Department of Pathology
Sapporo Medical University School of Medicine

SELECTED PUBLICATIONS

• Loss of tapasin in tumors potentiates T cell recognition and anti-tumor effects of immune checkpoint blockade.
  Keigo Moniwa, Serina Tokita, Toshiyuki Sumi, Hiroshi Saijo, Shintaro Sugita, Kotomi Arioka, Yoshihiko Hirohashi, Hirofumi Chiba, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Cancer Science. 2025 (in press).(^*corresponding author)
• Identification and phenotypic characterization of neoantigen-specific cytotoxic CD4+ T cells in endometrial cancer.
  Minami Fusagawa, Serina Tokita, Kenji Murata, Tasuku Mariya, Mina Umemoto, Shintaro Sugita, Kazuhiko Matsuo, Yoshihiko Hirohashi, Tsuyoshi Saito, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Cancer Immunology Research. 2025 Feb 3;13(2):171-184. (^*corresponding author)
• Identification of immunogenic HLA class I and II neoantigens using surrogate immunopeptidomes.
  Serina Tokita, Minami Fusagawa, Satoru Matsumoto, Tasuku Mariya, Mina Umemoto, Yoshihiko Hirohashi, Fumitake Hata, Tsuyoshi Saito, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Science Advances. 2024 Sep 20;10(38):eado6491. (^*corresponding author)
• Neoantigen prioritization based on antigen processing and presentation.
  Serina Tokita, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Frontiers in Immunology. 2024 Nov 6;15:1487378. (^*corresponding author)
• HLA class II neoantigen presentation for CD4 + T cell surveillance in HLA class II-negative colorectal cancer.
  Satoru Matsumoto, Takahiro Tsujikawa, Serina Tokita, Mai Mohamed Bedeir, Kazuhiko Matsuo, Fumitake Hata, Yoshihiko Hirohashi, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Oncoimmunology. 2024 Dec 31;13(1):2404665. (^*corresponding author)
• Proteogenomic identification of an immunogenic antigen derived from human endogenous retrovirus in renal cell carcinoma.
  Shin Kobayashi, Serina Tokita, Keigo Moniwa, Katsuyuki Kitahara, Hiromichi Iuchi, Kazuhiko Matsuo, Hidehiro Kakizaki, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  JCI Insight. 2023 Aug 22;8(16):e167712. (^*corresponding author)
• Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer.
  Masanori Someya ^*, Serina Tokita, Takayuki Kanaseki ^*, Mio Kitagawa, Tomokazu Hasegawa, Takaaki Tsuchiya, Yuki Fukushima, Toshio Gocho, Yoh Kozuka, Shoh Mafune, Yutaro Ikeuchi, Mamoru Takahashi, Keigo Moniwa, Kazuhiko Matsuo, Tadashi Hasegawa, Toshihiko Torigoe, Koh-Ichi Sakata.
  Cancer Science. 2022 Dec;113(12):4394-4400. (^*corresponding author)
• Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry.
  Koji Kato, Munehide Nakatsugawa ^*, Serina Tokita, Yoshihiko Hirohashi, Terufumi Kubo, Tomohide Tsukahara, Kenji Murata, Hirofumi Chiba, Hiroki Takahashi, Naoto Hirano, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Journal of Immunology. 2022 Jun 15;208(12):2856-2865. (^*corresponding author)
• Therapeutic Potential of Cancer Vaccine Based on MHC Class I Cryptic Peptides Derived from Non-Coding Regions.
  Serina Tokita, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Immuno. 2021, 1(4), 424-431. (^*corresponding author)
• CD8+ T-cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA PVT1.
  Yasuhiro Kikuchi, Serina Tokita, Tomomi Hirama, Vitaly Kochin, Munehide Nakatsugawa, Tomoyo Shinkawa, Yoshihiko Hirohashi, Tomohide Tsukahara, Fumitake Hata, Ichiro Takemasa, Noriyuki Sato, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Cancer Immunology Research. 2021 Nov;9(11):1342-1353. (^*corresponding author)
• Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair-deficient colorectal cancer tissue.
