Department of Pathology
Sapporo Medical University School of Medicine

2024

• Sci Adv. Tokita et al. “Identification of immunogenic HLA class I and II neoantigens using surrogate immunopeptidomes.”
• Anticancer Res. Uchiyama et al. “Prognostic Impact of Human Lymphocyte Antigen (HLA) Class I Expression in Patients With Breast Cancer.”
• Cancer Genomics Proteomics. Tsunematsu et al. “Restoration of ARID1A Protein in ARID1A-deficient Clear Cell Carcinoma of the Ovary Attenuates Reactivity to Cytotoxic T Lymphocytes.”
• Anticancer Res. Mafune et al. “Analysis of Treatment Response With Proteins Related to Tumor Immunity in Postoperative Irradiated Cervical Cancer Patients.”
• Cancers (Basel). Umemoto et al. “Prediction of Mismatch Repair Status in Endometrial Cancer from Histological Slide Images Using Various Deep Learning-Based Algorithms.”
• HLA. Kubo et al. “Assessment of cancer cell-expressed HLA class I molecules and their immunopathological implications.”
• In Vivo. Hasegawa et al. “Identification and Quantification of Radiotherapy-related Protein Expression in Cancer Tissues Using the Qupath Software and Prediction of Treatment Response.”
• Anticancer Res. Shirosaki et al. “Aldehyde Dehydrogenese-1 High Cancer Stem-like Cells/Cancer-initiating Cells Escape from Cytotoxic T Lymphocytes due to Lower Expression of Human Leukocyte Antigen Class 1.”
• J Dermatol. Shogase N et al. “Characterization of CD4 T-cell phenotype in human leukocyte antigen class II-positive acral melanoma.”
• Anticancer Res. Satoyoshi T et al. “CD8-positive T Cell Infiltration With Human Leukocyte Antigen Class 1 Expression Predicts Patients With Stage IV Colorectal Cancer Survival.”
• Biochem Biophys Res Commun. Kubo T et al. “Distinct induction pathways of heat shock protein 27 in human keratinocytes: Heat stimulation or capsaicin through phosphorylation of heat shock factor 1 at serine 326 and/or suppression of ΔNp63.”
• J Cancer Res Clin Oncol. Shijubou N et al. “Prognostic significance of immunohistochemical classification utilizing biopsy specimens in patients with extensive-disease small-cell lung cancer treated with first-line chemotherapy and immune checkpoint inhibitors.”
• Immunol Med. Murai A et al. “NF9 peptide specific cytotoxic T lymphocyte clone cross react to Y453F mutation of SARS-CoV-2 virus spike protein.”
• J Clin Exp Hematop. Fujimi et al. “High-grade B-cell lymphoma, not otherwise specified, presenting as primary peritoneal lymphomatosis and successfully treated with dose-adjusted EPOCH-R.”
• Cureus. Hosaka M et al. “Severe Acute Pancreatitis Rapidly Developed Into Pulmonary Edema and Diffuse Alveolar Hemorrhage Leading to Respiratory Failure: An Autopsy Case.”

2023

• J Dermatol. Shogase N et al. “Characterization of CD4 T-cell phenotype in human leukocyte antigen class II-positive acral melanoma.”
• J Dermatol. Maeda R et al. “Analysis of the immune microenvironment in the indolent form of primary cutaneous extranodal natural killer/T-cell lymphoma: A case report.”
• Cancer Sci. Wada A et al. “Eribulin is an immune potentiator in breast cancer that upregulates human leukocyte antigen class I expression via the induction of NOD-like receptor family CARD domain-containing 5.”
• Cancer Sci. Hamada S et al. “Development of T cell receptor-engineered T cells targeting the sarcoma-associated antigen papillomavirus binding factor.”
• Med Mol Morphol. Kashiwagi H et al. “Pregnancy-specific beta-1-glycoprotein 6 is a potential novel diagnostic biomarker of placenta accreta spectrum.”
• Heliyon. Yajima Y et al. “SARS-CoV-2 spike protein-derived immunogenic peptides that are promiscuously presented by several HLA-class II molecules and their potential for inducing acquired immunity.”
• Cancers. Sekiguchi S et al. “ACLP Activates Cancer-Associated Fibroblasts and Inhibits CD8+ T-Cell Infiltration in Oral Squamous Cell Carcinoma.”
• Anticancer Res. Saijo H et al. “Anti-CTLA-4 Antibody Might Be Effective Against Non-small Cell Lung Cancer With Large Size Tumor.”
• Cancers. Willis J et al. “Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore.”
• Cureus. Hosaka M et al. “Severe Acute Pancreatitis Rapidly Developed Into Pulmonary Edema and Diffuse Alveolar Hemorrhage Leading to Respiratory Failure: An Autopsy Case”
• JCI Insight. Kobayashi S et al. “Proteogenomic identification of an immunogenic antigen derived from human endogenous retrovirus in renal cell carcinoma.”
• Med Mol Morphol. Ikeuchi Y et al. “Immunohistological evaluation of patients treated with intra-arterial chemoradiotherapy and surgery for oral cancer.”
• Cancer Sci. Miyamoto S et al. “Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy.”
• Hum Cell. Emori M et al. “Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, SMU-DDCS, harboring an IDH1 mutation.”
• Allergy. Saito K et al. “Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s.”
• Cancer Immunol Immunother. Millar DG et al. “Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.”
• J Pathol. Minowa T et al. “Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes.”
• Oxf Med Case Reports. Hatanaka S et al. “Ischemia-induced intestinal de-epithelization and consequent cholangitis lenta after usage of extracorporeal membrane oxygenation in COVID-19 patients: an autopsy series.”
• Cancer Immunol Immunother. Millar DG et al. “Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.”
• Int J Mol Sci. Tamura Y et al. “A Sulfur Containing Melanogenesis Substrate, N-Pr-4-S-CAP as a Potential Source for Selective Chemoimmunotherapy of Malignant Melanoma.”
• Anticancer Res. Sasaki K et al. “SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells.”
• Immunol Med. Shijubou N et al. “Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity?”
• Front Immunol. Iwabuchi S et al. “B cell receptor repertoire analysis from autopsy samples of COVID-19 patients.”
• Cancer Immunol Immunother. Yamada S et al. “Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma.”
• Pathol Res Pract. Kubo T et al. “Immunohistochemical analysis of arachidonate 5-lipoxygenase expression in B-cell lymphomas: Implication for B cell differentiation and its analogy with lymphomagenesis.”
• Cancers. Mlecnik B et al. “Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer.”
• Int J Mol Sci. Ichioka H et al. “G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells.”

2022

• Med Mol Morphol. Someya M et al. “Predictive value of an exosomal microRNA-based signature for tumor immunity in cervical cancer patients treated with chemoradiotherapy.”
• Br J Cancer. Watanabe Y et al. “Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.”
• Cancers. Wakamatsu K et al. “Molecular Events in the Melanogenesis Cascade as Novel Melanoma-Targeted Small Molecules: Principle and Development.”
• J Oncol. Tanabe A et al. “YTHDC2 Promotes Malignant Phenotypes of Breast Cancer Cells.”
• World J Clin Cases. Kyuno D et al. “COVID-19-associated disseminated mucormycosis: An autopsy case report.”
• Cancer Med. Sasaya et al. “Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma.”
• J Immunol. Murata K et al. “Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation.”
• Cancer Sci. Someya M et al. “Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer.”
• Cancers (Basel). Mlecnik B et al. “Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.”
• Int J Mol Sci. Tamura Y et al. Immunomodulation of Melanoma by Chemo-Thermo-Immunotherapy Using Conjugates of Melanogenesis Substrate NPrCAP and Magnetite Nanoparticles: A Review.
• Sci Rep. Kijima T et al. “Cancer immunohistogram representing cancer-immunity cycle by immunohistochemistry predicts the efficacy of immune checkpoint inhibitors in urological cancer patients”
• J Immunol. Kato K et al. “Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry”
• Pathol Res Pract. Kubo T et al. “Spindle cell tumor with histiocytic and myogenic marker expression in the lymph node of a human T-cell leukemia virus type 1 carrier”
• Intern Med. Murao K. “Simultaneous Pseudoprogression and an Immune-related Adverse Event of Pulmonary Pleomorphic Carcinoma after Combined Therapy with Cytotoxic Anticancer Agents and Immune Checkpoint Inhibitor”
• Sci Adv. Cheng K et al. “The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys”
• Cancers. Nagaoka K et al. “Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy”
• Jpn J Radiol. Someya M et al. “Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy.”

2021

• Sugata K, Matsunaga Y, Yamashita Y, Nakatsugawa M, Guo T, Halabelian L, Ohashi Y, Saso K, Rahman MA, Anczurowski M, Wang CH, Murata K, Saijo H, Kagoya Y, Ly D, Burt BD, Butler MO, Mak TW, Hirano N. Nat Biotechnol. 2021 Mar 1. doi: 10.1038/s41587-021-00836-4. Online ahead of print. PMID: 33649568 [Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.]
• Mariya T, Sato T, Fujibe Y, Ishido M, Shimada H, Kubo T, Nagai Y, Arai W, Tanaka SE, Ashikawa K, Sakuraba Y, Ishioka S, Yokota SI, Saito T. Med Mol Morphol. 2021 Jul 21. doi: 10.1007/s00795-021-00298-2. Online ahead of print.PMID: 34287707 [Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection.]
• Shionoya Y, Hirohashi Y, Takahashi H, Hashimoto M, Nishiyama K, Takakuwa Y, Nakatsugawa M, Kubo T, Kanaseki T, Tsukahara T, Torigoe T. Anticancer Res. 2021 Jul;41(7):3699-3706. doi: 10.21873/anticanres.15161.PMID: 34230169 [Possible Pseudo-progression of Non-small Cell Lung Carcinoma in a Patient With Clinical Hyper-progression Associated With Trousseau Syndrome Who Was Treated With Pembrolizumab: A Case Report.]
• Hirama T, Tokita S, Nakatsugawa M, Murata K, Nannya Y, Matsuo K, Inoko H, Hirohashi Y, Hashimoto S, Ogawa S, Takemasa I, Sato N, Hata F, Kanaseki T, Torigoe T. JCI Insight. 2021 Jul 22;6(14):146356. doi: 10.1172/jci.insight.146356.PMID: 34185709 [Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair-deficient colorectal cancer tissue.]
• Kubo T, Shinkawa T, Kikuchi Y, Murata K, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T. Front Oncol. 2021 Jul 5;11:679095. doi: 10.3389/fonc.2021.679095. eCollection 2021.PMID: 34290982 Review. [Fundamental and Essential Knowledge for Pathologists Engaged in the Research and Practice of Immune Checkpoint Inhibitor-Based Cancer Immunotherapy.]
• Rahman MA, Murata K, Burt BD, Hirano N.Curr Opin Immunol. 2021 Apr;69:1-9. doi: 10.1016/j.coi.2020.11.003. Epub 2020 Dec 8.PMID: 33307272[Changing the landscape of tumor immunology: novel tools to examine T cell specificity.]
• Someya M, Tsuchiya T, Fukushima Y, Hasegawa T, Hori M, Kitagawa M, Gocho T, Mafune S, Ikeuchi Y, Hirohashi Y, Torigoe T, Iwasaki M, Matsuura M, Saito T, Matsumoto Y, Sakata KI.Med Mol Morphol. 2021 May 8. doi: 10.1007/s00795-021-00290-w. Online ahead of print.PMID: 33963949[Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy.]
• Kubo T, Sato S, Hida T, Minowa T, Hirohashi Y, Tsukahara T, Kanaseki T, Murata K, Uhara H, Torigoe T.Immun Inflamm Dis. 2021 Apr 1. doi: 10.1002/iid3.427. Online ahead of print.[IL-13 modulates ?Np63 levels causing altered expression of barrier- and inflammation-related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis.]
• Kubo T, Hirohashi Y, Keira Y, Akimoto M, Ikeda T, Kikuchi N, Iwaki H, Kikuchi T, Obata M, Morita R, Kasai K, Segawa K, Tsukahara T, Kanaseki T, Murata K, Kikuchi Y, Shinkawa T, Hasegawa T, Torigoe T.Cancer Sci. 2021 Mar;112(3):1320-1325. doi: 10.1111/cas.14773. Epub 2021 Jan 18.[Identification of characteristic subepithelial surface granulomatosis in immune-related adverse event-associated enterocolitis.]
• Matsuki M, Inoue R, Murai A, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Hirohashi Y, Torigoe T.Biochem Biophys Res Commun. 2021 Mar 18;552:128-135. doi: 10.1016/j.bbrc.2021.03.038. Online ahead of print.[Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells.]
• Kano T, Kokubun T, Murata K, Oka Y, Ozone K, Arakawa K, Morishita Y, Takayanagi K, Kanemura N.Connect Tissue Res. 2021 Mar 4:1-13. doi: 10.1080/03008207.2021.1889529. Online ahead of print.[Influence of the site of injury on the spontaneous healing response in a rat model of total rupture of the anterior cruciate ligament.]
• Sugata K, Matsunaga Y, Yamashita Y, Nakatsugawa M, Guo T, Halabelian L, Ohashi Y, Saso K, Rahman MA, Anczurowski M, Wang CH, Murata K, Saijo H, Kagoya Y, Ly D, Burt BD, Butler MO, Mak TW, Hirano N.Nat Biotechnol. 2021 Mar 1. doi: 10.1038/s41587-021-00836-4. Online ahead of print.[Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.]
• Kubo T, Hirohashi Y, Tsukahara T, Kanaseki T, Murata K, Hasegawa T, Torigoe T.Hum Vaccin Immunother. 2021 Feb 11:1-3. doi: 10.1080/21645515.2020.1870364. Online ahead of print.[Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy.]
• Saito T, Tsukahara T, Suzuki T, Nojima I, Tadano H, Kawai N, Kubo T, Hirohashi Y, Kanaseki T, Torigoe T, Li L.Cancer Sci. 2021 Feb;112(2):550-562. doi: 10.1111/cas.14735. Epub 2020 Dec 4.[Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.]
• Shinkawa T, Tokita S, Nakatsugawa M, Kikuchi Y, Kanaseki T, Torigoe T.Oncoimmunology. 2021 Jan 18;10(1):1870062. doi: 10.1080/2162402X.2020.1870062.[Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions.]
• Front Immunol. Ito K et al. “Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity.”
• Biochem Biophys Res Commun. Wakamiya T et al. “High aldehyde dehydrogenase 1 activity is related to radiation resistance due to activation of AKT signaling after insulin stimulation in prostate cancer.”
• Cancer Med. Nambu Y et al. “A screening assistance system for cervical cytology of squamous cell atypia based on a two-step combined CNN algorithm with label smoothing.”
• J Gynecol Oncol. Hanley SJB et al. “Evaluation of partial genotyping with HPV16/18 for triage of HPV positive, cytology negative women in the COMPACT study.”
• Gastroenterology. Kawazu M et al. “HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.”
• Immunol Med. Kubo T et al. “Immunopathological basis of immune-related adverse events induced by immune checkpoint blockade therapy.”
• Clin Case Rep. Omori G et al. “Programmed cell death ligand 1 expression in a case of poorly differentiated lymphocyte-rich hepatocellular carcinoma.”
• Cancer Immunol Immunother. Matsuki M et al. “Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma.”
• Cancer Immunol Res. Kikuchi Y et al. ‘CD8+ T-cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA PVT1.’
• Cancer Immunol Immunother. Miyata H et al. “GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy.”
• Allergy. Orimo K et al. “Direct platelet adhesion potentiates group 2 innate lymphoid cell functions.”

