiology   1-11   Oct 2016 
  6. Okayama A, Okuda N, Miura K, Okamura T, Hayakawa T, Akasaka H, Ohnishi H, Saitoh S, Arai Y, Kiyohara Y, Takashima N, Yoshita K, Fujiyoshi A, Zaid M, Ohkubo T, Ueshima H, NIPPON DATA80 Research Group. Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study. BMJ open   6(7) e011632   Jul 2016
  7. Okuda N, Okayama A, Miura K, Yoshita K, Saitoh S, Nakagawa H, Sakata K, Miyagawa N, Chan Q, Elliott P, Ueshima H, Stamler J.  Food sources of dietary sodium in the Japanese adult population: the international study of macro-/micronutrients and blood pressure (INTERMAP). European journal of nutrition   1-12   Feb 2016 
  8. Ohnishi H, Saitoh S, Akasaka H, Furukawa T, Mori M, Miura T. Impact of longitudinal status change in metabolic syndrome defined by two different criteria on new onset of type 2 diabetes in a general Japanese population: the Tanno–Sobetsu Study. Diabetol Metab Syndr (2016) 8:64. DOI 10.1186/s13098-016-0182-0
  9. Ichinohe N, Ishii M, Tanimizu N, Kon J, Yoshioka Y, Ochiya T, Mizuguchi T, Hirata K, Mitaka T.: Transplantation of Thy1+ Cells Accelerates Liver Regeneration by Enhancing the Growth of Small Hepatocyte-like Progenitor Cells via IL17RB Signaling. Stem Cells. 35:920-931, 2017
  10. Kutomi G, Mizuguchi T, Satomi F, Maeda H, Shima H, Kimura Y, Hirata K. Current status of the prognostic molecular biomarkers in breast cancer: A systematic review. Oncol Lett. 13:1491-1498, 2017.
  11. Ishii M, Kon J, Ichinohe N, Tanimizu N, Ninomiya T, Suzuki H, Mizuguchi T, Hirata K, Mitaka T.: Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture. Sci. Rep. 7, 46177, 2017.
  12. Yamaguchi H, Kimura Y, Imamura M, Nagayama M, Ito T, Nobuoka T, Mizuguchi T, Takemasa I. Oncological features and outcomes of curatively resected non-functional pancreatic neuroendocrine tumor: single institute experiences. JOP. 18:380-386, 2017
  13. Takesue Y, Kusachi S, Mikamo H, Sato J, Watanabe A, Kiyota H, Iwata S, Kaku M, Hanaki H, Sumiyama Y, Kitagawa Y, Mizuguchi T, Ambo Y, Konosu M, Ishibashi K, Matsuda A, Hase K, Harihara Y, Okabayashi K, Seki S, Hara T, Matsui K, Matsuo Y, Kobayashi M, Kubo S, Uchiyama K, Shimizu J, Kawabata R, Ohge H, Akagi S, Oka M, Wakatsuki T, Suzuki K, Okamoto K, Yanagihara K. Corrigendum to 'Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014-2015. J Infect Chemother. 2017 Jun;23(6):339-348.
  14. Ogawa T, Hirohashi Y, Murai A, Nishidate T, Okita K, Wang L, Ikehara Y, Satoyoshi T, Usui A, Kubo T, Nakastugawa M, Kanaseki T, Tsukahara T, Kutomi G, Furuhata T, Hirata K, Sato N, Mizuguchi T, Takemasa I, Torigoe T. ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway.  Oncotarget. 2017 Nov 8;8(68):112550-112564.
