Kura A, Saito K, Konno T, Kohno T, Shimada H, Okada T, Nishida S, Ishii D, Matsuura M, Saito T, Kojima T.
Tissue Barriers 2024; 2361976 (Online ahead of print)
The roles of tight junction protein cingulin in human endometrioid endometrial cancer.
Muramatsu J, Arihara Y, Yoshida M, Kubo T, Nakamura H, Ishikawa K, Fujita H, Sugita S, Konno T, Kojima T, Kawano Y, Kobune M, Takada K.
Cancer Sci. 2024; 115(5):1564-1575.
Gap junction beta-4 accelerates cell cycle progression and metastasis through MET–AKT activation in pancreatic cancer.
Ishii D, Shindo Y, Arai W, Konno T, Kohno T, Honda K, Miyajima M, Watanabe A, Kojima T.
Int. J. Mol. Sci. 2024; 24;25(3):1411.
The roles and regulatory mechanisms of tight junction protein cingulin and transcription factor forkhead box protein O1 in human lung adenocarcinoma A549 cells and normal lung epithelial cells.
Konno T, Kohno T, Kikuchi S, Kura A, Saito K, Okada T, Shimada H, Yamazaki Y, Sugiyama T, Matsuura M, Ohsaki Y, Saito T, Kojima T.
Tissue Barriers 2024; 2304443 (Online ahead of print)
The interplay between the epithelial permeability barrier, cell migration and mitochondrial metabolism of growth factors and their inhibitors in a human endometrial carcinoma cell line.
TOP
Sekiguchi S, Yorozu A, Okazaki F, Niinuma T, Takasawa A, Yamamoto E, Kitajima H, Kubo T, Hatanaka Y, Nishiyama K, Ogi K, Dehari H, Kondo A, Kurose M, Obata K, Kakiuchi A, Kai M, Hirohashi Y, Torigoe T, Kojima T, Osanai M, Takano K, Miyazaki A, Suzuki H.
Cancers 2023; 15(17):4303.
ACLP activates cancer-associated fibroblasts and inhibits CD8+ T-cell infiltration in oral squamous cell carcinoma.
Saito K, Konno T, Kohno T, Shimada H, Matsuura M, Okada T, Kura A, Ishii D, Kondoh M, Saito T, Kojima T.
Tissue Barriers 2023; 11(3):2106113.
LSR antibody promotes apoptosis and disrupts epithelial barriers via signal pathways in endometrial cancer.
Kikuchi S, Kohno T, Kojima T, Tatsumi H, Ohsaki Y, Ninomiya T.
Cell Mol. Neurobiol. 2023; 43(3):1267-1280.
Oxygen-glucose deprivation decreases the motility and length of axonal mitochondria in cultured dorsal root ganglion cells of rats.
Arai W, Konno T, Kohno T, Kodera Y, Tsujiwaki M, Shindo Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T.
Oncotarget 2023; 14:261-275.
Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
TOP
Kohno T, Kojima T.
Cancers 2022; 14(20):5056.
Atypical Macropinocytosis Contributes to Malignant Progression: A Review of Recent Evidence in Endometrioid Endometrial Cancer Cells.
Nakano M, Ohwada K, Shindo Y, Konno T, Kohno T, Kikuchi S, Tsujiwaki M, Ishii D, Nishida S, Kakuki T, Obata K, Miyata R, Kurose M, Kondoh A, Takano K, Kojima T.
Cancers 2022; 14(11):2584.
Inhibition of HDAC and signal transduction pathways induces tight junctions and promotes differentiation in p63-positive salivary duct adenocarcinoma.
Takumi-Tanimukai Y, Yamamoto S, Ogasawara N, Nakabayashi S, Mizuta K, Yamamoto K, Miyata R, Kakuki T, Jitsukawa S, Sato T, Tsutsumi H, Kojima T, Takano K, Yokota SI.
J. Virol. Methods. 2022; 304:114528.
A hydroxypropyl methylcellulose plaque assay for human respiratory syncytial virus.