2020

• Takeshita T, Torigoe T, Yan L, Huang JL, Yamashita H, Takabe K.Cancers (Basel). 2020 Dec 31;13(1):110. doi: 10.3390/cancers13010110.[The Impact of Immunofunctional Phenotyping on the Malfunction of the Cancer Immunity Cycle in Breast Cancer.]
• Saito T, Tsukahara T, Suzuki T, Nojima I, Tadano H, Kawai N, Kubo T, Hirohashi Y, Kanaseki T, Torigoe T, Li L. Cancer Sci. 2020 Nov 15. doi: 10.1111/cas.14735. Online ahead of print.PMID: 33190360[Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.].
• Mlecnik B, Bifulco C, Bindea G, Marliot F, Lugli A, Lee JJ, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Borger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grutzmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Leonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Lafontaine L, Bruni D, Lanzi A, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Paustian C, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mu?in? AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Fox BA, Pages F, Galon J. J Clin Oncol. 2020 Nov 1;38(31):3638-3651. doi: 10.1200/JCO.19.03205. Epub 2020 Sep 8.PMID: 32897827[Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.].
• Tadano H, Tsukahara T, Mizushima E, Akamatsu A, Watanabe K, Nojima I, Kubo T, Kanaseki T, Hirohashi Y, Sato N, Torigoe T. Br J Cancer. 2020 Oct;123(9):1387-1394. doi: 10.1038/s41416-020-1017-1. Epub 2020 Aug 5.PMID: 32753678[Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8.].
• Someya M, Tsuchiya T, Fukushima Y, Hasegawa T, Takada Y, Hori M, Miura K, Kitagawa M, Gocho T, Hirohashi Y, Torigoe T, Iwasaki M, Matsuura M, Saito T, Sakata KI. Jpn J Clin Oncol. 2020 Oct 22;50(11):1290-1297. doi: 10.1093/jjco/hyaa149.PMID: 33089868[Association between cancer immunity and treatment results in uterine cervical cancer patients treated with radiotherapy.].
• Suzuki T, Yamamoto Y, Torigoe T, Mizukami S, Shigehara K. Case Rep Surg. 2020 Sep 7;2020:8833573. doi: 10.1155/2020/8833573. eCollection 2020.PMID: 32963874[Primary Appendiceal Adenocarcinoma Presenting with Hematochezia due to the Invading Tumor in the Sigmoid Colon.].
• Tsuchihashi K, Nakatsugawa M, Kobayashi JI, Sasaya T, Morita R, Kubo T, Kanaseki T, Tsukahara T, Asanuma H, Hasegawa T, Hirano H, Miyazaki A, Hirohashi Y, Torigoe T. AnticancerRes. 2020 Aug;40(8):4319-4326. doi: 10.21873/anticanres.14434.PMID: 32727759[Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma.].
• Koike K, Dehari H, Ogi K, Shimizu S, Nishiyama K, Sonoda T, Sasaki T, Sasaya T, Tsuchihashi K, Hasegawa T, Torigoe T, Hiratsuka H, Miyazaki A. PLoS One. 2020 Aug 12;15(8):e0237465. doi: 10.1371/journal.pone.0237465. eCollection 2020.PMID: 32785290[Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.].
• Ueki Y, Matsuki M, Kubo T, Morita R, Hirohashi Y, Sato S, Horibe R, Matsuo K, Tsukahara T, Kanaseki T, Takakuwa Y, Satoh M, Itoh N, Torigoe T. IJU Case Rep. 2020 Aug 12;3(6):266-269. doi: 10.1002/iju5.12211. eCollection 2020 Nov.PMID: 33163921[Non-bacterial cystitis with increased expression of programmed death-ligand 1 in the urothelium: An unusual immune-related adverse event during treatment with pembrolizumab for lung adenocarcinoma.].
• Kagoya Y, Guo T, Yeung B, Saso K, Anczurowski M, Wang CH, Murata K, Sugata K, Saijo H, Matsunaga Y, Ohashi Y, Butler MO, Hirano N. Cancer Immunol Res. 2020 Jul;8(7):926-936. doi: 10.1158/2326-6066.CIR-18-0508. Epub 2020 Apr 22.PMID: 32321775[Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy.].
• Kubo T, Sugawara T, Shinkawa T, Kurisu T, Kouzen N, Tanaka T, Fukuta F, Yamasaki K, Sugita S, Matsuo K, Morita R, Hirohashi Y, Tsukahara T, Kanaseki T, Hasegawa T, Masumori N, Torigoe T. Immunol Med. 2020 Jul 7:1-6. doi: 10.1080/25785826.2020.1788229. Online ahead of print.PMID: 32634346[Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma.].
• Saito Y, Takasawa A, Takasawa K, Aoyama T, Akimoto T, Ota M, Magara K, Murata M, Hirohashi Y, Hasegawa T, Sawada N, Saito T, Osanai M. Cancer Sci. 2020 Jun 12. doi: 10.1111/cas.14524. Online ahead of print.PMID: 32530543[Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma.].
• Hiraoka N, Ino Y, Hori S, Yamazaki-Itoh R, Naito C, Shimasaki M, Esaki M, Nara S, Kishi Y, Shimada K, Nakamura N, Torigoe T, Heike Y. Cancer Sci. 2020 Jun 3. doi: 10.1111/cas.14514. Online ahead of print.PMID: 32495519[Expression of classical human leukocyte antigen class I antigens, HLA-E and HLA-G, is adversely prognostic in pancreatic cancer patients.].
• Mariya T, Kubo T, Hirohashi Y, Yanagawa J, Tabuchi Y, Matsuo K, Furumura K, Morita R, Nakatsugawa M, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Torigoe T. Med Mol Morphol. 2020 May 14. doi: 10.1007/s00795-020-00254-6. Online ahead of print.PMID: 32410009[Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer.].
• van de Veen W, Globinska A, Jansen K, Straumann A, Kubo T, Verschoor D, Wirz OF, Castro-Giner F, Tan G, Ruckert B, Ochsner U, Herrmann M, Stani? B, van Splunter M, Huntjens D, Wallimann A, Fonseca Guevara RJ, Spits H, Ignatova D, Chang YT, Fassnacht C, Guenova E, Flatz L, Akdis CA, Akdis M. Sci Adv. 2020 May 13;6(20):eaaz3559. doi: 10.1126/sciadv.aaz3559. eCollection 2020 May.PMID: 32426497[A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.].
• Murata K, Nakatsugawa M, Rahman MA, Nguyen LT, Millar DG, Mulder DT, Sugata K, Saijo H, Matsunaga Y, Kagoya Y, Guo T, Anczurowski M, Wang CH, Burt BD, Ly D, Saso K, Easson A, Goldstein DP, Reedijk M, Ghazarian D, Pugh TJ, Butler MO, Mak TW, Ohashi PS, Hirano N. Elife. 2020 Apr 21;9:e53244. doi: 10.7554/eLife.53244.PMID: 32314731[Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma.].
• Hori K, Hirohashi Y, Aoyagi T, Taniguchi N, Murakumo M, Miyata H, Torigoe T, Abe T, Shinohara N, Morita K. Exp Ther Med. 2020 Mar;19(3):1903-1907. doi: 10.3892/etm.2020.8423. Epub 2020 Jan 3.[Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma-unique pathological features of the primary specimen: A case report.].
• Koike K, Dehari H, Shimizu S, Nishiyama K, Sonoda T, Ogi K, Kobayashi J, Sasaki T, Sasaya T, Tsuchihashi K, Tsukahara T, Hasegawa T, Torigoe T, Hiratsuka H, Miyazaki A. Cancer Sci. 2020 Mar 13. doi: 10.1111/cas.14388. [Epub ahead of print][Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma.].
• Orth MF, Holting TLB, Dallmayer M, Wehweck FS, Paul T, Musa J, Baldauf MC, Surdez D, Delattre O, Knott MML, Romero-Perez L, Kasan M, Cidre-Aranaz F, Gerke JS, Ohmura S, Li J, Marchetto A, Henssen AG, Ozen O, Sugita S, Hasegawa T, Kanaseki T, Bertram S, Dirksen U, Hartmann W, Kirchner T, Grunewald TGP. Cancers (Basel). 2020 Mar 10;12(3). pii: E644. doi: 10.3390/cancers12030644. [High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma.].
• Tsukahara T, Watanabe K, Murata K, Takahashi A, Mizushima E, Shibayama Y, Kameshima H, Hatae R, Ohno Y, Kawahara R, Murai A, Nakatsugawa M, Kubo T, Kanaseki T, Hirohashi Y, Terui T, Asanuma H, Hasegawa T, Sato N, Torigoe T. Cancer Immunol Immunother. 2020 Feb;69(2):189-197. doi: 10.1007/s00262-019-02455-0. Epub 2019 Dec 18.[Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma.].
• Tsuchiya T, Someya M, Takada Y, Hasegawa T, Kitagawa M, Fukushima Y, Gocho T, Hori M, Nakata K, Hirohashi Y, Torigoe T, Saito T, Sakata KI. Strahlenther Onkol. 2020 Jan 17. doi: 10.1007/s00066-019-01571-1. [Epub ahead of print][Association between radiotherapy-induced alteration of programmed death ligand 1 and survival in patients with uterine cervical cancer undergoing preoperative radiotherapy.].

2019

• Kubo T, Kikuchi N, Shiina S, Torigoe T, Iwaki H. Auris Nasus Larynx. 2019 Oct 22. pii: S0385-8146(19)30444-4. doi: 10.1016/j.anl.2019.10.001. [Epub ahead of print][Occult carcinoma confirmed to be a diffuse sclerosing variant of papillary thyroid carcinoma with unusual immunohistochemical features: A pitfall of clinicopathological diagnosis.].
• Mizushima E, Tsukahara T, Emori M, Murata K, Akamatsu A, Shibayama Y, Hamada S, Watanabe Y, Kaya M, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T. Cancer Sci. 2019 Nov 9. doi: 10.1111/cas.14229. [Epub ahead of print][Osteosarcoma-initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B.].
• Kanaseki T, Gan To Kagaku Ryoho. 2019 Sep;46(9):1377-1381. Review. Japanese.[Proteogenomics HLA Ligandome Analysis for Cancer Antigen Research].
• Kanaseki T, Torigoe T.Immunol Med. 2019 Jul 18:1-6. doi: 10.1080/25785826.2019.1640500. [Epub ahead of print]Proteogenomics: advances in cancer antigen research.
• Kanaseki T, Tokita S, Torigoe T. Pathol Int. 2019 Aug 9. doi: 10.1111/pin.12841. [Epub ahead of print] Review. Proteogenomic discovery of cancer antigens: Neoantigens and beyond.
• Tagami Y, Sugita S, Kubo T, Iesato N, Emori M, Takada K, Tsujiwaki M, Segawa K, Sugawara T, Kikuchi T, Hasegawa T.Pathol Res Pract. 2019 Mar 27:152399. doi: 10.1016/j.prp.2019.03.027. [Epub ahead of print] Spindle cell rhabdomyosarcoma in a lumbar vertebra with FUS-TFCP2 fusion.
• Sugita K, Altunbulakli C, Morita H, Sugita A, Kubo T, Kimura R, Goto H, Yamamoto O, Ruckert B, Akdis M, Akdis CA.Allergy. 2019 Jun 5. doi: 10.1111/all.13935. [Epub ahead of print] No abstract availableHuman type 2 innate lymphoid cells disrupt skin keratinocyte tight junction barrier by IL-13.
• Kanaseki T, Shastri N.Methods Mol Biol. 2019;1988:101-108. doi: 10.1007/978-1-4939-9450-2_8. Biochemical Analysis of Naturally Processed Antigenic Peptides Presented by MHC Class I Molecules.
• Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T. Cancer Sci. 2019 Aug;110(8):2378-2385. doi: 10.1111/cas.14106. Epub 2019 Jul 23. Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.
• Berlow NE, Rikhi R, Geltzeiler M, Abraham J, Svalina MN, Davis LE, Wise E, Mancini M, Noujaim J, Mansoor A, Quist MJ, Matlock KL, Goros MW, Hernandez BS, Doung YC, Thway K, Tsukahara T, Nishio J, Huang ET, Airhart S, Bult CJ, Gandour-Edwards R, Maki RG, Jones RL, Michalek JE, Milovancev M, Ghosh S, Pal R, Keller C.BMC Cancer. 2019 Jun 17;19(1):593. doi: 10.1186/s12885-019-5681-6. Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma.
• Honjo O, Kubo T, Sugaya F, Nishizaka T, Kato K, Hirohashi Y, Takahashi H, Torigoe T. J Immunother Cancer. 2019 Apr 3;7(1):97. doi: 10.1186/s40425-019-0582-4. Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report.
• Kawai N, Hirohashi Y, Ebihara Y, Saito T, Murai A, Saito T, Shirosaki T, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Shichinohe T, Li L, Hirano S, Torigoe T. LoS One. 2019 May 13;14(5):e0216503. doi: 10.1371/journal.pone.0216503. eCollection 2019. ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD.
• Matsuki M, Hirohashi Y, Torigoe T.Gan To Kagaku Ryoho. 2019 May;46(5):850-854[PD-L1-Mediated Immune Escape Mechanism of Cancer Stem-Like Cells].
• Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T.Cancer Sci. 2019 Jun 17. doi: 10.1111/cas.14099. [Epub ahead of print] Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: analysis of an autopsy series.
• Hongo A, Kanaseki T, Tokita S, Kochin V, Miyamoto S, Hashino Y, Codd A, Kawai N, Nakatsugawa M, Hirohashi Y, Sato N, Torigoe T. J Immunol. 2019 Apr 1. pii: ji1900029. doi: 10.4049/jimmunol.1900029. [Epub ahead of print] Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8+ T Cell Responses.
• Li D, Toji S, Watanabe K, Torigoe T, Tsukahara T. Cancer Sci. 2019 Feb 15. doi: 10.1111/cas.13973. [Epub ahead of print] Identification of novel human leukocyte antigen-A*11:01-restricted cytotoxic T-lymphocyte epitopes derived from osteosarcoma antigen papillomavirus binding factor.
• Kato J, Hida T, Someya M, Sato S, Sawada M, Horimoto K, Fujioka M, Minowa T, Matsui Y, Tsuchiya T, Kitagawa M, Nakata K, Sakata KI, Torigoe T, Uhara H. J Dermatol. 2019 Feb 13. doi: 10.1111/1346-8138.14805. [Epub ahead of print] Efficacy of combined radiotherapy and anti-programmed death 1 therapy in acral and mucosal melanoma.
• Morita H, Kubo T, Ruckert B, Ravindran A, Soyka MB, Rinaldi AO, Sugita K, Wawrzyniak M, Wawrzyniak P, Motomura K, Tamari M, Orimo K, Okada N, Arae K, Saito K, Altunbulakli C, Castro-Giner F, Tan G, Neumann A, Sudo K, O'Mahony L, Honda K, Nakae S, Saito H, Mjosberg J, Nilsson G, Matsumoto K, Akdis M, Akdis CA. J Allergy Clin Immunol. 2019 Jan 22. pii: S0091-6749(19)30088-0. doi: 10.1016/j.jaci.2018.12.1018. [Epub ahead of print] Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid.
• Benveniste PM, Nakatsugawa M, Nguyen L, Ohashi PS, Hirano N, Zuniga-Pflucker JC. Immunol Cell Biol. 2019 Jan 11. doi: 10.1111/imcb.12231. [Epub ahead of print] In vitro-generated MART-1-specific CD8 T cells display a broader T cell receptor repertoire than naive ex vivo and tumor infiltrating lymphocytes.

2018

• Sugita S, Kubo T, Aoyama T, Moriya J, Okuni T, Wanibuchi M, Yamashita K, Onodera M, Tsujiwaki M, Segawa K, Sugawara T, Hasegawa T. Diagn Cytopathol. 2018 Dec 27. doi: 10.1002/dc.24142. [Epub ahead of print] Imprint cytology of biphenotypic sinonasal sarcoma of the paranasal sinus: A case report.
• Benveniste PM, Roy S, Nakatsugawa M, Chen ELY, Nguyen L, Millar DG, Ohashi PS, Hirano N, Adams EJ, Zuniga-Pflucker JC. Sci Immunol. 2018 Dec 14;3(30). pii: eaav4036. doi: 10.1126/sciimmunol.aav4036. Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells.
• Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T. Exp Mol Pathol. 2018 Nov 29. pii: S0014-4800(18)30465-9. doi: 10.1016/j.yexmp.2018.11.013. [Epub ahead of print] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.
• Kamiya S, Kato J, Kamiya T, Yamashita T, Sumikawa Y, Hida T, Horimoto K, Sato S, Takahashi H, Sawada M, Kubo T, Torigoe T, Uhara H. Asia Pac J Clin Oncol. 2018 Nov 8. doi: 10.1111/ajco.13102. [Epub ahead of print] Association between PD-L1 expression and lymph node metastasis in cutaneous squamous cell carcinoma.
• Kubo T, Hirohashi Y, Fujita H, Sugita S, Kikuchi Y, Shinkawa T, Nakatsugawa M, Tsujiwaki M, Sudo Y, Asai Y, Umeda Y, Takahashi H, Hasegawa T, Torigoe T. Respir Med Case Rep. 2018 Oct 18;25:306-308. doi: 10.1016/j.rmcr.2018.10.013. eCollection 2018. Occult ovarian clear-cell carcinoma diagnosed as primary adenocarcinoma of the lung: A case report of a diagnostic pitfall for clinicians and pathologists.
• Watanabe K, Tsukahara T, Toji S, Saitoh S, Hirohashi Y, Nakatsugawa M, Kubo T, Kanaseki T, Kameshima H, Terui T, Sato N, Torigoe T. Cancer Sci. 2018 Oct 30. doi: 10.1111/cas.13854. [Epub ahead of print] Development of a TCR multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells.
• Kubo T, Tsujiwaki M, Hirohashi Y, Tsukahara T, Kanaseki T, Nakatsugawa M, Hasegawa T, Torigoe T. Lab Invest. 2018 Sep 25. doi: 10.1038/s41374-018-0132-6. [Epub ahead of print] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma.
• Fukushima Y, Someya M, Nakata K, Hori M, Kitagawa M, Hasegawa T, Tsuchiya T, Gocho T, Ikeda H, Hirohashi Y, Torigoe T, Sugita S, Hasegawa T, Himi T, Sakata KI. Radiother Oncol. 2018 Sep 21. pii: S0167-8140(18)33463-7. doi: 10.1016/j.radonc.2018.08.023. [Epub ahead of print] Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma.
• Segawa K, Sugita S, Aoyama T, Kubo T, Asanuma H, Sugawara T, Ito Y, Tsujiwaki M, Fujita H, Emori M, Hasegawa T. Diagn Pathol. 2018 Sep 15;13(1):73. doi: 10.1186/s13000-018-0752-6. Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor.
• Shima H, Kutomi G, Satomi F, Imamura M, Kimura Y, Mizuguchi T, Watanabe K, Takahashi A, Murai A, Tsukahara T, Kanaseki T, Hirohashi Y, Iwayama Y, Tsuruma T, Kameshima H, Sato N, Torigoe T, Takemasa I. Cancer Immunol Immunother. 2018 Aug 1. doi: 10.1007/s00262-018-2217-x. [Epub ahead of print] Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine.
• Baldauf MC, Gerke JS, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio RA, Kanaseki T, Kiran MM, Dallmayer M, Musa J, Akpolat N, Akatli AN, Rosman FC, Ozen O, Sugita S, Hasegawa T, Sugimura H, Baumhoer D, Knott MML, Sannino G, Marchetto A, Li J, Busch DH, Feuchtinger T, Ohmura S, Orth MF, Thiel U, Kirchner T, Grunewald TGP. Oncoimmunology. 2018 Jul 23;7(9):e1481558. doi: 10.1080/2162402X.2018.1481558. eCollection 2018. Systematic identification of cancer-specific MHC-binding peptides with RAVEN.
• Pages F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Borger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grutzmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Leonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mu?in? AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J. The Lancet. 2018 May 10. pii: S0140-6736(18)30789-X. doi: 10.1016/S0140-6736(18)30789-X. [Epub ahead of print] International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.
• Kagoya Y, Nakatsugawa M, Saso K, Guo T, Anczurowski M, Wang CH, Butler MO, Arrowsmith CH, Hirano N. Nat Commun. 2018 May 15;9(1):1915. doi: 10.1038/s41467-018-04262-0. DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.
• Anczurowski M, Yamashita Y, Nakatsugawa M, Ochi T, Kagoya Y, Guo T, Wang CH, Rahman MA, Saso K, Butler MO, Hirano N. Sci Rep. 2018 Mar 19;8(1):4804. doi: 10.1038/s41598-018-22931-4. Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP84Gly.
• Miyazaki A, Nakai H, Sonoda T, Hirohashi Y, Kaneko MK, Kato Y, Sawa Y, Hiratsuka H. Oncotarget. 2018 Apr 20;9(30):21156-21165. doi: 10.18632/oncotarget.24986. eCollection 2018 Apr 20. LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer.
• Aoyama-Kikawa S, Fujita H, Hanley SJB, Kasamo M, Kikuchi K, Torigoe T, Matsuno Y, Tamakoshi A, Sasaki T, Matsuura M, Kato Y, Dong P, Watari H, Saito T, Sengoku K, Sakuragi N. Cancer Sci. 2018 Apr 16. doi: 10.1111/cas.13608. [Epub ahead of print] Comparison of HPV genotyping and cytology triage, COMPACT-Study: Design, methods and baseline results in 14,642 women.
• Kusumoto H, Hirohashi Y, Nishizawa S, Yamashita M, Yasuda K, Murai A, Takaya A, Mori T, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Kondo T, Sato N, Hara I, Torigoe T. Cancer Sci. 2018 Mar;109(3):741-750. doi: 10.1111/cas.13501. Epub 2018 Feb 20. Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1.
• Miyamoto S, Kochin V, Kanaseki T, Hongo A, Tokita S, Kikuchi Y, Takaya A, Hirohashi Y, Tsukahara T, Terui T, Ishitani K, Hata F, Takemasa I, Miyazaki A, Hiratsuka H, Sato N, Torigoe T. Cancer Immunol Res. 2018 Jan 25. doi: 10.1158/2326-6066.CIR-17-0518. [Epub ahead of print] The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer.