  15.   Nakai M, Miyamoto Y, Higashiyama A, Murakami Y, Nishimura K, Yatsuya H, Saitoh S, Sakata K, Iso H, Miura K, Ueshima H, Okamura T, EPOCH-JAPAN Research Group. Calibration between the Estimated Probability of the Risk Assessment Chart of Japan Atherosclerosis Society and Actual Mortality Using External Population: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN). Journal of atherosclerosis and thrombosis   23(2) 195   Sep 2015 ]
  16. Midori Sato M, Ohnishi H,  Ohnishi-Kameyama M, Matsunaga I, Naito S, Ippoushi K, Oike H, Nagata T, Akasaka H, Saitoh S, Shimamoto K, Kobori M. Estimated Daily Intake and Seasonal Food Sources of Quercetin in Japan. Nutrients 7: 2345-2358; 2015. doi:10.3390/nu7042345 (registering DOI)
  17. Fujii M, Ohnishi H, Saitoh S, Akasaka H, Miura T, Mori M. The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset hypertension in the general Japanese population: the Tanno–Sobetsu study. Hypertens Res 38: 426-432; advance online publication, March 19, 2015; doi:10.1038/hr.2015.27
  18. Ohnishi H, Saitoh S, Akasaka H, Furukawa T, Mori M, Miura T. Combination of type 2 diabetes and smoking increases total cancer mortality in Japanese men using competing risk analysis: the Tanno-Sobetsu study. Diabetol Int. 2016. DOI 10.1007/s13340-015-0232-0
  19. Furuhashi M, Yuda S, MD, Muranaka A, Kawamukai M, Matsumoto M, Tanaka M, Moniwa N, Ohnishi H, Saitoh S. Circulating Fatty Acid-Binding Protein 4 Concentration Predicts the Progression of Carotid Atherosclerosis in a General Population Without Medication.Circ J. doi: 10.1253/circj.CJ-17-1295
  20. Akasaka H, Ohnishi H, Narita Y, Kameda M, Miki T, Takahashi H, Wari Yamamot Y, Sohma H, SPRUCE project investigators. The Serum Level of KL-6 is Associated with the Risk of Insulin Resistance and New-onset Diabetes Mellitus: The Tanno-Sobetsu Study.  Intern Med. DOI: 10.2169/internalmedicine.8716-16)
  21. Imamura M, Kimura Y, Ito T, Kyuno T, Nobuoka T, Mizuguchi T, Hirata K.: Effects of antecolic versus retrocolic reconstruction for gastro/duodenojejunostomy on delayed gastric emptying after pancreatoduodenectomy: a systematic review and meta-analysis. J Surg Res,  200:147-57, 2016
  22. Tanimizu N, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, Hirata K, Miyajima A, Mitaka T.: Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement. Hepatology. 64:175-88, 2016
  23. Kinoshita M, Kubo S, Nakanuma Y, Sato Y, Takemura S, Tanaka S, Hamano G, Ito T, Terajima H, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Sugawara Y, Yamamoto T, Abue M, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Shirabe K, and Shibata T.: Pathological spectrum of bile duct lesions from chronic bile duct injury to invasive cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 23:92-101, 2016.
  24. Morita R, Hirohashi Y, Torigoe T, Ito-Inoda S, Takahashi A, Mariya T, Asanuma H, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Kutomi G, Mizuguchi T, Terui T, Ishitani K, Hashino S, Kondo T, Minagawa N, Takahashi N, Taketomi A, Todo S, Asaka M, Sato N: Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy. Clin Cancer Res, 22:3298-309, 2016
  25. Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Hamano G, Ito T, Koda M, Aota T, Yamamoto T, Terajima H, Tachiyama G, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Tomimaru Y, Sugawara Y, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Kimura K, Shirabe K, Saiura A, Uesaka K, Taniguchi H, Fukuda A, Chong JM, Kuwae Y, Ohsawa M, Sato Y, Nakanuma Y. Outcomes after resection of occupational cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 2016 Sep;23(9):556-64.
  26. Tanimizu N, Ichinohe N, Ishii M, Kino J, Mizuguchi T, Hirata K, Mitaka T.: Liver progenitors isolated from adult healthy mouse liver efficiently differentiate to functional hepatocytes in vitro and repopulate liver tissue. Stem Cells. 34:2889-2901, 2016
  27. Ota S, Nishimura M, Murakami Y, Birukawa NK, Yoneda A, Nishita H, Fujita R, Sato Y, Minomi K, Kajiwara K, Miyazaki M, Uchiumi M, Mikuni S, Tamura Y, Mizuguchi T, Imamura M, Meguro M, Kimura Y, Hirata K, Niitsu Y. Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy. PLoS One. 2016 11:e0165747.
  28. Rodriguez-Araujo G, Nakagami H, Takami Y, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Morishita R, Rakugi H, Kaneda Y. Low alpha-synuclein levels in the blood are associated with insulin resistance. Sci Rep. 2015; 5: 12081.
  29. Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H. Disease-associated polymorphisms in 9p21 are not associated with extreme longevity. Geriatr Gerontol Int. 2015; 15(6): 797-803.
  30. Mita T, Furuhashi M, Hiramitsu S, Ishii J, Hoshina K, Ishimura S, Fuseya T, Watanabe Y, Tanaka M, Ohno K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T. FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms. Obesity. 2015; 23(2): 359-367.
  31. Furuhashi M, Moniwa N, Mita T, Fuseya T, Ishimura S, Ohno K, Shibata S, Tanaka M, Watanabe Y, Akasaka H, Ohnishi H, Yoshida H, Takizawa H, Saitoh S, Ura N, Shimamoto K, Miura T. Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker. Am J Hypertens. 2015; 28(1): 15-21.
