札幌医科大学医学部 病理学第一講座

箕輪智幸大学院生が令和5年度札幌医大大学院医学研究科「若手研究者最優秀論文賞」を受賞しました。

イベントに冬期研修会プログラム(2023 Winter)を追加しました。

People（スタッフ紹介）を更新しました。

J Dermatol. Shogase N et al. “Characterization of CD4 T-cell phenotype in human leukocyte antigen class II-positive acral melanoma.”

J Dermatol. Maeda R et al. “Analysis of the immune microenvironment in the indolent form of primary cutaneous extranodal natural killer/T-cell lymphoma: A case report.”

Cancer Sci. Wada A et al. “Eribulin is an immune potentiator in breast cancer that upregulates human leukocyte antigen class I expression via the induction of NOD-like receptor family CARD domain-containing 5.”

Cancer Sci. Hamada S et al. “Development of T cell receptor-engineered T cells targeting the sarcoma-associated antigen papillomavirus binding factor.”

Med Mol Morphol. Kashiwagi H et al. “Pregnancy-specific beta-1-glycoprotein 6 is a potential novel diagnostic biomarker of placenta accreta spectrum.”

Heliyon. Yajima Y et al. “SARS-CoV-2 spike protein-derived immunogenic peptides that are promiscuously presented by several HLA-class II molecules and their potential for inducing acquired immunity.”

Cancers. Sekiguchi S et al. “ACLP Activates Cancer-Associated Fibroblasts and Inhibits CD8+ T-Cell Infiltration in Oral Squamous Cell Carcinoma.”

Anticancer Res. Saijo H et al. “Anti-CTLA-4 Antibody Might Be Effective Against Non-small Cell Lung Cancer With Large Size Tumor.”

Cancers. Willis J et al. “Multi-Institutional Evaluation of Pathologists' Assessment Compared to Immunoscore.”

Cureus. Hosaka M et al. “Severe Acute Pancreatitis Rapidly Developed Into Pulmonary Edema and Diffuse Alveolar Hemorrhage Leading to Respiratory Failure: An Autopsy Case”

臨床試験に関する情報「肺がん組織のTapasin発現と免疫療法治療効果に関する後向き観察研究」

イベントに夏期研修会プログラム(2023 Summer)を追加しました。

JCI Insight. Kobayashi S et al. “Proteogenomic identification of an immunogenic antigen derived from human endogenous retrovirus in renal cell carcinoma.”

Med Mol Morphol. Ikeuchi Y et al. “Immunohistological evaluation of patients treated with intra-arterial chemoradiotherapy and surgery for oral cancer.”

Cancer Sci. Miyamoto S et al. “Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy.”

Hum Cell. Emori M et al. “Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, SMU-DDCS, harboring an IDH1 mutation.”

Allergy. Saito K et al. “Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s.”

Cancer Immunol Immunother. Millar DG et al. “Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.”

People（スタッフ紹介）を更新しました。

People（スタッフ紹介）を更新しました。

J Pathol. Minowa T et al. “Fusion with type 2 macrophages induces melanoma cell heterogeneity that potentiates immunological escape from cytotoxic T lymphocytes.”

Oxf Med Case Reports. Hatanaka S et al. “Ischemia-induced intestinal de-epithelization and consequent cholangitis lenta after usage of extracorporeal membrane oxygenation in COVID-19 patients: an autopsy series.”

Cancer Immunol Immunother. Millar DG et al. “Identification of antigenic epitopes recognized by tumor infiltrating lymphocytes in high grade serous ovarian cancer by multi-omics profiling of the auto-antigen repertoire.”

Int J Mol Sci. Tamura Y et al. “A Sulfur Containing Melanogenesis Substrate, N-Pr-4-S-CAP as a Potential Source for Selective Chemoimmunotherapy of Malignant Melanoma.”

Anticancer Res. Sasaki K et al. “SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells.”

Immunol Med. Shijubou N et al. “Metastatic pulmonary pleomorphic carcinoma replaced by a granulomatous lesion after spontaneous regression and PD-1 blockade-induced regression: can epithelioid granuloma be a histological hallmark of cancer immunity?”

Front Immunol. Iwabuchi S et al. “B cell receptor repertoire analysis from autopsy samples of COVID-19 patients.”

