|
|
消化器腫瘍を対象とした遺伝子診断法とヒト型抗体による分子標的治療の開発
|
 |
|
Section
|
Dep. of Internal Medicine I
|
Reseacher
|
Yasuhisa Sinomura,Shigeru Sasaki,Hiroyuki Yamamoto
|
|
第一内科では、患者さん中心の実践的研究を推進して遺伝子診断、分子標的療法やオーダーメイド医療の開発につながる臨床に還元できる価値ある成果を目指して精力的に研究を行っております。ジェネティック異常やエピジェネティック異常を網羅的に解析し、遺伝子情報に基づく消化器腫瘍の発生・進展の分子機構の解明およびその診断・治療への応用研究を展開しております。また、アポトーシスを誘導する抗erbB-2抗体CH401の樹立に成功し、分子標的癌免疫治療としての抗体医療への応用を展望したヒト型抗癌抗体の作製を産学官連携のもと、行っております。
|
|
Cytoprotective intracellular signaling in the cardiomyocyte and its clinical
application
|
 |
|
Section
|
Dep. of Internal Medicine II |
Reseacher
|
Tetsuji Miura,Takayuki Miki,Toshiyuki Yano,Kazuaki Shimamoto
|
|
Currently, ischemic heart disease and heart failure are two major causes
of death in industrialized and developing countries. To develop novel strategies
for treatment of these myocardial disorders, we have focused on signal
transductions leading to cardiomycoyte protection and their modification
by co-morbidities. We have characterized signal pathways responsible for
myocardial protection afforded by ischemic preconditioning and that by
erythropoietin receptor activation. Results of our recent studies indicate
that gap junctional connexin-43 and glycogen synthase kinase-3beta are
two important molecular effectors functioning in decision making on cell
death versus survival. Furthermore, we identified involvement of angiotensin
II type 1 receptor and elevated ER stress in dysfunction of cytoprotective
signaling by heart failure and diabetes.
|
|
Impact of Insulin resistance on athrosclerosis disease
|
 |
|
Section
|
Dep. of Internal Medicine III |
Reseacher
|
Nobuyuki Ura,Katsuhiro Higashiura,Yoshinori Miyazaki,Hideaki Yoshida,Kazuaki
Shimamoto
|
|
Insulin resistance is thought to be one of the causes of metabolic syndrome,
hypertension, diabetes, dyslipidemia, and obesity, which increase the risk
of developing atherosclerosis and cardiovascular disease. However, it is
not clear in detail. Therefore, to clarify the mechanism, we are doing
the basic and the clinical study.
|
|
Quantitative assessment of left ventricular and left atrial function using
strain rate imaging and I-123-metaiodobenzylguanidine imaging
|
 |
|
Section
|
Dep. of Internal Medicine II
|
Reseacher
|
Satoshi Yuda,Akiyoshi Hashimoto,Kazufumi Tsuchihashi, Kazuaki Shimamoto
|
|
Strain rate imaging, which can be calculated as spatial difference in tissue
Doppler velocities between two different myocardial regions, is a novel
echocardiographic technique for assessing left atrial function and enables
quantification of left atrial function. We have reported that strain rate
imaging can reveal left atrial dysfunction in patients with hypertension
or diabetes mellitus, even in the absence of left atrial dilation or functional
impairment of left atrium assessed by conventional Doppler echocardiography.I-123-metaiodobenzylguanidine
(MIBG) imaging enables quantitative assessment of left ventricular cardiac
sympathetic function. We have reported that sympathetic function quantified
by cardiac MIBG imaging can predict effects of drug treatment and cardiac
events in patients with heart failure.
|
|
Studying the effect and the therapeutic agent of Pulmonary fibrosis inhibition
with using ANGIOTENSIN II-receptor antagonist
|
 |
|
Section
|
Dep. of Internal Medicine III
|
Reseacher
|
Hiroki Takahashi,Shiratori Masanori,Mitsuo Otsuka
|
| Pulmonary fibrosis is one of the intractable pneumonic
diseases which does not have an effective approach to be cure and needs an
early development of medicine. We have clarified that ANGIOTENSIN II-receptor antagonist
(ARB) inhibition Pulmonary fibrosis through the use of animal models. In the future,
ARB could be an effective medicine for Pulmonary fibrosis and needs more studies.