  32. Mizuguchi T, Kawamoto M, Nakamura Y, Meguro M, Harada K, Ota S, Hui TT, Hirata K.:      New technique of extracorponeal hepatic inflow control for pure laparoscopic liver resection. Surg Laparosc Endosc Percutan Tech 25:e16-20, 2015
  33. Mizuguchi T, Kawamoto M, Meguro M, Okita K, Ota S, Ishii S, Ueki T, Kimura Y, Furuhata T,  Hirata K.: The impact of aging on morbidity and mortality after liver resection: a systematic review and meta-analysis. Surg Today 45:259-270, 2015
  34. Keira Y, Takasawa A, Murata M, Nojima M, Takasawa K, Ogino J, Higashiura Y, Sasaki A, Kimura Y, Mizuguchi T, Tanaka S, Hirata K, Sawada N, Hasegawa T.: An immunohistochemical marker panel including claudin-18, maspin, and p53 improves diagnostic accuracy of bile duct neoplasms in surgical and presurgical biopsy specimens. Virchows Arch. 466:265-277, 2015
  35. Satomi F, Shima H, Mizuguchi T, Torigoe T, Kutomi G, Kimura Y, Hirohashi Y, Tamura Y,  Tsukahara T, Kanaseki T, Takahashi A, Asanuma H, Ito Y, Hayashi H, Sugita O, Sato N, Hirata K.: Phase I Clinical Study of Survivin-Derived Peptide Vaccine for Patients with Advanced Gastrointestinal Cancers. Int J Cancer Clin Res 2:1, 2015
  36. Iwayama Y, Tsuruma T, Mizuguchi T, Furuhata T, Toyota N, Matsumura M, Torigoe T, Sato N,  Hirata K.: Prognostic value of HLA class I expression in patients with colorectal cancer. World J Surg Oncol 13: 36, 2015
  37. Sato Y, Ohnuma H, Hirakawa M, Takahashi M, Osuga T, Okagawa Y, Murase K, Takada K, Kawano Y, Iyama S, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kobune M, Okita K, Mizuguchi T, Furuhata T, Hirata K, Kato J.: A dose-escalation study of oxaliplatin/capecitabine/irinotecan (XELOXIRI) and bevacizumab as a first-line therapy for patients with metastatic colorectal cancer. Cancer Chemother Pharmacol 75:587-594, 2015
  38. Meguro M, Mizuguchi T, Nishidate T, Okita K, Ishii M, Ota S, Ueki T, Akizuki E, Hirata K.: Prognostic roles of preoperative a-fetoprotein and des-g-carboxy prothrombin in hepatocellular carcinoma patients. World J Gastroenterol 21:4933-45, 2015
  39. Meguro M, Mizuguchi T, Kawamoto M, Ota S, Ishii M, Nishidate T, Okita K, Kimura Y, Hirata K.: Clinical comparison of laparoscopic and open liver resection after propensity matching selection. Surgery 158:573-87, 2015
  40. Beppu T, Wakabayashi G, Hasegawa K, Gotohda N, Mizuguchi T, Takahashi Y, Hirokawa F, Taniai N, Watanabe M, Katou M, Nagano H, Honda G, Baba H, Kokudo N, Konishi M, Hirata K, Yamamoto M, Uchiyama K, Uchida E, Kusachi S, Keiichi K, Mori M, Takahashi K, Kikuchi K, Miyata H, Takahara T, Nakamura M, Kaneko H, Yamaue H, Miyazaki M, Takada T.: Long-term and perioperative outcomes of laparoscopic vs open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study.  J Hepatobiliary Pancreat Sci. 22:711-20, 2015
  41. Takahara T, Wakabayashi G, Beppu T, Aihara A, Hasegawa K, Gotohda N, Hatano E, Tanahashi Y, Mizuguchi T, Kamiyama T, Ikeda T, Tanaka S, Taniai N, Baba H, Tanabe M, Kokudo N, Konishi M, Uemoto S, Sugioka A, Hirata K, Taketomi A, Maehara Y, Kubo S, Uchida E, Miyata H, Nakamura M, Kaneko H, Yamaue H, Miyazaki M, Takada T.: Long-term and perioperative outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with propensity score matching: a multi-institutional Japanese study.  Long-term and perioperative outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with propensity score matching: a multi-institutional Japanese study.  J Hepatobiliary Pancreat Sci, 22:721-7, 2015
  42. Ishii M, Kimura Y, Sugita S, Imamura M, Ito T, Nobuoka T, Meguro M, Hasegawa T, Mizuguchi T, Hirata K.: Surgical and oncological impact of main pancreatic duct spread in invasive ductal adenocarcinoma: A clinicopathological study of 184 resected cases. Pancreatology, 15:681-7, 2015
  43. Ishiyama G, Nishidate T, Ishiyama Y, Nishio A, Tarumi K, Kawamura M, Okita K, Mizuguchi T, Fujimiya M, Hirata K.: Anal cushion lifting method is a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications. World J Gastrointest Surg, 7:273-8, 2015
  44. Okazaki Y, Furuhashi M, Tanaka M, Mita T, Fuseya T, Ishimura S, Watanabe Y, Hoshina K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T. Urinary excretion of fatty acid-binding protein 4 is associated with albuminuria and renal dysfunction. PLoS One. 2014; 9(12): e115429.
