As part of Hokkaido Prefecture’s comprehensive development, Hokkaido Women’s Medical College was expanded in 1950 to become Sapporo Medical University. In April 1993, the School of Health Sciences was established with the reorganization of the Health Sciences Junior College (which opened in April 1983) attached to Sapporo Medical College.
In April 2007, the university made the transition to become an independent corporate entity known as Hokkaido Public University Corporation Sapporo Medical University.

April 1945	Hokkaido Women’s Medical College was founded.

April 1950	Sapporo Medical College opened.
June 1950	Opening ceremony held (June 25 designated as the college foundation day).
September 1955	Cancer Research Institute established as an affiliate research institution.
March 1956	Establishment of the Graduate School of Medicine approved (enrollment capacity is 25 students).
January 1958	Premedical course started.
September 1968	Marine Biomedical Institute established.
April 1979	Divided courses (premedical and special courses) abolished.
April 1983	Junior College of Health Sciences affiliated with Sapporo Medical College opened.

April 1993	School of Health Sciences (Departments of Nursing, Physical Therapy and Occupational Therapy) established to accept 90 students.
April 1998	Graduate School of Health Sciences (Nursing, Physical Therapy and Occupational Therapy) established (enrollment capacity is 24 students).
April 1999	Information Center of Computer Communication established.
April 2000	Doctoral course for Physical Therapy and Occupational Therapy established in the Graduate School of Health Sciences (enrollment capacity is 6 students).
April 2001	Graduate School of Medicine reorganized to incorporate Departments of Community Health & Comprehensive Medicine, Molecular & Organ Regulation and Signal Transduction Medicine.
April 2006	Collaboration Center for Community and Industry established.
April 2007	Transition to Hokkaido Public University Corporation Sapporo Medical University.
April 2008	Medical Science Course (Master’s Program) opened in the Graduate School of Medicine (enrollment capacity is 10 students)
October 2008	Center for Medical Education established
April 2011	Cancer Research Institute and other facilities reorganized into the Research Institute for Frontier Medicine in the School of Medicine
April 2012	Graduate Course in Midwifery established (enrollment capacity is 20 students)
April 2014	Admission Center established.
October 2014	Health Administration Center established.