2017

• Ogawa T, Hirohashi Y, Murai A, Nishidate T, Okita K, Wang L, Ikehara Y, Satoyoshi T, Usui A, Kubo T, Nakastugawa M, Kanaseki T, Tsukahara T, Kutomi G, Furuhata T, Hirata K, Sato N, Mizuguchi T, Takemasa I, Torigoe T. Oncotarget. 2017 Nov 8;8(68):112550-112564. doi: 10.18632/oncotarget.22545. eCollection 2017 Dec 22. ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway.
• Nishizawa S, Hirohashi Y, Kusumoto H, Wakamiya T, Iguchi T, Yamashita S, Iba A, Kikkawa K, Kohjimoto Y, Torigoe T, Hara I. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):693-699. doi: 10.1016/j.bbrc.2017.10.146. Epub 2017 Oct 28. Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB8.
• Codd AS, Kanaseki T, Torigo T, Tabi Z. Immunology. 2017 Nov 18. doi: 10.1111/imm.12866. [Epub ahead of print] Review. Cancer stem cells as targets for immunotherapy.
• Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, Torigoe T.　 Sci Rep. 2017 Oct 27;7(1):14225. doi: 10.1038/s41598-017-14676-3. Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.
• Okamoto JY, Miyazaki A, Kobayashi JI, Miyamoto S, Sasaki T, Kanaseki T, Hirohashi Y, Torigoe T, Hiratsuka H. Anticancer Res. 2017 Sep;37(9):4889-4897.Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma.
• Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T. Cancer Sci. 2017 Sep;108(9):1739-1745. doi: 10.1111/cas.13319. Epub 2017 Aug 7.Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.
• Tadano H, Torigoe T. Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(2):102-108. doi: 10.2177/jsci.40.102. Review. Japanese.Immune-related adverse events of immune checkpoint inhibitors.
• Miyamoto S, Kanaseki T, Hirohashi Y, Tsukahara T, Kikuchi Y, Sato N, Torigoe T. Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(1):40-47. doi: 10.2177/jsci.40.40.Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy.
• Kochin V, Kanaseki T, Tokita S, Miyamoto S, Shionoya Y, Kikuchi Y, Morooka D, Hirohashi Y, Tsukahara T, Watanabe K, Toji S, Kokai Y, Sato N, Torigoe T. Oncoimmunology. 2017 Feb 16;6(4):e1293214. doi: 10.1080/2162402X.2017.1293214. eCollection 2017.HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.
• Takahashi D, Fujihara M, Miyazaki T, Matsubayashi K, Sato S, Azuma H, Kato T, Kino S, Ikeda H, Takamoto S, Sato N, Torigoe T. J Immunol Methods. 2017 Aug;447:57-64. doi: 10.1016/j.jim.2017.04.009. Epub 2017 May 1. No abstract available.Flow cytometric quantitation of platelet phagocytosis by monocytes using a pH-sensitive dye, pHrodo-SE.
• Inoue R, Hirohashi Y, Kitamura H, Nishida S, Murai A, Takaya A, Yamamoto E, Matsuki M, Tanaka T, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Sato N, Masumori N, Torigoe T. Oncotarget. 2017 Apr 25;8(17):28826-28839. doi: 10.18632/oncotarget.16259.GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.
• Yasuda K, Hirohashi Y, Mariya T, Murai A, Tabuchi Y, Kuroda T, Kusumoto H, Takaya A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Hirano H, Hasegawa T, Saito T, Sato N, Torigoe T. Oncotarget. 2017 May 9;8(19):31540-31553. doi: 10.18632/oncotarget.16361.Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.
• Shionoya Y, Kanaseki T, Miyamoto S, Tokita S, Hongo A, Kikuchi Y, Kochin V, Watanabe K, Horibe R, Saijo H, Tsukahara T, Hirohashi Y, Takahashi H, Sato N, Torigoe T. Oncoimmunology. 2017 Jan 3;6(2):e1274476. doi: 10.1080/2162402X.2016.1274476. eCollection 2017.Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition.
• Kubo T, Hirohashi Y, Matsuo K, Sonoda T, Sakamoto H, Furumura K, Tsukahara T, Kanaseki T, Nakatsugawa M, Hirano H, Furuhata T, Takemasa I, Hasegawa T, Torigoe T. Anticancer Res. 2017 Mar;37(3):1289-1295.Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon.
• Horibe R, Hirohashi Y, Asano T, Mariya T, Suzuki T, Takaya A, Saijo H, Shionoya Y, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Watanabe K, Atsuyama E, Toji S, Hirano H, Hasegawa T, Takahashi H, Sato N, Torigoe T. PLoS One. 2017 Mar 1;12(3):e0171460. doi: 10.1371/journal.pone.0171460. eCollection 2017.Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy.
• Wang L, Hirohashi Y, Ogawa T, Shen M, Takeda R, Murai A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nishidate T, Okita K, Kutomi G, Sato N, Takemasa I, Torigoe T. Biochem Biophys Res Commun. 2017 Apr 29;486(2):232-238. doi: 10.1016/j.bbrc.2017.02.112. Epub 2017 Feb 24.LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells.
• Takeda R, Hirohashi Y, Shen M, Wang L, Ogawa T, Murai A, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nishidate T, Okita K, Kutomi G, Sato N, Takemasa I, Torigoe T. Biochem Biophys Res Commun. 2017 Apr 8;485(3):651-657. doi: 10.1016/j.bbrc.2017.02.081. Epub 2017 Feb 20.Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells.
• Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y. Oncotarget. 2017 Apr 11;8(15):24706-24718. doi: 10.18632/oncotarget.14960. Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer.

2016

• Kubo T, Hirohashi Y, Torigoe T. Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(5):468-472. Review. Dendritic cell and cancer immune checkpoint.
• Kajiwara T, Tanaka T, Kukita K, Kutomi G, Saito K, Okuya K, Takaya A, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Sato N, Tamura Y. Eur J Immunol. 2016 Dec;46(12):2842-2851. doi: 10.1002/eji.201646525. Epub 2016 Oct 18. Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells.
• Murata K, Tsukahara T, Emori M, Shibayama Y, Mizushima E, Matsumiya H, Yamashita K, Kaya M, Hirohashi Y, Kanaseki T, Kubo T, Himi T, Ichimiya S, Yamashita T, Sato N, Torigoe T. Oncoimmunology. 2016 Jun 8;5(6):e1165376. doi: 10.1080/2162402X.2016.1165376. eCollection 2016 Jun. Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance.
• Tsukahara T, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Sato N, Torigoe T. Pathol Int. 2016 Oct;66(10):547-553. doi: 10.1111/pin.12438. Epub 2016 Jul 19. Review. Peptide vaccination therapy: Towards the next generation.
• Saijo H, Hirohashi Y, Torigoe T, Horibe R, Takaya A, Murai A, Kubo T, Kajiwara T, Tanaka T, Shionoya Y, Yamamoto E, Maruyama R, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Sasaki Y, Tokino T, Suzuki H, Kondo T, Takahashi H, Sato N. Oncotarget. 2016 Aug 2;7(31):50043-50056. doi: 10.18632/oncotarget.10571. Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.
• Takaya A, Hirohashi Y, Murai A, Morita R, Saijo H, Yamamoto E, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Tamura Y, Takemasa I, Kondo T, Sato N, Torigoe T. PLoS One. 2016 Jul 14;11(7):e0158903. doi: 10.1371/journal.pone.0158903. eCollection 2016. Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480.
• Sato A, Kamekura R, Kawata K, Kawada M, Jitsukawa S, Yamashita K, Sato N, Himi T, Ichimiya S. PLoS One. 2016 Jul 1;11(7):e0158408. doi: 10.1371/journal.pone.0158408. eCollection 2016. Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation.
• Shima H, Kutomi G, Satomi F, Maeda H, Hirohashi Y, Hasegawa T, Mori M, Torigoe T, Takemasa I. Anticancer Res. 2016 Jun;36(6):2945-53. SOX2 and ALDH1 as Predictors of Operable Breast Cancer.
• Murata K, Tsukahara T, Torigoe T. Nihon Rinsho Meneki Gakkai Kaishi. 2016;39(1):18-22. doi: 10.2177/jsci.39.18. Review. Cancer immunotherapy and immunological memory.
• Tsukahara T, Emori M, Murata K, Mizushima E, Shibayama Y, Kubo T, Kanaseki T, Hirohashi Y, Yamashita T, Sato N, Torigoe T. Expert Opin Biol Ther. 2016 Aug;16(8):1049-57. doi: 10.1080/14712598.2016.1188075. Epub 2016 May 27. The future of immunotherapy for sarcoma.
• Ito N, Kamiguchi K, Nakanishi K, Sokolovskya A, Hirohashi Y, Tamura Y, Murai A, Yamamoto E, Kanaseki T, Tsukahara T, Kochin V, Chiba S, Shimohama S, Sato N, Torigoe T. Biochem Biophys Res Commun. 2016 Jun 10;474(4):626-33. doi: 10.1016/j.bbrc.2016.03.152. Epub 2016 Apr 28. A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.
• Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y. Br J Cancer. 2016 May 24;114(11):1227-34. doi: 10.1038/bjc.2016.105. Epub 2016 Apr 21. Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level.
• Mariya T, Hirohashi Y, Torigoe T, Tabuchi Y, Asano T, Saijo H, Kuroda T, Yasuda K, Mizuuchi M, Saito T, Sato N. Oncotarget. 2016 May 3;7(18):26806-22. doi: 10.18632/oncotarget.8645. Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.
• Yamauchi M, Hirohashi Y, Torigoe T, Matsumoto Y, Yamashita K, Kayama M, Sato N, Yotsuyanagi T.　Biochem Biophys Res Commun. 2016 May 13;473(4):845-52. doi: 10.1016/j.bbrc.2016.03.138. Epub 2016 Mar 30. Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism.
• Tanabe A, Tanikawa K, Tsunetomi M, Takai K, Ikeda H, Konno J, Torigoe T, Maeda H, Kutomi G, Okita K, Mori M, Sahara H. Cancer Lett. 2016 Jun 28;376(1):34-42. doi: 10.1016/j.canlet.2016.02.022. Epub 2016 Mar 17. RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.
• Yasuda K, Hirohashi Y, Kuroda T, Takaya A, Kubo T, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Sato N, Torigoe T. Biochem Biophys Res Commun. 2016 Apr 15;472(4):643-7. doi: 10.1016/j.bbrc.2016.03.004. Epub 2016 Mar 9. MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.
• Morita R, Hirohashi Y, Torigoe T, Ito-Inoda S, Takahashi A, Mariya T, Asanuma H, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Kutomi G, Mizuguchi T, Terui T, Ishitani K, Hashino S, Kondo T, Minagawa N, Takahashi N, Taketomi A, Todo S, Asaka M, Sato N. Clin Cancer Res. 2016 Jul 1;22(13):3298-309. doi: 10.1158/1078-0432.CCR-15-1709. Epub 2016 Feb 9. Olfactory Receptor Family 7 Subfamily C Member 1 Is a Novel Marker of Colon Cancer-Initiating Cells and Is a Potent Target of Immunotherapy.
• Asano T, Hirohashi Y, Torigoe T, Mariya T, Horibe R, Kuroda T, Tabuchi Y, Saijo H, Yasuda K, Mizuuchi M, Takahashi A, Asanuma H, Hasegawa T, Saito T, Sato N. Oncotarget. 2016 Mar 8;7(10):11223-37. doi: 10.18632/oncotarget.7165. Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy.
• Konishi T, Funayama N, Tsukahara T, Yamamoto T, Nishihara H. Eur Heart J Cardiovasc Imaging. 2016 Apr;17(4):467. doi: 10.1093/ehjci/jev355. Epub 2016 Jan 27. No abstract available. Multimodality assessment of spontaneous haemostasis of left ventricular free wall rupture after myocardial infarction.
• Yamashita M, Hirohashi Y, Torigoe T, Kusumoto H, Murai A, Imagawa T, Sato N. PLoS One. 2016 Jan 11;11(1):e0146501. doi: 10.1371/journal.pone.0146501. eCollection 2016. Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response.
• Lee JR, Sato N, Bechstein DJ, Osterfeld SJ, Wang J, Gani AW, Hall DA, Wang SX. Sci Rep. 2016 Jan 5;6:18692. doi: 10.1038/srep18692. Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors.
• Hirohashi Y, Torigoe T, Tsukahara T, Kanaseki T, Kochin V, Sato N. Cancer Sci. 2016 Jan;107(1):12-7. doi: 10.1111/cas.12830. Epub 2015 Nov 12. Review. Immune responses to human cancer stem-like cells/cancer-initiating cells