  45. Miki T, Tobisawa T, Sato T, Tanno M, Yano T, Akasaka H, Kuno A, Ogasawara M, Murase H, Saitoh S, Miura T. Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes? Cardiovasc Diabetol. 2014; 13(1): 125.
  46. Fuseya T, Furuhashi M, Yuda S, Muranaka A, Kawamukai M, Mita T, Ishimura S, Watanabe Y, Hoshina K, Tanaka M, Ohno K, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Shimamoto K, Miura T. Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population. Cardiovasc Diabetol. 2014; 13(1): 126.
  47. Yoshida H, Akasaka H, Saitoh S, Shimamoto K, Miura T. Comparative effects of telmisartan and valsartan as add-on agents for hypertensive patients with morning blood pressure insufficiently controlled by amlodipine monotherapy.
  48. Ohnishi H,  Midori Sato M, Ohnishi-Kameyama M, Matsunaga I, Naito S, Ippoushi K, Oike H, Nagata T, Akasaka H, Saitoh S, Shimamoto K, Kobori M. Estimated Daily Intake and Seasonal Food Sources of Quercetin in Japan. Nutrients 7: 2345-2358; 2015. doi:10.3390/nu7042345
  49. Okuda N, Stamler J, Brown IJ, Ueshima H, Miura K, Okayama A, Saitoh S, Nakagawa H, Sakata K, Yoshita K, Zhao L, Elliott P; INTERMAP Research Group. Individual efforts to reduce salt intake in China, Japan, UK, USA: what did people achieve? The INTERMAP Population Study. J Hypertens. 32: 2385-2392, 2014.
  50. Fuseya T, Furuhashi1 M, Yuda S, Muranaka A, Kawamukai M, MitaT, Ishimura S, Watanabe Y, HoshinaK, Tanaka M, Ohno K, Akasaka H, OhnishiH, YoshidaH, Saitoh S, Shimamoto K, Miura T. Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular di astolic dysfunction in a general population. Cardiovascular Diabetology 13: 1-9, 2014
  51. Miki T, Tobisaw T, Sato T, Tanno M, Yano T, Akasaka H, Kuno A, Ogasawara M, MuraseH, Saitoh S, MiuraT. Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?. Cardiovascular Diabetology, 2014, 13:125http://www.cardiab.com/content/13/1/125
  52. Kondo I, Ojima T, Nakamura M, Hayasaka S, Hozawa A, Saitoh S, Ohnishi H, Akasaka H, Hayasaka T, Murakami Y, Okuda N, Miura K, Okayama A Ueshima H, for the NIPPON DATA 80 research group. Consumpyion of dairy products and death from cardiovascular disease in Japanese general population: The NIPPON DATA80. J Epidemiol 23: 47-54, 2014
  53. 西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 目黒 誠, 水口 徹, 平田公一:直腸癌術後surgical site infection発生リスク因子の検討 特に腹腔鏡下手術の関与. 日外感染症会誌 11: 307-310, 2014
  54. 品川長夫, 谷口正哲, 平田公一, 古畑智久, 水口 徹, 長内宏之, 柳内良之, 秦 史壯, 鬼原 史, 佐々木 一晃, 大野敬祐, 中村誠志, 渋谷 均, 長谷川 格, 木村雅美, 渡部公祥, 星川 剛, 大島秀紀, 相川直樹, 佐々木淳一, 鈴木 昌, 関根和彦, 安倍晋也, 竹山廣光, 若杉健弘, 真下啓二, 田中守嗣, 水野 章, 石川雅一, 岩井昭彦, 齋藤高明, 村元雅之, 久保正二, 李 栄柱, 福原研一朗, 小林康人, 山上裕機, 廣野誠子, 竹末芳生, 藤原俊義, 篠浦 先, 木村秀幸, 岩垣博巳, 徳永尚之, 末田泰二郎, 檜山英三, 村上義昭, 大毛宏喜, 上村健一郎, 津村裕昭, 金廣哲也, 竹内仁司, 田中屋 宏爾, 岩崎充博:外科感染症分離菌とその薬剤感受性2011年度分離菌を中心に. Jpn J Antibiot 67:339-383, 2014
  55. 中村ゆかり, 中江舞美, 松本宏美, 三浦千秋, 向谷怜奈, 横山麻美, 西舘敏彦, 目黒 誠, 川本雅樹, 古畑智久, 水口 徹, 杉目典子, 平田公一:手指衛生に対する教育的介入の効果とMRSA・緑膿菌感染検出数との関連性の検討. 日外感染会誌 11 :103-108, 2014
  56. Nakamura Y, Mizuguchi T, Tanimizu N, Ichinohe N, Ooe H, Kawamoto M, Meguro M, Hirata K, Mitaka T.: Preoperative hepatocyte transplantation improves the survival of rats with non -alcoholic steatohepatitis-related cirrhosis after partial hepatectomy. Cell Transplant 2014;23:1243-1254.