鳥越俊彦教授が令和4年度北海道科学技術賞を受賞しました。

松本哲大学院生が第51回日本免疫学会学術集会「ベストポスター賞」を受賞しました。

Cancer Immunol Immunother. Yamada S et al. “Cisplatin resistance driver claspin is a target for immunotherapy in urothelial carcinoma.”

Pathol Res Pract. Kubo T et al. “Immunohistochemical analysis of arachidonate 5-lipoxygenase expression in B-cell lymphomas: Implication for B cell differentiation and its analogy with lymphomagenesis.”

Cancers. Mlecnik B et al. “Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer.”

Int J Mol Sci. Ichioka H et al. “G-Protein-Coupled Receptors Mediate Modulations of Cell Viability and Drug Sensitivity by Aberrantly Expressed Recoverin 3 within A549 Cells.”

Med Mol Morphol. Someya M et al. “Predictive value of an exosomal microRNA-based signature for tumor immunity in cervical cancer patients treated with chemoradiotherapy.”

Br J Cancer. Watanabe Y et al. “Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.”

Cancers. Wakamatsu K et al. “Molecular Events in the Melanogenesis Cascade as Novel Melanoma-Targeted Small Molecules: Principle and Development.”

J Oncol. Tanabe A et al. “YTHDC2 Promotes Malignant Phenotypes of Breast Cancer Cells.”

World J Clin Cases. Kyuno D et al. “COVID-19-associated disseminated mucormycosis: An autopsy case report.”

鳥越俊彦教授が2022年度秋山記念生命科学振興財団「秋山財団賞」を受賞しました。

箕輪智幸大学院生が第81回日本癌学会「若手研究者ポスター賞」を受賞しました。

Cancer Med. Sasaya et al. “Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma.”

J Immunol. Murata K et al. “Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation.”

Cancer Sci. Someya M et al. “Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer.”

Cancers (Basel). Mlecnik B et al. “Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.”

イベントに夏期研修会プログラム(2022 Summer)を追加しました。

茂庭慶吾大学院生が第26回日本がん免疫学会若手研究奨励賞を受賞しました。

Int J Mol Sci. Tamura Y et al. Immunomodulation of Melanoma by Chemo-Thermo-Immunotherapy Using Conjugates of Melanogenesis Substrate NPrCAP and Magnetite Nanoparticles: A Review.

Sci Rep. Kijima T et al. “Cancer immunohistogram representing cancer-immunity cycle by immunohistochemistry predicts the efficacy of immune checkpoint inhibitors in urological cancer patients”

J Immunol. Kato K et al. “Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry”

Pathol Res Pract. Kubo T et al. “Spindle cell tumor with histiocytic and myogenic marker expression in the lymph node of a human T-cell leukemia virus type 1 carrier”

Intern Med. Murao K. “Simultaneous Pseudoprogression and an Immune-related Adverse Event of Pulmonary Pleomorphic Carcinoma after Combined Therapy with Cytotoxic Anticancer Agents and Immune Checkpoint Inhibitor”

Sci Adv. Cheng K et al. “The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys”

Cancers. Nagaoka K et al. “Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy”

イベントに冬期研修会プログラム(2021 Winter)を追加しました。

Front Immunol. Ito K et al. “Palladium-Induced Temporal Internalization of MHC Class I Contributes to T Cell-Mediated Antigenicity.”

Biochem Biophys Res Commun. Wakamiya T et al. “High aldehyde dehydrogenase 1 activity is related to radiation resistance due to activation of AKT signaling after insulin stimulation in prostate cancer.”

Jpn J Radiol. Someya M et al. “Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy.”

Cancer Med. Nambu Y et al. “A screening assistance system for cervical cytology of squamous cell atypia based on a two-step combined CNN algorithm with label smoothing.”

J Gynecol Oncol. Hanley SJB et al. “Evaluation of partial genotyping with HPV16/18 for triage of HPV positive, cytology negative women in the COMPACT study.”

Gastroenterology. Kawazu M et al. “HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.”

Immunol Med. Kubo T et al. “Immunopathological basis of immune-related adverse events induced by immune checkpoint blockade therapy.”

Clin Case Rep. Omori G et al. “Programmed cell death ligand 1 expression in a case of poorly differentiated lymphocyte-rich hepatocellular carcinoma.”

Cancer Immunol Immunother. Matsuki M et al. “Tumor-infiltrating CD8+ T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma.”

