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Publications

2016

  • Kubo T, Hirohashi Y, Torigoe T. Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(5):468-472. Review. Dendritic cell and cancer immune checkpoint.
  • Kajiwara T, Tanaka T, Kukita K, Kutomi G, Saito K, Okuya K, Takaya A, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Sato N, Tamura Y. Eur J Immunol. 2016 Dec;46(12):2842-2851. doi: 10.1002/eji.201646525. Epub 2016 Oct 18. Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells.
  • Murata K, Tsukahara T, Emori M, Shibayama Y, Mizushima E, Matsumiya H, Yamashita K, Kaya M, Hirohashi Y, Kanaseki T, Kubo T, Himi T, Ichimiya S, Yamashita T, Sato N, Torigoe T. Oncoimmunology. 2016 Jun 8;5(6):e1165376. doi: 10.1080/2162402X.2016.1165376. eCollection 2016 Jun. Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance.
  • Tsukahara T, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Sato N, Torigoe T. Pathol Int. 2016 Oct;66(10):547-553. doi: 10.1111/pin.12438. Epub 2016 Jul 19. Review. Peptide vaccination therapy: Towards the next generation.
  • Saijo H, Hirohashi Y, Torigoe T, Horibe R, Takaya A, Murai A, Kubo T, Kajiwara T, Tanaka T, Shionoya Y, Yamamoto E, Maruyama R, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Sasaki Y, Tokino T, Suzuki H, Kondo T, Takahashi H, Sato N. Oncotarget. 2016 Aug 2;7(31):50043-50056. doi: 10.18632/oncotarget.10571. Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.
  • Takaya A, Hirohashi Y, Murai A, Morita R, Saijo H, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Takemasa I, Kondo T, Sato N, Torigoe T. PLoS One. 2016 Jul 14;11(7):e0158903. doi: 10.1371/journal.pone.0158903. eCollection 2016. Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480.
  • Sato A, Kamekura R, Kawata K, Kawada M, Jitsukawa S, Yamashita K, Sato N, Himi T, Ichimiya S. PLoS One. 2016 Jul 1;11(7):e0158408. doi: 10.1371/journal.pone.0158408. eCollection 2016. Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation.
  • Shima H, Kutomi G, Satomi F, Maeda H, Hirohashi Y, Hasegawa T, Mori M, Torigoe T, Takemasa I. Anticancer Res. 2016 Jun;36(6):2945-53. SOX2 and ALDH1 as Predictors of Operable Breast Cancer.
  • Murata K, Tsukahara T, Torigoe T. Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(1):18-22. doi: 10.2177/jsci.39.18. Review. Cancer immunotherapy and immunological memory.
  • Tsukahara T, Emori M, Murata K, Mizushima E, Shibayama Y, Kubo T, Kanaseki T, Hirohashi Y, Yamashita T, Sato N, Torigoe T. Expert Opin Biol Ther. 2016 Aug;16(8):1049-57. doi: 10.1080/14712598.2016.1188075. Epub 2016 May 27. The future of immunotherapy for sarcoma.
  • Ito N, Kamiguchi K, Nakanishi K, Sokolovskya A, Hirohashi Y, Tamura Y, Murai A, Yamamoto E, Kanaseki T, Tsukahara T, Kochin V, Chiba S, Shimohama S, Sato N, Torigoe T. Biochem Biophys Res Commun. 2016 Jun 10;474(4):626-33. doi: 10.1016/j.bbrc.2016.03.152. Epub 2016 Apr 28. A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.
  • Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y. Br J Cancer. 2016 May 24;114(11):1227-34. doi: 10.1038/bjc.2016.105. Epub 2016 Apr 21. Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level.
  • Mariya T, Hirohashi Y, Torigoe T, Tabuchi Y, Asano T, Saijo H, Kuroda T, Yasuda K, Mizuuchi M, Saito T, Sato N. Oncotarget. 2016 May 3;7(18):26806-22. doi: 10.18632/oncotarget.8645. Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.
  • Yamauchi M, Hirohashi Y, Torigoe T, Matsumoto Y, Yamashita K, Kayama M, Sato N, Yotsuyanagi T. Biochem Biophys Res Commun. 2016 May 13;473(4):845-52. doi: 10.1016/j.bbrc.2016.03.138. Epub 2016 Mar 30. Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism.
  • Tanabe A, Tanikawa K, Tsunetomi M, Takai K, Ikeda H, Konno J, Torigoe T, Maeda H, Kutomi G, Okita K, Mori M, Sahara H. Cancer Lett. 2016 Jun 28;376(1):34-42. doi: 10.1016/j.canlet.2016.02.022. Epub 2016 Mar 17. RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.
  • Yasuda K, Hirohashi Y, Kuroda T, Takaya A, Kubo T, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Sato N, Torigoe T. Biochem Biophys Res Commun. 2016 Apr 15;472(4):643-7. doi: 10.1016/j.bbrc.2016.03.004. Epub 2016 Mar 9. MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.
  • Morita R, Hirohashi Y, Torigoe T, Ito-Inoda S, Takahashi A, Mariya T, Asanuma H, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Kutomi G, Mizuguchi T, Terui T, Ishitani K, Hashino S, Kondo T, Minagawa N, Takahashi N, Taketomi A, Todo S, Asaka M, Sato N. Clin Cancer Res. 2016 Jul 1;22(13):3298-309. doi: 10.1158/1078-0432.CCR-15-1709. Epub 2016 Feb 9. Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy.
  • Asano T, Hirohashi Y, Torigoe T, Mariya T, Horibe R, Kuroda T, Tabuchi Y, Saijo H, Yasuda K, Mizuuchi M, Takahashi A, Asanuma H, Hasegawa T, Saito T, Sato N. Oncotarget. 2016 Mar 8;7(10):11223-37. doi: 10.18632/oncotarget.7165. Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy.
  • Konishi T, Funayama N, Tsukahara T, Yamamoto T, Nishihara H. Eur Heart J Cardiovasc Imaging. 2016 Apr;17(4):467. doi: 10.1093/ehjci/jev355. Epub 2016 Jan 27. No abstract available. Multimodality assessment of spontaneous haemostasis of left ventricular free wall rupture after myocardial infarction.
  • Yamashita M, Hirohashi Y, Torigoe T, Kusumoto H, Murai A, Imagawa T, Sato N. PLoS One. 2016 Jan 11;11(1):e0146501. doi: 10.1371/journal.pone.0146501. eCollection 2016. Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response.
  • Lee JR, Sato N, Bechstein DJ, Osterfeld SJ, Wang J, Gani AW, Hall DA, Wang SX. Sci Rep. 2016 Jan 5;6:18692. doi: 10.1038/srep18692. Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors.
  • Hirohashi Y, Torigoe T, Tsukahara T, Kanaseki T, Kochin V, Sato N. Cancer Sci. 2016 Jan;107(1):12-7. doi: 10.1111/cas.12830. Epub 2015 Nov 12. Review. Immune responses to human cancer stem-like cells/cancer-initiating cells

2015

  • Guidance Development Review Committee; Working Group for Clinical Studies of Cancer Immunotherapy; Working Group for Effector Cell Therapy; Working Group for CMC/Non-clinical Studies; Working Group for Cancer Vaccines and Adjuvants; Working Group for Anti-immune Checkpoint Therapy and Comprehensive Cancer Immunotherapy; Biostatistics Subcommittee.Cancer Sci. 2015 Dec;106(12):1761-71. doi: 10.1111/cas.12819.2015 Guidance on cancer immunotherapy development in early-phase clinical studies.
  • Sasaki T, Kanaseki T, Shionoya Y, Tokita S, Miyamoto S, Saka E, Kochin V, Takasawa A, Hirohashi Y, Tamura Y, Miyazaki A, Torigoe T, Hiratsuka H, Sato N.Eur J Immunol. 2015 Dec 29. doi: 10.1002/eji.201545835. [Epub ahead of print]Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8+ T-cell recognition of stressed cells.
  • Yata K, Beder LB, Tamagawa S, Hotomi M, Hirohashi Y, Grenman R, Yamanaka N.Int J Oncol. 2015 Oct;47(4):1249-56. doi: 10.3892/ijo.2015.3145. Epub 2015 Aug 31.MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma.
  • Hirohashi Y, Torigoe T, Mariya T, Kochin V, Saito T, Sato N.Oncoimmunology. 2015 Mar 23;4(5):e1005507. eCollection 2015.HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictorof chemosensitivity in ovarian cancer.
  • Okita K, Mizuguchi T, Shigenori O, Ishii M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N,Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K. Surg Today. 2015 Jul 7. [Epub ahead of print] Pancreatic regeneration: basic research and gene regulation.
  • Tanaka T, Kajiwara T, Kutomi G, Kurotaki T, Saito K, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y. Immunol Lett. 2015 Sep;167(1):34-40. doi: 10.1016/j.imlet.2015.06.014. Epub 2015 Jun 30.CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitatingcross-presentation.
  • Emori M, Tsukahara T, Murata K, Sugita S, Sonoda T, Kaya M, Soma T, Sasaki M,Nagoya S, Hasegawa T, Wada T, Sato N, Yamashita T. J Surg Oncol. 2015 Jun;111(8):975-9. doi: 10.1002/jso.23934. Epub 2015 May 28. Prognostic impact of CD109 expression in myxofibrosarcoma.
  • Iwayama Y, Tsuruma T, Mizuguchi T, Furuhata T, Toyota N, Matsumura M, Torigoe T, Sato N, Hirata K World J Surg Oncol. 2015 Feb 12;13:36. doi: 10.1186/s12957-015-0456-2. Prognostic value of HLA class I expression in patients with colorectal cancer.
  • Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y. Eur J Immunol. 2015 Jul;45(7):2028-41. doi: 10.1002/eji.201445293. Epub 2015 Apr 28. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.
  • Kukita K, Tamura Y, Tanaka T, Kajiwara T, Kutomi G, Saito K, Okuya K, Takaya A,Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Furuhata T, Hirata K, Sato N. J Immunol. 2015 May 15;194(10):4988-96. doi: 10.4049/jimmunol.1303228. Epub 2015 Apr 13. Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class IMolecule via Oxidative Folding.
  • Mizuguchi T, Torigoe T, Satomi F, Shima H, Kutomi G, Ota S, Ishii M, Hayashi H, Asakura S, Hirohashi Y, Meguro M, Kimura Y, Nishidate T, Okita K, Ishino M, Miyamoto A,Hatakenaka M, Sato N, Hirata K. Surg Today. 2016 Feb;46(2):139-48. doi: 10.1007/s00595-015-1120-8. Epub 2015 Feb 5. Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of animproved prognosis?
  • Tanaka T, Kajiwara T, Torigoe T, Okamoto Y, Sato N, Tamura Y. J Immunol. 2015 Feb 15;194(4):2004-10. doi: 10.4049/jimmunol.1402538. Epub 2015 Jan 16. Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.
  • Nishida S, Hirohashi Y, Torigoe T, Nojima M, Inoue R, Kitamura H, Tanaka T, Asanuma H,Sato N, Masumori N. Anticancer Res. 2015 Jan;35(1):413-8. Expression of hepatocyte growth factor in prostate cancer may indicate abiochemical recurrence after radical prostatectomy.
  • Kitai H, Sakakibara-Konishi J, Oizumi S, Hirohashi Y, Saito W, Kanda A, Sato N, Nishimura M Lung Cancer. 2015 Jan;87(1):73-6. doi: 10.1016/j.lungcan.2014.10.015. Epub 2014 Nov 3. Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy
  • Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):205-11. doi: 10.1016/j.bbrc.2014.10.148. Epub 2014 Nov 4.Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.
  • Tanaka T, Okuya K, Kutomi G, Takaya A, Kajiwara T, Kanaseki T, Tsukahara T, Hirohashi Y,Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y. Cancer Sci. 2015 Jan;106(1):18-24. doi: 10.1111/cas.12570. Epub 2014 Dec 15. Heat shock protein 90 targets a chaperoned peptide to the static early endosomefor efficient cross-presentation by human dendritic cells.
  • Kasamatsu J, Takahashi S, Azuma M, Matsumoto M, Morii-Sakai A, Imamura M, Teshima T,Takahashi A, Hirohashi Y, Torigoe T, Sato N, Seya T. Immunobiology. 2015 Jan;220(1):74-82. doi: 10.1016/j.imbio.2014.08.017. Epub 2014 Aug 23.PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.