  Tomomi Hirama, Serina Tokita, Munehide Nakatsugawa, Kenji Murata, Yasuhito Nannya, Kazuhiko Matsuo, Hidetoshi Inoko, Yoshihiko Hirohashi, Shinichi Hashimoto, Seishi Ogawa, Ichiro Takemasa, Noriyuki Sato, Fumitake Hata, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  JCI Insight. 2021 Jul 22;6(14):e146356. (^*corresponding author)
• Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions.
  Tomoyo Shinkawa, Serina Tokita, Munehide Nakatsugawa, Yasuhiro Kikuchi, Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Oncoimmunology. 2021 Jan 18;10(1):1870062. (^*corresponding author)
• Proteogenomic discovery of cancer antigens: Neoantigens and beyond.
  Takayuki Kanaseki ^*, Serina Tokita, Toshihiko Torigoe.
  Pathology International. 2019 Sep;69(9):511-518. (^*corresponding author)
• Proteogenomics: advances in cancer antigen research.
  Takayuki Kanaseki ^*, Toshihiko Torigoe.
  Immunological Medicine. 2019 Jun;42(2):65-70. (^*corresponding author)
• Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8+ T Cell Responses.
  Ayumi Hongo, Takayuki Kanaseki ^*, Serina Tokita, Vitaly Kochin, Sho Miyamoto, Yuiko Hashino, Amy Codd, Noriko Kawai, Munehide Nakatsugawa, Yoshihiko Hirohashi, Noriyuki Sato, Toshihiko Torigoe.
  Journal of Immunology. 2019 May 15;202(10):2849-2855. (^*corresponding author)
• The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer.
  Sho Miyamoto, Vitaly Kochin, Takayuki Kanaseki ^*, Ayumi Hongo, Serina Tokita, Yasuhiro Kikuchi, Akari Takaya, Yoshihiko Hirohashi, Tomohide Tsukahara, Takeshi Terui, Kunihiko Ishitani, Fumitake Hata, Ichiro Takemasa, Akihiro Miyazaki, Hiroyoshi Hiratsuka, Noriyuki Sato, Toshihiko Torigoe.
  Cancer Immunology Research. 2018 Mar;6(3):358-369. (^*corresponding author)
• HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.
  Vitaly Kochin, Takayuki Kanaseki ^*, Serina Tokita, Sho Miyamoto, Yosuke Shionoya, Yasuhiro Kikuchi, Daichi Morooka, Yoshihiko Hirohashi, Tomohide Tsukahara, Kazue Watanabe, Shingo Toji, Yasuo Kokai, Noriyuki Sato, Toshihiko Torigoe.
  Oncoimmunology. 2017 Feb 16;6(4):e1293214. (^*corresponding author)
• Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition.
  Yosuke Shionoya, Takayuki Kanaseki ^*, Sho Miyamoto, Serina Tokita, Ayumi Hongo, Yasuhiro Kikuchi, Vitaly Kochin, Kazue Watanabe, Ryota Horibe, Hiroshi Saijo, Tomohide Tsukahara, Yoshihiko Hirohashi, Hiroki Takahashi, Noriyuki Sato, Toshihiko Torigoe.
  Oncoimmunology. 2017 Jan 3;6(2):e1274476. (^*corresponding author)
• Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8(+) T-cell recognition of stressed cells.
  Takanori Sasaki, Takayuki Kanaseki ^*, Yosuke Shionoya, Serina Tokita, Sho Miyamoto, Eri Saka, Vitaly Kochin, Akira Takasawa, Yoshihiko Hirohashi, Yasuaki Tamura, Akihiro Miyazaki, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Noriyuki Sato.
  European Journal of Immunology. 2016 Apr;46(4):929-40. (^*corresponding author)
• ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.
  Takayuki Kanaseki, Nicolas Blanchard, Gianna Elena Hammer, Federico Gonzalez, Nilabh Shastri^*.
  Immunity. 2006 Nov;25(5):795-806. (^*corresponding author)