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食品や体の抗酸化能の評価システムの開発 |
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Section |
School of health Science, Section of Chemistry |
Reseacher |
Hirotada Fujii |
酸化ストレスなどのストレスが体にかかってくると、生体の抗酸化能力は著しく影響を受け低下してくる。私達はこのような抗酸化能の体内動態を実験室でのレベル（in vitro系）や、実験動物・人を対象とするレベル（in vivo系）において定量的に評価する計測システムの構築を進めている。このシステムを利用すると、健康食品などの抗酸化特性を迅速に数値として定量評価することが可能であり、また、画像として視覚化することも可能です。 |
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Creation of personalized health education programs to achieve a “well-balanced
diet” and “desirable lifestyle”
for child-raising women, children, pubescent children and adolescent students~
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Section |
School of health Science. Liberal Arts & Sciences |
Reseacher |
Keiko Yamada |
| Section |
School of health Science, Section of Nursing |
Reseacher |
Yoko Katakura,Tomoko Maruyama |
Recently, there is considerable interest in health maintenance in Japan.
Although many guidelines for a “well-balanced diet” or “desirable lifestyle”
have been formulated, the results of many surveys show that application
of them is difficult in practice. When regarding the interaction between
health problems and dietary habits, we think it is necessary to consider
many other factors such as home factors (family) and social factors (job
or school) and to analyze their interrelationships from various perspectives.
We investigated many different life stages, studying not only diet and
dietary habits but personality, behavior, parents and family, school and
work. Based on these investigations, our goal is to create personalized
health education programs including dietary education.
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Nutrition of Vitamin B12 |
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Section |
School of health Science. Liberal Arts & Sciences |
Reseacher |
Keiko Yamada |
In 1926, VitaminB12 (B12) was discovered in the liver as a treatment factor
for pernicious anemia. Mostly, B12 is present in animal products but not
in vegetables. Therefore, in long-term adherents of a strict, uncooked
vegan diet, young dieters and old persons whose intake of animal food is
decreased, the B12 status is often compromised. In our studies we have
been searching for a natural vegetable source of B12, as well as investigating
problems caused by blending different nutrients in high concentrations
in dietary supplements, as well as the significance of feces of herbivorous
animals as resources for B12 and developing a useful method for determination
of B12. |
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Structure, Function, and Evolution of Tandem Repeats in Proteins |
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Section |
School of health Science, Section of Physics |
Reseacher |
Norio Matsushima |
Tandem repeats occur in 14% of all proteins. The repeat unit lengths range
from a single amino acid to more than 100 residues and the repeat number
is sometimes over 100. Understanding the structures, functions, and evolution
of these repeats is a significant goal in both proteomics and genomics.
From twenty years ago we have studied the structure, function and evolution
of various tandem repeats. The structures of tandem repeats including those
in the C-terminal repeat domain (CTD) of the largest subunit of RNA polymerase
II and ice nucleation protein were studied by nuclear magnetic resonance
(NMR) circular dichroism (CD) and/or small-angle x-ray scattering (SAXS).