2014

  • Mariya T, Hirohashi Y, Torigoe T, Asano T, Kuroda T, Yasuda K, Mizuuchi M, Sonoda T, Saito T,Sato N. Cancer Immunol Res. 2014 Dec;2(12):1220-9. doi: 10.1158/2326-6066.CIR-14-0101. Epub 2014 Oct 16. Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer.
  • Yasuda K, Torigoe T, Mariya T, Asano T, Kuroda T, Matsuzaki J, Ikeda K, Yamauchi M, Emori M,Asanuma H, Hasegawa T, Saito T, Hirohashi Y, Sato N. Lab Invest. 2014 Dec;94(12):1355-69. doi: 10.1038/labinvest.2014.122. Epub 2014 Oct 20. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
  • Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, Kojima T, Sugimoto K,Yoneta A, Sumikawa Y, Yamashita T, Sato N, Himi T, Ichimiya S. PLoS One. 2014 Aug 29;9(8):e105498. doi: 10.1371/journal.pone.0105498. eCollection 2014. ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.
  • Ota D, Kanayama M, Matsui Y, Ito K, Maeda N, Kutomi G, Hirata K, Torigoe T, Sato N, Takaoka A,Chambers AF, Morimoto J, Uede T. J Mol Med (Berl). 2014 Dec;92(12):1271-81. doi: 10.1007/s00109-014-1183-9. Epub 2014 Aug 8. Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts.
  • Tsukahara T, Emori M, Murata K, Hirano T, Muroi N, Kyono M, Toji S, Watanabe K, Torigoe T,Kochin V, Asanuma H, Matsumiya H, Yamashita K, Himi T, Ichimiya S, Wada T, Yamashita T,Hasegawa T, Sato N. J Biol Chem. 2014 Aug 8;289(32):22035-47. doi: 10.1074/jbc.M114.568725. Epub 2014 Jun 24. Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.
  • Torigoe T, Hirohashi Y, Tsukahara T, Kanaseki T, Kochin V, Sato N. Nihon Rinsho Meneki Gakkai Kaishi. 2014;37(2):90-5. [The path to innovative drug development of cancer vaccine: from discovery of tumor antigens to clinical trials].
  • Morita R, Hirohashi Y, Nakatsugawa M, Kanaseki T, Torigoe T, Sato N. Methods Mol Biol. 2014;1139:345-55. doi: 10.1007/978-1-4939-0345-0_28. Production of multiple CTL epitopes from multiple tumor-associated antigens.
  • Shastri N, Nagarajan N, Lind KC, Kanaseki T. Curr Opin Immunol. 2014 Feb;26:123-7. doi: 10.1016/j.coi.2013.11.006. Epub 2013 Dec 11. Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.
  • Tanaka T, Torigoe T, Hirohashi Y, Sato E, Honma I, Kitamura H, Masumori N, Tsukamoto T, Sato N. J Cancer Res Clin Oncol. 2014 Mar;140(3):503-13. doi: 10.1007/s00432-014-1593-7. Epub 2014 Jan 30. Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma.
  • Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A,Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N. Cancer Sci. 2014 Apr;105(4):389-95. doi: 10.1111/cas.12362. Epub 2014 Feb 24. Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.

2013

  • Emori M, Tsukahara T, Murase M, Kano M, Murata K, Takahashi A, Kubo T, Asanuma H, Yasuda K, Kochin V, Kaya M, Nagoya S, Nishio J, Iwasaki H, Sonoda T, Hasegawa T, Torigoe T, Wada T, Yamashita T, Sato N. PLoS One. 2013 Dec 20;8(12):e84187. doi: 10.1371/journal.pone.0084187. eCollection 2013. High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma.
  • Tanaka T, Kitamura H, Inoue R, Nishida S, Takahashi-Takaya A, Kawami S, Torigoe T, Hirohashi Y, Tsukamoto T, Sato N, Masumori N. Clin Dev Immunol. 2013;2013:262967. doi: 10.1155/2013/262967. Epub 2013 Nov 20. Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer--results from phase I clinical trials.
  • Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T,Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N. PLoS One. 2013 Nov 11;8(11):e69095. doi: 10.1371/journal.pone.0069095. eCollection 2013. Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.
  • Yasuda K, Torigoe T, Morita R, Kuroda T, Takahashi A, Matsuzaki J, Kochin V, Asanuma H, Hasegawa T,Saito T, Hirohashi Y, Sato N. PLoS One. 2013 Aug 13;8(8):e68187. doi: 10.1371/journal.pone.0068187. eCollection 2013. Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population.
  • Matsuzaki J, Torigoe T, Hirohashi Y, Tamura Y, Asanuma H, Nakazawa E, Saka E, Yasuda K, Takahashi S, Sato N. Pathol Int. 2013 Aug;63(8):391-7. doi: 10.1111/pin.12079. Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells.
  • Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N. Biochem Biophys Res Commun. 2013 Sep 13;439(1):96-102. doi: 10.1016/j.bbrc.2013.08.021. Epub 2013 Aug 13. Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
  • Yamamoto T, Tamura Y, Kobayashi J, Kamiguchi K, Hirohashi Y, Miyazaki A, Torigoe T, Asanuma H,Hiratsuka H, Sato N. Exp Cell Res. 2013 Oct 15;319(17):2617-26. doi: 10.1016/j.yexcr.2013.07.025. Epub 2013 Aug 2. Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication.
  • Torigoe T, Hirohashi Y, Yasuda K, Sato N. Int J Hyperthermia. 2013 Aug;29(5):436-41. doi: 10.3109/02656736.2013.814809. Constitutive expression and activation of stress response genes in cancer stem-like cells/tumour initiating cells: potent targets for cancer stem cell therapy.
  • Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L,Sato N, Delgado JC, Shastri N. J Immunol. 2013 Aug 15;191(4):1547-55. doi: 10.4049/jimmunol.1301043. Epub 2013 Jul 17. ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.
  • Ikeda K, Torigoe T, Matsumoto Y, Fujita T, Sato N, Yotsuyanagi T. Wound Repair Regen. 2013 Jul-Aug;21(4):616-23. doi: 10.1111/wrr.12062. Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts.
  • Kuroda T, Hirohashi Y, Torigoe T, Yasuda K, Takahashi A, Asanuma H, Morita R, Mariya T, Asano T,Mizuuchi M, Saito T, Sato N. PLoS One. 2013 Jun 6;8(6):e65158. doi: 10.1371/journal.pone.0065158. Print 2013. ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis.
  • Yamada R, Takahashi A, Torigoe T, Morita R, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Watarai K,Kondo T, Hirohashi Y, Sato N. Tissue Antigens. 2013 Jun;81(6):428-34. doi: 10.1111/tan.12113. Epub 2013 Apr 11. Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.
  • Kutomi G, Tamura Y, Tanaka T, Kajiwara T, Kukita K, Ohmura T, Shima H, Takamaru T, Satomi F, Suzuki Y, Torigoe T, Sato N, Hirata K. Cancer Sci. 2013 Aug;104(8):1091-6. doi: 10.1111/cas.12177. Epub 2013 May 21. Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancer.
  • Tamura Y, Saito K, Sato N. Nihon Rinsho. 2012 Nov;70 Suppl 8:135-9. [Heat shock protein inhibitor for molecular targeting therapy].
  • Kanaseki T, Shastri N. Methods Mol Biol. 2013;960:179-85. doi: 10.1007/978-1-62703-218-6_15. Biochemical analysis of naturally processed antigenic peptides presented by MHC class I molecules.
  • Nishida S, Hirohashi Y, Torigoe T, Inoue R, Kitamura H, Tanaka T, Takahashi A, Asanuma H, Masumori N, Tsukamoto T, Sato N. Cancer Sci. 2013 Apr;104(4):431-6. doi: 10.1111/cas.12104. Epub 2013 Feb 17. Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor.