Currently, we have studied in detail not only ARB but also the development of
more effective therapeutic agents. |
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone.
|
 |
|
Section
|
Dep. of Internal Medicine IIII
|
Reseacher
|
Junji Kato
|
|
There are currently no approved antifibrotic therapies for liver cirrhosis.
We used vitamin A-coupled liposomes to deliver small interfering RNA (siRNA)
against gp46, the rat homolog of human heat shock protein 47, to hepatic
stellate cells. Our approach exploits the key roles of these cells in both
fibrogenesis as well as uptake and storage of vitamin A. Five treatments
with the siRNA-bearing vitamin A-coupled liposomes almost completely resolved
liver fibrosis and prolonged survival in rats with otherwise lethal dimethylnitrosamine-induced
liver cirrhosis in a dose- and duration-dependent manner. Rescue was not
related to off-target effects or associated with recruitment of innate
immunity. Receptor-specific siRNA delivery was similarly effective in suppressing
collagen secretion and treating fibrosis induced by CCl(4) or bile duct
ligation. The efficacy of the approach using both acute and chronic models
of liver fibrosis suggests its therapeutic potential for reversing human
liver cirrhosis.
|
|
Expression of VEGF165b, a splice variant of VEGF-A, results in improvement of prognosis in colon cancer
|
 |
|
Section
|
Dep. of Surgery I
|
Reseacher
|
Makoto Tayama,Tomohisa Furuhata, Keiko Inafuku,Kennji Okitaoki,Hirata kouichi
|
|
The growth and metastasis of cancer depend on angiogenesis, and VEGF-A is known to be one of the most important proangiogenic factors.
VEGF 165b has recently been isolated from kidney epithelial cells. VEGF165b has been shown to bind to VEGF-R2, but not to stimulate phosphorylation, and to inhibit VEGF165-mediated phosphorylation in human umbilical vein endothelial cells.
To explain how VEGF-A in stromal tissue affects tumor progression, we examined the correlation between stromal VEGF-A expression and clinicopathological characteristics, and, in addition, we performed expression analysis of VEGF-165 and VEGF165b using fresh-frozen specimens.
|
|
Development and Clinical application of the internal thoracic artery detachment
with Ultrasonic scalpel
|
 |
| Section |
Dep. of Surgery II
|
Reseacher
|
Tetsuya Higami
|
|
The off pump coronary artery bypass(OPCAB), performing surgery on the pulsative heart not with using the heart-lung machine in cardiopulmonary arrest which is known as a conventional coronary artery bypass, is recognized the less invasive and favorable operative procedure. Dr. Higami developed the world’s first technique of the internal thoracic artery detachment with an ultrasonic scalpel, which made every coronary artery bypass with arterial grafts easier, and it has maintained the survival rate and the patency rate of the grafts over 99%. Moreover, the relapse rate of angina within 5 years is under 3 % which is excellent prognosis and using the particular ultrasonic device for the coronary artery deep buried in the heart to give the safe OPCAB.
|
|
Selective intercostals artery perfusion technique during operation of descending
thoracic and thoracoabdominal aortic aneurysm
|
 |
|
Section
|
Dep. of Surgery II
|
Reseacher
|
Nobuyoshi Kawaharada
|
|
It is recognized that the entire surgical care of aortic aneurysm get improved
its outcome in recent years; on the other hand, the surgical care of the
thoracoabdominal aortic aneurysm has a huge influence of surgical stress,
especially the problem of spinal cord disorder (paraplegia) is a critical
issue. Aortic aneurysm stent-grafting is regarded as less-frequency occurring
spinal cord disorder; however, the most decisive difference than anything
else from the open surgery is that the stent-grafting does not involve
ischemia caused by aortic blockage. For that reason, we perform the selective
intercostals artery perfusion technique during operation with the newly
developed catheter on the open surgery to avoid anterior spinal artery
get collapsed so that the specific quantity of the blood flow maintains
constantly to those anterior spinal artery.