Moreover, the sequence and structural analyses of leucine rich repeats
that are present in over 60,000 proteins were performed by bioinformatics
approach including new methods developed by us. In two recent review articles
we demonstrated that there are two classes of tandem repeats in proteins
-those with globular structures and those without. The globular can be
divided into two subclasses. In one the repeat units form a helix or solenoid;
examples include ankyrin, HEAT, leucine rich repeat, and armadillo. In
the other the domains are relatively stable when isolated; they do not
form a helix in the multidomain protein. Examples include zinc-fingers,
EF-hands, WD repeats, and SUSHI domain (SCR repeat). The non-globular repeats
are also found in two groups -those that form stable helices, like collagen,
and those whose structures are flexible or inherently disordered, for example
polyglutamine (polyGln). |
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対象物操作における手指機能の運動制御に関する研究 |
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Section |
Graduate School of Psychiatric rehabilitation |
Reseacher |
Yuuji Sawada |
日常生活のなかで多種多様な対象物を操作している手は,その様々な属性に応じて円滑な操作を行っている.このとき手指の表在感覚,関節固有感覚などからの情報から運動制御を行ない,関節角度の調節や把握・把持力の調節を適切に行なっている.その手指の運動制御を動作解析や筋電図,圧力センサーなどを用いて解析する.また手指のもつ機能的役割の解明を目指す。 |
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Encouraging parents of pediatric child to give up on smoking
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Section |
Dept.of Maternal and Child Nursing |
Reseacher |
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Although the harmful effect of smoking became widely come to public attention, smoking rates of parents in the child-raising remains still high and it is fearful about secondhand smoking influence on child to grow. While children are hospitalized, we support their parents and family to promote their sense of well-being by encouraging them to give up smoking. |
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Development of a sick-child care guideline for reducing secondhand smoking
in the home |
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| Section |
Dept.of Maternal and Child Nursing |
Reseacher |
Miki Konno |
Because nurses cannot obtain enough information about family’s smoking
situation or take an advantage of that information very well, there is
not effective support given for parents to encourage them to give up smoking
in the home or separate the smoking area. We have evaluated a tactics to
help parents stop smoking and acknowledged the need for child-nursing practitioners
to intervene in helping parents to give up smoking while we have studied
to develop care guideline concerning to quitting smoking of parents in
a sick-child care. |
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プレパレィション：大人が、医療処置を受ける子どもが頑張れるように関わること |
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Section |
Dept.of Maternal and Child Nursing |
Reseacher |
Michiko Ebina |
子どもは、伝統的に「説明してもわからない」ということで、説明なしで不意打ち的に医療処置を実施され、びっくりして泣き叫ぶと大勢の医療職によって押さえ込まれてきました。これは倫理的に問題があります。我々の調査では、子どもの発達に合わせた理解を考慮しながら医療処置の話をすると、子どもは頑張りますし、自己肯定感を高め、病気であっても健康的な自分像を描きます。この関わり方をプレパレィションといいます。 |
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アルツハイマー型認知症の行動・記憶障害に対する援助方法の確立
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Section |
Dept.of Applied Occupational Therapy
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Reseacher |
Satoe Takeda |
アルツハイマー型認知症の記憶障害や行動障害に対する援助法の確立のために，脳機能画像，神経心理学検査，生活歴聴取による結果から，１）認知症の程度，２）脳萎縮のタイプ，３）生活背景を明らかにし，それぞれの患者に，どのような援助方法が有効なのかを系統的に明らかにすることを目的とする． これによって，個々人の高次脳機能障害や生活背景に基づいた系統的治療の確立を目指す。 |
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作業療法場面における脳血流量評価の有用性の検討 近赤外線分光法(NIRS)を用いた脳血流変化と認知特性に関する研究 |
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Section |
Graduate School of Sensory Integrative Dysfunction |
Reseacher |
Yasuhito Sengoku,Yuji Nakamura |
作業療法で対象としている発達障害児や高次脳機能障害者，高齢者の認知機能を脳機能との関連で評価し，必要とされる認知機能や課題の段階付けを行った上で作業課題を提供することは重要である．我々は，脳機能を非侵襲的に計測できるNIRSを用い，様々な対象者に対し課題遂行中の脳血流量変化の測定を行い，作業療法場面における脳血流量評価の有用性を検討している． |
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作業療法場面における発達障害児の社会的行動評価の開発 |
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Section |
Graduate School of Sensory Integrative Dysfunction |
Reseacher |
Sonomi Nakajima,Yasuhito Sengoku |
発達障害児を対象とした作業療法では，神経学的評価と行動評価をあわせて行うことが，子どもの障害像を把握する上で重要である．しかし，行動評価はセラピストが子どもの様子をそのまま文章で記録したり，保護者や教師からの聞き取りが主要な方法となっており，主観的要因が強く影響し信頼性が低くなるという問題点がある．そこで，評価尺度を作成し，子どもの行動を定量的に示す方法の開発を進めている。 |
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Section |
Graduate School of Hand Therapy of Rehabilitation |
Reseacher |
Sadako Tsubota |
Because nurses cannot obtain enough information about family’s smoking
situation or take an advantage of that information very well, there is
not effective support given for parents to encourage them to give up smoking
in the home or separate the smoking area. We have evaluated a tactics to
help parents stop smoking and acknowledged the need for child-nursing practitioners