2012

  • Kukita K, Tamura Y, Oku-ya K, Saito K, Kutomi G, Sato N, Hirata K. Gan To Kagaku Ryoho. 2012 Nov;39(12):1800-2. Japanese. [Human endoplasmic reticulum oxidoreductin 1-like α regulates immune response of cancer cells via modulation of major histocompatibility complex class I expression and oxidation].
  • Tamura Y, Torigoe T, Kutomi G, Hirata K, Sato N. Curr Mol Med. 2012 Nov 1;12(9):1198-206. New paradigm for intrinsic function of heat shock proteins as endogenous ligands in inflammation and innate immunity.
  • Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N. Cell Stress Chaperones. 2012 Nov;17(6):757-63. doi: 10.1007/s12192-012-0348-0. Epub 2012 Jul 11. Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes.
  • Morita R, Hirohashi Y, Suzuki H, Takahashi A, Tamura Y, Kanaseki T, Asanuma H, Inoda S, Kondo T, Hashino S, Hasegawa T, Tokino T, Toyota M, Asaka M, Torigoe T, Sato N. Exp Mol Pathol. 2012 Oct 9. doi:pii: S0014-4800(12)00151-7. 10.1016/j.yexmp.2012.10.004. [Epub ahead of print] DNA methyltransferase 1 is essential for initiation of the colon cancers.
  • Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, Arndt H, Asslaber M, Maio M, Masucci GV, Mihm M, Vidal-Vanaclocha F, Allison JP, Gnjatic S, Hakansson L, Huber C, Singh-Jasuja H, Ottensmeier C, Zwierzina H, Laghi L, Grizzi F, Ohashi PS, Shaw PA, Clarke BA, Wouters BG, Kawakami Y, Hazama S, Okuno K, Wang E, O'Donnell-Tormey J, Lagorce C, Pawelec G, Nishimura MI, Hawkins R, Lapointe R, Lundqvist A, Khleif SN, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Palmqvist R, Nagtegaal ID, Wang Y, D'Arrigo C, Kopetz S, Sinicrope FA, Trinchieri G, Gajewski TF, Ascierto PA, Fox BA. J Transl Med. 2012 Oct 3;10:205. doi: 10.1186/1479-5876-10-205. Cancer classification using the Immunoscore: a worldwide task force.
  • Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Kobayashi J, Sasaki T, Fujino J, Asanuma H, Tamura Y, Nakamori K, Hasegawa T, Hiratsuka H, Sato N. Pathol Int. 2012 Oct;62(10):684-9. doi: 10.1111/j.1440-1827.2012.02851.x. Epub 2012 Aug 16. High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
  • Kawaguchi S, Tsukahara T, Ida K, Kimura S, Murase M, Kano M, Emori M, Nagoya S, Kaya M, Torigoe T, Ueda E, Takahashi A, Ishii T, Tatezaki S, Toguchida J, Tsuchiya H, Osanai T, Sugita T, Sugiura H, Ieguchi M, Ihara K, Hamada K, Kakizaki H, Morii T, Yasuda T, Tanizawa T, Ogose A, Yabe H, Yamashita T, Sato N, Wada T. Cancer Sci. 2012 Sep;103(9):1625-30. doi: 10.1111/j.1349-7006.2012.02370.x. Epub 2012 Aug 7. SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group.
  • Tsukahara T, Takasawa A, Murata M, Okumura K, Nakayama M, Sato N, Hasegawa T. Diagn Pathol. 2012 Aug 29;7:114. doi: 10.1186/1746-1596-7-114. NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax.
  • Tamura Y, Torigoe T, Kukita K, Saito K, Okuya K, Kutomi G, Hirata K, Sato N. Immunotherapy. 2012 Aug;4(8):841-52. doi: 10.2217/imt.12.75. Review. Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity.
  • Matsuki K, Tanabe A, Hongo A, Sugawara F, Sakaguchi K, Takahashi N, Sato N, Sahara H. Cancer Sci. 2012 Aug;103(8):1546-52. doi: 10.1111/j.1349-7006.2012.02333.x. Epub 2012 Jun 20. Anti-angiogenesis effect of 3'-sulfoquinovosyl-1'-monoacylglycerol via upregulation of thrombospondin 1.
  • Ara S, Kikuchi T, Matsumiya H, Kojima T, Kubo T, Ye RC, Sato A, Kon S, Honma T, Asakura K, Hasegawa T, Himi T, Sato N, Ichimiya S. Cancer Sci. 2012 Jul;103(7):1356-62. doi: 10.1111/j.1349-7006.2012.02296.x. Epub 2012 Jun 4. Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
  • Nishida S, Hirohashi Y, Torigoe T, Kitamura H, Takahashi A, Masumori N, Tsukamoto T, Sato N. J Urol. 2012 Jul;188(1):294-9. doi: 10.1016/j.juro.2012.02.2555. Epub 2012 May 16. Gene expression profiles of prostate cancer stem cells isolated by aldehyde dehydrogenase activity assay.
  • Ishii-Osai Y, Yamashita T, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Nakayama E, Okura M, Jimbow K. J Dermatol Sci. 2012 Jul;67(1):51-60. doi: 10.1016/j.jdermsci.2012.04.009. Epub 2012 May 2. N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model.
  • Nishizawa S, Hirohashi Y, Torigoe T, Takahashi A, Tamura Y, Mori T, Kanaseki T, Kamiguchi K, Asanuma H, Morita R, Sokolovskaya A, Matsuzaki J, Yamada R, Fujii R, Kampinga HH, Kondo T, Hasegawa T, Hara I, Sato N. Cancer Res. 2012 Jun 1;72(11):2844-54. doi: 10.1158/0008-5472.CAN-11-3062. Epub 2012 May 2. HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.
  • Torigoe T, Asanuma H, Nakazawa E, Tamura Y, Hirohashi Y, Yamamoto E, Kanaseki T, Hasegawa T, Sato N. Pathol Int. 2012 May;62(5):303-8. doi: 10.1111/j.1440-1827.2012.02789.x. Epub 2012 Mar 16. Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues.
  • Matsuzaki J, Torigoe T, Hirohashi Y, Kamiguchi K, Tamura Y, Tsukahara T, Kubo T, Takahashi A, Nakazawa E, Saka E, Yasuda K, Takahashi S, Sato N. Carcinogenesis. 2012 May;33(5):996-1003. doi: 10.1093/carcin/bgs118. Epub 2012 Mar 12. ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells.
  • Mizuuchi M, Hirohashi Y, Torigoe T, Kuroda T, Yasuda K, Shimizu Y, Saito T, Sato N. Exp Mol Pathol. 2012 Feb;92(1):185-90. doi: 10.1016/j.yexmp.2011.10.002. Epub 2011 Oct 15. Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses.
  • Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Kondo T, Greene MI, Hara I, Sato N. Exp Mol Pathol. 2012 Feb;92(1):27-32. doi: 10.1016/j.yexmp.2011.09.016. Epub 2011 Oct 2. Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population.
  • Hirohashi Y, Torigoe T, Inoda S, Morita R, Kochin V, Sato N. Oncoimmunology. 2012 Jan 1;1(1):123-125. Cytotoxic T lymphocytes: Sniping cancer stem cells.

2011

  • Tamura Y, Hirohashi Y, Kutomi G, Nakanishi K, Kamiguchi K, Torigoe T, Sato N. Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity. J. Immunol. 186:4325-4330, 2011.
  • Oura, J., Tamura, Y., Kamiguchi, K., Kutomi, G., Sahara, H., Torigoe, T., Himi, T., and Sato, N. Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells. Int. Immunol., 23:223-237, 2011.
  • Kano, M., Tsukahara, T., Emori, M., Murase, M., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N. Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma. Cancer Sci. April 22 issue, 2011.
  • Tanaka T, Kitamura H, Torigoe T, Hirohashi Y, Sato E, Masumori N, Sato N, Tsukamoto T. Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential marker for renal cell carcinoma. J Cancer Res Clin Oncol. 137:789-794.2011.
  • Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N: The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. Exp Mol Pathol. 90:55-60, 2011.
  • Nakatsugawa, M., Hirohashi, Y., Torigoe, T., Inoda, S., Kiriyama, K., Tamura Y., Sato, E., Takahashi H. and Sato, N.:Comparison of speedy PCR-SSP method and serological typing of HLA-A24 for Japanese cancer patients. J Immunoassay Immunoch . 32:93-102, 2011.
  • Inoda S., Hirohashi Y., Torigoe T., Takahashi A., Morita R., Nishizawa S., Tamura Y., Nakatsugawa M., Tsuruma T., Terui T., Ishitani K., Hirata K. and Sato N.. Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am. J. Pathol., 178:1805-1813, 2011.
  • Miyazaki, A., Kobayashi, J., Torigoe, T., Hirohashi, Y., Yamamoto, T., Yamaguchi, A., Michifuri, Y., Nakamori, K., Nagai, I., Sato, N. and Hiratsuka, H.:A phase I clinical trial of survivin-derived peptide vaccine therapy in HLA-A24-positive patients with oral cancer. Cancer Sci. 102:324-329, 2011.
  • Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Sato, N and Hirata, K. Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in patients with advanced colorectal cancer. Cancer Sci, 102:1181-1187, 2011.
  • Nagashima, T., Ichimiya, S., Kikuchi, T., Saito, Y., Matsumiya, H., Ara, S., Koshiba, S., Zhang, J., Hatate, S., Tonooka, A., Kubo, T., Hirose, B., Shirasaki, H., Izumi, T., Takami, T., Himi, T. and Sato, N. Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlong primary B cells and their cognate T cell help. Am. J. Pathol., 171:222-232, 2011.
  • Hirohashi Y, Sato N. Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity. Immunotherapy. 2011 Aug;3(8):945-7.
  • Nakatsugawa M, Horie K, Yoshikawa T, Shimomura M, Kikuchi Y, Sakemura N, Suzuki S, Nobuoka D, Hirohashi Y, Torigoe T, Harada K, Takasu H, Sato N, Nakatsura T.  Identification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from the lung carcinoma antigen, Lengsin. Int J Oncol. 2011 Jun 17. doi: 10.3892/ijo.2011.1089. [Epub ahead of print]
  • Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N. Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses. Exp Mol Pathol. 2011 Oct 15. [Epub ahead of print]
  • Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Kondo T, Greene MI, Hara I, Sato N. Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population. Exp Mol Pathol. 2011 Oct 15. [Epub ahead of print]
  • Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma H., Tamura Y., Hasegawa T., Takahashi, H. and Sato, N.: SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential. Lab Invest. 2011 Sep 19. doi: 10.1038/labinvest.2011.140. [Epub ahead of print]

2010

  • Okuya, K., Tamura, Y., Saito, K., Kutomi, G., Torigoe, T., Hirata, K., Sato, N. Extracellular heat shock protein 90 (Hsp90) directs self-DNA to static early endosome-resident TLR-9, leading to type I interferon production. J. Immunol., 184:7092-7099, 2010.
  • Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N., Sato, N. : Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells. Exp Mol Pathol. 88:128-132, 2010.
  • Ohno, K., Nishimori, H., Yasoshima, T., Kamiguchi, K., Hata, F., Fukui, R., Okuya, K., Kimura, Y., Denno, R., Kon, S., Uede, T., Sato, N. Hirata, K. Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model. Surg. Today, 40:347-356, 2010
  • Sato, A., Tamura, Y., Sato, N., Yamashita, T., Takada, T., Sato, m., Ohura, M., Ono, I., Ito, A., Honda, H., Wakamatsu, K., ito, S. and Jimbow, K.:Melanoma-Specific Intracellular Hyperthermia Using N-propiony1-4-S-cysteamimylphenol-Magnetite nanoparticle Elicits Immunogenic Cell Death Through the Release of heat Shock Protein-Peptide Complex. Cancer Science, 101:1939-1946, 2010.
  • Yabe H, Tsukahara T, Kawaguchi S, Wada T, Torigoe T, Sato N, Terai C, Aoki M, Hirose S, Morioka H, Yabe H. : Prognostic significance of HLA Class I expression in ewing's sarcoma family of tumors. J Surg Oncol. 2010 Dec 28. [Epub ahead of print]
  • Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Nakatsugawa, M., Tamura, Y., Toyota, M. and Sato, N.:Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells. Immunotherapy, 2: 201-211, 2010.