  57. Mizuguchi T, Kawamoto M, Meguro M, Ota S, Ishii S, Okita K, Kimura Y, Furuhata T, Hirata K.: Left Lateral Sectionectomy Performed Under Minimal Open Access after the Completion of Hand-Assisted Laparoscopic Mobilization. J Liver 2:141, 2014
  58. Meguro M, Mizuguchi T, Kawamoto M, Nishidate T, Ishii M, Tatsumi H, Kimura Y, Furuhata T, Hirata K.: Highest intraoperative lactate level could predict postoperative infectious complications after hepatectomy, reflecting the Pringle maneuver especially in chronic liver disease. J Hepatobiliary Pancreat Sci 21:489-498, 2014
  59. Kikkawa Y, Miwa T, Tanimizu N, Kadoya Y, Ogawa T, Katagiri F, Hozumi K, Nomizu M,  Mizuguchi T, Hirata K, Mitaka T.: Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511 in vitro. Exp Cell Res 328:197-206, 2014
  60. Kubo S, Kinoshita M, Takemura S, Tanaka S, Shinkawa H, Nishioka T, Hamano G, Ito T, Abue M, Aoki M, Nakagawa K, Unno M, Hijioka S, Fujiyoshi T, Shimizu Y, Mizuguchi T, Shirabe K, Nishie A, Oda Y, Takenaka K, Kobarai T, Hisano T, Saiura A, Numao H, Toda M, Kuwae Y, Nakanuma Y, Endo G.: Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma.  J Hepatobiliary Pancreat Sci. 21:809-17, 2014
  61. Ishii S, Mizuguchi T, Kawamoto M, Meguro M, Ota S, Nishidate T, Okita K, Kimura Y, Hui TT, Hirata K.: Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma. World J Gastroenterol 20:3335-3342, 2014
  62. Mizuguchi T, Kawamoto M, Meguro M, Okita K, Nishidate T, Furuhata T, Hui TT, Hirata K.:   Saline injection method for facilitating the liver hanging maneuver during hepatectomy for a large right liver tumor. J Am Col Surg 219:e11-14, 2014
  63. 伊東竜哉, 木村康利, 今村将史, 目黒 誠, 信岡隆幸, 水口 徹, 平田公一:六君子湯投与の膵頭十二指腸切除術後胃排出遅延に与える影響. 胆膵の病態生理 31: 35-42, 2015
  64. Furuhata T, Okita K, Nishidate T, Ito T, Yamaguchi H, Ueki T, Akizuki E, Meguro M, Ogawa T, Kukita K, Kimura Y, Mizuguchi T, Hirata K.: Clinical feasibility of laparoscopic lateral pelvic lymph node dissection following total mesorectal excision for advanced rectal cancer. Surg Today 45:310-314, 2015
  65. Harada K, Mizuguchi T, Kawamoto M, Meguro M, Ota S, Sasaki S, Miyanishi K, Hatakenaka M, Shinomura Y, Kato J, Hirata K.: Prediction of postoperative liver failure and evaluation of modified criteria for liver resection with computed volume analysis. Hepatogastroenterology 2014 (in press).
  66. Yoshihara M, Akasaka H, Ohnishi H, Miki T, Furukawa T, Saitoh S, Miura T. Glucagon-Like Peptide-1 Secretory Function as an Independent Determinant of Blood Pressure: Analysis in the Tanno-Sobetsu Study. PLoS ONE 8(7): e67578. 1-8. doi:10.1371/journal.pone.0067578. 2013.
  67. Ishimura S, Furuhashi M, Watanabe Y, Hoshina K, Fuseya T, Mita T, Okazaki Y, Koyama M, Tanaka M, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T. Circulating levels of fatty acide-binding protein family and metabolic phenotype in the general population. PLoS ONE 8(11): e81318, 1-7.