Kojima T, Shindo Y, Konno T, Kodera Y, Arai W, Miyakawa M, Ohwada K, Tanaka H, Tsujiwaki M, Sakuma Y, Kikuchi S, Ohkuni T, Takano K, Watanabe A, Kohno T.
Tissue Barriers. 2022; 10(2):1972760.
Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells.
Kakuki T, Kohno T, Nishida S, Konno T, Kikuchi S, Ohwada K, Nakano M, Tezuka M, Takano K, Kojima T.
Histochem. Cell Biol. 2022; 157(4):415.
FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells.
TOP
Shimada H, Kohno T, Konno T, Okada T, Saito K, Shindo Y, Kikuchi S, Tsujiwaki M, Ogawa M, Matsuura M, Saito T, Kojima T.
Cancers. 2021; 13(24):6341.
The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma.
Ohwada K, Konno T, Kohno T, Nakano M, Ohkuni T, Miyata R, Kakuki T, Kondoh M, Takano K, Kojima T.
Int. J. Mol. Sci. 2021; 22(16):8390.
Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells.
Kohno T, Konno T, Kikuchi S, Kondoh M, Kojima T.
FASEB J. 2021; 35(9):e21742.
Translocation of LSR from tricellular corners causes macropinocytosis at cell-cell interface as a trigger for breaking out of contact inhibition.
Sakuma Y, Hirai S, Sumi T, Tada M, Kojima T, Niki T, Yamaguchi M.
Exp. Cell Res. 2021; 406(2):112763.
MCL1 inhibition enhances the efficacy of docetaxel against airway-derived squamous cell carcinoma cells
Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T.
Histochem. Cell Biol. 2021; 155(6):637-653.
Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells.
Konno T, Kohno T, Miyakawa M, Tanaka H, Kojima T.
Tissue Barriers. 2021; 9(2):1890526.
Pyk2 inhibitor prevents epithelial hyperpermeability induced by HMGB1 and inflammatory cytokines in Caco-2 cells.
Kyuno D, Takasawa A, Kikuchi S, Takemasa I, Osanai M, Kojima T.
Biochim Biophys Acta Biomembr. 2021; 1863(3):183503.
Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells.
Kakiuchi A, Kakuki T, Ohwada K, Kurose M, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Kohno T, Himi T, Takano K, Kojima T.
Oncol. Rep. 2021; 45(4):46.
HDAC inhibitors suppress proliferation, migration and invasion of human head and neck squamous cell carcinoma cells via p63-mediated tight junction molecules and p21-mediated growth arrest.
TOP
Miyakawa M, Konno T, Kohno T, Kikuchi S, Tanaka H, Kojima T.
Int. J. Mol. Sci. 2020; 21(22):8434.
Increase in Epithelial Permeability and Cell Metabolism by High Mobility Group Box 1, Inflammatory Cytokines and TPEN in Caco-2 Cells as a Novel Model of Inflammatory Bowel Disease.
Kodera Y, Kohno T, Konno T, Arai W, Tsujiwaki M, Shindo Y, Chiba H, Miyakawa M, Tanaka H, Sakuma Y, Watanabe A, Takahashi H, Kojima T.
Tissue Barriers. 2020; 8(4):1805997.
HMGB1 enhances epithelial permeability via p63/TGF-β signaling in lung and terminal bronchial epithelial cells.
Okada T, Konno T, Kohno T, Shimada H, Saito K, Satohisa S, Saito T, Kojima T.
Reprod. Sci. 2020; 27(11):2092-2103.
Possibility of Targeting Claudin-2 in Therapy for Human Endometrioid Endometrial Carcinoma.
Kodera Y, Chiba H, Konno T, Kohno T, Takahashi H, Kojima T.
Biochem Biophys Res Commun. 2020; 527(2):553-560.
HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells.
Konno T, Kohno T, Okada T, Shimada H, Satohisa S, Kikuchi S, Saito T, Kojima T.
Histochem. Cell Biol. 2020; 154(2):197-213.
ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer.
Kyuno T, Kohno T, Konno T, Yamaguchi H, Kyuno D, Imamura M, Kimura Y, Kojima T, Takemasa I.
Pancreas. 2020; 49(2):273-280.