2015

• Guidance Development Review Committee; Working Group for Clinical Studies of Cancer Immunotherapy; Working Group for Effector Cell Therapy; Working Group for CMC/Non-clinical Studies; Working Group for Cancer Vaccines and Adjuvants; Working Group for Anti-immune Checkpoint Therapy and Comprehensive Cancer Immunotherapy; Biostatistics Subcommittee.Cancer Sci. 2015 Dec;106(12):1761-71. doi: 10.1111/cas.12819.2015 Guidance on cancer immunotherapy development in early-phase clinical studies.
• Sasaki T, Kanaseki T, Shionoya Y, Tokita S, Miyamoto S, Saka E, Kochin V, Takasawa A, Hirohashi Y, Tamura Y, Miyazaki A, Torigoe T, Hiratsuka H, Sato N.Eur J Immunol. 2015 Dec 29. doi: 10.1002/eji.201545835. [Epub ahead of print]Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8+ T-cell recognition of stressed cells.
• Yata K, Beder LB, Tamagawa S, Hotomi M, Hirohashi Y, Grenman R, Yamanaka N.Int J Oncol. 2015 Oct;47(4):1249-56. doi: 10.3892/ijo.2015.3145. Epub 2015 Aug 31.MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma.
• Hirohashi Y, Torigoe T, Mariya T, Kochin V, Saito T, Sato N.Oncoimmunology. 2015 Mar 23;4(5):e1005507. eCollection 2015.HLA class I as a predictor of clinical prognosis and CTL infiltration as　a predictorof chemosensitivity in ovarian cancer.
• Okita K, Mizuguchi T, Shigenori O, Ishii M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N,Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K. Surg Today. 2015 Jul 7. [Epub ahead of print]Pancreatic regeneration: basic research and gene regulation.
• Tanaka T, Kajiwara T, Kutomi G, Kurotaki T, Saito K, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y. Immunol Lett. 2015 Sep;167(1):34-40. doi: 10.1016/j.imlet.2015.06.014. Epub 2015 Jun 30.CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitatingcross-presentation.
• Emori M, Tsukahara T, Murata K, Sugita S, Sonoda T, Kaya M, Soma T, Sasaki M,Nagoya S, Hasegawa T, Wada T, Sato N, Yamashita T. J Surg Oncol. 2015 Jun;111(8):975-9. doi: 10.1002/jso.23934. Epub 2015 May 28. Prognostic impact of CD109 expression in myxofibrosarcoma.
• Iwayama Y, Tsuruma T, Mizuguchi T, Furuhata T, Toyota N, Matsumura M, Torigoe T, Sato N, Hirata K World J Surg Oncol. 2015 Feb 12;13:36. doi: 10.1186/s12957-015-0456-2. Prognostic value of HLA class I expression in patients with colorectal cancer.
• Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y. Eur J Immunol. 2015 Jul;45(7):2028-41. doi: 10.1002/eji.201445293. Epub 2015 Apr 28. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.
• Kukita K, Tamura Y, Tanaka T, Kajiwara T, Kutomi G, Saito K, Okuya K, Takaya A,Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Furuhata T, Hirata K, Sato N. J Immunol. 2015 May 15;194(10):4988-96. doi: 10.4049/jimmunol.1303228. Epub 2015 Apr 13. Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class IMolecule via Oxidative Folding.
• Mizuguchi T, Torigoe T, Satomi F, Shima H, Kutomi G, Ota S, Ishii M, Hayashi H, Asakura S, Hirohashi Y, Meguro M, Kimura Y, Nishidate T, Okita K, Ishino M, Miyamoto A,Hatakenaka M, Sato N, Hirata K. Surg Today. 2016 Feb;46(2):139-48. doi: 10.1007/s00595-015-1120-8. Epub 2015 Feb 5. Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of animproved prognosis?
• Tanaka T, Kajiwara T, Torigoe T, Okamoto Y, Sato N, Tamura Y. J Immunol. 2015 Feb 15;194(4):2004-10. doi: 10.4049/jimmunol.1402538. Epub 2015 Jan 16. Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.
• Nishida S, Hirohashi Y, Torigoe T, Nojima M, Inoue R, Kitamura H, Tanaka T, Asanuma H,Sato N, Masumori N. Anticancer Res. 2015 Jan;35(1):413-8. Expression of hepatocyte growth factor in prostate cancer may indicate abiochemical recurrence after radical prostatectomy.
• Kitai H, Sakakibara-Konishi J, Oizumi S, Hirohashi Y, Saito W, Kanda A, Sato N, Nishimura M Lung Cancer. 2015 Jan;87(1):73-6. doi: 10.1016/j.lungcan.2014.10.015. Epub 2014 Nov 3. Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy
• Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):205-11. doi: 10.1016/j.bbrc.2014.10.148. Epub 2014 Nov 4.Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.
• Tanaka T, Okuya K, Kutomi G, Takaya A, Kajiwara T, Kanaseki T, Tsukahara T, Hirohashi Y,Torigoe T, Hirata K, Okamoto Y, Sato N, Tamura Y. Cancer Sci. 2015 Jan;106(1):18-24. doi: 10.1111/cas.12570. Epub 2014 Dec 15. Heat shock protein 90 targets a chaperoned peptide to the static early endosomefor efficient cross-presentation by human dendritic cells.
• Kasamatsu J, Takahashi S, Azuma M, Matsumoto M, Morii-Sakai A, Imamura M, Teshima T,Takahashi A, Hirohashi Y, Torigoe T, Sato N, Seya T. Immunobiology. 2015 Jan;220(1):74-82. doi: 10.1016/j.imbio.2014.08.017. Epub 2014 Aug 23.PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.

2014

• Mariya T, Hirohashi Y, Torigoe T, Asano T, Kuroda T, Yasuda K, Mizuuchi M, Sonoda T, Saito T,Sato N. Cancer Immunol Res. 2014 Dec;2(12):1220-9. doi: 10.1158/2326-6066.CIR-14-0101. Epub 2014 Oct 16. Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer.
• Yasuda K, Torigoe T, Mariya T, Asano T, Kuroda T, Matsuzaki J, Ikeda K, Yamauchi M, Emori M,Asanuma H, Hasegawa T, Saito T, Hirohashi Y, Sato N. Lab Invest. 2014 Dec;94(12):1355-69. doi: 10.1038/labinvest.2014.122. Epub 2014 Oct 20. Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
• Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, Kojima T, Sugimoto K,Yoneta A, Sumikawa Y, Yamashita T, Sato N, Himi T, Ichimiya S. PLoS One. 2014 Aug 29;9(8):e105498. doi: 10.1371/journal.pone.0105498. eCollection 2014. ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.
• Ota D, Kanayama M, Matsui Y, Ito K, Maeda N, Kutomi G, Hirata K, Torigoe T, Sato N, Takaoka A,Chambers AF, Morimoto J, Uede T. J Mol Med (Berl). 2014 Dec;92(12):1271-81. doi: 10.1007/s00109-014-1183-9. Epub 2014 Aug 8. Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts.
• Tsukahara T, Emori M, Murata K, Hirano T, Muroi N, Kyono M, Toji S, Watanabe K, Torigoe T,Kochin V, Asanuma H, Matsumiya H, Yamashita K, Himi T, Ichimiya S, Wada T, Yamashita T,Hasegawa T, Sato N. J Biol Chem. 2014 Aug 8;289(32):22035-47. doi: 10.1074/jbc.M114.568725. Epub 2014 Jun 24. Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.
• Torigoe T, Hirohashi Y, Tsukahara T, Kanaseki T, Kochin V, Sato N. Nihon Rinsho Meneki Gakkai Kaishi. 2014;37(2):90-5. [The path to innovative drug development of cancer vaccine: from discovery of tumor antigens to clinical trials].
• Morita R, Hirohashi Y, Nakatsugawa M, Kanaseki T, Torigoe T, Sato N. Methods Mol Biol. 2014;1139:345-55. doi: 10.1007/978-1-4939-0345-0_28. Production of multiple CTL epitopes from multiple tumor-associated antigens.
• Shastri N, Nagarajan N, Lind KC, Kanaseki T. Curr Opin Immunol. 2014 Feb;26:123-7. doi: 10.1016/j.coi.2013.11.006. Epub 2013 Dec 11. Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.
• Tanaka T, Torigoe T, Hirohashi Y, Sato E, Honma I, Kitamura H, Masumori N, Tsukamoto T, Sato N. J Cancer Res Clin Oncol. 2014 Mar;140(3):503-13. doi: 10.1007/s00432-014-1593-7. Epub 2014 Jan 30. Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma.
• Morita R, Nishizawa S, Torigoe T, Takahashi A, Tamura Y, Tsukahara T, Kanaseki T, Sokolovskaya A,Kochin V, Kondo T, Hashino S, Asaka M, Hara I, Hirohashi Y, Sato N. Cancer Sci. 2014 Apr;105(4):389-95. doi: 10.1111/cas.12362. Epub 2014 Feb 24. Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.

2013

• Emori M, Tsukahara T, Murase M, Kano M, Murata K, Takahashi A, Kubo T, Asanuma H, Yasuda K, Kochin V, Kaya M, Nagoya S, Nishio J, Iwasaki H, Sonoda T, Hasegawa T, Torigoe T, Wada T, Yamashita T, Sato N. PLoS One. 2013 Dec 20;8(12):e84187. doi: 10.1371/journal.pone.0084187. eCollection 2013. High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma.
• Tanaka T, Kitamura H, Inoue R, Nishida S, Takahashi-Takaya A, Kawami S, Torigoe T, Hirohashi Y, Tsukamoto T, Sato N, Masumori N. Clin Dev Immunol. 2013;2013:262967. doi: 10.1155/2013/262967. Epub 2013 Nov 20. Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer--results from phase I clinical trials.
• Takahashi A, Hirohashi Y, Torigoe T, Tamura Y, Tsukahara T, Kanaseki T, Kochin V, Saijo H, Kubo T,Nakatsugawa M, Asanuma H, Hasegawa T, Kondo T, Sato N. PLoS One. 2013 Nov 11;8(11):e69095. doi: 10.1371/journal.pone.0069095. eCollection 2013. Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells.
• Yasuda K, Torigoe T, Morita R, Kuroda T, Takahashi A, Matsuzaki J, Kochin V, Asanuma H, Hasegawa T,Saito T, Hirohashi Y, Sato N. PLoS One. 2013 Aug 13;8(8):e68187. doi: 10.1371/journal.pone.0068187. eCollection 2013. Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population.
• Matsuzaki J, Torigoe T, Hirohashi Y, Tamura Y, Asanuma H, Nakazawa E, Saka E, Yasuda K, Takahashi S, Sato N. Pathol Int. 2013 Aug;63(8):391-7. doi: 10.1111/pin.12079. Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells.
• Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Fujino J, Tamura Y, Tsukahara T, Kanaseki T, Kobayashi J, Sasaki T, Takahashi A, Nakamori K, Yamaguchi A, Hiratsuka H, Sato N. Biochem Biophys Res Commun. 2013 Sep 13;439(1):96-102. doi: 10.1016/j.bbrc.2013.08.021. Epub 2013 Aug 13. Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal.
• Yamamoto T, Tamura Y, Kobayashi J, Kamiguchi K, Hirohashi Y, Miyazaki A, Torigoe T, Asanuma H,Hiratsuka H, Sato N. Exp Cell Res. 2013 Oct 15;319(17):2617-26. doi: 10.1016/j.yexcr.2013.07.025. Epub 2013 Aug 2. Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication.
• Torigoe T, Hirohashi Y, Yasuda K, Sato N. Int J Hyperthermia. 2013 Aug;29(5):436-41. doi: 10.3109/02656736.2013.814809. Constitutive expression and activation of stress response genes in cancer stem-like cells/tumour initiating cells: potent targets for cancer stem cell therapy.
• Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L,Sato N, Delgado JC, Shastri N. J Immunol. 2013 Aug 15;191(4):1547-55. doi: 10.4049/jimmunol.1301043. Epub 2013 Jul 17. ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.
• Ikeda K, Torigoe T, Matsumoto Y, Fujita T, Sato N, Yotsuyanagi T. Wound Repair Regen. 2013 Jul-Aug;21(4):616-23. doi: 10.1111/wrr.12062. Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts.
• Kuroda T, Hirohashi Y, Torigoe T, Yasuda K, Takahashi A, Asanuma H, Morita R, Mariya T, Asano T,Mizuuchi M, Saito T, Sato N. PLoS One. 2013 Jun 6;8(6):e65158. doi: 10.1371/journal.pone.0065158. Print 2013. ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis.
• Yamada R, Takahashi A, Torigoe T, Morita R, Tamura Y, Tsukahara T, Kanaseki T, Kubo T, Watarai K,Kondo T, Hirohashi Y, Sato N. Tissue Antigens. 2013 Jun;81(6):428-34. doi: 10.1111/tan.12113. Epub 2013 Apr 11. Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene.
• Kutomi G, Tamura Y, Tanaka T, Kajiwara T, Kukita K, Ohmura T, Shima H, Takamaru T, Satomi F, Suzuki Y, Torigoe T, Sato N, Hirata K. Cancer Sci. 2013 Aug;104(8):1091-6. doi: 10.1111/cas.12177. Epub 2013 May 21. Human endoplasmic reticulum oxidoreductin 1-α is a novel predictor for poor prognosis of breast cancer.
• Tamura Y, Saito K, Sato N. Nihon Rinsho. 2012 Nov;70 Suppl 8:135-9. [Heat shock protein inhibitor for molecular targeting therapy].
• Kanaseki T, Shastri N. Methods Mol Biol. 2013;960:179-85. doi: 10.1007/978-1-62703-218-6_15. Biochemical analysis of naturally processed antigenic peptides presented by MHC class I molecules.
• Nishida S, Hirohashi Y, Torigoe T, Inoue R, Kitamura H, Tanaka T, Takahashi A, Asanuma H, Masumori N, Tsukamoto T, Sato N. Cancer Sci. 2013 Apr;104(4):431-6. doi: 10.1111/cas.12104. Epub 2013 Feb 17. Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor.

2012

• Kukita K, Tamura Y, Oku-ya K, Saito K, Kutomi G, Sato N, Hirata K. Gan To Kagaku Ryoho. 2012 Nov;39(12):1800-2. Japanese. [Human endoplasmic reticulum oxidoreductin 1-like α regulates immune response of cancer cells via modulation of major histocompatibility complex class I expression and oxidation].
• Tamura Y, Torigoe T, Kutomi G, Hirata K, Sato N. Curr Mol Med. 2012 Nov 1;12(9):1198-206. New paradigm for intrinsic function of heat shock proteins as endogenous ligands in inflammation and innate immunity.
• Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N. Cell Stress Chaperones. 2012 Nov;17(6):757-63. doi: 10.1007/s12192-012-0348-0. Epub 2012 Jul 11. Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes.
• Morita R, Hirohashi Y, Suzuki H, Takahashi A, Tamura Y, Kanaseki T, Asanuma H, Inoda S, Kondo T, Hashino S, Hasegawa T, Tokino T, Toyota M, Asaka M, Torigoe T, Sato N. Exp Mol Pathol. 2012 Oct 9. doi:pii: S0014-4800(12)00151-7. 10.1016/j.yexmp.2012.10.004. [Epub ahead of print] DNA methyltransferase 1 is essential for initiation of the colon cancers.
• Galon J, Pages F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, Arndt H, Asslaber M, Maio M, Masucci GV, Mihm M, Vidal-Vanaclocha F, Allison JP, Gnjatic S, Hakansson L, Huber C, Singh-Jasuja H, Ottensmeier C, Zwierzina H, Laghi L, Grizzi F, Ohashi PS, Shaw PA, Clarke BA, Wouters BG, Kawakami Y, Hazama S, Okuno K, Wang E, O'Donnell-Tormey J, Lagorce C, Pawelec G, Nishimura MI, Hawkins R, Lapointe R, Lundqvist A, Khleif SN, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Palmqvist R, Nagtegaal ID, Wang Y, D'Arrigo C, Kopetz S, Sinicrope FA, Trinchieri G, Gajewski TF, Ascierto PA, Fox BA. J Transl Med. 2012 Oct 3;10:205. doi: 10.1186/1479-5876-10-205. Cancer classification using the Immunoscore: a worldwide task force.
• Michifuri Y, Hirohashi Y, Torigoe T, Miyazaki A, Kobayashi J, Sasaki T, Fujino J, Asanuma H, Tamura Y, Nakamori K, Hasegawa T, Hiratsuka H, Sato N. Pathol Int. 2012 Oct;62(10):684-9. doi: 10.1111/j.1440-1827.2012.02851.x. Epub 2012 Aug 16. High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis.
• Kawaguchi S, Tsukahara T, Ida K, Kimura S, Murase M, Kano M, Emori M, Nagoya S, Kaya M, Torigoe T, Ueda E, Takahashi A, Ishii T, Tatezaki S, Toguchida J, Tsuchiya H, Osanai T, Sugita T, Sugiura H, Ieguchi M, Ihara K, Hamada K, Kakizaki H, Morii T, Yasuda T, Tanizawa T, Ogose A, Yabe H, Yamashita T, Sato N, Wada T. Cancer Sci. 2012 Sep;103(9):1625-30. doi: 10.1111/j.1349-7006.2012.02370.x. Epub 2012 Aug 7. SYT-SSX breakpoint peptide vaccines in patients with synovial sarcoma: a study from the Japanese Musculoskeletal Oncology Group.
• Tsukahara T, Takasawa A, Murata M, Okumura K, Nakayama M, Sato N, Hasegawa T. Diagn Pathol. 2012 Aug 29;7:114. doi: 10.1186/1746-1596-7-114. NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax.
• Tamura Y, Torigoe T, Kukita K, Saito K, Okuya K, Kutomi G, Hirata K, Sato N. Immunotherapy. 2012 Aug;4(8):841-52. doi: 10.2217/imt.12.75. Review. Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity.
• Matsuki K, Tanabe A, Hongo A, Sugawara F, Sakaguchi K, Takahashi N, Sato N, Sahara H. Cancer Sci. 2012 Aug;103(8):1546-52. doi: 10.1111/j.1349-7006.2012.02333.x. Epub 2012 Jun 20. Anti-angiogenesis effect of 3'-sulfoquinovosyl-1'-monoacylglycerol via upregulation of thrombospondin 1.
• Ara S, Kikuchi T, Matsumiya H, Kojima T, Kubo T, Ye RC, Sato A, Kon S, Honma T, Asakura K, Hasegawa T, Himi T, Sato N, Ichimiya S. Cancer Sci. 2012 Jul;103(7):1356-62. doi: 10.1111/j.1349-7006.2012.02296.x. Epub 2012 Jun 4. Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
• Nishida S, Hirohashi Y, Torigoe T, Kitamura H, Takahashi A, Masumori N, Tsukamoto T, Sato N. J Urol. 2012 Jul;188(1):294-9. doi: 10.1016/j.juro.2012.02.2555. Epub 2012 May 16. Gene expression profiles of prostate cancer stem cells isolated by aldehyde dehydrogenase activity assay.
• Ishii-Osai Y, Yamashita T, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Nakayama E, Okura M, Jimbow K. J Dermatol Sci. 2012 Jul;67(1):51-60. doi: 10.1016/j.jdermsci.2012.04.009. Epub 2012 May 2. N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model.
• Nishizawa S, Hirohashi Y, Torigoe T, Takahashi A, Tamura Y, Mori T, Kanaseki T, Kamiguchi K, Asanuma H, Morita R, Sokolovskaya A, Matsuzaki J, Yamada R, Fujii R, Kampinga HH, Kondo T, Hasegawa T, Hara I, Sato N. Cancer Res. 2012 Jun 1;72(11):2844-54. doi: 10.1158/0008-5472.CAN-11-3062. Epub 2012 May 2. HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.
• Torigoe T, Asanuma H, Nakazawa E, Tamura Y, Hirohashi Y, Yamamoto E, Kanaseki T, Hasegawa T, Sato N. Pathol Int. 2012 May;62(5):303-8. doi: 10.1111/j.1440-1827.2012.02789.x. Epub 2012 Mar 16. Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues.
• Matsuzaki J, Torigoe T, Hirohashi Y, Kamiguchi K, Tamura Y, Tsukahara T, Kubo T, Takahashi A, Nakazawa E, Saka E, Yasuda K, Takahashi S, Sato N. Carcinogenesis. 2012 May;33(5):996-1003. doi: 10.1093/carcin/bgs118. Epub 2012 Mar 12. ECRG4 is a negative regulator of caspase-8-mediated apoptosis in human T-leukemia cells.
• Mizuuchi M, Hirohashi Y, Torigoe T, Kuroda T, Yasuda K, Shimizu Y, Saito T, Sato N. Exp Mol Pathol. 2012 Feb;92(1):185-90. doi: 10.1016/j.yexmp.2011.10.002. Epub 2011 Oct 15. Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses.
• Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Kondo T, Greene MI, Hara I, Sato N. Exp Mol Pathol. 2012 Feb;92(1):27-32. doi: 10.1016/j.yexmp.2011.09.016. Epub 2011 Oct 2. Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population.
• Hirohashi Y, Torigoe T, Inoda S, Morita R, Kochin V, Sato N. Oncoimmunology. 2012 Jan 1;1(1):123-125. Cytotoxic T lymphocytes: Sniping cancer stem cells.