  68. Ichinohe N, Tanimizu N, Ooe H, Nakamura Y, Mizuguchi T, Kon J, Hirata K, Mitaka T.: Differentiation capacity of hepatic stem/progenitor cells isolated from D-galactOsamine-treated rat livers. Hepatology 57:1192-1202, 2013
  69. Mizuguchi T, Kawamoto M, Meguro M, Nakamura Y, Ota S, Hui TT, Hirata K.: Prognosis and Predictors of Surgical Complications in Hepatocellular Carcinoma Patients With or Without Cirrhosis after Hepatectomy. World J Surg 37:1379-1387, 2013
  70. Meguro M, Mizuguchi T, Kawamoto M, Nakamura Y, Ota S, Kukita K, Ishii M, Tatsumi H, Hirata K.: Continuous monitoring of central venous oxygen saturation predicts postoperative liver dysfunction after liver resection. Surgery 154:351-362, 2013
  71. Tatsumi H, Masuda Y, Imaizumi H, Yoshida S, Goto K, Yama N, Mizuguchi T, Hirata K.: Asialoglycoprotein receptor scintigraphy with 99mTc-galactosyl human serum albumin (99mTc-GSA) as an early predictor of survival in acute liver failure. Anaesth Intensive Care 41:523-528, 2013
  72. Kyuno D, Kimura Y, Imamura M, Uchiyama M, Ishii M, Meguro M, Kawamoto M, Mizuguchi T, Hirata K.: Pancreaticoduodenectomy for biliary tract carcinoma with situs inversus totalis: difficulties and technical notes based on two cases. World J Surg Oncol 11:312, 2013
  73. Tanimizu N, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T.: Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci 126:5239-5246, 2013
  74. 目黒 誠, 水口 徹, 川本雅樹, 平田公一:肝胆膵領域の手術部位ドレーン関連感染症. 日外感染症会誌 10: 233-240, 2013
総説
  1. 斎藤重幸.収縮期血圧140mmHg,薬剤を追加して下げるべきか? 循環器ジャーナル 2018,66:48-57.
  2. 斎藤重幸.高血圧とその管理.日本冠動脈学会雑誌 2017,23:103-107.
  3. Nagayama M, Mizuguchi T, Yamaguchi H, Imamura M, Kutomi G, Okita K, Nishidate T, Takemasa I, Kimura Y.: Technical aspects and surgical complications of laparoscopic liver resection. Ann Laparosc Endosc Surg 2: 61, 2017
  4. Kutomi G, Mizuguchi T, Satomi F, Maeda H, Shima H, Kimura Y, Hirata K. Current status of the prognostic molecular biomarkers in breast cancer: A systematic review. Oncol Lett. 2017 Mar;13(3):1491-1498.
  5. 斎藤重幸.どうして高血圧を治療しなければならないのか? 循環器ナーシング2016,6;23-31.
  6. 斎藤重幸.体質を考慮した高血圧の予防と治療.日本体質学会雑誌 2016,78;32-36.
  7. 斎藤重幸.疫学研究と臨床研究の接点は?循環器内科2016,79;243-247.
  8. 斎藤重幸.日本と欧米のガイドラインの相違.medicina 2016, 53:1712-1715.
  9. 斎藤重幸.今、ある看護系大学で行われていること.ベストナース2016:36-37.
  10. Mizuguchi T, Torigoe T, Satomi F, Shima H, Kutomi G, Ota S, Ishii M, Hayashi H, Asakura S, Hirohashi Y, Meguro M, Kimura Y, Nishidate T, Okita K, Ishino M, Miyamoto A, Hatakenaka M, Sato N, Hirata K.: Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis? Surg Today, 46:139-48, 2016
  11. Okita K, Mizuguchi T, Ota S, Ishii M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K.: Pancreatic regeneration: basic research and gene regulation. Surg Today, 46:633-40, 2016
  12. 水口 徹, 木村康利:腹腔鏡下肝部分切除術. 消外39: 773-781, 2016
  13. 斎藤重幸、赤坂、憲、大西浩文、島本和明、甲斐久史.JSH2014理解と応用―実地医家へのアンケート調査より―.血圧 2015,22;893-897.
  14. 斎藤重幸.高血圧治療におけるRAS抑制薬の位置づけ-わが国のガイドラインの立場から.Angiotensin Research. 2015, 12:17-21.
  15. 斎藤重幸.高血圧.Mordan Physician.2015,35:213-215.
  16. 斎藤重幸.高血圧ガイドライン:JSH2009からJSH2014はの変更の概要.プラクティス.2015,32:155-161.