Glucose-Dependent FOXM1 Promotes Epithelial-to-Mesenchymal Transition Via Cellular Metabolism and Targeting Snail in Human Pancreatic Cancer.
Konno T, Kohno T, Kikuchi S, Shimada H, Satohisa S, Saito T, Kondoh M, Kojima T.
Tissue Barriers. 2020; 8(1):1695475.
Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1.
Kohno T, Konno T, Kojima T.
Tight Junctions: Classification, Structure and Functions. Nova Science Publishers; 2020; ISBN: 978-1-53617-327-7
A Resourceful Alteration of Tricellular Tight Junction Proteins: Roles in Endometrial Cancer Progression.
Konno T, Kohno T, Kikuchi S, Shimada H, Satohisa S, Takano K, Saito T, Kojima T.
J. Histochem. Cytochem. 2020; 68(1):59-72.
Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells.
Kyuno T, Kyuno D, Kohno T, Konno T, Kikuchi S, Arimoto C, Yamaguchi H, Imamura M, Kimura Y, Kondoh M, Takemasa I, Kojima T.
Histochem. Cell Biol. 2020; 153(1):5-16.
Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line.
TOP
Konno T, Kohno T, Takano K, Miyata R, Miyakawa M, Tanaka H, Kojima T.
Advances in Medicine and Biology. Nova Science Publishers; 2019; Vol. 146, Chap. 2, ISBN: 978-1-53615-961-5
Guanylate Binding Protein-1-Mediated Epithelial Barrier via Tight Junctions.
Kohno T, Konno T, Kojima T.
Int. J. Mol. Sci. 2019; 20(14):3555.
Role of Tricellular Tight Junction Protein Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Cancer Cells.
Kakiuchi A, Kohno T, Kakuki T, Kaneko Y, Konno T, Hosaka Y, Hata T, Kikuchi S, Ninomiya T, Himi T, Takano K, Kojima T.
J. Histochem. Cytochem. 2019; 67(7):523-535.
Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells.
Kaneko Y, Konno T, Kohno T, Kakuki T, Miyata R, Ohkuni T, Kakiuchi A, Yajima R, Ohwada K, Kurose M, Himi T, Takano K, Kojima T.
Am. J. Transl. Res. 2019; 11(2):599-611.
Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells.
TOP
Tanaka Y, Yamaguchi M, Hirai S, Sumi T, Tada M, Saito A, Chiba H, Kojima T, Watanabe A, Takahashi H, Sakuma Y.
Exp. Cell Res. 2018; 372(2):141-149.
Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung.
Yajima R, Takano K, Konno T, Kohno T, Kaneko Y, Kakuki T, Nomura K, Kakiuchi A, Himi T, Kojima T.
J. Mol. Histol. 2018; 49(6):577-587.
Mechanism of fibrogenesis in submandibular glands in patients with IgG4-RD.
Murata M, Osanai M, Takasawa A, Takasawa K, Aoyama T, Kawada Y, Yamamoto A, Ono Y, Hiratsuka Y, Kojima T, Sawada N.
Exp. Cell Res. 2018; 366(2):172-180.
Occludin induces microvillus formation via phosphorylation of ezrin in a mouse hepatic cell line.
Konno T, Takano K, Kaneko Y, Kakuki T, Nomura K, Yajima R, Kakiuchi A, Kohno T, Himi T, Kojima T.
Exp. Cell Res. 2018; 371(1):31-41.
Guanylate binding protein-1-mediated epithelial barrier in human salivary gland duct epithelium.
TOP
Kaneko Y, Kohno T, Kakuki T, Takano K, Ogasawara N, Miyata R, Kikuchi S, Konno T, Ohkuni T, Kakiuchi A, Yajima R, Yokota S, Himi T, Kojima T.
Scientific Rep. 2017; 7(1):10935
The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells.
Kojima T, Kohno T, Kubo T, Kaneko Y, Kakuki T, Kakiuchi A, Kurose M, Takano KI, Ogasawara N, Obata K, Nomura K, Miyata R, Konno T, Ichimiya S, Himi T.
Ann. N. Y. Acad. Sci. 2017; 1405(1):25-31.