2009

  • Tsukahara, T., Kimura, S., Ichimiya, S., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T. and Sato, N.:Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. Cancer Sci., 100(1): 47-53. 2009.
  • Kobayashi, J., Hirohashi, Y., T Torigoe, T., Yamamoto, T., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Hariu, H., Hiratsuka, H. and Sato, N.:Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma. Hum Immunol. 70(2): 89-95. 2009.
  • Tonooka, A., Kubo, T., Ichimiya, S., Tamur, Y., Ilmarinen, T., Ulmanen, I., Kimura, S., Yokoyama, S., Takano, Y., Kikuchi, T. and Sato, N.: Wind-type AIRE cooperates with p63 in HLA class Ⅱ expression of medullary thymic stromal cells. Biochem Biophys Res Commun. 13; 379(3): 765-70, 2009.
  • Matsumoto, Y., Fujita, T., Hirai, I., Sahara, H., Torigoe, T., Ezoe, K., Saito, T., Cruikshank, W., Yotsuyanagi, T, and Sato, N. : Immunosuppressive Effect on T cell Activation by Interleukin-16 (IL-16)-16 and Interleukin-10 (IL-10)- cDNA- Double- Transfected Human Squamous Cell Line. Burns., 35 (3): 383-389, 2009.
  • Sugawara, A., Torigoe, T., Tamura, Y., Kamiguchi, K., Nemoto, K., Oguro, H., Sato, N.: Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells. Cell Stress Chaperone, 14: 133-139, 2009.
  • Kobayashi, J., Torigoe, T., Hirohashi, Y., Idenoue, S., Miyazaki, A., Yamaguchi, A., Hiratsuka, H. and Sato, N. : Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients. J. Transl. Med. 7:1-11, 2009.
  • Yamano, K., Goto, A., Miyoshi, M., Furuya, K., Sawada, Y., Sato, N. : Diagnosis of alveolar echinococcosis using immunoblotting with pleural low molecular weight antigens. J. Helminthol., 83: 57-61, 2009.
  • Yoshida, S., Hazama, S., Tokuno, K., Sakamoto, K., Takashima, M., Tamesa, T., Torigoe, T., Sato, N. and Oka, M.:Concomitant overexpession of heat-shock protein 70 and HLA class Ⅰ in hepatitis C virus-related hepatocellular carcinoma. Anticancer Res. 29: 539-44, 2009.
  • Tsukahara, T., Kawaguchi, S., Torigoe, T., Murase, M., Wada, T., Kaya, M., Nagoya, S., Yamashita, T. and Sato, N.: HLA-A*0201-restricted clonal CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor. J. Transl. Med., 12;7: 44, 2009.
  • Honma, I., Kitamura, H., Torigoe, T. Takahashi,. A, Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Tsukamoto, T., Sato, N.:Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer. Cancer Immunol. Immunother., 58:1801-7, 2009.
  • Sato, M., Yamashita, T., Ohura, M., Osai, Y., Sato, A., Takada, T., Matsusaka, H., Ono, I., Tamura, Y., Sato, N., Sasaki, Y., Ito, A., Honda, H., Wakamatsu, K., Ito, S. and Jimbow, K.:N-Propionyl-Cysteaminylphenol-Magnetite Conjugate (NPrCAP/M) is a Nanoparticle for the Targeted Growth Suppreesion of Melanoma Cells. J. Invest. Dermatol., 129:2233-2241, 2009.
  • Tahara, H., Sato, M., Thurin, M., Wang, E., Butterfield, LH., Disis, ML., Fox, BA., Lee, PP., Khleif, SN., Wigginton, JM., Ambs, S., Akutsu, Y., Chaussabel, D., Doki, Y., Eremin, O., Fridman, WH., Hirohashi, Y., Imai, K., Jacobson, J., Jinushi, M., Kanamoto, A., Kashani-Sabrt, M., Kato, K., Kawakami, Y., Kirkwood, JM, Kleen, TO., Lahmann, PV., Liotta, L., Lotze, MT., Malyguine, A., Masucci, G., Matsubara, H., Nakamura, K., Nishikawa, H., Palucka, AK., Petricoin, EF., Pos, Z., Ribas, A., Rivoltini, L., Sato, N., Shiku, H., Slingluff, CL., Streicher, H., Stroncek, DF., Takeuchi, H., Toyota, M., Wada, H., Wu, X., Wulfkuhle, J., Yaguchi, T., Zeskind, B., Zhao, Y., Zocca, MB. And Marincola, FM. : Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology. Journal of Translational Medicine, 7:45, 2009.
  • Nakatsugawa, M., Hirohashi, Y., Torigoe, T., Asanuma, H., Takahashi, A., Inoda, S., Kiriyama, K., Nakazawa, E., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Shijubo, N., Honda, R., Nomura, N., Hasegawa, T., Takahashi, H. and Sato, N.:Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. Cancer Sci., 100: 1485-93, 2009.
  • Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Nakazawa, E., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Wang, Q., Greene, MI., Hasegawa, T., Hirata, K. and Sato, N.: Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother. 32: 474-85, 2009.
  • Kutomi, G., Tamura, Y., Okuya, K., Yamamoto, T., Hirohashi, Y., Kamiguchi, K., Oura, J., Saito, K., Torigoe, T., Ogawa, S., Hirata, K. and Sato, N.:Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen-regulated protein 150-peptide complexes. J Immunol. 183: 5861-9, 2009.
  • Takada, T., Yamashita, T., Sato, M., Sato, A., Ono, I., Tamura, Y., Sato, N., Miyamoto, A., Ito, A., Honda, H., Wakamatsu, K., Ito, S., Jimbow, K. : Growth inhibition of re-challenge B16 melanoma transplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy. J Biomed Biotechnol. :457936, 2009.
  • Murase, M., Kano, M., Tsukahara, T., Takahashi, A., Torigoe, T., Kawaguchi, S., Kimura, S., Wada, T., Uchihashi, Y., Kondo, T., Yamashita, T., Sato N. : Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas. Br J Cancer. 20;101(8):1425-32, 2009.
  • Honma, I., Torigoe, T., Hirohashi, Y., Kitamura, H., Sato, E., Masumori, N., Tamura, Y., Tsukamoto, T. and Sato, N.:Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer. J Transl. Med., 7: 103, 2009.
  • Homma, I., Kitamura, H., Torigoe, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T. : Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer: Its association with clinical characteristics and survival after cystectomy. Cancer Sci. 100:2331-2334, 2009
  • Hirohashi, Y., Torigoe, T., Inoda, S., Kobayashi, J., Nakatsugawa, M., Mori, T., Hara, I. and Sato, N.:The functioning antigens; beyond just as the immunologic targets. Cancer Sci., 100: 798-806, 2009.
  • Sato, N., Hirohashi, Y., Tsukahara, T., Kikuchi, T., Sahara, H., Kamiguchi, K., Ichimiya, S., Tamura, H. and Torigoe, T.:Molecular pathologic approaches to human tumor immunology. Pathol. Int., 59: 205-217, 2009.
  • Torigoe, T., Tamura, Y., Sato, N. : Heat shock proteins and immunity: Application of hyperthermia for immunomodulation. Int. J. Hyperthermia 25:610-616, 2009.

2008

  • Mori, Y., Sahara, H., Matsumoto, K., Takahashi, N., Yamazaki, T., Ohta, K., Aoki, S., Miura, M., Sugawara, F., Sugawara, F., Sakaguchi, K. and Sato. N.:Downregulation of tie2 gene by a novel antitumor sulfolipid, 3’-sulfoquinovosyl-1’-monoacylglycerol, targeting angiogenesis. Cancer Sci., 99(5): 1063-1070, 2008.
  • Tsukahara, T., Kawaguchi, S., Torigoe, T., Kimura, S., Murase, M., Ichimiya, S., Wada, T., Kaya, M., Nagoya, S., Ishii, T., Ishii, T., Tazaki, S., Yamashita, T. and Sato, N:Prognostic impact and immunogenicity of a novel osteosarcoma ntigen, papillomavirus binding factor, in patients with osteosarcoma. Cancer. Sci., 99(2): 368-275, 2008.
  • Kamiguchi, K., Torigoe, T., Fujiwara, O., Oshima, S., Hirohashi, Y., Sahara, H., Hirai, I., Kohgo, Y. and Sato, N.:Disruption of the association of 73kD heat shock protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum. Microbiol. Immunol., 52(2): 94-106, 2008.
  • Koshiba, S., Ichimiya, S., Nagashima, T., Tonooka, A., Kubo, T., Kikuchi, T., Himi, T., Sato, N. :Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin 6 to support B-cell development via p63/p73 transcription factors. J. Pathol., 214(1): 75-84, 2008.
  • Tsuruma, T., Iwayama, Y., Ohmura, T., Katsuramaki, T., Hata, F., Furuhata, T., Yamaguchi, K., Kimura, Y., Torigoe, T., Toyota, N., Yagihashi, A., Hirohashi, Y., Asanuma, H., Shimozawa, K., Okazaki, M., Mizushima, Y., Nomura, N., Sato, N. and Hirata, K.:Clinical and Immunological Evaluation of Anti-apoptosis Protein, Survivin-derived Peptide Vaccine in Phase I Clinical Study for Patients with Advanced or Recurrent Breast Cancer. J. Translational Med., 6: 24, 10 May, 2008.
  • Kubo, T., Ichimiya, S., Tonooka, A., Nagashima, T., Kikuchi, T. and Sato, N. :p63 Induces CD4? T-cell chemoattractant TARC/CCL17 in Human Epithelial Cells.  Journal of Interferon & Cytokine Research., 28: 725-732, 2008.
  • Kimura, S., Kozakai, Y., Kawaguchi, S., Tsukahara, T., Ida, K., Murase, M., Matsumura, T., Kaya, m., Torigoe, T., Wada, T., Sato, N. and Yamashita, T. : Clonal T cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206. J. Orthop. Res., 26(2): 271-278, 2008.
  • Yabe, H., Tsukahara, T., Kawaguchi, S., Wada, T., Sato, N., Morioka, H. and Yabe, H.: Overexpression of papillomavirus binding factor in Ewing’s sarcoma family of tumors conferring poor prognosis. Oncology Reports., 19: 129-134, 2008.
  • Sato, E., Torigoe, T., Hirohashi, Y., Kitamura, H., Honma, I., Asanuma, H., Masumori, N., Ito, N., Tsukamoto, T. and Sato, N.: Identification of immunogenic CTL epitopes of HIFPH3 for specific immunotherapy of renal cell carcinoma. Clin. Cancer Res., 14(21): 6919-6923, 2008.
  • Takeuchi, H., Kawaguchi, S., Mizuno, S., Kirita, T., Takebayashi,T., Shimozawa, K., Torigoe, T., Sato, N. and Yamashita, T.: Gene expression profile of dorsal root ganglion in a lumbar radiculopathy model. Spine., 1; 33(23): 2483-2488, 2008.
  • Tsukahara, T., Torigoe, T., Tamura, Y., Kawaguchi, S., Wada, T. and Sato, N.:Antigenic peptide vaccination: Provoking immune response and clinical benefit for cancer. Current Immunol Rev., 4:235-241, 2008.

2007

  • Maeda, N., Kokai, Y., Ohtani, S., Sahara, H., Kuriyama, I., Kamisuki, S., Takahashi, S., Sakaguchi, K., Sugawara, F., Yoshida, H., Sato, N. and Mizushima, Y.:Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase α. Biochemical and Biophysical Research Communications., 352: 390-396, 2007.
  • Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K., Tsukahara, T., Sato, N., Kitamura, H., Iwasaki, N., Takeda, N., Minami, A. and Nishimura, T.:Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral Immune system. Int. J. Oncol., 30: 461-467, 2007.
  • Kikuchi, T., Naruse, TK., Onizuka, M., Li, S., Kimura, T., Oka, A., Morishima, Y., Kulski, JK., Ichimiya, S., Sato, N., Inoko, H.:Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22. Immunogenetics., 59: 99-108, 2007.
  • Kitamura, H., Honma, I., Torigoe, T., Asanuma, H., Sato, N. and Tsukamoto, T.:Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma. J. Urol., 177: 1269-1272, 2007.
  • Tanaka, T., Kitamura, H., Sahara, H., Imai, A., Itohl, Y., Honma, I., Sato, E.,Kobayashi,K., Maeda, T., Takenouchi, M., Ohta, K., Sugawara, F., Sakaguchi, K., Ando, A., Inoko, H., Sato, N. and Tsukamoto, T.:Effects of new immunosuppressive agent, β-SQAG9, in swine kidney transplantation. Transplant Immunol., 18: 67-71, 2007.
  • Imai, A., Sahara, H., Tamura, Y., Jimbow, K., Saito, T., Ezoe, K., Yotsuyanagi, T. and Sato, N.:Inhibition of endogenous MHC classⅡ- restricted antigen presentation by tacrolimus (FK506) via FKBP51. Eur. J. Immunol., 37 : 1730-1738, 2007.
  • Kurotaki, T., Tamura, Y., Ueda, G., Oura, J., Kutomi, G., Hirohashi, Y., Sahara,H.,Torigoe, T., Hiratsuka, H., Sunakawa, H., Hirata, K. and Sato, N.: Efficient cross-presentation by Heat shock protein 90 peptide complex-loaded dendritic cells via an endosomal pathway. J. Immunol., 179: 1803-13, 2007.
  • Tabata, A., Morikawa, M., Bennet, BL., Satoh, Y., Huang, J., Tamura, Y., Sato, N. and Abe,T.:Suppression of alloreactivity and allograft rejection by SP600125, a small molecule inhibitor of c-Jun N-terminal kinase. Transplantation., 83: 1358-1364, 2007.
  • Takeuchi, H., Kawaguchi, S., Ohwada, O., Kobayashi, H., Hayakawa, M., Takebayashi, T., Torigoe, T., Sato, N. and Yamashita, T.:Plasma neuropeptides in patients undergoing lumbar discectomy. Spine., 32: E79-84, 2007.
  • Kitamura, H., Torigoe, T., Honma, I., Hariu, H., Asanuma, H., Hirohashi, Y., Tamura, Y., Sato, N. and Tsukamoto, T::Expression of livin in renal cell carcinoma and detection of anti-livin autoantibody in patients. Urology., 70: 38-42, 2007.
  • Kitamura, H., Torigoe, T., Asanuma, H., Honma, I., Sato, N. and Tsukamoto, T. :Down-Regulation of HLA Class I Antigens in prostate Cancer Tissues and Up-Regulation by Histone Deacetylase Inhibition. J. Urology., 178: 692-696, 2007.
  • Maeda, N., Kokai, Y., Ohtani, S., Sahara, H., Hada, T., Ishimaru, C., Kuriyama, I., Yonezawa, Y., Iijima, H., Yoshida, H., Sato, N. and Mizushima, Y.:Anti-Tumor Effects of the Glycolipids Fraction from Spinach which Inhibited DNA Polymerase Activity. Nutrition.Cancer., 57(2): 216-223, 2007.
  • Maeda, H., Sahara, H., Mori, Y., Torigoe, T., Kamiguchi, K., Tamura, Y., Tamura, Y., Hirata, K. and Sato, N. :Biological Heterogeneity of the Peptide-binding Motif of the 70-kDa Heat Shock Protein by Surface Plasmon Resonance Analysis. J. Biol. Chem., 282: 26956-26962, 2007.
  • Takahashi, H., Shigehara, K., Yamamoto, M., Suzuki, C., Naishiro, Y., Tamura, Y., Hirohashi, Y., Satoh, N., Shijubo, N., Shinomura, Y. and Imai, K.:Interferon γ assay for detecting latent tuberculosis infection in rheumatoid arthritis patients during infliximab administration. Rheumatol Int., 27: 1143-1148, 2007.
  • Shima, H., Tsuruma, T., Sahara, H., Takenouchi, M., Takahashi, N., Iwayama, Y., Yagihashi, A., Watanabe, N., Sato, N. and Hirata, K.:Protective mechanism of β-SQAG9 liposome, a sulfonoglycolipid extracted from sea urchin intestines, against hepatic ischemia reperfusion inhury. Shock., 28: 94-100, 2007.
  • Fukui, R., Nishimori, H., Hata, F., Yasoshima, T., Ohno, K., Yanai, Y., Kamiguchi, K., denno, R., Sato, N. and Hirata, K.:Inhibitory effect of endothlin A receptor bloc Kade on tumor growth and liver me tastasis of a human gastric cancer cell line. Gastric Cancer., 10:123-128, 2007.