  17. Furuhashi M, Saitoh S, Shimamoto K, Miura T.  Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases. Clinical Medicine Insights: Cardiology. Supplementary Issue: Inflammation, Atherosclerosis and Coronary Artery Disease.  2015.  Clin Med Insights Cardiol. 2015 Feb 2;8(Suppl 3):23-33. doi: 10.4137/CMC.S17067
  18. 木村康利, 今村将史, 伊東竜哉, 及能拓朗, 信岡隆幸, 目黒 誠, 水口 徹, 平田公一:上部消化管あるいは膵に対する手術既往のある症例に対する膵手術. 消外38:57-67, 2015
  19. 斎藤重幸.高血圧.最新肥満症学‐日本臨床増刊号.2014,74;582-585.
  20. 斎藤重幸.JNC8ガイドライン(米国高血圧合同委員会第8次報告).血圧 2014,21;496-497.
  21. 斎藤重幸.JCN8ガイドラインの作成方針と作成方法.血圧.2104:15-18.
  22. 斎藤重幸.肥満症・メタボリックシンドローム、高血圧発症・進展の関わり.最新臨床高血圧学-日本臨床増刊号.2014,72:269-272.
  23. 斎藤重幸.日本高血圧学会高血圧治療ガイドライン(JSH)の変遷-JSH2009からJSH2014.循環器内科.2014,76:385-391.
  24. 斎藤重幸.糖尿病合併高血圧の降圧目標をめぐって.血圧 2014,21;926-931.
  25. 斎藤重幸.高血圧治療ガイドラインUpdate-糖尿病合併高血圧の治療のありかた-.Diabetes Journal.2014,41:182-187.
  26. 平田公一, 木村康利, 今村将史, 石井雅之, 太田盛道, 及能大輔, 久木田 和晴, 及能拓朗, 水口 徹, 樋上哲哉:ハイブリッド手術室での取り組み 消化器外科領域. 消外 37:87-94, 2014
  27. 里見蕗乃, 島 宏彰, 九富五郎, 水口 徹, 平田公一:肥満の分子メカニズム オーバービュー. Surg Fronti 21:385-388, 2014
  28. 信岡隆幸, 伊東竜哉, 及能拓朗, 西舘俊彦, 今村将史, 木村康利, 水口 徹, 古畑智久, 平田公一:  腹腔鏡下幽門側胃切除術. 消外37:1775-1783, 2014
  29. 水口 徹, 目黒 誠, 沖田憲司, 西舘敏彦, 植木 知身, 石井雅之, 太田盛道, 木村康利, 平田 公一:肝予備能評価法の実際. 外科76:1210-1216, 2014
  30. 釣田義一郎, 谷澤健太郎, 篠崎大, 安井 寛, 今井浩三, 石井 浩, 尾阪将人, 島 宏彰, 水口 徹,    林 宏至, 鳥越 俊彦, 佐藤 昇志:膵癌に対するサバイビン免疫療法の研究. 膵・胆道癌Frontier 4:96-101, 2014
  31. 木村康利, 今村将史, 伊東竜哉, 沖田憲司, 川本 樹, 巽 博臣, 信岡隆幸, 水口 徹, 平田公一:周術期胆道炎の診断におけるガイドラインの位置づけ. 日外感染会誌 11:255-233, 2014
  32. 西舘敏彦, 古畑智久, 沖田憲司, 植木知身, 秋月恵美, 川本雅樹, 目黒 誠, 水口 徹, 平田公一:   回盲部切除術におけるreduced port surgery. 消外 37:1115-1120, 2014
  33. 平田公一, 沖田憲司, 西舘敏彦, 石井雅之, 及能拓朗, 今村将史, 木村康利, 水口 徹:虚血性腸疾患の成因と分類および外科治療の留意点. 消外 37:973-978, 2014
  34. 平田公一, 木村康利, 水口 徹, 今村将史, 沖田憲司, 原田敬介:消化器外科救急医療の現状と展望. 臨外69:522-530, 2014
  35. 平田公一,里見蕗乃,島 宏彰,九富五郎,水口 徹:生体防御における免疫反応の新知見. Surg Fronti 21:13-18, 2014
  36. 市戸義久, 石井雅之, 谷水直樹, 水口 徹, 平田公一, 三高俊広:組織幹細胞と組織修復. Surg Fronti 21:299-303, 2014
  37. Ishii M, Mizuguchi T, Harada K, Ota S, Meguro M, Ueki T, Nishidate T, Okita K, Hirata K.: Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system. World J Hepatol 27;6:745-751, 2014
  38. Mizuguchi T, Kawamoto M, Meguro M, Hui TT, Hirata K.: Preoperative liver function assessments to estimate the prognosis and safety of liver resections. Surg Today 44:1-10, 2014
  39. 斎藤重幸.日本における動脈硬化性疾患の疫学.プラクティス.2013,30:43-50.