2011

• Tamura Y, Hirohashi Y, Kutomi G, Nakanishi K, Kamiguchi K, Torigoe T, Sato N. Tumor-Produced Secreted Form of Binding of Immunoglobulin Protein Elicits Antigen-Specific Tumor Immunity. J. Immunol. 186:4325-4330, 2011.
• Oura, J., Tamura, Y., Kamiguchi, K., Kutomi, G., Sahara, H., Torigoe, T., Himi, T., and Sato, N. Extracellular heat shock protein 90 plays a role in translocating chaperoned antigen from endosome to proteasome for generating antigenic peptide to be cross-presented by dendritic cells. Int. Immunol., 23:223-237, 2011.
• Kano, M., Tsukahara, T., Emori, M., Murase, M., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T., Sato, N. Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma. Cancer Sci. April 22 issue, 2011.
• Tanaka T, Kitamura H, Torigoe T, Hirohashi Y, Sato E, Masumori N, Sato N, Tsukamoto T. Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential marker for renal cell carcinoma. J Cancer Res Clin Oncol. 137:789-794.2011.
• Inoda S, Morita R, Hirohashi Y, Torigoe T, Asanuma H, Nakazawa E, Nakatsugawa M, Tamura Y, Kamiguchi K, Tsuruma T, Terui T, Ishitani K, Hashino S, Wang Q, Greene MI, Hasegawa T, Hirata K, Asaka M, Sato N: The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma. Exp Mol Pathol. 90:55-60, 2011.
• Nakatsugawa, M., Hirohashi, Y., Torigoe, T., Inoda, S., Kiriyama, K., Tamura Y., Sato, E., Takahashi H. and Sato, N.：Comparison of speedy PCR-SSP method and serological typing of HLA-A24 for Japanese cancer patients. J Immunoassay Immunoch . 32:93-102, 2011.
• Inoda S., Hirohashi Y., Torigoe T., Takahashi A., Morita R., Nishizawa S., Tamura Y., Nakatsugawa M., Tsuruma T., Terui T., Ishitani K., Hirata K. and Sato N.. Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. Am. J. Pathol., 178:1805-1813, 2011.
• Miyazaki, A., Kobayashi, J., Torigoe, T., Hirohashi, Y., Yamamoto, T., Yamaguchi, A., Michifuri, Y., Nakamori, K., Nagai, I., Sato, N. and Hiratsuka, H.：A phase I clinical trial of survivin-derived peptide vaccine therapy in HLA-A24-positive patients with oral cancer. Cancer Sci. 102:324-329, 2011.
• Kameshima, H., Tsuruma, T., Torigoe, T., Takahashi, A., Hirohashi, Y., Tamura, Y., Tsukahara, T., Ichimiya, S., Kanaseki, T., Sato, N and Hirata, K. Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in patients with advanced colorectal cancer.　Cancer Sci, 102:1181-1187, 2011.
• Nagashima, T., Ichimiya, S., Kikuchi, T., Saito, Y., Matsumiya, H., Ara, S., Koshiba, S., Zhang, J., Hatate, S., Tonooka, A., Kubo, T., Hirose, B., Shirasaki, H., Izumi, T., Takami, T., Himi, T. and Sato, N. Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlong primary B cells and their cognate T cell help. Am. J. Pathol., 171:222-232, 2011.
• Hirohashi Y, Sato N. Tumor-associated dendritic cells: molecular mechanisms to suppress antitumor immunity. Immunotherapy. 2011 Aug;3(8):945-7.
• Nakatsugawa M, Horie K, Yoshikawa T, Shimomura M, Kikuchi Y, Sakemura N, Suzuki S, Nobuoka D, Hirohashi Y, Torigoe T, Harada K, Takasu H, Sato N, Nakatsura T. Identification of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from the lung carcinoma antigen, Lengsin.　Int J Oncol. 2011 Jun 17. doi: 10.3892/ijo.2011.1089. [Epub ahead of print]
• Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N. Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses. Exp Mol Pathol. 2011 Oct 15. [Epub ahead of print]
• Mori T, Nishizawa S, Hirohashi Y, Torigoe T, Tamura Y, Takahashi A, Kochin V, Fujii R, Kondo T, Greene MI, Hara I, Sato N. Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population. Exp Mol Pathol. 2011 Oct 15. [Epub ahead of print]
• Nakatsugawa, M., Takahashi, A., Hirohashi, Y., Torigoe, T., Inoda, S., Asanuma H., Tamura Y., Hasegawa T., Takahashi, H. and Sato, N.: SOX2 is expressed in stem-like cells of human lung adenocarcinoma and augments the tumor-initiating potential. Lab Invest. 2011 Sep 19. doi: 10.1038/labinvest.2011.140. [Epub ahead of print]

2010

• Okuya, K., Tamura, Y., Saito, K., Kutomi, G., Torigoe, T., Hirata, K., Sato, N.　Extracellular heat shock protein 90 (Hsp90) directs self-DNA to static early endosome-resident TLR-9, leading to type I interferon production. J. Immunol., 184:7092-7099, 2010.
• Hirohashi, Y., Torigoe, T., Hirai, I., Tamura, Y., Nakatsugawa, M., Inoue, Y., Kanaseki, T., Kamiguchi, K., Ikeda, H., Sasaki, A., Yamanaka, N., Sato, N. : Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells. Exp Mol Pathol. 88:128-132, 2010.
• Ohno, K., Nishimori, H., Yasoshima, T., Kamiguchi, K., Hata, F., Fukui, R., Okuya, K., Kimura, Y., Denno, R., Kon, S., Uede, T., Sato, N. Hirata, K.　Inhibition of osteopontin reduces liver metastasis of human pancreatic cancer xenografts injected into the spleen in a mouse model.　Surg. Today, 40:347-356, 2010
• Sato, A., Tamura, Y., Sato, N., Yamashita, T., Takada, T., Sato, m., Ohura, M., Ono, I., Ito, A., Honda, H., Wakamatsu, K., ito, S. and Jimbow, K.：Melanoma-Specific Intracellular Hyperthermia Using N-propiony1-4-S-cysteamimylphenol-Magnetite nanoparticle Elicits Immunogenic Cell Death Through the Release of heat Shock Protein-Peptide Complex. Cancer Science, 101:1939-1946, 2010.
• Yabe H, Tsukahara T, Kawaguchi S, Wada T, Torigoe T, Sato N, Terai C, Aoki M, Hirose S, Morioka H, Yabe H. : Prognostic significance of HLA Class I expression in ewing's sarcoma family of tumors. J Surg Oncol. 2010 Dec 28. [Epub ahead of print]
• Hirohashi, Y., Torigoe, T., Inoda, S., Takahashi, A., Morita, R., Nishizawa, S., Nakatsugawa, M., Tamura, Y., Toyota, M. and Sato, N.:Immune response against tumor antigens expressed on human cancer-stem cells/tumor-initiating cells. Immunotherapy, 2: 201-211, 2010.

2009

• Tsukahara, T., Kimura, S., Ichimiya, S., Torigoe, T., Kawaguchi, S., Wada, T., Yamashita, T. and Sato, N.：Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. Cancer Sci., 100(1): 47-53. 2009.
• Kobayashi, J., Hirohashi, Y., T Torigoe, T., Yamamoto, T., Tamura, Y., Kamiguchi, K., Miyazaki, A., Yamaguchi, A., Hariu, H., Hiratsuka, H. and Sato, N.：Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma. Hum Immunol. 70(2): 89-95. 2009.
• Tonooka, A., Kubo, T., Ichimiya, S., Tamur, Y., Ilmarinen, T., Ulmanen, I., Kimura, S., Yokoyama, S., Takano, Y., Kikuchi, T. and Sato, N.: Wind-type AIRE cooperates with p63 in HLA class Ⅱ expression of medullary thymic stromal cells. Biochem Biophys Res Commun. 13; 379(3): 765-70, 2009.
• Matsumoto, Y., Fujita, T., Hirai, I., Sahara, H., Torigoe, T., Ezoe, K., Saito, T., Cruikshank, W., Yotsuyanagi, T, and Sato, N. : Immunosuppressive Effect on T cell Activation by Interleukin-16 (IL-16)-16 and Interleukin-10 (IL-10)- cDNA- Double- Transfected Human Squamous Cell Line. Burns., 35 (3): 383-389, 2009.
• Sugawara, A., Torigoe, T., Tamura, Y., Kamiguchi, K., Nemoto, K., Oguro, H., Sato, N.： Polyamine compound deoxyspergualin inhibits heat shock protein-induced activation of immature dendritic cells. Cell Stress Chaperone, 14: 133-139, 2009.
• Kobayashi, J., Torigoe, T., Hirohashi, Y., Idenoue, S., Miyazaki, A., Yamaguchi, A., Hiratsuka, H. and Sato, N. ： Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients. J. Transl. Med. 7:1-11, 2009.
• Yamano, K., Goto, A., Miyoshi, M., Furuya, K., Sawada, Y., Sato, N. ： Diagnosis of alveolar echinococcosis using immunoblotting with pleural low molecular weight antigens. J. Helminthol., 83: 57-61, 2009.
• Yoshida, S., Hazama, S., Tokuno, K., Sakamoto, K., Takashima, M., Tamesa, T., Torigoe, T., Sato, N. and Oka, M.：Concomitant overexpession of heat-shock protein 70 and HLA class Ⅰ in hepatitis C virus-related hepatocellular carcinoma. Anticancer Res. 29: 539-44, 2009.
• Tsukahara, T., Kawaguchi, S., Torigoe, T., Murase, M., Wada, T., Kaya, M., Nagoya, S., Yamashita, T. and Sato, N.: HLA-A*0201-restricted clonal CTL epitope of a novel osteosarcoma antigen, papillomavirus binding factor. J. Transl. Med., 12;7: 44, 2009.
• Honma, I., Kitamura, H., Torigoe, T. Takahashi,. A, Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Tsukamoto, T., Sato, N.：Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer. Cancer Immunol. Immunother., 58:1801-7, 2009.
• Sato, M., Yamashita, T., Ohura, M., Osai, Y., Sato, A., Takada, T., Matsusaka, H., Ono, I., Tamura, Y., Sato, N., Sasaki, Y., Ito, A., Honda, H., Wakamatsu, K., Ito, S. and Jimbow, K.：N-Propionyl-Cysteaminylphenol-Magnetite Conjugate (NPrCAP/M) is a Nanoparticle for the Targeted Growth Suppreesion of Melanoma Cells. J. Invest. Dermatol., 129:2233-2241, 2009.
• Tahara, H., Sato, M., Thurin, M., Wang, E., Butterfield, LH., Disis, ML., Fox, BA., Lee, PP., Khleif, SN., Wigginton, JM., Ambs, S., Akutsu, Y., Chaussabel, D., Doki, Y., Eremin, O., Fridman, WH., Hirohashi, Y., Imai, K., Jacobson, J., Jinushi, M., Kanamoto, A., Kashani-Sabrt, M., Kato, K., Kawakami, Y., Kirkwood, JM, Kleen, TO., Lahmann, PV., Liotta, L., Lotze, MT., Malyguine, A., Masucci, G., Matsubara, H., Nakamura, K., Nishikawa, H., Palucka, AK., Petricoin, EF., Pos, Z., Ribas, A., Rivoltini, L., Sato, N., Shiku, H., Slingluff, CL., Streicher, H., Stroncek, DF., Takeuchi, H., Toyota, M., Wada, H., Wu, X., Wulfkuhle, J., Yaguchi, T., Zeskind, B., Zhao, Y., Zocca, MB. And Marincola, FM. : Emerging concepts in biomarker discovery; The US-Japan workshop on immunological molecular markers in oncology. Journal of Translational Medicine, 7:45, 2009.
• Nakatsugawa, M., Hirohashi, Y., Torigoe, T., Asanuma, H., Takahashi, A., Inoda, S., Kiriyama, K., Nakazawa, E., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Shijubo, N., Honda, R., Nomura, N., Hasegawa, T., Takahashi, H. and Sato, N.：Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4. Cancer Sci., 100: 1485-93, 2009.
• Inoda, S., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Kiriyama, K., Nakazawa, E., Harada, K., Takasu, H., Tamura, Y., Kamiguchi, K., Asanuma, H., Tsuruma, T., Terui, T., Ishitani, K., Ohmura, T., Wang, Q., Greene, MI., Hasegawa, T., Hirata, K. and Sato, N.： Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma. J Immunother. 32: 474-85, 2009.
• Kutomi, G., Tamura, Y., Okuya, K., Yamamoto, T., Hirohashi, Y., Kamiguchi, K., Oura, J., Saito, K., Torigoe, T., Ogawa, S., Hirata, K. and Sato, N.：Targeting to static endosome is required for efficient cross-presentation of endoplasmic reticulum-resident oxygen-regulated protein 150-peptide complexes. J Immunol. 183: 5861-9, 2009.
• Takada, T., Yamashita, T., Sato, M., Sato, A., Ono, I., Tamura, Y., Sato, N., Miyamoto, A., Ito, A., Honda, H., Wakamatsu, K., Ito, S., Jimbow, K. : Growth inhibition of re-challenge B16 melanoma transplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy. J Biomed Biotechnol. :457936, 2009.
• Murase, M., Kano, M., Tsukahara, T., Takahashi, A., Torigoe, T., Kawaguchi, S., Kimura, S., Wada, T., Uchihashi, Y., Kondo, T., Yamashita, T., Sato N. : Side population cells have the characteristics of cancer stem-like cells/cancer-initiating cells in bone sarcomas. Br J Cancer. 20;101(8):1425-32, 2009.
• Honma, I., Torigoe, T., Hirohashi, Y., Kitamura, H., Sato, E., Masumori, N., Tamura, Y., Tsukamoto, T. and Sato, N.：Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer. J Transl. Med., 7: 103, 2009.
• Homma, I., Kitamura, H., Torigoe, T., Tanaka, T., Sato, E., Hirohashi, Y., Masumori, N., Sato, N. and Tsukamoto, T. : Human leukocyte antigen class I down-regulation in muscle-invasive bladder cancer: Its association with clinical characteristics and survival after cystectomy. Cancer Sci. 100:2331-2334, 2009
• Hirohashi, Y., Torigoe, T., Inoda, S., Kobayashi, J., Nakatsugawa, M., Mori, T., Hara, I. and Sato, N.：The functioning antigens; beyond just as the immunologic targets. Cancer Sci., 100: 798-806, 2009.
• Sato, N., Hirohashi, Y., Tsukahara, T., Kikuchi, T., Sahara, H., Kamiguchi, K., Ichimiya, S., Tamura, H. and Torigoe, T.：Molecular pathologic approaches to human tumor immunology. Pathol. Int., 59: 205-217, 2009.
• Torigoe, T., Tamura, Y., Sato, N. : Heat shock proteins and immunity: Application of hyperthermia for immunomodulation. Int. J. Hyperthermia 25:610-616, 2009.