Cancer Immunol Res. Kikuchi Y et al. ‘CD8+ T-cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA PVT1.’

Cancer Immunol Immunother. Miyata H et al. “GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy.”

Allergy. Orimo K et al. “Direct platelet adhesion potentiates group 2 innate lymphoid cell functions.”

Nat Biotechnol. Sugata K et al.“Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells. ”

Med Mol Morphol. Mariya T et al.“Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection.”

Anticancer Res. Shionoya Y et al.“Possible Pseudo-progression of Non-small Cell Lung Carcinoma in a Patient With Clinical Hyper-progression Associated With Trousseau Syndrome Who Was Treated With Pembrolizumab: A Case Report.”

JCI Insight. Hirama T et al.“Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair-deficient colorectal cancer tissue.”

Front Oncol.　Kubo T et al.“Fundamental and Essential Knowledge for Pathologists Engaged in the Research and Practice of Immune Checkpoint Inhibitor-Based Cancer Immunotherapy.”

Curr Opin Immunol. Rahman MA et al.“Changing the landscape of tumor immunology: novel tools to examine T cell specificity.”

Med Mol Morphol. Someya M et al.“ Prediction of treatment response from the microenvironment of tumor immunity in cervical cancer patients treated with chemoradiotherapy.”

Immun Inflamm Dis. Kubo T et al.“IL-13 modulates ?Np63 levels causing altered expression of barrier- and inflammation-related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis.”

Cancer Sci. Kubo T et al.“Identification of characteristic subepithelial surface granulomatosis in immune-related adverse event-associated enterocolitis.”

Biochem Biophys Res Commun.Matsuki M et al.“Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells.”

Connect Tissue Res.Kano T et al.“Influence of the site of injury on the spontaneous healing response in a rat model of total rupture of the anterior cruciate ligament.”

Nat Biotechnol.Sugata K et al.“Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells.”

Hum Vaccin Immunother.Kubo T et al.“Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy.”

Cancer Sci.Saito T et al.“Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.”

Oncoimmunology.Shinkawa T et al.“Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutions.”

Cancers (Basel).Takeshita T et al. “The Impact of Immunofunctional Phenotyping on the Malfunction of the Cancer Immunity Cycle in Breast Cancer.”

イベントに冬期研修会プログラム(2020 Winter)を追加しました。

Cancer Sci. Saito T et al. “Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.”

J Clin Oncol. Mlecnik B et al. “Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.”

Br J Cancer. Tadano H et al. “Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8.”

Jpn J Clin Oncol. Someya M et al. “Association between cancer immunity and treatment results in uterine cervical cancer patients treated with radiotherapy.”

Case Rep Surg. Suzuki T et al. “Primary Appendiceal Adenocarcinoma Presenting with Hematochezia due to the Invading Tumor in the Sigmoid Colon.”

AnticancerRes. Tsuchihashi K et al. “Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma.”

PLoS One. Koike K et al. “Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.”

IJU Case Rep. Ueki Y et al. “Non-bacterial cystitis with increased expression of programmed death-ligand 1 in the urothelium: An unusual immune-related adverse event during treatment with pembrolizumab for lung adenocarcinoma.”

久保輝文助教が令和２年度日本病理学会学術奨励賞を受賞しました。

Cancer Immunol Res. Kagoya Y et al. “Genetic Ablation of HLA Class I, Class II, and the T-cell Receptor Enables Allogeneic T Cells to Be Used for Adoptive T-cell Therapy.”

Immunol Med. Kubo T et al. “Fatal fulminant hepatitis induced by combined ipilimumab and nivolumab therapy despite favorable histologic response and confirmed by autopsy in a patient with clear cell renal cell carcinoma.”

Cancer Sci. Saito Y et al. “Aldolase A promotes epithelial-mesenchymal transition to increase malignant potentials of cervical adenocarcinoma.”

Cancer Sci. Hiraoka N et al. “Expression of classical human leukocyte antigen class I antigens, HLA-E and HLA-G, is adversely prognostic in pancreatic cancer patients.”

Med Mol Morphol. Mariya T et al. “Less correlation between mismatch repair proteins deficiency and decreased expression of HLA class I molecules in endometrial carcinoma: a different propensity from colorectal cancer.”

Sci Adv. van de Veen W et al. “A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.”