|
|
|
 |
|
Section
|
Dep. of Surgery II
|
Reseacher
|
Masanori Nakamura
|
|
The study of Sarpogrelate effect to prevent a blood clot after Off-pump
coronary artery bypasses grafting (OPCAB). OPCAB, without using the heart-lung
machine, is now popularized as it makes the occurrences frequency of brain
infarcts during operation reduced. On the other hand, against the backdrop
of the brain infarcts caused by blood hepercoagulable state from operative
stress has exposed. Despite of the speculation that the antiplatelet agent
works to prevent the blood from clotting, the influence caused by the antiplatelet
which is performed to coagulated fibrinolytic system after OPCAB has not
reported. Sarpogrelate is the antiplatelet agent which inhabits the platelet-activating
factors and vascular constriction by antagonizing the serotonin receptor
released with platelet activation. It is a issue to be comparative discussions
from Warfarin potassium from the standpoint of the influence toward coagulated
fibrinolytic system after OPCAB.
|
|
Development of new procedure of main pulmonary artery blockage during thoracoscopic
surgery
|
 |
|
Section
|
Dep. of Surgery II
|
Reseacher
|
Atsushi Watanabe
|
|
While the surgery which requires the pulmonary blood vessel manipulation with thoracoscopy has been popularized, the risk due to pulmonary aortic injury associated with the surgery compared with it of open chest surgery has been growing. To be different from the open chest surgery, the difficulties of pulmonary artery blockage procedure with thoracoscopy and the narrowness of the operative field imposes a tremendous burden. We have developed new procedure of the main pulmonary artery blockage to improve this problem and performed thoracoscopic surgery accurately and safely. The new procedure does not require artery clamp or tourniquet for the pulmonary artery blockage but with using two pieces of surgical silk so that makes the blockage and release of pulmonary artery in very narrowed operative field. This procedure of blockage contributes to expand an indication of the thoracoscopic surgery and the safe blockage and the release of pulmonary artery with 40-cm incision is now possible. We have now planned to develop the access device to facilitate this issue.
|
|
超音波メスによる内胸動脈剥離法の開発と臨床応用
|
 |
|
Section
|
胸部心臓血管外科
|
Reseacher
|
Tetsuya Higami
|
|
近年、冠動脈バイパス術は従来から行われている人工心肺を使用し、心臓の拍動を一時的に停止した状態で行われる手術法以外に、人工心肺を使用せず心臓が拍動した状態で手術を行う心拍動下冠動脈バイパス術(OPCAB: off pump coronary artery bypass)がより低侵襲で術後の回復が良好な手術方法として認知されている（図１）。樋上は世界で初めて超音波メスによる内胸動脈剥離法を開発し（図２）、これにより全て動脈グラフトによる冠動脈バイパス術が容易となり、99％以上の救命率と長期グラフト開存率（図３、図４）を保っている。また5年以内の狭心症再発率は3％以下で極めて良好な成績を維持できている。また特殊な超音波装置を用い、心筋内に深く埋没した冠動脈に対しても、安全にOPCABを行っている。
|
|
テトラネクチンの骨折治療への臨床応用
|
 |
|
Section
|
Dept.of Orthopedic Surgery
|
Reseacher
|
Kousuke Iba
|
|
整形外科領域において骨形成能を促進することは、骨折をはじめ種々の疾患治療において重要である。これまでの基礎的研究で細胞外基質蛋白の1つであり、ヒト血清中にも存在するテトラネクチンが骨形成過程において強く発現し何らかの重要な役割をもつことがわかってきた。 現在、骨折を中心とした外傷、骨疾患への臨床応用について研究をおこなっている。
|
|
難治性慢性疼痛に対する有効な治療法の開発
|
 |
|
Section
|
Dept.of Orthopedic Surgery
|
Reseacher
|
Toshihiko Yamashita
|
|
Section
|
Div. of Rehabilitation
|
Reseacher
|
