北海道公立大学法人 札幌医科大学医学部 衛生学講座

論文外部研究資金および研究プロジェクト

  • 原著論文・英文総説
    2017年
  • ・Navarro R, Nair R, Peda A, Aung MS, Ashwinie GS, Gallagher CA, Malik YS, Kobayashi N, Ghosh S. Molecular characterization of canine parvovirus and canine enteric coronavirus in diarrheic dogs on the island of St. Kitts: First report from the Caribbean region. Virus Res. 2017, 240:154-160.

  • ・Aung MS, San T, Aye MM, Mya S, Maw WW, Zan KN, Htut WHW, Kawaguchiya M, Urushibara N, Kobayashi N. Prevalence and Genetic Characteristics of Staphylococcus aureus and Staphylococcus argenteus Isolates Harboring Panton-Valentine Leukocidin, Enterotoxins, and TSST-1 Genes from Food Handlers in Myanmar. Toxins (Basel). 2017, 9(8). pii: E241. doi: 10.3390/toxins9080241.
  • ・Sumi A, Toyoda S, Kanou K, Fujimoto T, Mise K, Kohei Y, Koyama A, Kobayashi N. Association between meteorological factors and reported cases of hand, foot, and mouth 2 disease from 2000 to 2015 in Japan. Epidemiol Infect, 2017, in press.
  • ・Chen B, Sumi, A, Wang L, Zhou W, Kobayashi N. Role of Meteorological Conditions in Reported Chickenpox Cases in Wuhan and Hong Kong, China. BMC Infectious Diseases, 2017, in press.
  • ・Chowdhury NF, Paul SK, Aung MS, Hossain MA, Ahmed F, Ahmed S, Haque N, Nasreen SA, Khan SI, Rahman SMM, Rahman ASMM, Ferdouse F, Ahmed R, Sultan SM, Ahmed MU, Urushibara N, Kobayashi N. Nationwide prevalence of Rickettsia felis infections in patients with febrile illness in Bangladesh. New Microbes and New Infections 2017, in press.
  • ・Edslev SM, Westh HT, Andersen PS, Skov R, Kobayashi N, Bartels MD, Vandenesh F, Petersen A, Worning P, Larsen AR, Stegger M. Identification of a PVL-negative SCCmec-IVa sub-lineage of the methicillin-resistant Staphylococcus aureus CC80 lineage: Understanding the clonal origin of CA-MRSA. Clin Microbiol Infect 2017, in press.

  • ・Navarro R, Chan Y, Nair R, Peda A, Aung MS, Ketzis J, Malik YS, Kobayashi N, Ghosh S, Molecular characterization of complete genomic segment-2 of picobirnavirus strains detected in a cat and a dog. Infect Genet Evol, 2017, in press.
  • ・Kattoor JJ, Saurabh S, Malik YS, Sircar S, Dhama K, Ghosh S, Banyai K, Kobayashi N, Singh RK. Unexpected detection of porcine rotavirus C strains carrying human origin VP6 gene. Vet Q. 2017, 23:1-19.
  • ・Togashi A, Aung MS, Yoto Y, Tsugawa T, Sueoka H, Kawaguchiya M, Tsutsumi1 H, Kobayashi N. Septic arthritis caused by an emerging ST121 methicillin-susceptible, PVL-negative Staphylococcus aureus harboring a variant of bone sialoprotein-binding protein gene. New Microbes and New Infections 2017, in press.