Elife. Murata K et al. “Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma.”

Exp Ther Med. Hori K et al. “Abscopal effect following nivolumab induction in a patient with metastatic renal cell carcinoma-unique pathological features of the primary specimen: A case report.”

Cancer Sci. Koike K et al. “Prognostic value of HLA class I expression in patients with oral squamous cell carcinoma.”

Cancers (Basel). Orth MF et al. “High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma.”

Cancer Immunol Immunother. Tsukahara T et al. “Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma.”

Strahlenther Onkol. Tsuchiya T et al. “Association between radiotherapy-induced alteration of programmed death ligand 1 and survival in patients with uterine cervical cancer undergoing preoperative radiotherapy.”

イベントに冬期研修会プログラム(2019 Winter)を追加しました。

Auris Nasus Larynx. Kubo T et al. “Occult carcinoma confirmed to be a diffuse sclerosing variant of papillary thyroid carcinoma with unusual immunohistochemical features: A pitfall of clinicopathological diagnosis.”

Cancer Sci Mizushima E,et al. “Osteosarcoma-initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B.”

Pathol Int. Kanaseki T et al. “Proteogenomic discovery of cancer antigens: Neoantigens and beyond.”

Gan To Kagaku Ryoho. Kanaseki T et al. “Proteogenomics HLA Ligandome Analysis for Cancer Antigen Research.”

Immunol Med Kanaseki T et al. “Proteogenomics: advances in cancer antigen research.”

イベントに夏期研修会プログラム(2019 Summer)を追加しました。

Pathol Res Pract. Tagami Y et al. “Spindle cell rhabdomyosarcoma in a lumbar vertebra with FUS-TFCP2 fusion.”

Allergy.Sugita K et al. “Human type 2 innate lymphoid cells disrupt skin keratinocyte tight junction barrier by IL-13.”

Methods Mol Biol Kanaseki T et al. “Biochemical Analysis of Naturally Processed Antigenic Peptides Presented by MHC Class I Molecules.”

Cancer Sci. Shima H et al. “Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.”

BMC Cancer. Berlow NE et al. “Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma.”

J Immunother Cancer. Honjo O et al. “Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report.”

LoS One. Kawai N et al. “ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD.”

Gan To Kagaku Ryoho.Matsuki M et al. “[PD-L1-Mediated Immune Escape Mechanism of Cancer Stem-Like Cells].”

Cancer Sci. Kubo T et al. “Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: analysis of an autopsy series..”

J Immunol. Hongo A et al. “Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8+ T Cell Responses.”

Cancer Sci. Li D et al. “EIdentification of novel human leukocyte antigen-A*11:01-restricted cytotoxic T-lymphocyte epitopes derived from osteosarcoma antigen papillomavirus binding factor.”

J Dermatol. Kato J et al. “Efficacy of combined radiotherapy and anti-programmed death 1 therapy in acral and mucosal melanoma.”

J Allergy Clin Immunol. Morita H et al. “Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid. ”

Immunol Cell Biol. Benveniste PM et al. “In vitro-generated MART-1-specific CD8 T cells display a broader T cell receptor repertoire than naive ex vivo and tumor infiltrating lymphocytes.”

Diagn Cytopathol. Sugita S et al. “Imprint cytology of biphenotypic sinonasal sarcoma of the paranasal sinus: A case report.”

Sci Immunol. Benveniste PM et al. “Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells.”

イベントに冬期研修会プログラム(2018 Winter)を追加しました。

Exp Mol Pathol. Tabuchi Y, et al. “Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.”

Asia Pac J Clin Oncol. Kamiya S, et al. “Association between PD-L1 expression and lymph node metastasis in cutaneous squamous cell carcinoma.”

Respir Med Case Rep. Kubo T, et al. “Occult ovarian clear-cell carcinoma diagnosed as primary adenocarcinoma of the lung: A case report of a diagnostic pitfall for clinicians and pathologists.”

Cancer Sci. Watanabe K, et al. “Development of a TCR multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells.”

Lab Invest. Kubo T, et al. “Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma.”

Radiother Oncol. Fukushima Y, et al. “Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma.”

Diagn Pathol. Segawa K et al. “Detection of specific gene rearrangements by fluorescence in situ hybridization in 16 cases of clear cell sarcoma of soft tissue and 6 cases of clear cell sarcoma-like gastrointestinal tumor.”