Takanori Murakami
|
|
慢性的な痛みに悩む患者は多い。なかでも神経因性疼痛に対する有効な薬物はまだないのが現状である。また、慢性疼痛症例には心理的・環境的要因が関与することがあり、病態を更に複雑にしている。われわれは、８年前より全国でもユニークな慢性疼痛外来を開設し、難治性疼痛症例を対象とし、種々の薬剤の経口投与、クモ膜下腔投与など新しい薬物療法の試みを行っている。また、複数の診療科やコメディカルと連携した集学的診療体制を構築している。
|
|
Strategy for chronic pain with lumbar radiculopathy
|
 |
|
Section
|
Dept.of Orthopedic Surgery
|
Reseacher
|
Tsuneo Takebayashi,Toshihiko Yamashita
|
|
Lumbar radicular pain associated with lumbar spinal canal stenosis and lumbar disc herniation, is one of the most common complains handled by orthopaedic surgeons. As the cause of sciatica, the mechanical compression of the nerve root and the chemical reactions induced by herniated disc containing nucleus pulposus have been reported, however, the pathological mechanism is still unknown. Recently we have established a rat model of lumbar radiculopathy with constricting root and examined the properties of DRG neurons related to pain-transmission and the exciting changes of spinal horn neuron in spinal cord with comprehensive study using behavioral, neurophysiological, and immunohistochemical techniques.
|
|
Practical study of neural reconstruction for brain infarct treatment using
autologous bone marrow stem cell
|
 |
|
Section
|
Dept. of Neurosurgery
|
Reseacher
|
Kiyohiro Houkin
|
|
It has been reported that useful stem cells identified in a bone-marrow
cells are remarkably effective to neural regeneration in the medical treatment
of brain infarction. The stem cell does not have to be injected directly
into the brain, and reaches the infarcted area of brain by intra-vernous
administration, so that it enables brain to reconstruct which is said to
be difficult. The safety and therapeutic effect of this stem cell have
been already started evaluating in the clinical study with brain infarction
patients.
|
|
Effects of Retinoid to Endometrial Carcinoma Department
of Obstetrics and Gynecology
|
 |
|
Section
|
Dept.of Obsterics and Gynecology
|
Reseacher
|
Takahiro Suzuki,Tsuyoshi Saito
|
|
Expression of Gap Junction decreases according to endometrial carcinogenesis.
For gene therapy to endometrial carcinoma, it is necessary to recover the
gap junctional inter cellular communication. (GJIC) , In this study, cell
growth was suppressed by Retinoid in endometrial cells, on the other hand,
GJIC was accelerated in the condition. These evidence suggest that Retinoid
promotes bystabnder-effects via accelerating GJIC.
|
|
ヒトパルボウイルスB19感染による多彩な病態とゲノム変異との関連性
|
 |
|
Section
|
Dept. of Pediatrics
|
Reseacher
|
Hiroyuki Tsutsumi,Yuko Yoto
|
|
ヒトパルボウイルスB19は伝染性紅斑の原因として知られているが、それ以外にも関連する病態は非常に多彩である。当小児科においても保存血清よりB19
DNAの後方視的スクリーニングを行い、B19感染に様々な病態が伴うことを報告してきた。通常は一過性に終わるB19感染が再活性化を呈する症例も見いだされた。多彩な病態とB19ゲノムの塩基配列変異に関連性がないかを検討し、その変異がmRNA転写調節に何らかの影響を与えていないかを現在まで研究している。
|
|
Analyzing the ophthalmic blood flow in Laser Speckle flowgraphy
|
 |
|
Section
|
Dept of. Ophthalmology
|
Reseacher |
Hiroshi Ohguro
|
|
Although the ophthalmic blood flow levels have been recognized as an important factor to explain visual improvement after the vitreoretinal surgeries, there was no possible way to analyze the ocular hemodynamics in real-time.
