$B!!%+%j%7%&%$%k%9$N%H%T%C%/%9$K$D$$$F!"\$7$/=R$Y$i$l$k$H;W$o$l$k!#(B3)$B$K$D$$$F$O!":rG/$NK\8&5f2q$GIpEDD>OB@h@8$,>\$7$/Js9p$5$l$F$$$k$,!"$=$N8e$NOCBj$rDs6!$9$k!#(B
1) $B?GCGJ}K!(B
Norovirus$B$N?GCGJ}K!$K$O!"EE;R82Hy6@4Q;!!"93868!=P(BELISA$BK!!"(BRT-PCR, Real time PCR$BK!$J$I$,$"$j!"46EY!"FC0[@-!"7PHq(B, $BB,Dj;~4V!"B,Dj8!BN?t$J$I$K$O0lD90lC;$,$"$k!#(B" Laboratory diagnosis of norovirus: which method is the best ? Rabenau HF et al" $B$K$h$k$H!"(B
$B!!!!(BSensitivity: PCR 94.1%, TEM 58.3%, ELISA 31.3%
Specificity: TEM 98.0%, ELISA 94.9%, PCR 92.4%
$B$G!"$I$NJ}K!$b1V3X8!::$J$I$KE,$7$F$$$k$,!"?GCG$K$O>/$J$/$H$bFs$D$NJ}K!$NF1;~;HMQ$r?d>)$7$F$$$k!#2f!9$N3+H/$7$?(BELISA$BK!$N8=>u!&?J9T>u67$K$D$$$F$b=R$Y$k!#(B
2) Zoonosis$B$H$7$F$N%+%j%7%&%$%k%9(B
$B%V%?!"5m$N(Bnorovirus(NLV)$B$O$9$G$KJs9p$5$l$F$$$k!#(Bbovine enteric caliciviruses(BECs)$B$G$O!"(BJena, NA-2$B$,(BNorovirus$B$K!"(BNB-BECs$B$,(BSapoviruses/Lagoviruses$B$K0dEA;R3XE*$K6a$$$H$5$l$F$$$k!#(BRT-PCR$BK!$rMQ$$$?8!=PJ}K!$N9=C[$H%R%H%+%j%7%&%$%k%9$H$NAj4X$K$D$$$F(BSaif, LJ$B$i$NJs9p!"$^$?!"(BBridger, JC$B$i$NJs9p$,$"$j!"$3$N7k2L%&%7%+%j%7%&%$%k%9$O%R%H(BGI/GII genogroups $B$K
3) ABO-H$B7?J*
(1) Norwalk virus $B$,7l1U7?$K$h$C$F46@w@-$,0[$J$k%G!<%?(B($B:8H>J,(B)$B!#(B
| NV noninfected | NV infected | Se+ | Se- | ||
| Asymptomatic | Symptomatic | ||||
| O | 4 | 31/50/ | $B!!(B65/50/29 (%) | 75 | O |
| A | 22 | 11/53/ | 67/47/42 | 53 | O |
| B | 40 | 60/87/ | 0/13/26 | 43 | O |
| AB | 100 | 0/ 0/ | 100/ 0/3 | O | ND |
| Estes/MacDonald/Ours | Baric R. et al | ||||
4) $B$=$NB>(B
(1) Norovirus $B$NM=KI$K$O!"(BVLPs$B$N%o%/%A%s!"(BORF2$BAH$_9~$_(Btransgenic potato$BEy$,$"$k!#%^%&%9%N%m%&%$%k%9$rMQ$$$?(BKarst SM$B$i$NJs9p$G$O!"%7%0%J%kEAC#@-E>
(2) $B%N%m%&%$%k%9$N(BORF 1$B$K(Btrans activity $B$,$"$k$+$b$7$l$J$$$H$$$&Js9p$,$"$k!#(B
$B0J>e$NE@$K$D$$$F!"OCBjDs6!$$$?$7$^$9!#(B