Cancer Immunol Immunother. Shima H, et al. “Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine.”

Oncoimmunology. Baldauf MC et al. “Systematic identification of cancer-specific MHC-binding peptides with RAVEN.”

イベントに夏期研修会プログラム(2018 Summer)を追加しました。

The Lancet. Pages F et al. “International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.”

Nat Commun. Kagoya Y et al. “DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.”

Sci Rep. Anczurowski M et al. “Mechanisms underlying the lack of endogenous processing and CLIP-mediated binding of the invariant chain by HLA-DP84Gly.”

Oncotarget. Miyazaki A et al. “LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer.”

Cancer Sci. Aoyama-Kikawa S et al. “Comparison of HPV genotyping and cytology triage, COMPACT-Study: Design, methods and baseline results in 14,642 women.”

Cancer Sci. Kusumoto H et al. “Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1.”

Cancer Immunol Res.　Miyamoto S et al. “The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer.”

Oncotarget. Ogawa T et al. “ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway.”

金関貴幸講師が 平成29年度北海道科学技術奨励賞を受賞しました。

守田玲奈先生が平成29年度札幌医大大学院若手研究者最優秀論文賞を受賞しました。

Biochem Biophys Res Commun. Nishizawa S et al. “Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB8.”

Immunology. Codd AS et al. “Cancer stem cells as targets for immunotherapy.”

Sci Rep. Hashimoto S et al. “Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues.”

イベントに冬期研修会プログラム(2017 Winter)を追加しました。

Anticancer Res. Okamoto JY et al. “Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma.”

J Pathol. Jitsukawa S et al. “Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression.”

Intern Med.Saijo H et al. “Occult Thyroid Follicular Carcinoma Diagnosed as Metastasis to the Chest Wall.”

Immunol Lett. Matsumiya H et al. “High frequency of Bob1lo T follicular helper cells in florid reactive follicular hyperplasia.”

Cancer Sci. Shibayama Y et al. “Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.”

Nihon Rinsho Meneki Gakkai Kaishi. Tadano H et al. “Immune-related adverse events of immune checkpoint inhibitors.”

Cancer Lett. Takasawa K et al. “Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.”

イベントに夏期研修会プログラム(2017 Summer)を追加しました。

Nihon Rinsho Meneki Gakkai Kaishi.Miyamoto S et al.”Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy.”

Oncoimmunology. Kochin V et al.” HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.”

J Immunol Methods. Takahashi D et al.”Flow cytometric quantitation of platelet phagocytosis by monocytes using a pH-sensitive dye, pHrodo-SE.”

Oncotarget. Inoue R et al.”GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.”

Oncotarget.Yasuda K et al.”Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27.”

Oncoimmunology.Shionoya Y et al.”Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition.”

Anticancer Res. Kubo T et al.”Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon.”

PLoS One. Horibe R et al.”Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy.”

Biochem Biophys Res Commun. Wang L et al.”LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells.”

Biochem Biophys Res Commun. Takeda R et al.”Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells.”

Oncotarget. Tanaka T et al.”Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer.”

Nihon Rinsho Meneki Gakkai Kaishi.Kubo T et al.” Dendritic cell and cancer immune checkpoint.”

Eur J Immunol. Kajiwara T et al.”Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-α-mediated oxidative folding in murine tumor cells.”

イベントに冬期研修会プログラム(2016 Winter)を追加しました。

佐藤昇志名誉教授が第２１回日本癌学会「長與又郎賞」を授賞いたしました。

Oncoimmunology. Murata K et al.”Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance.”

Pathol Int. Tsukahara T et al.”Peptide vaccination therapy: Towards the next generation.”

Oncotarget. Saijo H et al.”Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.”

PLoS One. Takaya A et al.”Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480.”

PLoS One. Sato A et al.”Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation.”

Anticancer Res. Shima H et al.”SOX2 and ALDH1 as Predictors of Operable Breast Cancer.”

Nihon Rinsho Meneki Gakkai Kaishi.Murata K et al.”Cancer immunotherapy and immunological memory.”

菊地浩吉名誉教授が平成２７年度北海道大学大学院医学研究科・医学部医学科「特別賞」を授賞いたしました。

イベントに夏期研修会プログラム(2016 Summer)を追加しました。

Expert Opin Biol Ther. Tsukahara T et al.”The future of immunotherapy for sarcoma.”

