講師 齋藤 悠城

論文

1.  Saito Y, Miyajima M, Yamamoto S, Miura N, Sato T, Kita A, Ijima S, Fujimiya M, Chikenji TS. Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus. Stem Cells Transl Med. Jun 22;11(6):644-658. 2022.

2. Kita A, Saito Y(責任著者), Miura N, Miyajima M, Yamamoto S, Sato T, Yotsuyanagi T, Fujimiya M, Chikenji TS. Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing. Commun Biol. Apr 5;5(1):310. 2022.

3. Ijima S, Saito Y(責任著者), Nagaoka K, Yamamoto S, Sato T, Miura N, Iwamoto T, Miyajima M, Chikenji TS. Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis. Front Immunol. Nov 17;13:960601. 2022.

4. Hirota K, Watanabe K, Teramoto A, Saito Y, Katayose M. Flexor hallucis longus tendinous slips and the relationship to toe flexor strength. Foot Ankle Surg. Dec;27(8):851-854. 2021 .

5. Saito Y, Miyajima M, Yamamoto S, Sato T, Miura N, Fujimiya M, Chikenji TS. Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior. Front Immunol. Nov 3;12:692321. 2021 .

6. Saito Y, Chikenji TS. Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics. Front Pharmacol. Sep 6;12:739510. 2021 .

7. Nakano M, Kubota K, Hashizume S, Kobayashi E, Chikenji TS, Saito Y, Fujimiya M. An enriched environment prevents cognitive impairment in an Alzheimer's disease model by enhancing the secretion of exosomal microRNA-146a from the choroid plexus. Brain Behav Immun Health. Sep 22;9:100149. 2020 .

8. Himori K, Ashida Y, Tatebayashi D, Abe M, Saito Y, Chikenji T, Westerblad H, Andersson DC, Yamada T. Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies. Arthritis Rheumatol. May;73(5):848-857. 2021 .

9. Osanami Y, Aoki M, Shirato R, Saito Y, Hidaka E, Miyamoto H, Uchiyama E. Tensile load on the flexor digitorum profundus tendon during palmar and lateral blocking exercises: Influence on blocking force and distal interphalangeal joint flexion angle. J Hand Ther. Dec;34(4):555-560. 2021 .

10. Nakano M, Kubota K, Kobayashi E, Chikenji TS, Saito Y, Konari N, Fujimiya M. Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus. Sci Rep. Jul 1;10(1):10772. 2020 .

11. Saito Y, Chikenji TS, Matsumura T, Nakano M, Fujimiya M. Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. Nat Commun. Feb 14;11(1):889. 2020 .

12. Saito Y, Chikenji TS, Takata Y, Kamiya T, Uchiyama E. Can an insole for obese individuals maintain the arch of the foot against repeated hyper loading? BMC Musculoskelet Disord. Oct 11;20(1):442. 2019 .

13. Hirota K, Watanabe K, Saito Y, Katayose M. Flexor hallucis longus tendon branch test: Development and validation of a new method to assess anatomical variation of the tendinous slip. Foot Ankle Surg. Aug;26(6):607-613. 2020 .

14. Chikenji TS, Saito Y, Konari N, Nakano M, Mizue Y, Otani M, Fujimiya M. p16INK4A-expressing mesenchymal stromal cells restore the senescence-clearance-regeneration sequence that is impaired in chronic muscle inflammation. EBioMedicine. Jun;44:86-97. 2019 .

15. Matsumura T, Saito Y, Suzuki T, Teramoto A, Ozasa Y, Yamashita T, Fujimiya M, Saito-Chikenji T. Phosphorylated Platelet-Derived Growth Factor Receptor-Positive Cells With Anti-apoptotic Properties Accumulate in the Synovium of Patients With Rheumatoid Arthritis. Front Immunol. Feb 15;10:241. 2019 .

16. Saito Y, Chikenji T, Ozasa Y, Fujimiya M, Yamashita T, Gingery A, Iba K. PDGFR Signaling Mediates Hyperproliferation and Fibrotic Responses of Subsynovial Connective Tissue Cells in Idiopathic Carpal Tunnel Syndrome. Sci Rep. Nov 23;7(1):16192. 2017 .

17. Nakano M, Nagaishi K, Konari N, Saito Y, Chikenji T, Mizue Y, Fujimiya M. Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes. Sci Rep. Apr 22;6:24805. 2016 .