LSFG is a quite new noninvasive method to monitor the blood flow dynamics Thus this can be applicable to analyze the ophthalmic blood changes in vitreoretinal conditions, and will encourage us to understand the relationship between ocular blood flow dynamics and pathophysiology of several vitreoretinal diseases.
|
|
The mechanism of oral allergy syndrome in birch-allergic patients
|
 |
|
Section
|
Dept. Of Otolaryngology
|
Reseacher
|
Hideaki Shirasaki,Tetsuo Himi
|
|
In the north of Japan and Scandinavian countries, birch pollen is the major allergen in pollinosis. It has been well known that birch-sensitized patients with nasal allergy are frequently accompanied with oral allergy syndrome (OAS). The most frequent foods causing OAS were apples, and the cross-reactivity was also observed between birch pollen and some foods. The common food allergy is immediate or delayed ?typed allergic reactions in the intestines. On the contrary, allergic reaction of OAS is immediate-typed allergic reaction in oral mucosa. We have investigated the mechanism of oral allergy syndrome.
|
|
Study of nasal membrane epithelial barriers, antigen recognition and presenting
mechanism of allergic rhinitis
|
 |
|
Section
|
Dept. Of Otolaryngology
|
Reseacher
|
Mitsuru Go,Kenichi Takano,Ryuta Kamekura,Tetsuo Himi
|
|
Nasopharynx act as the central fronts of biological defense against adventitious
pathogen while it functions as an important factor for the natural immunity
and acquired immunity. Our department has studied the expression regulation
of tight junction which performs as epithelial barrier and becomes its
key elements with using nasal membrane, tonsil and adenoid epithelial cells.
Especially in the study of allergic rhinitis, we have found the tight junction
expresses not only on the epithelial surface but also in CD11c positive
dendritic cells, antigen presenting cells, and we showed the result that
a mechanism exist which uptakes antigen without destroying the epithelial
barrier. Currently, we have conducted a research of expression regulation
of cytokine- and PKC signaling pathway-mediated tight junction such as
TSLP by using nasal membrane cells transfected with hTERT which is continuously-
cultivatable and primary cultured nasal membrane cells.
|
|
Understanding mechanisms of cancer pain and development of novel strategies
of cancer pain treatment
|
 |
|
Section
|
Dept. Of Anesthesiology
|
Reseacher
|
Tomoyuki Kawamata,Yukitoshi Niiyama,Jun Yamamoto
Shingo Furuse,Akiyoshi
Namiki
|
|
We have performed in vivo experiments using a mouse model of bone cancer
pain and in vitro experiments using cultured cells in order to clarify
mechanisms of intractable bone cancer pain and develop novel therapeutic
strategies. Recently, we have shown that the expression of TRPV1 was increased
in the peripheral nervous system and that TRPV1 was sensitized under a
bone cancer condition. These findings indicate that TRPV1 is a molecular
target for the treatment of bone cancer pain. Our next step is to find
novel molecular targets for the development of treatment of bone cancer
pain. （kawamata@sapmed.ac.jp）
|
|
Discovering the natural history of Benign Prostatic
Hyperplasia and Lower Urinary Tract Symptoms
|
 |
|
Section
|
Dept. of Urology
|
Reseacher
|
Naoya Masumori,Fumimasa Fukuta,Taiji Tsukamoto
|
|
We, Department of Urologic Surgery and Andrology, conduct the cross sectional
community-based study on male citizen ages 40 to 79 at Shimamaki village
in Hokkaido between1992 and 1993 to calculate the prevalence of Benign
Prostatic Hyperplasia and Lower Urinary Tract Symptoms. The result from
this analysis is now frequently cited in the paper as exclusive and internationally
comparable data.