to intervene in helping parents to give up smoking while we have studied
to develop care guideline concerning to quitting smoking of parents in
a sick-child care. |
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Research Topic 1: Functional Lesion of Musicians’ Fingers, Hands, and
Upper Limbs |
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Section |
Graduate School of Hand Therapy of Rehabilitation |
Reseacher |
Sadako Tsubota |
It is reported in Europe and America that the occupation of musicians is similar to that of athletes in terms of overworking their physical and mental capacities, and that many of them suffer from physical lesion and psychological stress. It was also apparent from our investigation done on the Japanese symphony orchestra members that 70% or more had some forms of Playing Related Musculoskeletal Disorder (PRMD). This is a result of long hours of practice, concentrating only on developing the playing techniques from early childhood. It is our wish to do a basic research to find ways of conditioning these musicians to be able to continue their performance activities, to improve their existing functional lesion, and to examine effective rehabilitation programs for them. |
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Upper Limb Amputees |
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Section |
Graduate School of Hand Therapy of Rehabilitation |
Reseacher |
Sadako Tsubota |
Utility of prosthetic limb of upper limb amputees - “Striving for utilization of artificial arms in daily activities “The utilization rate of functional upper limb prosthesis of upper limb amputees for daily activity is rather low at about 20%. From our research, we have found the following problems with regards to the use of “Hook” type artificial hand. 1. It has no sensory feedback mechanism and is difficult to reproduce physiological movements. 2. It is made of metal and the weight gives discomfort to users. 3. Operation is difficult since the source of power is gained from wire operation, requiring much strength in the initial movement. Although there are high performance prosthetic limbs such as electromyo prosthesis, the system to issue these limbs to amputees is still very limited.
We will examine the “Hook” type prosthetic limbs, in current use or to be considered for renewal use, in terms of the wire power source; the feedback control mechanism; and its material, including weight, color, and design. |
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Early Interventional Therapeutic Exercise for High-risk Infants after
Developmental Care |
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Section |
Dept.of Applied Physical Therapy
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Reseacher |
Naoki Kozuka |
Developmental care is an approach to help High-risk Infants (premature baby, Low birth weight infant and infant with developmental disease). Specifically this care is performed by reducing external stress (excess light and sound stimuli) as much as possible and providing appropriate care according to infants’ response. However, infants need to adjust themselves to an external environment little by little as they grow, thus we have performed early interventional therapeutic exercise for infants and evaluated its effect by assessing their growth for the long term. |
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ウエアラブル心電図を応用した健康支援サービスシステムの開発研究 |
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Section |
Dept.of Applied Physical Therapy
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Reseacher |
Masaki Katayose |
健康増進にはフィットネスに応じた運動の量と質を安全に確保することが必要である。我々はウエアラブル心電図の開発を進め、得られたデータを携帯電話や無線LANを利用してサーバ管理する健康運動支援システムの開発を進めている。これにより日常生活や普段の運動時の心電図を簡便に記録できる環境を提供する。あわせて楽しく継続して適切な運動を確保できるフィードバックの開発を行っており、生活習慣からスポーツ活動という個人の生活を包括モニターしたメディカルフィットネスへの利活用が期待できる。 |
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Slow, healthy and lively life |
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Section |
Dept.of Physical and Therapeutic Science |
Reseacher |
Hidekatsu Takeda |
Physical function decline with advancing age, Valuable tips to slow or prevent the course include moderate habitual exercise and eating in a happy atmosphere. Exercise and pleasant meal seem to have helpful effects such as reducing anxiety about lifestyle-related disease. Gaining knowledge is important, but it is more important to be aware that one must take responsibility for one’s own health. |
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作業療法場面における脳血流量評価の有用性の検討
近赤外線分光法(NIRS)を用いた脳血流変化と認知特性に関する研究
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Section |
Graduate School of Sensory Integrative Dysfunction |
Reseacher |
Yasuhito Sengoku |
作業療法で対象としている発達障害児や高次脳機能障害者，高齢者の認知機能を脳機能との関連で評価し，必要とされる認知機能や課題の段階付けを行った上で作業課題を提供することは重要である．我々は，脳機能を非侵襲的に計測できるNIRSを用い，様々な対象者に対し課題遂行中の脳血流量変化の測定を行い，作業療法場面における脳血流量評価の有用性を検討している。 |
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