2006

  • Tsukahara, T., Kawaguchi, S., Ida, K., Kimura, S., Tamura, Y., Ikeda, T., Torigoe, T., Nagoya, S., Wada, T., Sato, N. and Yamashita, T.:HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node. J. Orthop. Res., 24: 94-101, 2006
  • Hatakeyama, N., Tamura, Y., Sahara, H., Suzuki, N., Suzuki, K., Hori, T., Mizue, N., Torigoe, T., Tsutsumi, H. and Sato, N.:Induction of autologous CD4- and CD8-mediated T-cell responses against acute lymphocytic leukemia cell line using apoptotic tumor cell-loaded dendritic cells. Exp. Hematol., 34: 197-207, 2006
  • Ueda, G., Sunakawa, H., Nakamori, K., Shinya, T., Tsuhako, W., Tamura, Y., Kosugi, T., Sato, N., Ogi, K. and Hiratsuka, H.:Aberrant expression of β-and γ-catenin is an independent prognostic marker in oral squamous cell carcinoma. Int. J. Oral Maxillofacial Surg., 35: 356-361, 2006
  • Kitamura, H., Torigoe, T., Asanuma, H., Tamura, Y., Hisasue, S., Suzuki, K., Tsukamoto,T., Sato, M. and Sato, N.:Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. Histopathology., 48: 157-161, 2006
  • Kitamura, H., Torigoe, T., Honma, I., Asanuma, H., Nakazawa, E., Shimozawa, K., Hirohashi, Y., Sato, E., Sato, N. and Tsukamoto T.:Expression and antigenicity of urviving, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy. Urology., 67: 955-959, 2006
  • Kitamura, H., Torigoe, T., Honma, I., Sato, E., Asanuma, H., Hirohashi, Y., Sato, N. and Tsukamoto, T.:Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus Calmette-Guerin immunotherapy for bladder cancer. Clin. Cancer Res., 12: 4641-4644, 2006
  • Tsukahara, T., Kawaguchi, S., Torigoe, T., Asanuma, H., Nakazawa, E., Shimozawa, K., Nabeta, Y., Kimura, S., Kaya, M., Nagoya, S., Wada, T., Yamashita, T. and Sato, N.:Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5. Cancer Sci., 97: 1374-1380, 2006
  • Komori, H., Nakatsura, T., Senju, S., Ikuta, Y., Yokomine, K., Yoshitake, Y., Motomura, Y., Beppu, T., Matsui, M., Torigoe, T., Sato, N., Baba, H., and Nishimura, Y.:Identification of HLA-A2- or ?A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy for hepatocellular carcinoma. Clin. Cancer Res., 12: 2689-2697, 2006
  • Hirohashi, Y., Wang, Q., Liu, Q., Xiulian, Du., Zhang, H., Sato, N. and Greene, M. I.:p78/MCRS1 forms a centrosomal protein complex with NudE and plays an essential role in mitosis. Oncogene., 25: 4937-4946, 2006
  • Hirohashi, Y., Wang, Q., Liu, Q., Li, B., Du, X., Zhang, H., Furuuchi, K., Masuda, K., Sato, N. and Greene, M. I.:Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. Oncogene., 25: 6048-6055, 2006
  • Hatamoto, K., Torigoe, T., Mano, Y., Asai, Y. and Sato, N.:Disruption of the interaction between retinoblastoma protein and 70 kD heat shock protein leads to growth acceleration of tumor cells. Tumor Res., 41: 43-57, 2006
  • Sato, N., Hirohashi, Y., Tsukahara, T., Kamiguchi, K., Ichimiya, S., Sahara, H., Takahashi, N., Tsuruma, T., Hirata, K., Miyazaki, A., Yamaguchi, A., Hiratsuka, H., Tsukamoto, T., Kawaguchi, S., Wada, T., Yamashita, T., Shijubo, N., Takahashi, H., Ogasawara, M., Tamura, Y. and Torigoe, T.:Current progress and perspectives for human tumor immunotherapy. Tumor Res., 41: 1-13, 2006

2005

  • Kondo, N., Ichimiya, S., Tamura, Y., Tonooka, A., Koshiba, S., Torigoe, T., Kamiguchi, K., Takenaga, K. and Sato, N.:A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen. Microbiol. Immunol., 49: 49-56, 2005
  • Hariu, H., Hirohashi, Y., Torigoe, T., Asanuma, H., Hariu, M., Tamura, Y., Aketa, K., Nabeta, C., Nakanishi, K., Kamiguchi, K., Mano, Y., Kitamura, H., Kobayashi, J., Tsukahara, T., Shijubo, N. and Sato, N.:Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in Lung Cancer. Clin. Cancer Res., 11: 1000-1009, 2005
  • Idenoue, S., Hirohashi, Y., Torigoe, T., Sato, Y., Tamura, Y., Hariu, H., Yamamoto, M., Kurotaki, T., Tsuruma, T., Asanuma, H., Kanaseki, T., Ikeda, H., Kashiwagi, K., Okazaki, M., Sasaki, K., Sato, T., Ohmura, T., Hata, F., Yamaguchi, K., Hirata, K. and Sato, N.:A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin. Cancer Res., 11:1474-82, 2005
  • Takenouchi, M., Sahara, H., Yamamoto,Y., Matsumoto, Y., Imai, A., Fujita, T., Tamura, Y., Takahashi, N., Gasa, S., Matsumoto, K., Ohta, K., Sugawara, F., Sakaguchi, K., Jimbow, K. and Sato, N. : Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug β-SQAG9, which inhibits the response of the CD62L+ T cell subset. Transplant. Proc., 37:139-142, 2005
  • Yagihashi, A., Asanuma, K., Kobayashi, D., Tsuji, N., Shijubo, Y., Abe, S., Hirohashi, Y., Torigoe, T., Sato, N., and Watanabe, N. Detection of autoantibodies to livin and survivin in Sera from lung cancer patients. Lung Cancer., 48: 217-221, 2005
  • Ingu, A., Komatsu, K., Ichimiya, S., Sato, N., Hirayama, Y., Morikawa, M. and Abe, T.:Effects of inhaled FK506 on the suppression of acute rejection after lung transplantation: Use of a rat orthotopic lung transplantation model. J. Heart Lung Transplant., 24: 538-543, 2005
  • Inomata, S., Shijubo, N., Kon, S., Maeda, M., Yamada, G., Sato, N., Abe, S. and Uede, T.:Circulating interleukin-18 and osteopontin are useful to evaluate disease activity in patients with turberculosis. Cytokine., 30: 203-211, 2005
  • Suzuki, K., Tanaka, H., Sahara, H., Tanaka, N., Tamura, Y., Naruse, T., Inoko, H.,Tsushima, K., Kubo, K., Abe, S. and Sato, N.:HLA class Ⅱ DPB1, DQA1, DQB1 and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom. Tissue Antigens., 65: 459-466, 2005
  • Nakashima, S., Morikawa, M., Komatsu, K., Matsuura, A., Sato, N. and Abe, T.: Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J. Heart Lung Transplantation., 24: 462-469, 2005
  • Shima, H., Tsuruma, T., Sahara, H., Takenouchi, M., Takahashi, N., Iwayama, Y.,Yagihashi, A., Watanabe, N., Sato, N. and Hirata, K.:Treatment with beta-SQAG9 prevents rat hepatic ischemia-reperfusion injury. Transplant. Proc., 37: 417-421, 2005
  • Suzuki, A., Shijubo, N., Yamada, G., Ichimiya, S., Satoh, M., Abe, S. and Sato, N.:Napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs. Pathology Research and Practice., 201: 579-586, 2005
  • Kawaguchi, S., Wada, T., Ida, K., Sato, Y., Nagoya, S., Tsukahara, T., Kimura, S., Sahara, H., Ikeda, H., Shimozawa, K., Asanuma, H., Torigoe, T., Hiraga, H., Ishii, T., Tatezaki, SI, Sato, N. and Yamashita, T.:Phase Ⅰvaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma. J. Transl. Med., 3: 1, 2005
  • Yagihashi, A., Ohmura, T., Asanuma, K., Kobayashi, D., Tsuji, N., Torigoe, T., Sato, N., Hirata, K. and Watanabe, N.:Detection of autoantibodies to survivin and livin in sera from patients with breast cancer. Clin. Chim. Acta., 362: 125-130, 2005
  • Fukui, R., Nishimori, H., Hata, F., Yasoshima, T., Ohno, K., Nomura, H., Yanai, Y., Tanaka, H., Kamiguchi, K., Denno, R., Sato, N. and Hirata, K.:Metastases-related genes in the classification of liver and peritoneal metastasis in human gastric cancer. J. Surg. Res., 129: 94-100, 2005
  • Yagihashi, A., Asanuma, K., Kobayashi, D., Tsuji, N., Torigoe, T., Sato, N. and Watanabe, N.:Autoantibodies to survivin in patients with chronic hepatitis and hepatocellular carcinoma. Autoimmunity., 38: 445-448, 2005
  • Kojima, H., Shijubo N., Yamada G., Ichimiya S., Abe, S., Satoh, M., and Sato, N.:Clinical significance of vascular endothelial growth factor-C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma. Cancer., 104: 1668-1677, 2005
  • Yamamoto, M., Torigoe, T., Kamiguchi, K., Hirohashi, Y., Nakanishi, K., Nabeta, C., Asanuma, H., Tsuruma, T., Sato, T., Hata, F., Omura, T., Yamaguchi, K., Kurotaki, T., Hirata, K. and Sato, N.:A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis. Cancer Res., 65: 8706-8714, 2005
  • Asanuma, H., Torigoe, T., Kamiguchi, K., Hirohashi, Y., Ohmura, T., Hirata, K., Sato, M. and Sato, N.:Survivin expression is regulated by coexpression of Human Epidermal Growth Factor Receptor 2 and Epidermal Growth Factor Receptor via Phosphatidylinositol 3- Kinase/AKT signaling pathway in breast cancer cells. Cancer Res., 65: 11018-11025, 2005
  • Sato, T., Masuoka, S., Toda, K., Watabe, K., Igarashi, T., Yamamoto, M., Sogahata, K., Idenoue, S., Kiriyama, K., Ito, T., Meguro, M., Kutomi, G., Takashima, T., Tsuruma, T.,Ohmura, T., Someya, T., Katsuramaki, T., Asaishi, K., Sato, N. and Hirata, K.:Characterization of p53 gene mutations in fine-needle aspirated breast cancer: correlation with clinicopathological features and short-term relapse. Tumor Res., 40: 25-35, 2005
  • Tsuruma, T., Torigoe, T., Hata, F., Furuhata, T., Ohmura, T., Katsuramaki, T., Yamaguchi, K., Kimura, Y., Sato, N. and Hirata, K.:Peptide-based vaccination for colorectal cancer. Expert Opinion on Biological Therapy., 5: 799-807, 2005
  • Kawaguchi, S., Wada, T., Tsukahara, T., Ida, K., Sato, Y., Torigoe, T., Sato, N. and Yamashita, T.:A quest for therapeutic antigens in bone and soft tissue sarcoma. J. Translational Medicine., 3: 31, 2005