|
|
Targeting Survivin for cancer therapeutic and diagnosis
|
 |
|
Section
|
Dept. of Clinical Laboratory Medicine
|
Reseacher
|
Naoki Tsuji,Naoki Watanabe
|
|
Anti-apoptotic molecule Survivin is overexpressed in variety of cancers. Survivin benefits cancer cells not only by antagonizing apoptotic stimuli but also by immortalizing and conferring immune privilege to them by upregulation of human telomerase reverse transcriptase(hTERT) and Fas can be utilized for cancer diagnosis. Survivin is a promising therapeutic target as the down regulation leads cancer cells to apoptosis.
|
|
Development of peptide vaccine therapy to oral cancer with peptide of
survivin gene product
|
 |
|
Section
|
Dept. of Oral Surgery
|
Reseacher
|
Hiroyoshi Hiratsuka
|
|
Our immune system has an innate ability to monitor and eliminate the cancer
cells arising in the body and it is known that the cancer vaccine improves
this immune system. From the survivin gene product frequently expressed
in cancer, we synthesized the antigenic peptide presented to HLA-A24 that
appears a lot among Japanese to oral cancer case and through the administration
of those antigenic peptide as the peptide vaccine, it showed the result
that the level of its tumor maker decreased while neoplastic lesion has
shrunk. We are currently in the process of developing the more effective
peptide vaccine therapy with a combination of the interferon alpha and
the adjuvant.
|
|
The regeneration of cartilage tissue using mesenchymal stem cells derived
from bone marrow and the clinical trial
|
 |
|
Section
|
Dep. of Plastic and Reconstructive Surgery
|
Reseacher
|
Yoshitaka Matsumoto,Takatoshi Yotsuyanagi,
Kyori Ezoe,Tamotsu Saitoh
|
|
Autologous cartilage transplantation is one of the standard surgical methods
in the field of plastic reconstructive surgery, but it has problems of
donor site. Tissue engineering is most expected method to solve donor-site
problems fundamentally. Although many methods using tissue engineering
technique has been performed to regenerate cartilage tissue, but there
are still various problems toward the clinical standard method. We investigate
the regeneration of cartilage tissue using bone marrow mesenchymal stem
cells and the clinical application using tissue engineering technique.
|
|
Molecular involvement of histone deacetylase SIRT in neurodegenerative
disorder
|
 |
|
Section
|
Dep. of Neurology
|
Reseacher
|
Shin Hisahara,Takashi Hayashi,Shun Shimohama
|
|
SIRT family is one of the type III histone deacetylase molecules. Previously, we found that SIRT1 expresses in the subventricular zone of adult brain. This finding indicates that SIRT1 constantly expresses in undifferentiated neural progenitor cells including neural stem cells. We also have disclosed that SIRT1 plays a significant role for neuronal and oligodendrocyte differentiation including cellular migration and neurite extension. Our next aim is to clarify molecular involvement of SIRT family in the pathogenicity of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.
|
|
|
|
 |
|
Section
|
Dep. of Neurology
|
Reseacher
|
Tomihiro Imai,Shun Shimohama
|
|
Electrophysiological stud on masseter fatigue in myasthenia gravis
We have proposed 1) malfunction of neuromuscular transmission and 2) impairment of excitation-contraction coupling as underlying neurophysiological mechanisms for fatiguability of masseter in myasthenia gravis(MS). We are conducing an objective assessment of bite force using a pressure-sensitive sheet and measurement of anti-MuSK and anti-Ryanodine receptor antibodies. We examine a correlation among masseter weakness, electrodiagnostic abnormalities and autoantibody assays to elucidate easy fatiguability of masseter in MG
|
|
|
To Achieve the more individual medical treatment
|
 |
|
Section
|
Dept. of Hospital Pharmacy
|
Reseacher
|
Atsushi Miyamoto
|
|
To support cultivating the quality of life for our patient, we have provided
the best pharmaceutical care and developed not only the fundamental research
of the medical pharmacy such as how the side-effect and the medicinal benefits
express, and how their disposition (breathing, distribution, metabolism
and egesting) has changed when the medication is administered but also
the clinical research which is significant for the personalized medication
as an important pillar of the next-generation medical pharmacy to provide
the better medical treatment.