Biochem Biophys Res Commun. Ito N et al.”A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.”

Br J Cancer. Tanaka T et al.”Cancer-associated oxidoreductase ERO1-α drives the production of VEGF via oxidative protein folding and regulating the mRNA level.”

Oncotarget.Mariya T et al.” Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer.”

Biochem Biophys Res Commun. Yamauchi M et al.”Wound healing delays in α-Klotho-deficient mice that have skin appearance similar to that in aged humans - Study of delayed wound healing mechanism.”

Cancer Lett. Tanabe A et al.”RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.”

Biochem Biophys Res Commun. Yasuda K et al.”MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.”

Clin Cancer Res. Morita R,et al.”Olfactory receptor family receptor, family 7, subfamily C, member 1 is a novel marker of colon cancer-initiating cells and is a potent target of immunotherapy.”

Oncotarget. Asano T et al.”Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy.”

Eur Heart J Cardiovasc Imaging. Konishi T et al.”Multimodality assessment of spontaneous haemostasis of left ventricular free wall rupture after myocardial infarction.”

PLoS One. Yamashita M et al.”Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response.”

Sci Rep. Lee JR et al.”Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors.”

Cancer Sci. Hirohashi Y et al.” Immune responses to human cancer stem-like cells/cancer-initiating cells.”

Cancer Sci. Guidance Development Review Committee “2015 Guidance on cancer immunotherapy development in early-phase clinical studies.”

Eur J Immunol. Sasaki T et al.”Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8+ T-cell recognition of stressed cells.”

Int J Oncol. Yata K et al.”MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma.”

イベントに冬期研修会プログラム(2015 Winter)を追加しました。

10月１日をもって鳥越俊彦先生が当講座の教授に就任致しました。

Oncoimmunology. Hirohashi Y et al.”HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer.”

Surg Today. Okita K et al.”Pancreatic regeneration: basic research and gene regulation.”

Immunol Lett. Tanaka T et al.”CpG-A stimulates Hsp72 secretion from plasmacytoid dendritic cells, facilitating cross-presentation.”

J Surg Oncol. Emori M et al.”Prognostic impact of CD109 expression in myxofibrosarcoma.”

イベントに夏期研修会プログラム(2015 Summer)を追加しました。

World J Surg Oncol. Iwayama Y et al.” Prognostic value of HLA class I expression in patients with colorectal cancer.”

Eur J Immunol. Saito K et al.”Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.”

J Immunol. Kukita K et al.”Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding.”

Surg Today. Mizuguchi T et al.”Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?”

病理夏の学校のお知らせ

2015年7月4日(土)～5日(日)

詳しくはこちらをご参照下さい。

J Immunol. Tanaka T et al. ”Cancer-Associated Oxidoreductase ERO1-α Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding.”

Anticancer Res. Nishida S et al. “ Expression of hepatocyte growth factor in prostate cancer may indicate a biochemical recurrence after radical prostatectomy.”

Lung Cancer. Kitai H et al. “ Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy.”

Biochem Biophys Res Commun. Kubo T et al. “Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.”

Cancer Sci. Tanaka T et al. “Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells.”

進行膵臓がんのペプチドワクチン治験参加者の募集をリンクしました。詳しくはこちらをご参照下さい。

イベントに冬期研修会プログラム(2014 Winter)を追加しました。

Immunobiology. Kasamatsu J et al. “PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.”

Cancer Immunol Res. Mariya T et al. “Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunological profiles in epithelial ovarian cancer.”

Lab Invest. Yasuda K et al. “Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.”

PLoS One. Kubo T et al. “ΔNp63 Controls a TLR3-Mediated Mechanism That Abundantly Provides Thymic Stromal Lymphopoietin in Atopic Dermatitis.”

J Mol Med (Berl). Ota D et al. “Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts.”

J Biol Chem. Tsukahara T et al. “Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor Peptide, using an artificial monoclonal antibody.”

Nihon Rinsho Meneki Gakkai Kaishi. Torigoe T et al. “[The path to innovative drug development of cancer vaccine: from discovery of tumor antigens to clinical trials].”

Methods Mol Biol. Morita R et al. “Production of multiple CTL epitopes from multiple tumor-associated antigens.”

Curr Opin Immunol. Shastri N et al. “Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.”