2008

• Mori, Y., Sahara, H., Matsumoto, K., Takahashi, N., Yamazaki, T., Ohta, K., Aoki, S., Miura, M., Sugawara, F., Sugawara, F., Sakaguchi, K. and Sato. N.：Downregulation of tie2 gene by a novel antitumor sulfolipid, 3’-sulfoquinovosyl-1’-monoacylglycerol, targeting angiogenesis. Cancer Sci., 99(5): 1063-1070, 2008.
• Tsukahara, T., Kawaguchi, S., Torigoe, T., Kimura, S., Murase, M., Ichimiya, S., Wada, T., Kaya, M., Nagoya, S., Ishii, T., Ishii, T., Tazaki, S., Yamashita, T. and Sato, N：Prognostic impact and immunogenicity of a novel osteosarcoma ntigen, papillomavirus binding factor, in patients with osteosarcoma. Cancer. Sci., 99(2): 368-275, 2008.
• Kamiguchi, K., Torigoe, T., Fujiwara, O., Oshima, S., Hirohashi, Y., Sahara, H., Hirai, I., Kohgo, Y. and Sato, N.：Disruption of the association of 73kD heat shock protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum. Microbiol. Immunol., 52(2): 94-106, 2008.
• Koshiba, S., Ichimiya, S., Nagashima, T., Tonooka, A., Kubo, T., Kikuchi, T., Himi, T., Sato, N. ：Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin 6 to support B-cell development via p63/p73 transcription factors. J. Pathol., 214(1): 75-84, 2008.
• Tsuruma, T., Iwayama, Y., Ohmura, T., Katsuramaki, T., Hata, F., Furuhata, T., Yamaguchi, K., Kimura, Y., Torigoe, T., Toyota, N., Yagihashi, A., Hirohashi, Y., Asanuma, H., Shimozawa, K., Okazaki, M., Mizushima, Y., Nomura, N., Sato, N. and Hirata, K.：Clinical and Immunological Evaluation of Anti-apoptosis Protein, Survivin-derived Peptide Vaccine in Phase I Clinical Study for Patients with Advanced or Recurrent Breast Cancer. J. Translational Med., 6: 24, 10 May, 2008.
• Kubo, T., Ichimiya, S., Tonooka, A., Nagashima, T., Kikuchi, T. and Sato, N. ：p63 Induces CD4? T-cell chemoattractant TARC/CCL17 in Human Epithelial Cells. 　Journal of Interferon & Cytokine Research., 28: 725-732, 2008.
• Kimura, S., Kozakai, Y., Kawaguchi, S., Tsukahara, T., Ida, K., Murase, M., Matsumura, T., Kaya, m., Torigoe, T., Wada, T., Sato, N. and Yamashita, T. ： Clonal T cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206. J. Orthop. Res., 26(2): 271-278, 2008.
• Yabe, H., Tsukahara, T., Kawaguchi, S., Wada, T., Sato, N., Morioka, H. and Yabe, H.: Overexpression of papillomavirus binding factor in Ewing’s sarcoma family of tumors conferring poor prognosis. Oncology Reports., 19: 129-134, 2008.
• Sato, E., Torigoe, T., Hirohashi, Y., Kitamura, H., Honma, I., Asanuma, H., Masumori, N., Ito, N., Tsukamoto, T. and Sato, N.： Identification of immunogenic CTL epitopes of HIFPH3 for specific immunotherapy of renal cell carcinoma. Clin. Cancer Res., 14(21): 6919-6923, 2008.
• Takeuchi, H., Kawaguchi, S., Mizuno, S., Kirita, T., Takebayashi,T., Shimozawa, K., Torigoe, T., Sato, N. and Yamashita, T.: Gene expression profile of dorsal root ganglion in a lumbar radiculopathy model. Spine., 1; 33(23): 2483-2488, 2008.
• Tsukahara, T., Torigoe, T., Tamura, Y., Kawaguchi, S., Wada, T. and Sato, N.：Antigenic peptide vaccination: Provoking immune response and clinical benefit for cancer. Current Immunol Rev., 4:235-241, 2008.

2007

• Maeda, N., Kokai, Y., Ohtani, S., Sahara, H., Kuriyama, I., Kamisuki, S., Takahashi, S., Sakaguchi, K., Sugawara, F., Yoshida, H., Sato, N. and Mizushima, Y.：Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase α.　Biochemical and Biophysical Research Communications., 352: 390-396, 2007.
• Ishikura, H., Ikeda, H., Abe, H., Ohkuri, T., Hiraga, H., Isu, K., Tsukahara, T., Sato, N., Kitamura, H., Iwasaki, N., Takeda, N., Minami, A. and Nishimura, T.：Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral Immune system.　Int. J. Oncol., 30: 461-467, 2007.
• Kikuchi, T., Naruse, TK., Onizuka, M., Li, S., Kimura, T., Oka, A., Morishima, Y., Kulski, JK., Ichimiya, S., Sato, N., Inoko, H.：Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22.　Immunogenetics., 59: 99-108, 2007.
• Kitamura, H., Honma, I., Torigoe, T., Asanuma, H., Sato, N. and Tsukamoto, T.：Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma. J. Urol., 177: 1269-1272, 2007.
• Tanaka, T., Kitamura, H., Sahara, H., Imai, A., Itohl, Y., Honma, I., Sato, E.,Kobayashi,K., Maeda, T., Takenouchi, M., Ohta, K., Sugawara, F., Sakaguchi, K., Ando, A., Inoko, H., Sato, N. and Tsukamoto, T.：Effects of new immunosuppressive agent, β-SQAG9, in swine kidney transplantation. Transplant Immunol., 18: 67-71, 2007.
• Imai, A., Sahara, H., Tamura, Y., Jimbow, K., Saito, T., Ezoe, K., Yotsuyanagi, T. and Sato, N.：Inhibition of endogenous MHC classⅡ- restricted antigen presentation by tacrolimus (FK506) via FKBP51. Eur. J. Immunol., 37 : 1730-1738, 2007.
• Kurotaki, T., Tamura, Y., Ueda, G., Oura, J., Kutomi, G., Hirohashi, Y., Sahara,H.,Torigoe, T., Hiratsuka, H., Sunakawa, H., Hirata, K. and Sato, N.: Efficient cross-presentation by Heat shock protein 90 peptide complex-loaded dendritic cells via an endosomal pathway.　J. Immunol., 179: 1803-13, 2007.
• Tabata, A., Morikawa, M., Bennet, BL., Satoh, Y., Huang, J., Tamura, Y., Sato, N. and Abe,T.：Suppression of alloreactivity and allograft rejection by SP600125, a small molecule inhibitor of c-Jun N-terminal kinase. Transplantation., 83: 1358-1364, 2007.
• Takeuchi, H., Kawaguchi, S., Ohwada, O., Kobayashi, H., Hayakawa, M., Takebayashi, T., Torigoe, T., Sato, N. and Yamashita, T.：Plasma neuropeptides in patients undergoing lumbar discectomy.　Spine., 32: E79-84, 2007.
• Kitamura, H., Torigoe, T., Honma, I., Hariu, H., Asanuma, H., Hirohashi, Y., Tamura, Y., Sato, N. and Tsukamoto, T:：Expression of livin in renal cell carcinoma and detection of anti-livin autoantibody in patients. Urology., 70: 38-42, 2007.
• Kitamura, H., Torigoe, T., Asanuma, H., Honma, I., Sato, N. and Tsukamoto, T. ：Down-Regulation of HLA Class I Antigens in prostate Cancer Tissues and Up-Regulation by Histone Deacetylase Inhibition. J. Urology., 178: 692-696, 2007.
• Maeda, N., Kokai, Y., Ohtani, S., Sahara, H., Hada, T., Ishimaru, C., Kuriyama, I., Yonezawa, Y., Iijima, H., Yoshida, H., Sato, N. and Mizushima, Y.：Anti-Tumor Effects of the Glycolipids Fraction from Spinach which Inhibited DNA Polymerase Activity. Nutrition.Cancer., 57(2): 216-223, 2007.
• Maeda, H., Sahara, H., Mori, Y., Torigoe, T., Kamiguchi, K., Tamura, Y., Tamura, Y., Hirata, K. and Sato, N. ：Biological Heterogeneity of the Peptide-binding Motif of the 70-kDa Heat Shock Protein by Surface Plasmon Resonance Analysis. J. Biol. Chem., 282: 26956-26962, 2007.
• Takahashi, H., Shigehara, K., Yamamoto, M., Suzuki, C., Naishiro, Y., Tamura, Y., Hirohashi, Y., Satoh, N., Shijubo, N., Shinomura, Y. and Imai, K.：Interferon γ assay for detecting latent tuberculosis infection in rheumatoid arthritis patients during infliximab administration. Rheumatol Int., 27: 1143-1148, 2007.
• Shima, H., Tsuruma, T., Sahara, H., Takenouchi, M., Takahashi, N., Iwayama, Y., Yagihashi, A., Watanabe, N., Sato, N. and Hirata, K.：Protective mechanism of β-SQAG9 liposome, a sulfonoglycolipid extracted from sea urchin intestines, against hepatic ischemia reperfusion inhury. Shock., 28: 94-100, 2007.
• Fukui, R., Nishimori, H., Hata, F., Yasoshima, T., Ohno, K., Yanai, Y., Kamiguchi, K., denno, R., Sato, N. and Hirata, K.：Inhibitory effect of endothlin A receptor bloc Kade on tumor growth and liver me tastasis of a human gastric cancer cell line. Gastric Cancer., 10:123-128, 2007.

2006

• Tsukahara, T., Kawaguchi, S., Ida, K., Kimura, S., Tamura, Y., Ikeda, T., Torigoe, T., Nagoya, S., Wada, T., Sato, N. and Yamashita, T.：HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node.　J. Orthop. Res., 24: 94-101, 2006
• Hatakeyama, N., Tamura, Y., Sahara, H., Suzuki, N., Suzuki, K., Hori, T., Mizue, N., Torigoe, T., Tsutsumi, H. and Sato, N.：Induction of autologous CD4- and CD8-mediated T-cell responses against acute lymphocytic leukemia cell line using apoptotic tumor cell-loaded dendritic cells. Exp. Hematol., 34: 197-207, 2006
• Ueda, G., Sunakawa, H., Nakamori, K., Shinya, T., Tsuhako, W., Tamura, Y., Kosugi, T., Sato, N., Ogi, K. and Hiratsuka, H.：Aberrant expression of β-and γ-catenin is an independent prognostic marker in oral squamous cell carcinoma.　Int. J. Oral Maxillofacial Surg., 35: 356-361, 2006
• Kitamura, H., Torigoe, T., Asanuma, H., Tamura, Y., Hisasue, S., Suzuki, K., Tsukamoto,T., Sato, M. and Sato, N.：Cytosolic overexpression of p62 sequestosome 1 in neoplastic prostate tissue. Histopathology., 48: 157-161, 2006
• Kitamura, H., Torigoe, T., Honma, I., Asanuma, H., Nakazawa, E., Shimozawa, K., Hirohashi, Y., Sato, E., Sato, N. and Tsukamoto T.：Expression and antigenicity of urviving, an inhibitor of apoptosis family member, in bladder cancer: implications for specific immunotherapy. Urology., 67: 955-959, 2006
• Kitamura, H., Torigoe, T., Honma, I., Sato, E., Asanuma, H., Hirohashi, Y., Sato, N. and Tsukamoto, T.：Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus Calmette-Guerin immunotherapy for bladder cancer. Clin. Cancer Res., 12: 4641-4644, 2006
• Tsukahara, T., Kawaguchi, S., Torigoe, T., Asanuma, H., Nakazawa, E., Shimozawa, K., Nabeta, Y., Kimura, S., Kaya, M., Nagoya, S., Wada, T., Yamashita, T. and Sato, N.：Prognostic significance of HLA class I expression in osteosarcoma defined by anti-pan HLA class I monoclonal antibody, EMR8-5.　Cancer Sci., 97: 1374-1380, 2006
• Komori, H., Nakatsura, T., Senju, S., Ikuta, Y., Yokomine, K., Yoshitake, Y., Motomura, Y., Beppu, T., Matsui, M., Torigoe, T., Sato, N., Baba, H., and Nishimura, Y.：Identification of HLA-A2- or ?A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy for hepatocellular carcinoma. Clin. Cancer Res., 12: 2689-2697, 2006
• Hirohashi, Y., Wang, Q., Liu, Q., Xiulian, Du., Zhang, H., Sato, N. and Greene, M. I.：p78/MCRS1 forms a centrosomal protein complex with NudE and plays an essential role in mitosis.　Oncogene., 25: 4937-4946, 2006
• Hirohashi, Y., Wang, Q., Liu, Q., Li, B., Du, X., Zhang, H., Furuuchi, K., Masuda, K., Sato, N. and Greene, M. I.：Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. Oncogene., 25: 6048-6055, 2006
• Hatamoto, K., Torigoe, T., Mano, Y., Asai, Y. and Sato, N.：Disruption of the interaction between retinoblastoma protein and 70 kD heat shock protein leads to growth acceleration of tumor cells. Tumor Res., 41: 43-57, 2006
• Sato, N., Hirohashi, Y., Tsukahara, T., Kamiguchi, K., Ichimiya, S., Sahara, H., Takahashi, N., Tsuruma, T., Hirata, K., Miyazaki, A., Yamaguchi, A., Hiratsuka, H., Tsukamoto, T., Kawaguchi, S., Wada, T., Yamashita, T., Shijubo, N., Takahashi, H., Ogasawara, M., Tamura, Y. and Torigoe, T.：Current progress and perspectives for human tumor immunotherapy. Tumor Res., 41: 1-13, 2006

2005

• Kondo, N., Ichimiya, S., Tamura, Y., Tonooka, A., Koshiba, S., Torigoe, T., Kamiguchi, K., Takenaga, K. and Sato, N.：A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen.　Microbiol. Immunol., 49: 49-56, 2005
• Hariu, H., Hirohashi, Y., Torigoe, T., Asanuma, H., Hariu, M., Tamura, Y., Aketa, K., Nabeta, C., Nakanishi, K., Kamiguchi, K., Mano, Y., Kitamura, H., Kobayashi, J., Tsukahara, T., Shijubo, N. and Sato, N.：Aberrant expression and potency as a cancer immunotherapy target of inhibitor of apoptosis protein family, Livin/ML-IAP in Lung Cancer.　Clin. Cancer Res., 11: 1000-1009, 2005
• Idenoue, S., Hirohashi, Y., Torigoe, T., Sato, Y., Tamura, Y., Hariu, H., Yamamoto, M., Kurotaki, T., Tsuruma, T., Asanuma, H., Kanaseki, T., Ikeda, H., Kashiwagi, K., Okazaki, M., Sasaki, K., Sato, T., Ohmura, T., Hata, F., Yamaguchi, K., Hirata, K. and Sato, N.：A potent immunogenic general cancer vaccine that targets survivin, an inhibitor of apoptosis proteins. Clin. Cancer Res., 11:1474-82, 2005
• Takenouchi, M., Sahara, H., Yamamoto,Y., Matsumoto, Y., Imai, A., Fujita, T., Tamura, Y., Takahashi, N., Gasa, S., Matsumoto, K., Ohta, K., Sugawara, F., Sakaguchi, K., Jimbow, K. and Sato, N. : Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug β-SQAG9, which inhibits the response of the CD62L+ T cell subset. Transplant. Proc., 37:139-142, 2005
• Yagihashi, A., Asanuma, K., Kobayashi, D., Tsuji, N., Shijubo, Y., Abe, S., Hirohashi, Y., Torigoe, T., Sato, N., and Watanabe, N. Detection of autoantibodies to livin and survivin in Sera from lung cancer patients. Lung Cancer., 48: 217-221, 2005
• Ingu, A., Komatsu, K., Ichimiya, S., Sato, N., Hirayama, Y., Morikawa, M. and Abe, T.：Effects of inhaled FK506 on the suppression of acute rejection after lung transplantation: Use of a rat orthotopic lung transplantation model.　J. Heart Lung Transplant., 24: 538-543, 2005
• Inomata, S., Shijubo, N., Kon, S., Maeda, M., Yamada, G., Sato, N., Abe, S. and Uede, T.：Circulating interleukin-18 and osteopontin are useful to evaluate disease activity in patients with turberculosis.　Cytokine., 30: 203-211, 2005
• Suzuki, K., Tanaka, H., Sahara, H., Tanaka, N., Tamura, Y., Naruse, T., Inoko, H.,Tsushima, K., Kubo, K., Abe, S. and Sato, N.：HLA class Ⅱ DPB1, DQA1, DQB1 and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom.　Tissue Antigens., 65: 459-466, 2005
• Nakashima, S., Morikawa, M., Komatsu, K., Matsuura, A., Sato, N. and Abe, T.： Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J. Heart Lung Transplantation., 24: 462-469, 2005
• Shima, H., Tsuruma, T., Sahara, H., Takenouchi, M., Takahashi, N., Iwayama, Y.,Yagihashi, A., Watanabe, N., Sato, N. and Hirata, K.：Treatment with beta-SQAG9 prevents rat hepatic ischemia-reperfusion injury.　Transplant. Proc., 37: 417-421, 2005
• Suzuki, A., Shijubo, N., Yamada, G., Ichimiya, S., Satoh, M., Abe, S. and Sato, N.：Napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs. Pathology Research and Practice., 201: 579-586, 2005
• Kawaguchi, S., Wada, T., Ida, K., Sato, Y., Nagoya, S., Tsukahara, T., Kimura, S., Sahara, H., Ikeda, H., Shimozawa, K., Asanuma, H., Torigoe, T., Hiraga, H., Ishii, T., Tatezaki, SI, Sato, N. and Yamashita, T.：Phase Ⅰvaccination trial of SYT-SSX junction peptide in patients with disseminated synovial sarcoma.　J. Transl. Med., 3: 1, 2005
• Yagihashi, A., Ohmura, T., Asanuma, K., Kobayashi, D., Tsuji, N., Torigoe, T., Sato, N., Hirata, K. and Watanabe, N.：Detection of autoantibodies to survivin and livin in sera from patients with breast cancer. Clin. Chim. Acta., 362: 125-130, 2005
• Fukui, R., Nishimori, H., Hata, F., Yasoshima, T., Ohno, K., Nomura, H., Yanai, Y., Tanaka, H., Kamiguchi, K., Denno, R., Sato, N. and Hirata, K.：Metastases-related genes in the classification of liver and peritoneal metastasis in human gastric cancer.　J. Surg. Res., 129: 94-100, 2005
• Yagihashi, A., Asanuma, K., Kobayashi, D., Tsuji, N., Torigoe, T., Sato, N. and Watanabe, N.：Autoantibodies to survivin in patients with chronic hepatitis and hepatocellular carcinoma.　Autoimmunity., 38: 445-448, 2005
• Kojima, H., Shijubo N., Yamada G., Ichimiya S., Abe, S., Satoh, M., and Sato, N.：Clinical significance of vascular endothelial growth factor-C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma. Cancer., 104: 1668-1677, 2005
• Yamamoto, M., Torigoe, T., Kamiguchi, K., Hirohashi, Y., Nakanishi, K., Nabeta, C., Asanuma, H., Tsuruma, T., Sato, T., Hata, F., Omura, T., Yamaguchi, K., Kurotaki, T., Hirata, K. and Sato, N.：A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis.　Cancer Res., 65: 8706-8714, 2005
• Asanuma, H., Torigoe, T., Kamiguchi, K., Hirohashi, Y., Ohmura, T., Hirata, K., Sato, M. and Sato, N.：Survivin expression is regulated by coexpression of Human Epidermal Growth Factor Receptor 2 and Epidermal Growth Factor Receptor via Phosphatidylinositol 3- Kinase/AKT signaling pathway in breast cancer cells. Cancer Res., 65: 11018-11025, 2005
• Sato, T., Masuoka, S., Toda, K., Watabe, K., Igarashi, T., Yamamoto, M., Sogahata, K., Idenoue, S., Kiriyama, K., Ito, T., Meguro, M., Kutomi, G., Takashima, T., Tsuruma, T.,Ohmura, T., Someya, T., Katsuramaki, T., Asaishi, K., Sato, N. and Hirata, K.：Characterization of p53 gene mutations in fine-needle aspirated breast cancer: correlation with clinicopathological features and short-term relapse.　Tumor Res., 40: 25-35, 2005
• Tsuruma, T., Torigoe, T., Hata, F., Furuhata, T., Ohmura, T., Katsuramaki, T., Yamaguchi, K., Kimura, Y., Sato, N. and Hirata, K.：Peptide-based vaccination for colorectal cancer. Expert Opinion on Biological Therapy., 5: 799-807, 2005
• Kawaguchi, S., Wada, T., Tsukahara, T., Ida, K., Sato, Y., Torigoe, T., Sato, N. and Yamashita, T.：A quest for therapeutic antigens in bone and soft tissue sarcoma. J. Translational Medicine., 3: 31, 2005