  • ・Urushibara N, Suzaki K, Kawaguchiya M, Aung MS, Shinagawa M, Takahashi S, Kobayashi N. Contribution of type II topoisomerase mutations to fluoroquinolone resistance in Enterococcus faceium from Japanese clinical setting. Microb Drug Resist 2017, in press.
  • ・Kawaguchiya M, Urushibara N, Aung MS, Shinagawa M, Takahashi S, Kobayashi N. Serotype distribution, antimicrobial resistance, and prevalence of pilus islets in pneumococci following the use of conjugate vaccines. J Med Microbiol, 2017, in press.
  • ・Takamatsu A, Kawaguchiya M, Chang B, Ito M, Hirano Y, Katsuta S, Matsuzaka S, SerizawaY, Kobayashi N. First report of serotype 23B Streptococcus pneumoniae isolated from an adult patient with invasive infection in Japan. New Microbes and New Infections, 2017, in press.
  • ・Kawaguchiya M, Urushibara N, Kobayashi N. Multidrug resistance in non-PCV13 serotypes of Streptococcus pneumoniae in northern Japan. Microb Drug Resist, 2017, 23:206-214.
  • ・Gallagher CA, Navarro R, Cruz K, Aung MS, Ng A, Bajak E, Beierschmitt A, Lawrence M, Dore KM, Ketzis J, Malik YS, Kobayashi N, Ghosh S.  Detection of Picobirnaviruses in Vervet Monkeys (Chlorocebus sabaeus): Molecular Characterization of Complete Genomic Segment-2. Virus Res, 2017, in press.
  • ・Navarro R, Aung MS, Zuniga-Brenes K, Ketzis J, Gallagher CA, Beierschmitt A, Malik YS, Kobayashi N, Ghosh S. Whole genome analysis provides evidence for porcine-to-simian interspecies transmission of rotavirus-A. Infect Genet Evol. 2017, in press.
  • ・Saurabh S, Sircar S, Kattoor JJ, Ghosh S, Kobayashi N, Banyai K, Kumar ORV, De U, Sahoo NR, Dhama K, Malik YS. Analysis of porcine rotavirus A enterotoxin gene for structure-function relationship. J Vet Sci 2017, in press.
  • ・Ghosh S, Malik YS, Kobayashi N. Therapeutics and immunoprophylaxis against Noroviruses and Rotaviruses: the past, present, and future. Current Drug Metabolism. 2017, in press.
  • ・Aung MS, Nahar S, Aida S, Paul SK , Hossain MA, Ahmed S, Haque N, Ghosh S, Malik YS , Urushibara N, Kawaguchiya M, Sumi A, Kobayashi N. Distribution of two distinct Rotavirus B (RVB) strains in the north-central Bangladesh and evidence for reassortment event among human RVB revealed by whole genomic analysis. Infect Genet Evol. 2017, 47:77-86.
  • ・Sumi A, Telan EFO, Chagan-Yasutan H, Piolo MB, Hattori T, Kobayashi N. Effect of temperature, relative humidity and rainfall on dengue fever and leptospirosis infections in Manila, the Philippines. Epidemiol Infect, 2017, 145:78-86.

  • 2016年
  • ・Aung MS, Kawaguchiya M, Urushibara N, Sumi A, Ito M, Kudo K, Morimoto S, Hosoya S, Kobayashi N. Molecular characterization of methicillin-resistant Staphylococcus aureus (MRSA) from outpatients in northern Japan : increasing tendency of ST5/ST764 MRSA-IIa with arginine catabolic mobile element (ACME II’). Microb Drug Resist, 2016, DOI: 10.1089/mdr.2016.0176.
  • ・Aida S, Nahar S, Paul SK, Hossain MA, Kabir MR, Sarkar SR, Ahmed S, Ghosh S, Urushibara N, Kawaguchiya M, Aung MS, Sumi A, Kobayashi N. Whole genomic analysis of G2P[4] human Rotaviruses in Mymensingh, north-central Bangladesh. Heliyon, 2016, 2:e00168
  • ・Togashi A, Aung MS, Akane Y, Yoto Y, Tsugawa T, Kawaguchiya M, Tsutsumi H, Kobayashi N. First report of Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus ST88 harboring ΦSa2usa isolated from refractory breast abscesses in Japan. New Microbes and New Infections,2016, 13:62-64.
  • ・Malik YS , Kumar N, Sharma K, Saurabh S, Dhama K, Prasad M, Ghosh S, Bányai K, Kobayashi N, Singh RK. Multispecies reassortant bovine rotavirus strain carries a novel simian G3-like VP7 genotype. Infection Genetics and Evolution, 2016,41:63-72.
  • ・Kohei Y, Sumi A, Kobayashi N. Time series analysis of monthly age-specific numbers of newly registered cases of active tuberculosis in Japan from 1998 to 2013. Epidemiol Infect, 2016,144:2401-2414..
  • ・Urushibara N, Kawaguchia M, Onishi M, Mise K, Aung MS, Kobayashi N. Arginine catabolic mobile elements in methicillin-resistant Staphylococcus aureus (MRSA) genotype ST5-MRSA-II and ST764-MRSA-II in Japan: novel structures and temporal changes. Antimicrob Agents Chemother, 2016,60:3119-3122.