Regulation of claudin-4 via p63 in human epithelial cells.
Takano K, Kakuki T, Kaneko Y, Kohno T, Kikuchi S, Himi T, Kojima T.
PLOS ONE. 2017; 12(8):e0182291
Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells
Kikuchi S, Ninomiya T, Kohno T, Kojima T, Tatsumi H.
Cell Biol. Toxicol. 2017; 34(2):93-107.
Cobalt Inhibits Motility of Axonal Mitochondria and Induces Axonal Degeneration in Cultured Dorsal Root Ganglion Cells of Rat
Kohno T, Kikuchi S, Ninomiya T, Kojima T.
Ann. N. Y. Acad. Sci. 2017; 1397(1):185-194.
The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions.
Shimada H, Abe S, Kohno T, Satohisa S, Konno T, Takahashi S, Hatakeyama T, Arimoto C, Kakuki T, Kaneko Y, Takano K, Saito T, Kojima T.
Scientific Rep. 2017; 7:37049.
Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.
Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Miyajima M, Mishina T, Yamada G, Otsuka M, Hasegawa T, Kojima T, Niki T, Watanabe A, Takahashi H, Sakuma Y.
Lab Invest. 2017; 97(3):232-242.
Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis.
Shimada H, Satohisa S, Kohno T, Konno T, Takano K, Takahashi S, Hatakeyama T, Arimoto C, Saito T, Kojima T
Oncology Letters 2017; 14(6):6776-6782.
Downregulation of LSR promotes cell invasion via claudin-1-mediated MMPs in human endometrial cancer.
TOP
Takano K, Kakuki T, Obata K, Nomura K, Miyata R, Kondo A, Kurose M, Kakiuch A, Kaneko Y, Kohno T, Himi T, Kojima T.
Anticancer Research 2016; 36(11):5895-5904.
The behavior and role of lipolysis-stimulated lipoprotein receptor, a component of tricellular tight junctions, in head and neck squamous cell carcinomas.
Takasawa A, Murata M, Takasawa K, Ono Y, Osanai M, Tanaka S, Nojima M, Kono T, Hirata K, Kojima T, Sawada N.
Scientific Rep. 2016; 6:33582.
Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer.
Hashimoto S, Yamamoto S, Ogasawara N, Sato T, Yamamoto K, Katoh H, Kubota T, Shiraishi T, Kojima T, Himi T, Tsutsumi H, Yokota S.
PLOS ONE. 2016; 11(8):e0161793.
Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production.
Yamamoto K, Yamamoto S, Ogasawara N, Takano K, Shiraishi T, Sato T, Miyata R, Kakuki T, Kamekura R, Kojima T, Tsutsumi H, Himi T, Yokota S.
Pharmacol Res. 2016; 111:804-14.
Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3.
Kakuki T, Kaneko Y, Takano K, Ninomiya T, Kohno T, Kojima T, Himi T.
Adv. Otorhinolaryngol. 2016; 77:27-32.
Behavior of Primary Cilia and Tricellular Tight Junction Proteins during Differentiation in Temperature-Sensitive Mouse Cochlear Precursor Hair Cells.
Kurose M, Kakuki T, Takano K, Kondo A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Kohno T, Kojima T, Himi T.
Adv. Otorhinolaryngol. 2016; 77:92-97.
Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma.
Kojima T, Soyka MB.
Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis. EAACI; Section A, chater 19, pp51-53.
The epithelial barrier in the nose.
Shimada H, Satohisa S, Kohno T, Takahashi S, Hatakeyama T, Konno K, Tsujiwaki M, Saito T, Kojima T.
Oncotarget 2016; 7(19):27735-52.
The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells.
Kakuki T, Kurose M, Takano K, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Takahashi S, Hatakeyama T, Kohno T, Himi T, Kojima T.
Oncotarget 2016; 7(23):33887-900.
Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma.
Abe A, Takano K, Kojima T, Nomura K, Kakuki T, Kaneko Y, Yamamoto M, Takahashi H, Himi T.
J. Mol. Histol. 2016; 47(3):353-63.
Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.
Sakuma Y, Nishikiori H, Hirai S, Yamaguchi M, Yamada G, Watanabe A, Hasegawa T, Kojima T, Niki T, Takahashi H.