2004

  • Takamura, Y., Ikeda, H., Kanaseki, T., Toyota, M., Tokino, T., Imai, K., Hokin, K. and Sato, N.:Regulation of MHC class Ⅱ expression in glioma cells by class Ⅱ transactivator (C ⅡTA). Glia, 45:392-405, 2004
  • Ohchi, T., Shijubo, N., Kawabata, I., Ichimiya, S., Inomata, S., Yamaguchi, A., Umemori, Y., Itoh, Y., Abe, S. Hiraga, Y. and Sato, N.:Polymorphism of clara cell 10-kD protein gene of sarcoidosis. Am J. Respir. Crit. Care. Med., 169:180-186, 2004
  • Morimoto, Y., Toyota, M., Satoh, A., Murai, M., Mita, H., Suzuki, H., Takamura, Y., Ikeda, H., Ishida, T., Sato, N., Tokino, T. and Imai, K.:Inactivation of class Ⅱ transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-γ in haematopoietic tumor cells. British Journal of Cancer, 90:844-852, 2004
  • Nakamura, M., Tsuji, N., Asanuma, K., Kobayashi, D., Yagihashi, A., Hirata, K., Torigoe, T., Sato, N. and Watanabe, N.:Survivin as a predictor of cis-Damminedichloroplatinum sensitivity in gastric cancer patients. Cancer Sci., 95:44-51, 2004
  • Hara, I., Sato, N., Miyake, H., Murakami, M., Hikosaka, S. and Kamidono, S.:Introduction of 65kDa antigen of Mycobacterium tuberculosis to cancer cells enhances anti-tumor effect of BCG therapy. Microbiol. Immunol., 48: 289-295, 2004
  • Ueda, G., Tamura, Y., Hirai, I., Kamigichi, K., Ichimiya, S., Torigoe, T., Hiratsuka, H., Sunakawa, H. and Sato, N.:Tumor-derived heat shock protein70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity. Cancer Sci., 95: 248-253, 2004
  • Kikuchi,T., Ichimiya, S., Kojima, T., Crisa, L., Koshiba, S., Tonooka, A., Kondo, N., Van Der Saag PT., Yokoyama, S., Sato, N.:Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes. Int Immunol., 16:831-841, 2004
  • Tsuruma, T., Hata, F., Torigoe, T., Furuhata, T., Idenoue, S., Kurotaki, T., Yamamoto, M., Yagihashi, A., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Yasoshima, T., Sasaki, K., Mizushima, Y., Minamida, H., Kimura, H., Akiyama, M., Hirohashi, Y., Asanuma, H., Tamura, Y., Shimozawa, K., Sato, N. and Hirata, K. PhaseⅠ clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer. J. Translational Med., 2:19-29, 2004
  • Ida, K., Kawaguchi, S., Sato, Y., Tsukahara, T., Nabeta, Y., Sahara, H., Ikeda, H., Torigoe, T., Ichimiya, S., Kamiguchi, K., Wada, T., Nagoya, S., Hiraga, H., Kawai, A., Ishii, T., Araki, N., Myoui, A., Matsumoto, S., Ozaki, T., Yoshikawa, H., Yamashita, T. and Sato, N.:Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substitute. J. Immunol., 173: 1436-1443, 2004
  • Matsumoto, K., Takenouchi, M., Ohta, K., Ohta, Y., Imura, T., Oshige, M., Yamamoto, Y., Sahara, H., Sakai, H., Abe, M., Sugawara, F., Sato, N. and Sakaguchi, K.:Design of vesicles of 1, 2-di-ο-acyl-3-ο-(β- D- sulfoquinovosyl) -glyceride bearing two stearic acids (β-SQDG-C18), a novel immunosuppressive drug. Biochemical Pharmacology, 68: 2379-2386, 2004
  • Tsukahara, T., Nabeta, Y., Kawaguchi, S., Ikeda, H., Sato, Y., Shimozawa, K., Ida, K., Asanuma, H., Hirohashi, Y., Torigoe, T., Hiraga, H., Nagoya, S., Wada, T., Yamashita, T. and Sato, N.:Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor. Cancer Res., 64: 5442-5448, 2004
  • Nakanishi, K., Kamiguchi, K., Torigoe, T., Nabeta, C., Hirohashi, Y., Asanuma, H., Tobioka, H., Koge, N., Harada, O., Ichimiya, S., Nagano, H., Yano, S., Matsumoto, H. and Sato, N.:Localization and function in ER stress tolerance of ERdj3 molecule, a new member of HSP40 family protein. Cell Stress & Chaperones, 9: 253-264, 2004
  • Fujita, T., Miyagawa, S., Ezoe, K., Saito, T., Sato, N., Takahagi, Y., Murakami, H., Matsunami, K., Shirakura, R. and Taniguchi, N.:Skin graft of double transgenic pigs of N-acetylglucosaminyltransferase Ⅲ (Gn T-Ⅲ) and DAF (CD55) genes survived in cynomolgus monkey for 31days. Transplant Immunol., 13: 259-264, 2004
  • Takahashi, R., Shijubo, N., Shigehara, K., Hiraga, Y., Abe, S. and Sato, N.:T helper 1 inhibitor, TAK-603 inhibits IFN-γ and IL-12 production with no effect on IL-18 : an observation in sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis., 21: 204-211, 2004
  • Tsuruma, T., Sahara, H., Takenouchi, M., Yagihashi, A., Iwayama, Y., Shima, H., Furuhata, T., Torigoe, T., Hanashima, S., Yamazaki, T., Sugawara, F., Mizushina, Y., Ohta, K., Sakaguchi, K., Sato, N. and Hirata, K.:Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats. Transplant Proc., 36:1965-1969, 2004
  • Hata, F., Nishimori, H., Yasoshima, T., Tanaka, H., Ohno, K., Yanai, Y., Ezoe, E., Kamiguchi, K., Isomura, H., Denno, R., Sato, N. and Hirata, K.:Profiling analysis of differential gene expression between hematogenous and peritoneal metastatic sublines of human pancreatic cancer using a DNA chip. J. Exp. Clin. Cancer Res., 23: 513-520, 2004
  • Sagae, S., Saito, T., Satoh, M., Ikeda, H., Kimura, S., Mori, M., Sato, N. and Kudo, R.:The reproducibility of a binary tumor grading system for uterine endometrial endometrioid carcinoma, compared with FIGO system and nuclear grading. Oncology, 67: 344-350, 2004
  • Satoh, A., Toyota, M., Ikeda, H., Morimoto, Y., Akino, K., Mita, H., Suzuki, H., Sasaki, Y., Kanaseki, T., Takamura, Y., Soejima, H., Urano, T., Yanagihara, K., Endo, T., Hinoda, Y., Fujita, M., Hosokawa, M., Sato, N., Tokino, T. and Imai, K.:Epigenetic inactivation of a class Ⅱ transactivator (CⅡTA) is associated with the absence of interferon-γ-induced HLA-DR expression in colorectal and gastric cancer cells. Oncogene, 23: 8876-8886, 2004
  • Yamamoto, Y., Sahara, H., Takenouchi, M., Matsumoto, Y., Imai, A., Fujita, T., Tamura, Y., Takahashi, N., Gasa, S., Matsumoto, K., Ohta, K., Sugawara, F., Sakaguchi, K., Jimbow, K. and Sato, N.:Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, β-SQAG9 liposome that binds to CD62L molecule on the cell surface. Cell Immunol., 232: 105-115, 2004
  • Saikai, T., Tanaka, H., Sato, N., Abe, S. and Matsuura, A.:Mushroom plant workers experience a shift towards a T helper type 2 (TH2) dominant state: contribution of innate immunity to spore antigen. Clin. Exp. Immunol., 135: 119-124, 2004
  • Tsukahara, T., Kawaguchi, S., Nagoya, S., Wada, T., Yamashita, T., Tsuruma, T., Hirata, K., Sahara, H., Torigoe, T., Ikeda, H. and Sato, N.:Novel approach to immunotherapy for epithelial cancers, bone and soft-tissue sarcomas. Ann. Cancer Res. Ther., 12: 53-70, 2004