|
|
|
|
 |
|
Section
|
Dept. of Surgical Pathology
|
Reseacher
|
Tadashi Hasegawa,Tomoko Mitsuhashi
|
|
Among bone and soft tissue tumors, which have some difficulties in diagnosis and treatment, it is known that distinctive chromosomal and gene abnormalities such as chromosomal translocations and fusion genes resulting from these translocations can be detected. We have focused on the research and development of split-signal DNA probes for FISH analysis, which can establish an accurate diagnosis by detecting the specific fusion genes for bone and soft tissue tumors. Using these probes, we conduct the FISH analysis on formalin-fixed, paraffin-embedding histological specimens to apply these methods to the routine pathological diagnosis.
|
|
|
蘇生後脳症に対する脳低温療法の試み
|
 |
|
Section
|
札幌医科大学高度救命救急センター
|
Reseacher
|
Kazuhisa Mori,Yasufumi Asai,他
|
|
院外心肺停止症例に対する救命士を中心としたプレホスピタルケアおよび院内搬入後の心肺蘇生法の進歩により自己心拍再開を得ることが多くなって来ている。しかし、一定の脳虚血時間は回避不能であり蘇生後脳症の低減が救命センターでの最大の問題となっている。教室では1990年代早期より蘇生後脳症に対する脳低温療法を導入し、臨床および動物実験により本治療法の有効性を報告して来た。
|
|
|
心肺脳蘇生法におけるExtracorporeal cardiopulmonary resuscitation (ECPR)
の有用性
|
 |
|
Section
|
Dept. of Traumatology and Critical Care Medicine
|
Reseacher
|
Satoshi Nara,Mamoru Hase,Yasufumi Asai,他
|
|
院外心肺停止症例に対する心肺脳蘇生法としてECPRの臨床的有用性に関して、高いエビデンスレベルの報告は少ないが、近年本邦からの報告が国際的に注目されている。当教室は本邦におけるECPRの草分けであり、1998年から基礎的及び臨床的研究を開始し、200例を超える臨床経験を有している。更に最近では病院前救護に始まる救命の連鎖にECPR、心疾患に対するカテーテルインターベンション、蘇生後の脳低温療法を積極的に導入し、包括的救命医療の構築を目指し、良好な治療成績を得ている。
|
|
|
Funded Project: Integrative Palliative Care Education & Practice
|
 |
|
Section
|
Fund Project: Integrative Palliative Care Education & Practice
|
Reseacher |
Akiyoshi Namiki,Tomoyuki Kawamata,Hiroyuki Okuda,Yuko Hasegawa,Kikuko Iwamoto
|
|
Without practicing medical treatment and care as a scientific study based
on its evidence, which is Palliative care education, medical improvement
and its progress cannot be expected. To develop and disseminate the medical
treatment based on Palliative Care Education, it is critically important
to establish a variety of medical systems: obtaining the information and
technique from Palliative Care staff, educating medical students and collaborating
with community through enlightment activities for the public.
|
|
|
Development of therapeutic technique for neurological disease using bone
marrow stem cell
|
 |
|
Section
|
神経再生医学講座
|
Reseacher
|
Osamu Honmou
|
|
It has been reported that useful stem cells identified in a bone-marrow
cell group are remarkably effective to neurological diseases with an intellectual
difficulties such as brain infarction. The stem cell does not have to be
injected directly into the brain, and reaches the diseased area of brain
by intra-vernous administration, so that it relieves burdens on patients.
The safety and therapeutic effect of this stem cell have been already started
evaluating in the clinical study with brain infarction, however; to expand
the adaptable disease is an issue in the future.
|
|
|
|