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総説

  1. 内山英一, 齋藤悠城. 着地動作における足関節の衝撃吸収 -バイオメカニカルな観点から-, 臨床スポーツ医学 36(5): 526-530, 2019
  2. 千見寺貴子, 齋藤悠城, 藤宮峯子. 糖尿病性腎症に対する間葉系幹細胞の応用と新規治療薬の開発の可能性, 腎臓内科・泌尿器科, 9(4), 2019.
  3. 千見寺貴子, 齋藤悠城. 基礎的研究を身体障害領域の臨床作業療法に活かす, 北海道作業療法, 34(3), 2017.

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学会発表

  1. Yuki Saito, Takako Chikenji, Takashi Matsumura, Mineko Fujimiya. Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors, Annual Meeting 2020, Orthopaedic Research Society. (Phoenix), Feb, 2020. (New Investigator Recognition Award Finalist: Podium and Poster presentation)
  2. Yuki Saito, Takako S. Chikenji, Alyssa Vrieze, Tamara Tchkonia, James L. Kirkland, Peter C. Amadio, Anne Gingery. Cellular Senescence in Tendon Aging and Pathology, Annual Meeting 2020, Orthopaedic Research Society. (Phoenix), Feb, 2020. (Spotlight Session-podium presentation, ORS Tendon Section Podium Award Finalist).
  3. Takako S. Chikenji, Yuki Saito, Alyssa Vrieze, Sandra Passe, Tamara Tchkonia, James L. Kirkland, Peter C. Amadio, Anne Gingery. Senescent cells escape from immune clearance in fibrotic subsynovial connective tissue in carpal tunnel syndrome, Annual Meeting 2020, Orthopaedic Research Society. (Phoenix), Feb, 2020. (Podium presentation).
  4. Yuki Saito, Takako Chikenji. Platelet-Derived Growth Factor Receptor Alpha Signaling in Carpal Tunnel Syndrome, Musculoskeletal Research Conference, Mayo clinic, Rochester, April, 2019.
  5. Yuki Saito, Takako Chikenji, Yuka Mizue, Mineko Fujimiya. Exercise-Induced Muscle Inflammatory and Fibrosis in Choronic Myopathy is Caused by Insufficient Senescence of the Fibro-Adipogenic Progenitors, Keystone Symposia, Aging and Mechanisms of Aging-Related disease (E2), Yokohama, May, 2017.
  6. Takako Chikenji, Yuki Saito, Yuka Mizue, Mineko Fujimiya.Mesenchymal stromal cells stimulated by human placental extraction plays beneficial roles on reduction of chronic inflammation in multiple myositis, Keystone Symposia, Aging and Mechanisms of Aging-Related disease (E2), Yokohama, May, 2017.
  7. Yuki Saito, Takako Chikenji, Yasuhiro Ozasa, Takashi Matsumura, Mineko Fujimiya, Toshihiko Yamashita, Kousuke Iba, PDGFR Signaling Activate Mesenchymal Cells Proliferation via PI3K-Akt Signaling in Idiopathic Carpal Tunnel Syndrome and Block PDGFR Signaling Can Inhibit Cell Proliferation. The 63th Annual Meeting Orthopaedic Research Society. (San Diego), Mar, 2017.
  8. Takako Chikenji, Yuki Saito, Yasuhiro Ozasa, Takashi Matsumura, Mineko Fujimiya, Toshihiko Yamashita, Kousuke Iba, The Effects of Estradiol on Mesenchymal Stem Cells in Subsynovial Connective Tissue of Carpal Tunnel Syndrome In vitro. The 63th Annual Meeting Orthopaedic Research Society. (San Diego), Mar, 2017.
  9. Takashi Matsumura, Takako Chikenji, Yuki Saito, Yuka Mizue, Kanna Nagaishi, Tomoyuki Suzuki, Toshihiko Yamashita, Mineko Fujimiya, Treatment of Collagen Induced Arthritis in Rat Using Preconditioned Bone Marrow Mesenchymal Stem Cells with Fetal Appendage Extraction. he 63th Annual Meeting Orthopaedic Research Society. (San Diego), Mar, 2017.
  10. Kento Hirota, Kota Watanabe, Yuki Saito, Masaki Katayose, Toe Flexor Muscles Have Functional Compensatory Systems by the Tendinous Slip, The 63th Annual Meeting Orthopaedic Research Society. (San Diego), Mar, 2017.
  11. Yuki Saito, Takako Chikenji, Yuka Mizue, Kanna Nagaishi, Mineko Fujimiya, Toshihiko Yamashita, Kousuke Iba , Platelet-derived Growth Factor Receptor alpha Positive Mesenchymal Cell Accumulate in the Subsynovial Connective Tissue of Patients With Idiopathic Carpal Tunnel Syndrome, The 62th Annual Meeting Orthopaedic Research Society. (Orland), Mar 2016.
  12. Takako Chikenji, Yuki Saito, Yuka Mizue, Kanna Nagaishi, Mineko Fujimiya, Toshihiko Yamashita, Kousuke Iba, Mesenchymal Stem Cells in Subsynovial Connective Tissue in Carpal Tunnel, The 62th Annual Meeting Orthopaedic Research Society. (Orland), Mar 2016.
  13. Hiroki Miyamoto, Mitsuhiro Aoki, Egi Hidaka, Yuichi Takata, Rikiya Shirato, Yukihiro Osanami, Yuki Saito, Mineko Fujimiya, Eiichi Uchiyama, Measurement of Strain And Tensile Force of the Supraspinatus Tendon in Condition That Simulates Isometric Elevation of the Gleno-humeral Joint: Infuence Of Applied Torque and Joint Positioning, The 62th Annual Meeting Orthopaedic Research Society. (Orland), Mar 2016.
  14. Yuki Saito, Yuichi Takata, Takako Chikenji, Tomoaki Kamiya, Yukihiro Osanami, Eiichi Uchiyama. Can Insole For Obesity Maintain The Arch Of The Foot Against Repeated Hyper Loading? The 60th Annual Meeting Orthopaedic Research Society. (New Orleans), Mar 2014.
  15. Takata Yuichi, Yuki Saito, Kamiya Tomoaki, Osanami Yukihiro, Chikenji Takako, Uchiyama Eiichi. Height and Flexibility of Foot Arch - Influence of Obesity -, The 60th Annual Meeting Orthopaedic Research Society. (New Orleans), Mar 2014.
  16. Shouta Kaneko, Sadako Tsubota, Takako Chikenji, Yoshikazu Ikemoto, Yuki Saito, Yukihiro Osanami, Eiichi Uchiyama. Effect Of The Horizontal Extension Technique On The Cross-sectional Area Of The Carpal Tunnel. The 60th Annual Meeting Orthopaedic Research Society. (New Orleans), Mar 2014.
  17. Osanami Yukihiro, Aoki Mitsuhiro, Chikenji Takako, Shirato Rikiya, Takata Yuichi, Yuki Saito, Uchiyama Eiichi. Optimum Procedure To The Flexor Tendon Repair During Blocking Finger Exercise, The 60th Annual Meeting Orthopaedic Research Society. (New Orleans), Mar 2014.
  18. Yuki Saito, Eiichi Uchiyama, Takako Chikenji, Shuichi Sato. Contributions of ankle joint in leg to energy absorption during landing -Influence of difference in height-, The 59th Annual Meeting Orthopaedic Research Society. (San Antonio), Jan 2013.