  • ・Pokhrel RM , Aung MS, Thapa B, Chaudhary R, Mishra SK, Kawaguchiya M, Urushibara N, Kobayashi N. Detection of ST772 Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus (Bengal Bay clone) and ST22 S. aureus isolates with a genetic variant of elastin binding protein in Nepal. New Microbes and New Infections 2016,11:20-27.

  • ・Ahmed R, Paul SK, Hossain MA, Ahmed S, Mahmud MC, Nasreen SA, Ferdouse F, Sharmi RH, Ahamed F, Ghosh S, Urushibara N, Aung MS, Kobayashi N. Molecular detection of Rickettsia felis in humans, cats and cat fleas in Bangladesh, 2013-2014. Vector-Borne and Zoonotic Diseases, 2016,16:356-358.
  • ・Aung MS, Zi H, New KM, Maw WW, Aung MT, Min WW, Nyein N, Kawaguchiya M, Urushibara N, Sumi A, Kobayashi N. Drug resistance and genetic characteristics of clinical isolates of staphylococci in Myanmar : high prevalence of PVL among methicillin-susceptible Staphylococcus aureus belonging to various sequence types. New Microbes and New Infections, 2016,10:58-65.
  • ・Kawaguchiya M, Urushibara N, Aung MS, Morimoto S, Ito M, Kudo K, Sumi A, Kobayashi N. Emerging non-PCV13 serotypes of noninvasive Streptococcus pneumoniae with macrolide resistance genes in northern Japan. New Microbes and New Infections, 2016, 9:66-72.

  • 2015年
  • ・Chen B, Sumi A, Toyoda S, Hu Q, Zhou D, Mise K, Zhao J, Kobayashi N. Time series analysis of reported cases of hand, foot, and mouth disease from 2010 to 2013 in Wuhan, China. BMC Infect Dis, 2015,3;15(1):495. doi: 10.1186/s12879-015-1233-0.
  • ・Ghosh S, Navarro R, Malik YS, Willingham AL, Kobayashi N. Whole genomic analysis of a porcine G6P[13] rotavirus strain. Vet Microbiol, 2015, 18;180(3-4):286-98.
  • ・Kattoor JJ, Malik YS, Sasidharan A, Rajan VM, Dhama K, Ghosh S, Bányai K, Kobayashi N, Singh RK. Analysis of codon usage pattern evolution in avian rotaviruses and their preferred host. Infect Genet Evol. 2015, 34:17-25.
  • ・Quiñones D, Carvajal I, Perez Y, Hart M, Perez J, Garcia S, Salazar D, Ghosh S, Kawaguchiya M, Aung MS, Kobayashi N. High prevalence of blaOXA-23 in Acinetobacter spp. and detection of blaNDM-1 in A. soli in Cuba: Report from National Surveillance Program (2010-2012). New Microbes and New Infections, 2015, 7:52-6. doi: 10.1016/j.nmni.2015.06.002.

  • ・Ferdouse F, Hossain MA, Paul SK, Ahmed S, Mahmud MC, Haque AKMF, Khan MNA, Ghosh S, Urushibara N, Kobayashi N. Rickettsia felis infection among humans, Bangladesh, 2012-2013. Emerging Infectious Diseases, 2015, 21(8):1483-5.
  • ・Zhou X, Wang Y-H, Ghosh S, Tang W-F, Pang B-B, Liu M-Q, Peng J-S, ZhouD-J, Kobayashi N. Genomic characterization of G3P[6], G4P[6] and G4P[8] human rotaviruses from Wuhan, China: evidence for interspecies transmission and reassortment events. Infect Genet Evol, 2015, 33:55-71.
  • ・Harigane K, Sumi A, Mise K, Kobayashi N. The Role of Temperature in Reported Chickenpox Cases from 2000 1 to 2011 in Japan. Epidemiol Infect, 2015, 143(12):2666-78.
  • ・Ahmed S, Kawaguchiya M, Ghosh S, Paul SK, Urushibara N, Mahmud MC, Nahar K, Hossain MA, Kobayashi N. Drug resistance and molecular epidemiology of aerobic bacteria isolated from puerperal infections in Bangladesh. Microb Drug Resist, 2015,21(3):297-306.
  • ・Kawaguchiya M, Urushibara N, Kobayashi N. High prevalence of genotype 6E (putative “serotype 6E”) among non-invasive / colonization isolates of Streptococcus pneumoniae in northern Japan. Microb. Drug Resist, 2015, 21(2):209-14.