Lab Invest. 2016; 96(4):391-8.
Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype.
Okita K, Mizuguchi T, Shigenori O, Ishii M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K.
Surg Today. 2016; 46(6):633-40.
Pancreatic regeneration: basic research and gene regulation.
TOP
Kono T, Kondoh M, Kyuno D, Ito T, Kimura Y, Imamura M, Kohno T, Konno T, Furuhata T, Sawada N, Hirata K, Kojima T.
Pharmacol. Res. Perspect. 2015; 3(6):e00196.
Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway.
Kojima T, Kondoh M, Keira T, Takano KI, Kakuki T, Kaneko Y, Miyata R, Nomura K, Obata K, Kohno T, Konno T, Sawada N, Himi T.
Drug Deliv. 2015; 23(8):2703-2710.
Claudin-binder C-CPE mutants enhance permeability of insulin across human nasal epithelial cells.
Miyata R, Kakuki T, Nomura K, Ohkuni T, Ogasawara N, Takano KI, Konno T, Kohno T, Sawada N, Himi T, Kojima T.
Eur. J. Pharmacol. 2015; 761:375-82.
Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.
Kohno T, Ninomiya T, Kikuchi S, Konno T, Kojima T.
Mol. Pharmacol. 2015; 87(5):815-24.
Staurosporine Induces Formation of Two Types of Extra-Long Cell Protrusions: Actin-Based Filaments and Microtubule-Based Shafts.
Miyata R, Nomura K, Kakuki T, Takano KI, Kohno T, Konno T, Sawada N, Himi T, Kojima T.
J. Membr. Biol. 2015; 248(2):327-36.
Irsogladine Maleate Regulates Gap Junctional Intercellular Communication-Dependent Epithelial Barrier in Human Nasal Epithelial Cells.
Konno T, Ninomiya T, Kohno T, Kikuchi S, Sawada N, Kojima T.
Histochem. Cell Biol. 2015; 143(5):471-9.
c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model.
Tsujiwaki M, Murata M, Takasawa A, Hiratsuka Y, Fukuda R, Sugimoto K, Ono Y, Nojima M, Tanaka S, Hirata K, Kojima T, Sawada N.
Med. Mol. Morphol. 2015; 48(1):33-43.
Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.
TOP
Takano K, Kojima T, Sawada N, Himi T.
Excli. J. 2014; 13:1145-1162.
Role of tight junctions in signal transduction: an update.
Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S.
Biochem. Biophys. Res. Commun. 2014; 455(3-4):205-11.
Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.
Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, Kojima T, Sugimoto K, Yoneta A, Sumikawa Y, Yamashita T, Sato N, Himi T, Ichimiya S.
PLOS ONE. 2014; 9:e105498.
ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.
Kyuno D, Yamaguchi H, Ito T, Kono T, Kimura Y, Imamura M, Konno T, Hirata K, Sawada N, Kojima T.
World J. Gastroenterol. 2014; 20:10813-10824.
Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
Nomura K, Obata K, Keira T, Miyata R, Hirakawa S, Takano K, Kohno T, Sawada N, Himi T, Kojima T
Respir. Res. 2014; 15:21.
Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells.
Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N
Am. J. Physiol. Heart Circ. Physiol. 2014; 306:H1054-H1065.
Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2.
TOP
Kojima T, Yamaguchi H, Ito T, Kyuno D, Kono T, Konno T, Sawada N.
Tissue Barriers. 2013; 1(4):e24894
Tight junctions in human pancreatic duct epithelial cells.
Abiko Y, Kojima T, Murata M, Tsujiwaki M, Takeuchi M, Sawada N, Mori M.
J. Toxicol. Pathol. 2013; 26(4):433-8.
Changes of Tight Junction Protein Claudins in Small Intestine and Kidney Tissues of Mice Fed a DDC Diet.
Kojima T, Ninomiya T, Konno T, Kohno T, Taniguchi M, Sawada N.
Histol. Histopathol. 2013; 28(11):1383-92.
Expression of tricellulin in epithelial cells and non-epithelial cells.
Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S, Hirakawa S, Nomura K, Takasawa A, Murata M, Tanaka S, Fuchimoto J, Fujii N, Tsutsumi H, Himi T, Sawada N.
PLOS ONE. 2013; 8(9):e70225.
Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.
Hirakawa S, Kojima T, Obata K, Okabayashi T, Yokota S, Nomura K, Obonai T, Fuchimoto J, Himi T, Tsutsumi H, Sawada N.
J. Med. Virol. 2013; 85(12):2141-50.
Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells.
Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.
Cell Tissue Res. 2013; 354(2):481-94.
Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano.
Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R, Ogasawara N, Masaki T, Fuchimoto J, Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii N, Tsutsumi H, Himi T, Sawada N.
Biomed. Res. Int. 2013; 947072
Regulation of tight junctions in upper airway epithelium.
Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
Carcinogenesis. 2013; 34(6):1232-43.
Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer.
Fuchimoto J, Kojima T, Okabayashi T, Masaki T, Ogasawara N, Obata K, Nomura K, Hirakawa S, Kobayashi N, Shigyo T, Yokota S, Fujii N, Tsutsumi H, Himi T, Sawada N.
Med. Mol. Morphol. 2013; 46(4):203-9
Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells.
Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N.
Cell Tissue Res. 2013; 351(1):73-84.
Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions.
TOP
Fuchimoto J, Kojima T, Kobayashi N, Ohkuni T, Ogasawara N, Masaki T, Obata K, Nomura K, Kondoh A, Shigyo T, Himi T, Sawada N.
Am. J. Rhinol. Allergy. 2012; 26(6):433-8.
Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.
Kojima T, Kyuno D, Sawada N.
Expert. Opin. Ther. Targets. 2012; 16(9):881-7.
Targeting claudin-4 in human pancreatic cancer.
Kojima T, Sawada N.
Ann. N. Y. Acad. Sci. 2012; 1257:85-92.
Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells.
Ogawa M, Kojima T, Someya M, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.
Histochem. Cell Biol. 2012; 138(2):323-38.
Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines.
Ara S, Kikuchi T, Matsumiya H, Kojima T, Kubo T, Ye RC, Sato A, Kon S, Honma T, Asakura K, Hasegawa T, Himi T, Sato N, Ichimiya S.
Cancer Sci. 2012; 103(7):1356-62
Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
Nomura K, Kojima T, Fuchimoto J, Obata K, Keira T, Himi T, Sawada N.
Laryngoscope. 2012; 122(6):1185-92.
Regulation of interleukin-33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines.
Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T.
Clin. Exp. Allergy. 2012; 42(2):218-28.
The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis.
Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N.
Prostate. 2012; 72(4):351-60.
Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer.
TOP
Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
Cell Tissue Res. 2011; 346(3):369-81.
Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Tsutsumi H, Kojima T, Hirakawa S, Masaki T, Okabayashi T, Yokota S, Fujii N, Himi T, Sawada N.
Adv. Otorhinolaryngol. 2011; 72:153-6.
Respiratory syncytial virus infection and the tight junctions of nasal epithelial cells.
Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondo A, Ohkuni T, Masaki T, Kojima T, Sawada N, Tsutsumi H.
Adv. Otorhinolaryngol. 2011; 72:28-30.
Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells.
Ariki S, Kojima T, Gasa S, Saito A, Nishitani C, Takahashi M, Shimizu T, Kurimura Y, Sawada N, Fujii N, Kuroki Y.
J. Immunol. 2011; 187(5):2586-94.
Pulmonary collectins play distinct roles in host defense against Mycobacterium avium.
Okabayashi T, Kojima T, Masaki T, Yokota S, Imaizumi T, Tsutsumi H, Himi T, Fujii N, Sawada N.
Virus. Res. 2011; 160(1-2):360-6.
Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells.
Kojima T, Takasawa A, Kyuno D, Ito T, Yamaguchi H, Hirata K, Tsujiwaki M, Murata M, Tanaka S, Sawada N.
Exp. Cell Res. 2011; 317(16):2288-98.
Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells.
Kojima T, Sawada N.
Methods Mol. Biol. 2011; 762:233-44.