2003

  • Shigehara, K., Shijubo, N., Ohmichi, M., Kamiguchi, K., Takahashi, R., Morita-Ichimura, S., Ochi, T., Tatsuno, T., Hiraga, Y., Abe, S. and Sato, N.:Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis. Clin. Exp. Immunol., 132: 152-157, 2003
  • Kanaseki, T., Ikeda, H., Takamura, Y., Toyota, M., Hirohashi, Y., Tokino, T., Himi, T. and Sato, N.:Histone deacetylation, but not hypermethylation, modifies CIITA and MHC calss II gene expression in squamous cell carcinomas. J. Immunol.,170: 4980-4985, 2003
  • Nakajima, F., Nishimori, H., Hata, F., Yasoshima, T., Nomura, H., Tanaka, H., Ohno, K., Yanai, Y., Kamiguchi, K., Sato, N., Denno, R. and Hirata, K.:Gene expression screening using a cDNA macroarray to clarify the mechanisms of peritoneal dissemination of pancreatic cancer. Surg. Today, 33: 190-195, 2003
  • Ichinohe, T., Ichimiya, S., Kishi, A., Tamura, Y., Kondo, N., Ueda, G., Torigoe, T., Yamaguchi, A., Hiratsuka, H., Hirai, I., Kohama, G. and Sato, N.:T- cell receptor variableγchain gene expression in the interaction between rat γδ- type T cells and heat-shock protein 70-like molecule. Microbiol. Immunol., 47: 351-357, 2003
  • Kashiwagi, K., Ikeda, H., Hirohashi, Y., Yamamoto, M., Idenoue, S., Hirai, I., Kamiguchi, K., Tamura, Y., Torigoe, T., Wada, Y., Hirata, K. and Sato, N.:Analysis of a shared pancreatic cancer antigen recognized by an HLA-A*2601 -restricted cytotoxic T-lymphocyte clone. Pancreas, 26(4): 81-88, 2003
  • Momota, H., Ichimiya, S., Kondo, N., Kikuchi, T., Torigoe, T., Yamaki, T., Houkin, K. and Sato, N.:Histone H2AX sensitizes glioma cells to genotoxic stimuli by recruiting DNA double-strand break repair proteins. International Journal of Oncology, 23:311-315, 2003
  • Nagata, M., Shijubo, N., Andrew, F. Walls, Ichimiya, S., Abe, S. and Sato, N.:Chymase-positive mast cells in small sized adenocarcinoma of the lung. Virchows Arch., 443:565-573, 2003
  • Nabeta, Y., Kawaguchi, S., Sahara, H., Ikeda, H., Hirohashi, Y., Goroku, T., Sato, Y., Tsukahara, T., Torigoe, T., Wada, T., Kaya, M., Hiraga, H., Isu, K., Yamawaki, S., Ishii, S., Yamashita, T. and Sato, N.:Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line. J. Orthop. Sci., 8:554-559, 2003
  • Tanaka, H., Hata, F., Nishimori, H., Honmou, O., Yasoshima, T., Nomura, H., Ohno, K., Hirai, I., Kamiguchi, K., Isomura, H., Hirohashi, Y., Denno, R., Sato, N. and Hirata, K.:Differential Gene Expression Screening Between Parental and Highly Metastatic Pancreatic Cancer Variants Using a DNA Microarray. J. Exp. Clin. Can. Res., 22: 307-313, 2003
  • Yagihashi, A., Asanuma, H., Tsuji, N., Torigoe, T., Sato, N., Hirata, K. and Watanabe, N.:Detection of anti-livin antibody in gastrointestinal cancer patients. Clinical Chemistry, 49:1206-1208, 2003
  • Momota, H., Ichimiya, S., Ikeda, T., Yamaki, T., Kikuchi, T., Houkin, K. and Sato, N.:Immunohistochemical analysis of the p53 family members in human craniopharyngiomas. Brain Tumor Pathol., 20: 73-77, 2003
  • Ohno, K., Hata, F., Nishimori, H., Yasoshima, T., Yanai, Y., Sogahata, K., Ezoe, E., Tanaka, H., Kamiguchi, K., Isomura, H., Denno, R., Sato, N. and Hirata, K.:Metastatic-associated biological properties and differential gene expression profiles in established highly liver and peritoneal metastatic cell lines of human pancreatic cancer. J. Exp. Clin. Cancer Res., 22: 623-631, 2003
  • Shijubo, N., Kawabata, I., Sato, N. and Itoh, Y.:Clinical aspects of clara cell 10-kDa protein/uteroglobin (secretoglobin1A1). Current Pharmaceutical Design, 9: 1139-1149, 2003
  • Shijubo, N., Kojima, H., Nagata, M., Ohchi, T., Suzuki, A., Abe, S. and Sato, N.:Tumor angiogenesis of non-small cell lung cancer. Microscopy Res. Tech., 60: 186-190, 2003
  • Tamura, Y. and Sato, N.:Heat shock proteins; Chaperoning of innate and adaptive immunities. Jpn. J. Hyperthermic Oncology, 19:131-139, 2003

2002

  • Yamaguchi, A., Nepote, J. A., Kadivar, M., Tagami, Y., Fukushi, M., Kukichi, Y., Sato, N. and Kikuchi, K.:Allele specific PCR with microfluorometry: application to the detection of del F508 mutation in cystic fibrosis. Clinica. Chimica. Acta, 316:147-154, 2002
  • Yamaguchi, A., Hashimoto, N., Tsutae, W., Seino, K., Ebana, Y., Tokino, T., Sato, N. and Kikuchi, K.:Detection of human papillomavirus DNA by PCR/microfluorometry for screening of cervical cancer. Clinica. Chimica Acta., 318:41-49, 2002
  • Sahara, H., Hanashima, S., Yamazaki, T., Takahashi, S., Sugawara, F., Ohtani, S., Ishikawa, M., Mizushima, Y., Ohta, K., Shimozawa, K., Gasa, S., Jimbow, K., Sakaguchi, K. Sato, N., and Takahashi, N.:Antitumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols. Jpn J. Cancer Res., 93:85-92, 2002
  • Sahara, H., Nabeta, Y., Torigoe, T., Hirohashi, Y., Ichimiya, S., Wada, Y., Takahashi, N., Jimbow, K., Yajima, T., Watanabe, N., Kikuchi, K. and Sato, N.:A gene encoding human gastric signet ring cell carcinoma antigen recognized by HLA-A31- restricted cytotoxic T lymphocytes.  J. Immunother., 25:235-242, 2002
  • Nishimori, H., Yasoshima, T., Hata, F., Denno, R., Yanai, Y., Nomura, H., Tanaka, H., Kamiguchi, K., Sato, N. and Hirata, K.:A novel nude mouse model of liver metastasis and perotpneal dissemination from the same human pancreatic cancer line. Pancreas, 24: 242-250, 2002
  • Ichimiya, S., Kojima, T., Momota, H., Kondo, N., Ozaki, T., Nakagawara, A., Toribio, ML., Imamura, M. and Sato, N.:p73 is expressed in human thymic epithelial cells.  J. Histochem. & Cytochem., 50: 455-462, 2002
  • Rong, S., Ikeda, H., Sato, Y., Hirohashi, Y., Takamura, Y., Sahara, H., Sato, T., Maeda, A., Ohguro, H. and Sato, N.:Frequent detection of anti-recoverin cytotoxic T-lymphocytes precursor in peripheral blood of cancer patients by using an HLA-A24-recoverin-tetramer. Cancer Immunol. Immunother., 51:282-290, 2002
  • Fujita, T., Ezoe, K., Matsumoto, Y., Saito, T., Homma, K., Jimbow, K. and Sato, N.:TAK-603, New rheumatic drug, inhibits rat mixed lymphocyte reactions and prolonges rat skin allograft survival.Transplantation Proceedings, 34:1133-1135, 2002
  • Hirohashi, Y., Torigoe, T., Maeda, A., Nabeta, Y., Kamiguchi, K., Sato, T., Yoda, J., Ikeda, H., Hirata, K., Yamanaka, N. and Sato, N.:An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivin. Clin. Cancer Res., 8:1731-1739, 2002
  • Maeda, A., Maeda, T., Ohguro, H., Palczewski, K. and Sato, N.:Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur. J. Immunol., 32: 2300-2307, 2002
  • Matsumoto, Y., Sahara, H., Fujita, T., Shimozawa, K., Takenouchi, M., Torigoe, T., Hanashima, S., Yamazaki, T., Takahashi, S., Sugawara, F., Mizushima, Y., Ohta, K., Takahashi, N., Gasa, S., Jimbow, K., Sakaguchi, K. and Sato, N.:An immunosuppressive effect by synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin. Transplantation, 74: 261-267, 2002
  • Sato, Y., Nabeta, Y., Tsukahara, T., Hirohashi, Y., Rong, S., Maeda, A., Sahara, H., Ikeda, H., Torigoe, T., Ichimiya, S., Wada, T., Yamashita, T., Hiraga, H., Kawai, A., Ishii, T., Araki, N., Myoui, A., Matsumoto, S., Umeda, T., Ishii, S., Kawaguchi, S. and Sato, N.:Detection and induction of cytotoxic T lymphocytes specific for SYT-SSX-derived peptides in HLA-A24+ patients with synovial sarcoma. J. Immunol., 169: 1611-1618, 2002
  • Kondo, H., Sahara, H., Miyazaki, A., Nabeta, Y., Hirohashi, Y., Kanaseki, T., Yamaguchi, A., Yamada, N., Hirayama, K., Suzuki, M., Hamuro, J., Torigoe, T., Takahashi, N., Kohama, G., Ikeda, H. and Sato, N.:Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells.  Jap. J. Cancer Res., 93:917-924, 2002
  • Nomura, H., Nishimori, H., Yasoshima, T., Hata, F., Tanaka, H., Nakajima, F., Honma, T., Araya, J., Kamiguchi, K., Isomura, H., Sato, N., Denno, R. and Hirata, K.:A new liver metastatic and peritoneal dissemination model established from the same human pancreatic cancer cell line: analysis using cDNA macroarray. Clin. Exp. Metastasis, 19: 391-399, 2002
  • Kawaguchi, S., Yamashita, T., Katahira, G., Yokozawa, H., Torigoe, T. and Sato, N.:Chemokine profile of herniated intervertebral discs infiltrated with  monocytes and macrophages. Spine, 27:1511-1516, 2002
  • Kanaseki, T., Torigoe, T., Hirohashi, Y., Hirai, I., Himi, T. and Sato, N.: Identification of germline mutation of PTEN gene and analysis of apoptosis resistance of the lymphocytes in a patient with Cowden disease. Pathobiology, 70: 34-39, 2002
  • Sato, Y., Sahara, H., Tsukahara, T., Kondo, M., Hirohashi, Y., Nabeta, Y., Kawaguchi, S., Ikeda, H., Torigoe,T., Ichimiya, S., Tamura, Y., Wada, T., Yamashita, T., Goto, M., Takasu, H. and Sato, N.:Improved generation of HLA class I/peptide tetramers. J. Immunol. Methods, 271: 177-184, 2002
  • Torigoe, T., Ichinohe, T., Nakanishi, K., Gouroku, T., Nabeta, C., Kamiguchi, K., Sato, N. and Yano, S.:DNA array analysis of gene expression after exposure of lymphocytes to brief microgravity. Drop Tower Days 2002 in Japan., 253-258, 2002
  • Tanaka, H., Saikai, T., Suzuki, K., Matsuura, A., Sato, N. and Abe, S.:Mechanisms of new types of occupational respiratory allergy in mushroom workers. Recent Res. Devel. Allergy & Clin. Immunol., 3: 53-63, 2002