2004

• Takamura, Y., Ikeda, H., Kanaseki, T., Toyota, M., Tokino, T., Imai, K., Hokin, K. and Sato, N.：Regulation of MHC class Ⅱ expression in glioma cells by class Ⅱ transactivator (C ⅡTA).　Glia, 45:392-405, 2004
• Ohchi, T., Shijubo, N., Kawabata, I., Ichimiya, S., Inomata, S., Yamaguchi, A., Umemori, Y., Itoh, Y., Abe, S. Hiraga, Y. and Sato, N.：Polymorphism of clara cell 10-kD protein gene of sarcoidosis.　Am J. Respir. Crit. Care. Med., 169:180-186, 2004
• Morimoto, Y., Toyota, M., Satoh, A., Murai, M., Mita, H., Suzuki, H., Takamura, Y., Ikeda, H., Ishida, T., Sato, N., Tokino, T. and Imai, K.：Inactivation of class Ⅱ transactivator by DNA methylation and histone deacetylation associated with absence of HLA-DR induction by interferon-γ in haematopoietic tumor cells.　British Journal of Cancer, 90:844-852, 2004
• Nakamura, M., Tsuji, N., Asanuma, K., Kobayashi, D., Yagihashi, A., Hirata, K., Torigoe, T., Sato, N. and Watanabe, N.：Survivin as a predictor of cis-Damminedichloroplatinum sensitivity in gastric cancer patients. Cancer Sci., 95:44-51, 2004
• Hara, I., Sato, N., Miyake, H., Murakami, M., Hikosaka, S. and Kamidono, S.：Introduction of 65kDa antigen of Mycobacterium tuberculosis to cancer cells enhances anti-tumor effect of BCG therapy.　Microbiol. Immunol., 48: 289-295, 2004
• Ueda, G., Tamura, Y., Hirai, I., Kamigichi, K., Ichimiya, S., Torigoe, T., Hiratsuka, H., Sunakawa, H. and Sato, N.：Tumor-derived heat shock protein70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity. Cancer Sci., 95: 248-253, 2004
• Kikuchi,T., Ichimiya, S., Kojima, T., Crisa, L., Koshiba, S., Tonooka, A., Kondo, N., Van Der Saag PT., Yokoyama, S., Sato, N.：Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes. Int Immunol., 16:831-841, 2004
• Tsuruma, T., Hata, F., Torigoe, T., Furuhata, T., Idenoue, S., Kurotaki, T., Yamamoto, M., Yagihashi, A., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Yasoshima, T., Sasaki, K., Mizushima, Y., Minamida, H., Kimura, H., Akiyama, M., Hirohashi, Y., Asanuma, H., Tamura, Y., Shimozawa, K., Sato, N. and Hirata, K.　PhaseⅠ clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer. J. Translational Med., 2:19-29, 2004
• Ida, K., Kawaguchi, S., Sato, Y., Tsukahara, T., Nabeta, Y., Sahara, H., Ikeda, H., Torigoe, T., Ichimiya, S., Kamiguchi, K., Wada, T., Nagoya, S., Hiraga, H., Kawai, A., Ishii, T., Araki, N., Myoui, A., Matsumoto, S., Ozaki, T., Yoshikawa, H., Yamashita, T. and Sato, N.：Crisscross CTL induction by SYT-SSX junction peptide and its HLA-A*2402 anchor substitute. J. Immunol., 173: 1436-1443, 2004
• Matsumoto, K., Takenouchi, M., Ohta, K., Ohta, Y., Imura, T., Oshige, M., Yamamoto, Y., Sahara, H., Sakai, H., Abe, M., Sugawara, F., Sato, N. and Sakaguchi, K.：Design of vesicles of 1, 2-di-ο-acyl-3-ο-(β- D- sulfoquinovosyl) -glyceride bearing two stearic acids (β-SQDG-C18), a novel immunosuppressive drug.　Biochemical Pharmacology, 68: 2379-2386, 2004
• Tsukahara, T., Nabeta, Y., Kawaguchi, S., Ikeda, H., Sato, Y., Shimozawa, K., Ida, K., Asanuma, H., Hirohashi, Y., Torigoe, T., Hiraga, H., Nagoya, S., Wada, T., Yamashita, T. and Sato, N.：Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.　Cancer Res., 64: 5442-5448, 2004
• Nakanishi, K., Kamiguchi, K., Torigoe, T., Nabeta, C., Hirohashi, Y., Asanuma, H., Tobioka, H., Koge, N., Harada, O., Ichimiya, S., Nagano, H., Yano, S., Matsumoto, H. and Sato, N.：Localization and function in ER stress tolerance of ERdj3 molecule, a new member of HSP40 family protein. Cell Stress & Chaperones, 9: 253-264, 2004
• Fujita, T., Miyagawa, S., Ezoe, K., Saito, T., Sato, N., Takahagi, Y., Murakami, H., Matsunami, K., Shirakura, R. and Taniguchi, N.：Skin graft of double transgenic pigs of N-acetylglucosaminyltransferase Ⅲ (Gn T-Ⅲ) and DAF (CD55) genes survived in cynomolgus monkey for 31days.　Transplant Immunol., 13: 259-264, 2004
• Takahashi, R., Shijubo, N., Shigehara, K., Hiraga, Y., Abe, S. and Sato, N.：T helper 1 inhibitor, TAK-603 inhibits IFN-γ and IL-12 production with no effect on IL-18 : an observation in sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis., 21: 204-211, 2004
• Tsuruma, T., Sahara, H., Takenouchi, M., Yagihashi, A., Iwayama, Y., Shima, H., Furuhata, T., Torigoe, T., Hanashima, S., Yamazaki, T., Sugawara, F., Mizushina, Y., Ohta, K., Sakaguchi, K., Sato, N. and Hirata, K.：Synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin reduces hepatic ischemia-reperfusion injury in rats. Transplant Proc., 36:1965-1969, 2004
• Hata, F., Nishimori, H., Yasoshima, T., Tanaka, H., Ohno, K., Yanai, Y., Ezoe, E., Kamiguchi, K., Isomura, H., Denno, R., Sato, N. and Hirata, K.：Profiling analysis of differential gene expression between hematogenous and peritoneal metastatic sublines of human pancreatic cancer using a DNA chip.　J. Exp. Clin. Cancer Res., 23: 513-520, 2004
• Sagae, S., Saito, T., Satoh, M., Ikeda, H., Kimura, S., Mori, M., Sato, N. and Kudo, R.：The reproducibility of a binary tumor grading system for uterine endometrial endometrioid carcinoma, compared with FIGO system and nuclear grading.　Oncology, 67: 344-350, 2004
• Satoh, A., Toyota, M., Ikeda, H., Morimoto, Y., Akino, K., Mita, H., Suzuki, H., Sasaki, Y., Kanaseki, T., Takamura, Y., Soejima, H., Urano, T., Yanagihara, K., Endo, T., Hinoda, Y., Fujita, M., Hosokawa, M., Sato, N., Tokino, T. and Imai, K.：Epigenetic inactivation of a class Ⅱ transactivator (CⅡTA) is associated with the absence of interferon-γ-induced HLA-DR expression in colorectal and gastric cancer cells.　Oncogene, 23: 8876-8886, 2004
• Yamamoto, Y., Sahara, H., Takenouchi, M., Matsumoto, Y., Imai, A., Fujita, T., Tamura, Y., Takahashi, N., Gasa, S., Matsumoto, K., Ohta, K., Sugawara, F., Sakaguchi, K., Jimbow, K. and Sato, N.：Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, β-SQAG9 liposome that binds to CD62L molecule on the cell surface.　Cell Immunol., 232: 105-115, 2004
• Saikai, T., Tanaka, H., Sato, N., Abe, S. and Matsuura, A.：Mushroom plant workers experience a shift towards a T helper type 2 (TH2) dominant state: contribution of innate immunity to spore antigen.　Clin. Exp. Immunol., 135: 119-124, 2004
• Tsukahara, T., Kawaguchi, S., Nagoya, S., Wada, T., Yamashita, T., Tsuruma, T., Hirata, K., Sahara, H., Torigoe, T., Ikeda, H. and Sato, N.：Novel approach to immunotherapy for epithelial cancers, bone and soft-tissue sarcomas. Ann. Cancer Res. Ther., 12: 53-70, 2004

2003

• Shigehara, K., Shijubo, N., Ohmichi, M., Kamiguchi, K., Takahashi, R., Morita-Ichimura, S., Ochi, T., Tatsuno, T., Hiraga, Y., Abe, S. and Sato, N.：Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis. Clin. Exp. Immunol., 132: 152-157, 2003
• Kanaseki, T., Ikeda, H., Takamura, Y., Toyota, M., Hirohashi, Y., Tokino, T., Himi, T. and Sato, N.：Histone deacetylation, but not hypermethylation, modifies CIITA and MHC calss II gene expression in squamous cell carcinomas. J. Immunol.,170: 4980-4985, 2003
• Nakajima, F., Nishimori, H., Hata, F., Yasoshima, T., Nomura, H., Tanaka, H., Ohno, K., Yanai, Y., Kamiguchi, K., Sato, N., Denno, R. and Hirata, K.：Gene expression screening using a cDNA macroarray to clarify the mechanisms of peritoneal dissemination of pancreatic cancer. Surg. Today, 33: 190-195, 2003
• Ichinohe, T., Ichimiya, S., Kishi, A., Tamura, Y., Kondo, N., Ueda, G., Torigoe, T., Yamaguchi, A., Hiratsuka, H., Hirai, I., Kohama, G. and Sato, N.：T- cell receptor variableγchain gene expression in the interaction between rat　γδ- type T cells and heat-shock protein 70-like molecule. Microbiol. Immunol., 47: 351-357, 2003
• Kashiwagi, K., Ikeda, H., Hirohashi, Y., Yamamoto, M., Idenoue, S., Hirai, I., Kamiguchi, K., Tamura, Y., Torigoe, T., Wada, Y., Hirata, K. and Sato, N.：Analysis of a shared pancreatic cancer antigen recognized by an HLA-A*2601 -restricted cytotoxic T-lymphocyte clone. Pancreas, 26(4): 81-88, 2003
• Momota, H., Ichimiya, S., Kondo, N., Kikuchi, T., Torigoe, T., Yamaki, T., Houkin, K. and Sato, N.：Histone H2AX sensitizes glioma cells to genotoxic stimuli by recruiting DNA double-strand break repair proteins.　International Journal of Oncology, 23:311-315, 2003
• Nagata, M., Shijubo, N., Andrew, F. Walls, Ichimiya, S., Abe, S. and Sato, N.：Chymase-positive mast cells in small sized adenocarcinoma of the lung.　Virchows Arch., 443:565-573, 2003
• Nabeta, Y., Kawaguchi, S., Sahara, H., Ikeda, H., Hirohashi, Y., Goroku, T., Sato, Y., Tsukahara, T., Torigoe, T., Wada, T., Kaya, M., Hiraga, H., Isu, K., Yamawaki, S., Ishii, S., Yamashita, T. and Sato, N.：Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line. J. Orthop. Sci., 8:554-559, 2003
• Tanaka, H., Hata, F., Nishimori, H., Honmou, O., Yasoshima, T., Nomura, H., Ohno, K., Hirai, I., Kamiguchi, K., Isomura, H., Hirohashi, Y., Denno, R., Sato, N. and Hirata, K.：Differential Gene Expression Screening Between Parental and Highly Metastatic Pancreatic Cancer Variants Using a DNA Microarray.　J. Exp. Clin. Can. Res., 22: 307-313, 2003
• Yagihashi, A., Asanuma, H., Tsuji, N., Torigoe, T., Sato, N., Hirata, K. and Watanabe, N.：Detection of anti-livin antibody in gastrointestinal cancer patients.　Clinical Chemistry, 49:1206-1208, 2003
• Momota, H., Ichimiya, S., Ikeda, T., Yamaki, T., Kikuchi, T., Houkin, K. and Sato, N.：Immunohistochemical analysis of the p53 family members in human craniopharyngiomas. Brain Tumor Pathol., 20: 73-77, 2003
• Ohno, K., Hata, F., Nishimori, H., Yasoshima, T., Yanai, Y., Sogahata, K., Ezoe, E., Tanaka, H., Kamiguchi, K., Isomura, H., Denno, R., Sato, N. and Hirata, K.：Metastatic-associated biological properties and differential gene expression profiles in established highly liver and peritoneal metastatic cell lines of human pancreatic cancer. J. Exp. Clin. Cancer Res., 22: 623-631, 2003
• Shijubo, N., Kawabata, I., Sato, N. and Itoh, Y.：Clinical aspects of clara cell 10-kDa protein/uteroglobin (secretoglobin1A1). Current Pharmaceutical Design, 9: 1139-1149, 2003
• Shijubo, N., Kojima, H., Nagata, M., Ohchi, T., Suzuki, A., Abe, S. and Sato, N.：Tumor angiogenesis of non-small cell lung cancer.　Microscopy Res. Tech., 60: 186-190, 2003
• Tamura, Y. and Sato, N.：Heat shock proteins; Chaperoning of innate and adaptive immunities.　Jpn. J. Hyperthermic Oncology, 19:131-139, 2003