Expression and function of claudins in hepatocytes.
Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N.
Prostate. 2011; 72(4):351-60.
Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer.
Yamaguchi H, Kojima T, Ito T, Kyuno D, Kimura Y, Imamura M, Hirata K, Sawada N.
Cell Mol. Biol. Lett. 2011; 16(3):385-97.
Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells.
Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N.
Mol. Biol. Cell. 2011; 22(13):2144-56.
A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.
Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T.
Acta Otolaryngol. 2011; 131(8):861-8
Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.
Ito T, Kojima T, Yamaguchi H, Kyuno D, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
J. Cell Biochem. 2011; 112(7):1761-72.
Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells.
Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Kaibuchi K, Senga T, Kojima T, Kohno T, Hamaguchi M, Naoe T.
Eur. J. Haematol. 2011; 86(3):191-8.
FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.
Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
Acta Otolaryngol. 2011; 131(2):116-23.
Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids.
Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N.
Toxicol. Appl. Pharmacol. 2011; 250(1):29-38.
Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.
TOP
Kikuchi S, Ninomiya T, Kawamata T, Ogasawara N, Kojima T, Tachi N, Tatsumi H.
Arch Histol Cytol. 2010; 73(2):81-9.
The acid-sensing ion channel 2 (ASIC2) of ciliated cells in the developing rat nasal septum.
Kikuchi S, Ninomiya T, Tatsumi H, Sawada N, Kojima T.
J Histochem Cytochem. 2010; 58(12):1067-73.
Tricellulin is expressed in autotypic tight junctions of peripheral myelinating Schwann cells.
Ogasawara N, Kojima T, Go M, Takano K, Kamekura R, Ohkuni T, Koizumi J, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
Acta Otolaryngol. 2010; 131(2):116-23.
Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids.
Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N.
Toxicol Appl Pharmacol. 2010; 250(1):29-38.
Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.
Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, Koizumi J, Murata M, Nagayama M, Nobuoka T, Tanaka S, Hirata K, Sawada N.
Am J Pathol. 2010; 177(2):698-712.
Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells.
Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, Kikuchi S, Ogasawara N, Ohkuni T, Masaki T, Hirata K, Himi T, Sawada N.
J Cell Physiol. 2010; 225(3):720-33.
c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells.
Ogasawara N, Kojima T, Go M, Ohkuni T, Koizumi J, Kamekura R, Masaki T, Murata M, Tanaka S, Fuchimoto J, Himi T, Sawada N.
Pharmacol Res. 2010; 61(6):489-98.
PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.
Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
Histochem Cell Biol. 2010; 133(3):339-48.
Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.
Sawada K, Ariki S, Kojima T, Saito A, Yamazoe M, Nishitani C, Shimizu T, Takahashi M, Mitsuzawa H, Yokota S, Sawada N, Fujii N, Takahashi H, Kuroki Y.
J Biol Chem. 2010; 285(11):8434-43.
Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth.
TOP
Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, Go M, Takano K, Himi T, Sawada N.
Med Mol Morphol. 2009; 42(4):204-11.
Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.
Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N.
Cell Tissue Res. 2009; 338(2):283-93.
Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.
Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N.
Histol Histopathol. 2009; 24(11):1463-72.
Tight junction proteins and signal transduction pathways in hepatocytes.
Ogasawara N, Kojima T, Go M, Fuchimoto J, Kamekura R, Koizumi J, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
Biochem Biophys Res Commun. 2009; 389(3):543-9.
Induction of JAM-A during differentiation of human THP-1 dendritic cells.
Iba K, Hatakeyama N, Kojima T, Murata M, Matsumura T, Wewer UM, Wada T, Sawada N, Yamashita T.
Wound Repair Regen. 2009; 17(1):108-12.
Impaired cutaneous wound healing in mice lacking tetranectin.
Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N.
Histochem Cell Biol. 2009; 131(3):411-24.
Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.
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北海道公立大学法人 札幌医科大学
医学部附属がん研究所 細胞科学部門
〒060-8556
札幌市中央区南1条西17丁目
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Department of Cell Science, Institute of Cancer Research, School of Medicine,
Sapporo Medical University All Rights Reserved.
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