> Research
Our Department of pathology was established in 1945. Pathology is obviously a fundamental part of the medical school. Many doctors, scientists, graduate and undergraduate students have been participating in routine pathologic practice, research, education and social activities....
Professor
Toshihiko Torigoe, M.D., Ph.D.
Cellular stress responses are defense and adaptation mechanisms against environmental stress and infective stress, and conserved among all organisms, including prokaryotes and eukaryotes. Human also has such a stress response physiologically and its dysfunction is involved in a variety of diseases such as cancer, neurodegenerative diseases, ...
Associate Professor
Yoshihiko Hirohashi, M.D. Ph.D.
1. Establishment of cancer immunotherapy
Since acquired immune system recognize antigens, immunization of cancer patients using tumor-associated antigens (TAAs) will bring augmentation of anti-tumor immunity. On this point of view, ...
Associate Professor
Tomohide Tsukahara, M.D. Ph.D.
Research works in our team is focused on establishment of immunotherapy for bone and soft tissue sarcoma. We perform clinical peptide vaccination phase I trials, identify specific antigens of cancer stem-like cells/cancer-initiating cells, and develop artificial antibodies against HLA/peptide complex using antibody engineering technology...
Assistant Professor
Takayuki Kanaseki, M.D. Ph.D.
Circulating CD8+T cells specifically recognize virally infected or tumor cells expressing non-self antigens, therefore the immune surveillance targets and eliminates pathogenic cells without harming healthy host cells. The necessary hallmark of specific recognition is the generation and presentation of peptide / MHC class I complex (pMHCI) on the surface of target cells. ...