2002

• Yamaguchi, A., Nepote, J. A., Kadivar, M., Tagami, Y., Fukushi, M., Kukichi, Y., Sato, N. and Kikuchi, K.：Allele specific PCR with microfluorometry: application to the detection of del F508 mutation in cystic fibrosis. Clinica. Chimica. Acta, 316:147-154, 2002
• Yamaguchi, A., Hashimoto, N., Tsutae, W., Seino, K., Ebana, Y., Tokino, T., Sato, N. and Kikuchi, K.：Detection of human papillomavirus DNA by PCR/microfluorometry for screening of cervical cancer. Clinica. Chimica Acta., 318:41-49, 2002
• Sahara, H., Hanashima, S., Yamazaki, T., Takahashi, S., Sugawara, F., Ohtani, S., Ishikawa, M., Mizushima, Y., Ohta, K., Shimozawa, K., Gasa, S., Jimbow, K., Sakaguchi, K. Sato, N., and Takahashi, N.：Antitumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols. Jpn J. Cancer Res., 93:85-92, 2002
• Sahara, H., Nabeta, Y., Torigoe, T., Hirohashi, Y., Ichimiya, S., Wada, Y., Takahashi, N., Jimbow, K., Yajima, T., Watanabe, N., Kikuchi, K. and Sato, N.：A gene encoding human gastric signet ring cell carcinoma antigen recognized by HLA-A31- restricted cytotoxic T lymphocytes.　 J. Immunother., 25:235-242,　2002
• Nishimori, H., Yasoshima, T., Hata, F., Denno, R., Yanai, Y., Nomura, H., Tanaka, H., Kamiguchi, K., Sato, N. and Hirata, K.：A novel nude mouse model of liver metastasis and perotpneal dissemination from the same human pancreatic cancer line. Pancreas, 24: 242-250, 2002
• Ichimiya, S., Kojima, T., Momota, H., Kondo, N., Ozaki, T., Nakagawara, A., Toribio, ML., Imamura, M. and Sato, N.：p73 is expressed in human thymic epithelial cells. 　J. Histochem. & Cytochem., 50: 455-462, 2002
• Rong, S., Ikeda, H., Sato, Y., Hirohashi, Y., Takamura, Y., Sahara, H., Sato, T., Maeda, A., Ohguro, H. and Sato, N.：Frequent detection of anti-recoverin cytotoxic T-lymphocytes precursor in peripheral blood of cancer patients by using an HLA-A24-recoverin-tetramer. Cancer Immunol. Immunother., 51:282-290, 2002
• Fujita, T., Ezoe, K., Matsumoto, Y., Saito, T., Homma, K., Jimbow, K. and Sato, N.：TAK-603, New rheumatic drug, inhibits rat mixed lymphocyte reactions and prolonges rat skin allograft survival.Transplantation Proceedings, 34:1133-1135, 2002
• Hirohashi, Y., Torigoe, T., Maeda, A., Nabeta, Y., Kamiguchi, K., Sato, T., Yoda, J., Ikeda, H., Hirata, K., Yamanaka, N. and Sato, N.：An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivin. Clin. Cancer Res., 8:1731-1739, 2002
• Maeda, A., Maeda, T., Ohguro, H., Palczewski, K. and Sato, N.：Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur. J. Immunol., 32: 2300-2307, 2002
• Matsumoto, Y., Sahara, H., Fujita, T., Shimozawa, K., Takenouchi, M., Torigoe, T., Hanashima, S., Yamazaki, T., Takahashi, S., Sugawara, F., Mizushima, Y., Ohta, K., Takahashi, N., Gasa, S., Jimbow, K., Sakaguchi, K. and Sato, N.：An immunosuppressive effect by synthetic sulfonolipids deduced from sulfonoquinovosyl diacylglycerols of sea urchin. Transplantation, 74: 261-267, 2002
• Sato, Y., Nabeta, Y., Tsukahara, T., Hirohashi, Y., Rong, S., Maeda, A., Sahara, H., Ikeda, H., Torigoe, T., Ichimiya, S., Wada, T., Yamashita, T., Hiraga, H., Kawai, A., Ishii, T., Araki, N., Myoui, A., Matsumoto, S., Umeda, T., Ishii, S., Kawaguchi, S. and Sato, N.：Detection and induction of cytotoxic T lymphocytes specific for SYT-SSX-derived peptides in HLA-A24+ patients with synovial sarcoma. J. Immunol., 169: 1611-1618, 2002
• Kondo, H., Sahara, H., Miyazaki, A., Nabeta, Y., Hirohashi, Y., Kanaseki, T., Yamaguchi, A., Yamada, N., Hirayama, K., Suzuki, M., Hamuro, J., Torigoe, T., Takahashi, N., Kohama, G., Ikeda, H. and Sato, N.：Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells. 　Jap. J. Cancer Res., 93:917-924, 2002
• Nomura, H., Nishimori, H., Yasoshima, T., Hata, F., Tanaka, H., Nakajima, F., Honma, T., Araya, J., Kamiguchi, K., Isomura, H., Sato, N., Denno, R. and Hirata, K.：A new liver metastatic and peritoneal dissemination model established from the same human pancreatic cancer cell line: analysis using cDNA macroarray.　Clin. Exp. Metastasis, 19: 391-399, 2002
• Kawaguchi, S., Yamashita, T., Katahira, G., Yokozawa, H., Torigoe, T. and Sato, N.：Chemokine profile of herniated intervertebral discs infiltrated with 　monocytes and macrophages. Spine, 27:1511-1516, 2002
• Kanaseki, T., Torigoe, T., Hirohashi, Y., Hirai, I., Himi, T. and Sato, N.： Identification of germline mutation of PTEN gene and analysis of apoptosis resistance of the lymphocytes in a patient with Cowden disease. Pathobiology, 70: 34-39, 2002
• Sato, Y., Sahara, H., Tsukahara, T., Kondo, M., Hirohashi, Y., Nabeta, Y., Kawaguchi, S., Ikeda, H., Torigoe,T., Ichimiya, S., Tamura, Y., Wada, T., Yamashita, T., Goto, M., Takasu, H. and Sato, N.：Improved generation of HLA class I/peptide tetramers. J. Immunol. Methods, 271: 177-184, 2002
• Torigoe, T., Ichinohe, T., Nakanishi, K., Gouroku, T., Nabeta, C., Kamiguchi, K., Sato, N. and Yano, S.：DNA array analysis of gene expression after exposure of lymphocytes to brief microgravity. Drop Tower Days 2002 in Japan., 253-258, 2002
• Tanaka, H., Saikai, T., Suzuki, K., Matsuura, A., Sato, N. and Abe, S.：Mechanisms of new types of occupational respiratory allergy in mushroom workers.　Recent Res. Devel. Allergy & Clin. Immunol., 3: 53-63, 2002

2001

• Maeda,A., Ohguro,H., Nabeta,Y., Hirohashi,Y., Sahara,H., Maeda,T., Wada,Y., Sato,T., Chuns,Y., Torigoe,T., Nishimura,Y., Kuroki,Y. and Sato,N.：Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin,cancer-associated retinopathy antigen,related with a better prognosis in a paraneoplastic syndrome. Eur.J.Immunol.,31:563-572,2001
• Shigehara,K., Shujubo,N., Ohmichi,M., Takahashi,R., Kon,S., Okamura,H., Kurimoto,M., Hiraga,Y., Tatsuno,T., Abe,S. and Sato,N.： IL-12 and IL---18 are increased and stimulate IFN-γproduction in sarcoid lungs. J. Immunol.,166:642-649,2001
• Nomura,H., Nishimori,H., Yasoshima,T., Hata,F., Sogahata,K.,Tanaka,H., Nakajima,F., Ikeda,S., Kamiguchi,K., Isomura,H., Sato,N., Denno,R. and 　Hirata,K.：A new experimental mouse model of peritoneal dissemination of human gastric cancer cells: analysis of the mechanism of peritoneal dissemination using cDNA macroarrays.Jap.J.Cancer Res.,92:748-754,2001
• Kishi,A., Ichinohe,T., Kinebuchi,M., Hirai,I., Tamura,Y., Matsuura,A., Torigoe,T. and Sato,N.：Tha cell surface-expressed HSC70-like molecule preferentially reacts with rat T cell receptorδ 6 family. Immunogenetics,53:401-409,2001
• Nishimori,H., Yasoshima,T., Denno,R., Shishido,T., Hata,F., Homma, T., Ura,H., Yamaguchi,K., Yagihashi,A., Tanaka,H., Kawaguchi,S, Kamiguchi,K., Isomura,H., Sato,N. and Hirata,K：A new peritoneal dissemination model established from the human pancreatic cancer cell line: different mecganism in peritoneal dissemination and hematogeneous metastasis. Pancreas, 22:348-356,2001
• Kawaguchi,S., Yamashita,T., Yokogushi,K., Murakami,T., Ohwada,O. and Sato,N.：Immunophenotypic analysis of the inflammatory infiltrates in herniated intervertebral disc. Spine,26:1209-1214,2001
• Kajjino,Y., Yamaguchi,A., Hashimoto,N., Matsuurs,A., Sato,N. and Kikuchi,K.：β-catenin gene mutation in human hair follicle-related tumors. Pathol.Int., 51:543-548,2001
• Yamaguchi,A., Hashimoto,N., Tsutae,W., Seino,K., Osanai,H., Yamamoto,N., Tokino,T., Sato,N. and Kikuchi,K.：Dried feces spots as an 　　　 alternative DNA souces: Detection of k-ras mutations in colorectal cancer. Tumor Res.,36:7-13,2001 36:132-134,2001.
• Torigoe,T., Ichinohe,T., Sato,N. and Yano,S.：Analysis of gene expression of lymphocytes in microgravity. BiologicalSciences in Space,15:306-307,2001
• Shijubo,N., Shigehara,K., Okamura,H., Takahashi,R., Suzuki,A., Yamada,G., Sato,N. and Abe,S.：Interleukin-18 in inflammatory lung diseases. 　Recent Res.Devel.Resp.Critical Care Med.,1:223-231,2001

2000

• Matsuura,A., Kinebuchi,M., Chen,H.Z., Katabami,S., Shimizu,T., Hashimoto,Y., Kikuchi,K. and Sato,N.：NK T cells in the rat：organ- specific distribution on NK T cells expressing Va14 chains. J.Immunol.,164:3140-3148,2000
• Fujita,T., Matsumoto,Y., Hirai,I., Ezoe,K., Saito,T., Yagihashi, A., Torigoe,T., Homma,K., Takahashi,S., Cruikshank,W.W., Jimbow,K. and Sato,N.：Immunosuppressive effect on T cell activation by interleukin-16 cDNA-transfected human squamous cell line. Cell.Immunol.,202:54-60, 2000
• Shigehara,K., Shijubo,N., Ohmichi,M., Kon,S., Shibuya,Y., Takahashi, R., Morita-Ichimiya,S., Tatsuno,T., Hiraga,Y., Abe,S. and Sato,N.: Enhaced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis.Sarcoidosis.,17:151-157,2000
• Maeda,A., Ohguro,H., Maeda,T., Wada,I., Sato,N., Kuroki,Y. and Nakagawa,T.: Aberrant expression of photoreceptor specific calcium binding protein (recoverin) in cancer cell lines. Cancer Res.,60:1914-1920,2000
• Nagata,M., Akazawa,T., Tamura,Y., Kamiguchi,K., Hirai,I., Ohtani, S., Sagae,S., Kudo,R., Torigoe,T. and Sato,N.：The expression of a novel natural killer inhibitory molecule,Cho-1,on the chorionic cytotrophoblast cells of successful pregnancy, but not of spontaneous abortion. Pathol.Int.,50:824-831,2000
• Fujita,T., Takami,Y., Ezoe,K., Saito,T., Sato,K., Takeda,N., Yamamoto,Y., Homma,K., Jimbou,K. and Sato,N.：Successful preservation of human skin by vitrification. J. Burn Care Rehabil.,21:304-309,2000
• Shigehara,K., Shijubo,N., Ohmichi,M., Yamada,G., Takahashi,R., Okumura,H., Kurimoto,M., Hiraga,Y., Tatsuno,T., Abe,S. and Sato,N.: Increased levels of serum IL-18 in patients with pulmonary sarcoidosis. Am.J.Resp.Crit.Care Med., 162:1979-1982,2000
• Nabeta,Y., Sahara,H., Suzuki,K., Kondo,H., Nagata,M., Hirohashi, Y., Wada,Y., Sato,T., Wada,T., Kikuchi,K. and Sato,N.：Induction of CTL from peripheral blood of HLA-A31(+) gastric cancer patients by in vitro stimulation with antigenic peptide of signet ring cell carcinoma.Jap.J. Cancer Res.,91:616-621,2000
• Nishimori,H., Yasoshima,T., Denno,R., Shishido,T., Hata,F., Okada,Y., Ura,H., Yamaguchi,K., Isomura,H., Sato,N., and K.Hirata.： A novel experimental mouse model of peritoneal dissemination of human gastric cannar cells：different mechanisms in peritoneal dissemination and hematogeneous metastasis. Jap.J.Cancer Res., 91:715-722,2000
• Kanki,K., Torigoe,T., Hirai,I., Sahara,H., Kamiguchi,K., Tamura,Y., Yagihashi,A., and Sato,N.：Molecular cloning of rat NK target-structure-the possibility of CD44 involvement in NK cell-mediated lysis.Microbiol. Immunol.,44:1051-1061,2000
• Matsumoto,Y., Sahara,H., Fujita,T., Hanashima,S., Yamazaki,T., Takahashi,S., Sugawara,F., Mizushima,Y., Ohta,K., Takahashi,N., Jimbow,K., Sakaguchi,K., and Sato,N.：A novel immunosuppressive agent,SQG9, derived from sea urchin. Transplant.Proceed.,32:2051- 2053,2000
• Matsuura,A., Kinebuchi,M., Takami,T.,and Sato,N.：Diversity and organ-specific expression of rat invariant TCRalpha chain-implication in their interaction with CD1d. Rat Genoma,6:36,2000
• Matuura,A., Kinebuchi,M., and Sato,N.：Rat TL and CD1-similarity and distinction of CD1d reactive cells in different species. Tissue Antigen,55-56,2000
• Nabeta,Y., Kawaguchi,S., Sato,Y., Wada,T., Yamashita,T. and Sato,N.:Identification Strategy and Cataloguing of antigenic cacer epitope.Mdern Aspects of Immunobiology,1:17-19,2000
• Ichimiya,S., Nakagawara,A. Sakuma,Y., Kimura,S., Ikeda,T., Sato,M., Takahashi,N., Sato,N. and Mori,M.:p73:Structure and function.Pathol.Int.,50:589-593,2000
• Sato,N., Nabeta,Y., Kondo,H., Sahara,H., Hirohashi,Y., Kashiwagi,K., Kanaseki,T., Sato,Y., Rong,S., Hirai,I., Kamiguchi,K., Tamira,Y., Matsuura,A., Takahashi,S., Torigoe,T. and Ikeda,H.:Human CD8 and CD4 T cell epitopes of epithelial cancer antigens. Cancer Chemother Pharmacol.,46:86-90,2000

1999

• Akazawa,T., Hirai,I., Hirohashi,Y., Kamiguchi,K., Sahara,H., Torigoe,T., Nagasawa,S., Tamura,Y.and Sato,N.: A novel negative regulator Cho-1 moleucle is involved in the cytotoxicity by human natural killer cells but not in cytotoxic T lymphocytes. Microbiol.Immunol.,43: 285-291,1999
• Ishikura,H., Miyashita,M., Yagi,K., Sato,N., Matsuura,A., Kon,S., Oku,Y., Yamaguchi,T. and Kikuchi,K.: Studies on the epidemiological and taxonomical view point to Acanthocephala (Rudolph,1809) Perse1936,and Acanthocephalosis and in addition to the hystopatho-parasitological feature on the Muniliformis (Bremser,1811),Travassos,1915(1)・(2) Hokkaido Med.Soc.1999
• Tsuruma,T., Yagihashi,A., Torigoe,T., Araya,J., Watanabe,N., Sato, N.and Hirata,K.: Interleukin 10 reduces natural killer sensitivity of tumor cells by downregulating of NK target structure expression. Cell Immunol., 198:103-110,1999
• Shishido,T., Yasoshima,T., Hirata,K., Denno,R., Mukaiya,M., Ura, H., Yamaguchi,K., Kawaguchi,S.and Sato,N.: Establishment and characterization of human pancreatic carcinoma lines with a high metastatic potential in the liver of nude mice. Surg.Today,29:519- 525,1999
• Asanuma,H., Takahashi,S., Ishikawa,M., Kamiguchi,K., Sato,N., Poppema,S., Fujimoto,J.and Kikuchi,K.: A monoclonal antibody, 3G12, reacts with a novel surface molecule, Hal-1, with high expression in CD30-positive an aplastic large cell lymphomas. Brit.J.Hematol.,106:55-63,1999
• Suzuki,K., Sahara,H., Okada,Y., Yasoshima,T., Hirohashi,Y., Nabeta, Y., Hirai,I., Torigoe,T., Takahashi,S., Matsuura,A., Takahashi,N., Sasaki, A., Suzuki,M., Hamuro,J., Ikeda,H., Wada,Y., Hirata,K., Kikuchi,K.and Sato, N.: Identification of natural antigenic peptides of a human gastric signet ring cell carcinoma recognized by HLA-A31-restricted cytotoxic T lymphocytes. J.Immunol.,163:2783- 2791,1999
• Matsuura,A., Kinebuchi,M., Itoh,Y., Kasai,K., Yamada,K., Yoshida, M.C., Horie,M., Kikuchi,K.and Sato,N.: Genomic organization and chromosome location of the rat CD3ζ locus (Cd3z). Cytogenet Cell Genet, 85:301-305,1999
• Maeda,T., Ohguro,H., Maeda,A., Ogawa,K., Nakagawa,T., Hirai,I. and Sato,N.：Identification of Antigenic Site within hsc 70 by Serum Autoantibody in Patients with Cancer-associated Retinopathy.Tumor Research,34:49-56,1999
• Matsuura,A., Kinebuchi,M., Katabami,S., Chen,H., Yamada,K., Yoshida, M. C., Horie,M., Watanabe,T., Kikuchi,K,and Sato,N.: Correction and confirmation of the assignment of the evolutionarily conserved CD1D class gene to rat chromosome 2q34 and its relationship to human and mouse loci. Cytogenet. Cell Genet.,86:323-324,1999
• Matsuura,A., Kinebuchi,M., and Sato, N.: Rat TL and CD1. TumorBiol., 20:39,1999

1998

• Shishido,T., Yasoshima,T., Denno,R., Mukaiya,M., Sato,N. and Hirata,K.:Inhibition of liver metastasis of human pancreatic carcinoma by angiogensis inhibitor TNP-470 in combination with cisplatin. Jap.J.Cancer Res.,89:963-969,1998
• Tsuruma,T., Yagihashi,A., Torigoe,T., Sato,N., Kikuchi,K., Watanabe,N.and Hirata,K.:Interleukin-10 reduces natural killer sensitivity and downnregulates MHC class I expression on H-ras- transformed cells. Cell.Immunol., 184:121-128,1998
• Hirai,I., Sato,N., Qi,W., Ohtani,S., Torigoe,T. and Kikuchi,K.: Localization of pNT22 70kDa heat shock cognate-like protein in the plasma membrane. Cell Struct. Function,23:153-158,1998