  40. 斎藤重幸.肥満症を基盤とする関連病態、高血圧.日本臨床.2013,71:281-285.
  41. 斎藤重幸.基礎疾患・合併症の管理:糖尿病.循環器内科.2013,73:259-267.
  42. 斎藤重幸.糖尿病患者における高血圧の疫学と成因.月刊糖尿病.2013:6-14.
  43. 水口 徹, 橋本亜紀, 川本雅樹, 目黒 誠, 沖田憲司, 信岡隆幸, 木村康利, 古畑智久, 平田公一:   肝疾患に対する外科治療 高齢者に対する肝切除術の治療成績―最近のレヴューと傾向スコア解析. 北外誌 58:7-11, 2013
  44. 水口 徹, 目黒 誠, 川本雅樹, 沖田憲司, 西舘敏彦, 原田 敬介, 巽 博臣, 今村将史, 木村康利,    信岡 隆幸, 古畑智久, 平田公一:肝離断に用いるエネルギーデバイスの選択. 消外36:155-164, 2013
  45. 目黒 誠, 水口 徹, 川本雅樹, 中村幸雄, 太田盛道, 今村 将史, 木村 康利, 古畑 智久, 平田 公一: 肝切除術中FloTrac/Vigileoモニタリングの有用性について 肝切除術後肝障害予測の可能性も含めて. Shock 27:36-41, 2013
  46. 平田公一, 小川 宰司, 河野 剛, 石井雅之, 及能大輔, 九冨五郎, 木村康利, 水口 徹:肥満の疫学と最近のトピックス. Surg Fronti 20:9-14, 2013
症例報告
  1. Shima H, Kutomi G, Kyuno T, Satomi F, Uno S, Maeda H, Kameshima H, Omura T, Kimura Y, Mizuguchi T, Hirata K, Takemasa I. Flap revascularization in patients following immediate reconstruction using an autologous free dermal fat graft for breast cancer: a report of two cases. Surg Case Rep. 2:54, 2016
  2. Ishii M, Kimura Y, Imamura M, Kyuno D, Ueki T, Uchiyama M, Mizuguchi T, Mukaiya M, Hirata K.: Remnant pancreas reconstruction with duct-to-duct anastomosis after middle pancreatectomy: A report of two cases. Hepatogastroenterology 62: 190-194, 2015
  3. Iyama S, Sato T, Tatsumi H, Hashimoto A, Tatekoshi A, Kamihara Y, Horiguchi H, Ibata S, Ono K, Murase K, Takada K, Sato Y, Hayashi T, Miyanishi K, Akizuki E, Nobuoka T, Mizugichi T, Takimoto R, Kobune M, Hirata K, Kato J.: Efficacy of Enteral Supplementation Enriched with Glutamine, Fiber, and Oligosaccharide on Mucosal Injury following Hematopoietic Stem Cell Transplantation. Case Rep Oncol. 7:692-699, 2014

競争的資金

  1. 過冷却プログラム凍結したヒト肝幹細胞を利用した再生外科治療の橋渡し的基礎研究
    H26~H28 科学研究費助成金 (基盤研究C) 代表(水口徹)
  2. 肝切除後肝不全予防のための術中ビジリオモニタリングによる新規管理法の開発
    H26~H28 科学研究費助成金 (基盤研究C) 分担(水口徹)
  3. 進行膵がんを対象として複合型CTLワクチン療法 第2相試験
    H27~H28 AMED 代表(水口徹)
  4. バンキング肝幹細胞の臨床応用に向けた橋渡し研究
    H29~H31 科学研究費助成金 (基盤研究C)  代表(水口徹)
  5. 時系列データの混合効果モデルによる糖尿病と動脈硬化性疾患の発症要因の検討学術振興会研究費補助金 基盤研究(C)
    研究期間 :2013年 - 2015年 代表者 : 斎藤重幸
  6. ヒト小型肝幹細胞移植の臨床応用に向けた基盤的臨床前研究
    H25~H27 科学研究費助成金 (基盤研究B) 分担(水口徹)
  7. 循環器疾患における集団間格差のじっつたいと把握とその対策を目的とした大規模コホート研究:厚生労働科学研究費補助金
    研究期間 :2011年 - 2015年 代表者 : 岡村智教 分担者:斎藤重幸
  8. 膵がんに対するがん幹細胞標的ペプチドワクチン療法の開発
    H24~H26  科学研究費助成金 (挑戦的萌芽研究) 分担
  9. 超過冷却プログラムによるヒト小型肝細胞バンクとハイブリットマウス量産に向けた研究
    H23~H25   科学研究費助成金(基盤研究C) 代表