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受賞歴

米国整形外科基礎学会 (Orthopedic Research Society: ORS), New Investigator Recognition Award (NIRA), 2020年2月

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著書

齋藤悠城(2014), 足部・足関節．内山英一，青木光広(編/監),解剖からアプローチするからだの機能と運動療法, p1-39.メジカルビュー社

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競争的資金

  1. 筋疾患に対する運動が筋機能を悪化させる理由を間葉系前駆細胞の2面性から解明する, 若手研究(B), 平成28年度-平成29年度. 研究課題番号: 16K16430. 研究代表者: 齋藤悠城. 配分額: 2,900,000円
    The role of muscle mesenchymal progenitors in exercise; double-edged sword of mesenchymal progenitors in muscular disease.
  2. 運動が誘発するメタボリック/メカニカルストレスによる筋幹細胞と間葉系幹細胞の制御, 若手研究, 2018年度-2020年度, 研究課題番号: 18K17722, 研究代表者: 齋藤悠城. 配分額: 4,030,000円
    Title: Regulation of muscle stem cell and mesenchymal stem cell by exercise induced metabolic and mechanical stress
  3. 細胞老化制御に基づく組織再生リハビリテーション:セノリハビリテーションの基盤創成, 基盤研究B, 2021年度-2024年度, 研究課題番号: 21H03293, 研究代表者: 齋藤悠城. 分配額: 17,290,000円