2001

  • Maeda,A., Ohguro,H., Nabeta,Y., Hirohashi,Y., Sahara,H., Maeda,T., Wada,Y., Sato,T., Chuns,Y., Torigoe,T., Nishimura,Y., Kuroki,Y. and Sato,N.:Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin,cancer-associated retinopathy antigen,related with a better prognosis in a paraneoplastic syndrome. Eur.J.Immunol.,31:563-572,2001
  • Shigehara,K., Shujubo,N., Ohmichi,M., Takahashi,R., Kon,S., Okamura,H., Kurimoto,M., Hiraga,Y., Tatsuno,T., Abe,S. and Sato,N.: IL-12 and IL---18 are increased and stimulate IFN-γproduction in sarcoid lungs. J. Immunol.,166:642-649,2001
  • Nomura,H., Nishimori,H., Yasoshima,T., Hata,F., Sogahata,K.,Tanaka,H., Nakajima,F., Ikeda,S., Kamiguchi,K., Isomura,H., Sato,N., Denno,R. and  Hirata,K.:A new experimental mouse model of peritoneal dissemination of human gastric cancer cells: analysis of the mechanism of peritoneal dissemination using cDNA macroarrays.Jap.J.Cancer Res.,92:748-754,2001
  • Kishi,A., Ichinohe,T., Kinebuchi,M., Hirai,I., Tamura,Y., Matsuura,A., Torigoe,T. and Sato,N.:Tha cell surface-expressed HSC70-like molecule preferentially reacts with rat T cell receptorδ 6 family. Immunogenetics,53:401-409,2001
  • Nishimori,H., Yasoshima,T., Denno,R., Shishido,T., Hata,F., Homma, T., Ura,H., Yamaguchi,K., Yagihashi,A., Tanaka,H., Kawaguchi,S, Kamiguchi,K., Isomura,H., Sato,N. and Hirata,K:A new peritoneal dissemination model established from the human pancreatic cancer cell line: different mecganism in peritoneal dissemination and hematogeneous metastasis. Pancreas, 22:348-356,2001
  • Kawaguchi,S., Yamashita,T., Yokogushi,K., Murakami,T., Ohwada,O. and Sato,N.:Immunophenotypic analysis of the inflammatory infiltrates in herniated intervertebral disc. Spine,26:1209-1214,2001
  • Kajjino,Y., Yamaguchi,A., Hashimoto,N., Matsuurs,A., Sato,N. and Kikuchi,K.:β-catenin gene mutation in human hair follicle-related tumors. Pathol.Int., 51:543-548,2001
  • Yamaguchi,A., Hashimoto,N., Tsutae,W., Seino,K., Osanai,H., Yamamoto,N., Tokino,T., Sato,N. and Kikuchi,K.:Dried feces spots as an     alternative DNA souces: Detection of k-ras mutations in colorectal cancer. Tumor Res.,36:7-13,2001 36:132-134,2001.
  • Torigoe,T., Ichinohe,T., Sato,N. and Yano,S.:Analysis of gene expression of lymphocytes in microgravity. BiologicalSciences in Space,15:306-307,2001
  • Shijubo,N., Shigehara,K., Okamura,H., Takahashi,R., Suzuki,A., Yamada,G., Sato,N. and Abe,S.:Interleukin-18 in inflammatory lung diseases.  Recent Res.Devel.Resp.Critical Care Med.,1:223-231,2001

2000

  • Matsuura,A., Kinebuchi,M., Chen,H.Z., Katabami,S., Shimizu,T., Hashimoto,Y., Kikuchi,K. and Sato,N.:NK T cells in the rat:organ- specific distribution on NK T cells expressing Va14 chains. J.Immunol.,164:3140-3148,2000
  • Fujita,T., Matsumoto,Y., Hirai,I., Ezoe,K., Saito,T., Yagihashi, A., Torigoe,T., Homma,K., Takahashi,S., Cruikshank,W.W., Jimbow,K. and Sato,N.:Immunosuppressive effect on T cell activation by interleukin-16 cDNA-transfected human squamous cell line. Cell.Immunol.,202:54-60, 2000
  • Shigehara,K., Shijubo,N., Ohmichi,M., Kon,S., Shibuya,Y., Takahashi, R., Morita-Ichimiya,S., Tatsuno,T., Hiraga,Y., Abe,S. and Sato,N.: Enhaced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis.Sarcoidosis.,17:151-157,2000
  • Maeda,A., Ohguro,H., Maeda,T., Wada,I., Sato,N., Kuroki,Y. and Nakagawa,T.: Aberrant expression of photoreceptor specific calcium binding protein (recoverin) in cancer cell lines. Cancer Res.,60:1914-1920,2000
  • Nagata,M., Akazawa,T., Tamura,Y., Kamiguchi,K., Hirai,I., Ohtani, S., Sagae,S., Kudo,R., Torigoe,T. and Sato,N.:The expression of a novel natural killer inhibitory molecule,Cho-1,on the chorionic cytotrophoblast cells of successful pregnancy, but not of spontaneous abortion. Pathol.Int.,50:824-831,2000
  • Fujita,T., Takami,Y., Ezoe,K., Saito,T., Sato,K., Takeda,N., Yamamoto,Y., Homma,K., Jimbou,K. and Sato,N.:Successful preservation of human skin by vitrification. J. Burn Care Rehabil.,21:304-309,2000
  • Shigehara,K., Shijubo,N., Ohmichi,M., Yamada,G., Takahashi,R., Okumura,H., Kurimoto,M., Hiraga,Y., Tatsuno,T., Abe,S. and Sato,N.: Increased levels of serum IL-18 in patients with pulmonary sarcoidosis. Am.J.Resp.Crit.Care Med., 162:1979-1982,2000
  • Nabeta,Y., Sahara,H., Suzuki,K., Kondo,H., Nagata,M., Hirohashi, Y., Wada,Y., Sato,T., Wada,T., Kikuchi,K. and Sato,N.:Induction of CTL from peripheral blood of HLA-A31(+) gastric cancer patients by in vitro stimulation with antigenic peptide of signet ring cell carcinoma.Jap.J. Cancer Res.,91:616-621,2000
  • Nishimori,H., Yasoshima,T., Denno,R., Shishido,T., Hata,F., Okada,Y., Ura,H., Yamaguchi,K., Isomura,H., Sato,N., and K.Hirata.: A novel experimental mouse model of peritoneal dissemination of human gastric cannar cells:different mechanisms in peritoneal dissemination and hematogeneous metastasis. Jap.J.Cancer Res., 91:715-722,2000
  • Kanki,K., Torigoe,T., Hirai,I., Sahara,H., Kamiguchi,K., Tamura,Y., Yagihashi,A., and Sato,N.:Molecular cloning of rat NK target-structure-the possibility of CD44 involvement in NK cell-mediated lysis.Microbiol. Immunol.,44:1051-1061,2000
  • Matsumoto,Y., Sahara,H., Fujita,T., Hanashima,S., Yamazaki,T., Takahashi,S., Sugawara,F., Mizushima,Y., Ohta,K., Takahashi,N., Jimbow,K., Sakaguchi,K., and Sato,N.:A novel immunosuppressive agent,SQG9, derived from sea urchin. Transplant.Proceed.,32:2051- 2053,2000
  • Matsuura,A., Kinebuchi,M., Takami,T.,and Sato,N.:Diversity and organ-specific expression of rat invariant TCRalpha chain-implication in their interaction with CD1d. Rat Genoma,6:36,2000
  • Matuura,A., Kinebuchi,M., and Sato,N.:Rat TL and CD1-similarity and distinction of CD1d reactive cells in different species. Tissue Antigen,55-56,2000
  • Nabeta,Y., Kawaguchi,S., Sato,Y., Wada,T., Yamashita,T. and Sato,N.:Identification Strategy and Cataloguing of antigenic cacer epitope.Mdern Aspects of Immunobiology,1:17-19,2000
  • Ichimiya,S., Nakagawara,A. Sakuma,Y., Kimura,S., Ikeda,T., Sato,M., Takahashi,N., Sato,N. and Mori,M.:p73:Structure and function.Pathol.Int.,50:589-593,2000
  • Sato,N., Nabeta,Y., Kondo,H., Sahara,H., Hirohashi,Y., Kashiwagi,K., Kanaseki,T., Sato,Y., Rong,S., Hirai,I., Kamiguchi,K., Tamira,Y., Matsuura,A., Takahashi,S., Torigoe,T. and Ikeda,H.:Human CD8 and CD4 T cell epitopes of epithelial cancer antigens. Cancer Chemother Pharmacol.,46:86-90,2000

1999

  • Akazawa,T., Hirai,I., Hirohashi,Y., Kamiguchi,K., Sahara,H., Torigoe,T., Nagasawa,S., Tamura,Y.and Sato,N.: A novel negative regulator Cho-1 moleucle is involved in the cytotoxicity by human natural killer cells but not in cytotoxic T lymphocytes. Microbiol.Immunol.,43: 285-291,1999
  • Ishikura,H., Miyashita,M., Yagi,K., Sato,N., Matsuura,A., Kon,S., Oku,Y., Yamaguchi,T. and Kikuchi,K.: Studies on the epidemiological and taxonomical view point to Acanthocephala (Rudolph,1809) Perse1936,and Acanthocephalosis and in addition to the hystopatho-parasitological feature on the Muniliformis (Bremser,1811),Travassos,1915(1)・(2) Hokkaido Med.Soc.1999
  • Tsuruma,T., Yagihashi,A., Torigoe,T., Araya,J., Watanabe,N., Sato, N.and Hirata,K.: Interleukin 10 reduces natural killer sensitivity of tumor cells by downregulating of NK target structure expression. Cell Immunol., 198:103-110,1999
  • Shishido,T., Yasoshima,T., Hirata,K., Denno,R., Mukaiya,M., Ura, H., Yamaguchi,K., Kawaguchi,S.and Sato,N.: Establishment and characterization of human pancreatic carcinoma lines with a high metastatic potential in the liver of nude mice. Surg.Today,29:519- 525,1999
  • Asanuma,H., Takahashi,S., Ishikawa,M., Kamiguchi,K., Sato,N., Poppema,S., Fujimoto,J.and Kikuchi,K.: A monoclonal antibody, 3G12, reacts with a novel surface molecule, Hal-1, with high expression in CD30-positive an aplastic large cell lymphomas. Brit.J.Hematol.,106:55-63,1999
  • Suzuki,K., Sahara,H., Okada,Y., Yasoshima,T., Hirohashi,Y., Nabeta, Y., Hirai,I., Torigoe,T., Takahashi,S., Matsuura,A., Takahashi,N., Sasaki, A., Suzuki,M., Hamuro,J., Ikeda,H., Wada,Y., Hirata,K., Kikuchi,K.and Sato, N.: Identification of natural antigenic peptides of a human gastric signet ring cell carcinoma recognized by HLA-A31-restricted cytotoxic T lymphocytes. J.Immunol.,163:2783- 2791,1999
  • Matsuura,A., Kinebuchi,M., Itoh,Y., Kasai,K., Yamada,K., Yoshida, M.C., Horie,M., Kikuchi,K.and Sato,N.: Genomic organization and chromosome location of the rat CD3ζ locus (Cd3z). Cytogenet Cell Genet, 85:301-305,1999
  • Maeda,T., Ohguro,H., Maeda,A., Ogawa,K., Nakagawa,T., Hirai,I. and Sato,N.:Identification of Antigenic Site within hsc 70 by Serum Autoantibody in Patients with Cancer-associated Retinopathy.Tumor Research,34:49-56,1999
  • Matsuura,A., Kinebuchi,M., Katabami,S., Chen,H., Yamada,K., Yoshida, M. C., Horie,M., Watanabe,T., Kikuchi,K,and Sato,N.: Correction and confirmation of the assignment of the evolutionarily conserved CD1D class gene to rat chromosome 2q34 and its relationship to human and mouse loci. Cytogenet. Cell Genet.,86:323-324,1999
  • Matsuura,A., Kinebuchi,M., and Sato, N.: Rat TL and CD1. TumorBiol., 20:39,1999

1998

  • Shishido,T., Yasoshima,T., Denno,R., Mukaiya,M., Sato,N. and Hirata,K.:Inhibition of liver metastasis of human pancreatic carcinoma by angiogensis inhibitor TNP-470 in combination with cisplatin. Jap.J.Cancer Res.,89:963-969,1998
  • Tsuruma,T., Yagihashi,A., Torigoe,T., Sato,N., Kikuchi,K., Watanabe,N.and Hirata,K.:Interleukin-10 reduces natural killer sensitivity and downnregulates MHC class I expression on H-ras- transformed cells. Cell.Immunol., 184:121-128,1998
  • Hirai,I., Sato,N., Qi,W., Ohtani,S., Torigoe,T. and Kikuchi,K.: Localization of pNT22 70kDa heat shock cognate-like protein in the plasma membrane. Cell Struct. Function,23:153-158,1998
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