イベントに夏期研修会プログラム(2014 Summer)を追加しました。

J Cancer Res Clin Oncol. Tanaka T et al. "Hypoxia-inducible factor (HIF)-independent expression mechanism and novel function of HIF prolyl hydroxylase-3 in renal cell carcinoma."

Cancer Sci. Morita R et al. "Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells."

PLoS One. Emori M et al. "High Expression of CD109 Antigen Regulates the Phenotype of Cancer Stem-Like Cells/Cancer-Initiating Cells in the Novel Epithelioid Sarcoma Cell Line ESX and Is Related to Poor Prognosis of Soft Tissue Sarcoma."

Clin Dev Immnunol. Tanaka T et al. "Potential survival benefit of anti-apoptosis protein: survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer--results from phase I clinical trials."

PLoS One. Takahashi A et al. "Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells."

PLoS One. Yasuda K et al. "Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population."

Pathol Int. Matsuzaki J et al. "Expression of ECRG4 is associated with lower proliferative potential of esophageal cancer cells."

Biochem Biophys Res Commun. Michifuri Y et al. "Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signal."

Exp Cell Res. Yamamoto T et al. "Six-transmembrane epithelial antigen of the prostate-1 plays a role for in vivo tumor growth via intercellular communication."

Int J Hyperthermia. Torigoe T et al. "Constitutive expression and activation of stress response genes in cancer stem-like cells/tumour initiating cells: potent targets for cancer stem cell therapy."

田村保明講師が北海道大学先端生命科学研究院分子送達科学分野の特任教授に就任されました。

J Immunol. Kanaseki T et al. "ERAAP and Tapasin independently edit the Amino and Carboxyl termini of MHC Class I peptides."

Wound Repair Regen. Ikeda K et al. "Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts."

PLoS One. Kuroda K et al. "ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis."

イベントに夏期研修会プログラム(2013 Summer)を追加しました。

第10回 病理 夏の学校（札幌）のお知らせです。こちらの案内ポスターとスケジュールをご覧ください。

Tissue Antigens. Yamada R et al. "Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene."

Cancer Science. Kutomi G et al. "Human Endoplasmic Reticulum Oxidoreductin 1-α (hERO1-α) is a Novel Predictor for Poor Prognosis of Breast Cancer."

Nihon Rinsyo. Tamura Y et al. "Heat shock protein inhibitor for molecular targeting therapy."

Peopleを更新しました。

第102回日本病理学会総会へのリンクはこちらです。

Methods in Molecular Biology. Kanaseki T et al. "Biochemical analysis of naturally processed antigenic peptides presented by MHC class I molecules."

Cancer Science. Nishida S et al. "Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor."

Gan to Kagaku Ryoho. Kukita K et al. "Human endoplasmic reticulum oxidoreductin 1-like α regulates immune response of cancer cells via modulation of major histocompatibility complex class I expression and oxidation."

Anticancer Research. Kiriyama K et al. "Expression and Function of FERMT Genes in Colon Carcinoma Cells."

Virchows Arch. Kitamura H et al. "Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma."

イベントに冬期研修会プログラム(2012 Winter)を追加しました。

Cancer Science. Kameshima H et al. "Immunotherapeutic benefit of IFNα in survivin2B-derived peptide vaccination for advanced pancreatic cancer patients."

Exp Mol Pathol. Morita R et al. "DNA methyltransferase 1 is essential for initiation of the colon cancers."

Pathol Int. Michifuri Y et al. "High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis."

Immunotherapy. Tamura Y et al. "Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity."

Curr Mol Med. Tamura Y et al. "New paradigm for intrinsic function of heat shock proteins as endogenous ligands in inflammation and innate immunity."

Cell Stress Chaperones. Takahashi A et al. "Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes."

イベントに夏期研修会プログラム(2012 Summer)を追加しました。

Journal of Urology. Nishida S et al. "Gene Expression Profiles of Prostate Cancer Stem Cells Isolated by Aldehyde Dehydrogenase Activity Assay."

Cancer Research. Nishizawa S et al. "HSP DNAJB8 Controls Tumor-Initiating Ability in Renal Cancer Stem-like Cells."

Pathology International. Torigoe T et al. "Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue:..."

第71回日本癌学会学術総会へのリンクはこちらです。

ホームページをリニューアルしました。