  • 2014年
  • ・Sarkar SR, Ray NC, Hossain MA, Paul SK, Sarkar S, Kobayashi N. Multiplex polymerase chain reaction for detection of Campylobacter from stool specimen. Mymensingh Med J. 2014, 23:449-455.

  • ・Mullick S, Mandal P, Nayak MK, Ghosh S, De P, Rajendran K, Bhattacharya MK, Mitra U, Ramamurthy T, Kobayashi N, Chawla-Sarkar M. Hospital based surveillance and genetic characterization of rotavirus strains in children (<5 years) with acute gastroenteritis in Kolkata, India, revealed resurgence of G9 and G2 genotypes during 2011–2013. Vaccine, 2014, 32S :A20–A28
  • ・Quiñones D, Carmona Y, Zayas A, Abreu M, Salazar D, García S, Torres D, Kobayashi N, del Campo R. Resistencia antimicrobiana en aislamientos clínicos de Klebsiella spp. y producción de B-lactamasas de espectro extendido en hospitales de Cuba.  Revista Cubana de Medicina Tropical, 2014, 66:386-399.(spanish)
  • ・Santisteban Y, Carmona Y, Pérez Y, Díaz L, García S, Kobayashi N, Quiñones D. Infecciones por los géneros Klebsiella y Acinetobacter en hospitales pediátricos cubanos y resistencia antibiótica Revista Cubana de Medicina Tropical, 2014, 66:400-414. (spanish)
  • ・Malik Y, Kumar N, Sharma K, Shabbir MZ, Balasubramanian G, Kobayashi N, Banyai K, Dhama K. Epidemiology, phylogeny and evolution of emerging enteric picobirnaviruses of animal origin and their relationship to human strains. BioMed Research International, 2014, 780752.
  • ・Quinones D, Hart M, Espinosa F, Garcia S, Carmona Y, Ghosh G, Urushibara N, Kawaguchiya M, Kobayashi N. Emergence of Klebsiella pneumoniae clinical isolates producing KPC-2 carbapenemase in Cuba. New Microbes and New Infections, 2014, 2:123-126.
  • ・Malik YS, Kumar N, Sharma K, Ghosh S, Banyai K, Balasubramanian G, Kobayashi N, Matthijnssens J. Molecular analysis of non structural rotavirus group A enterotoxin gene of bovine origin from India. Infect Genet Evol, 2014, 25:20-27.
  • ・Kawaguchiya M, Urushibara N, Ghosh S, Kuwahara O, Morimoto S, Ito M, Kudo K, Kobayashi N. Serotype distribution and susceptibility to penicillin and erythromycin among non-invasive or colonization isolates of Streptococcus pneumoniae in northern Japan : a cross-sectional study in the pre-PCV7 routine-immunization period. Microb Drug Resist 2014, 20:456-465.
  • ・Malik YS, Sharma AK, Kumar N, Sharma K, Ganesh B, Kobayashi N. Identification and characterisation of a novel genogroup II picobirnavirus in a calf in India. Vet Rec  2014, 174:278.
  • ・Ghosh S, Kobayashi N. Genetic Diversity and Evolution of Human Rotaviruses Based on Whole Genome. British Journal of Virology, 2014, 1:1-9.
  • ・Quinones D, Valverde A, Rodriguez-Banos M, Kobayashi N, Zayaz A, Abreu M, Canton R, Del Campo R. High Clonal Diversity in a Non-Outbreak Situation of Clinical ESBL-Producing Klebsiella pneumoniae Isolates in the First National Surveillance Program in Cuba. Microb Drug Resist. 2014, 20:45-51.
  • ・Ghosh S, Kobayashi N. Exotic Rotaviruses in animals and Rotaviruses in exotic animals. VirusDisease, 2014, 25:158-172.
  • ・Wang YH, Pang BB, Ghosh S, Zhou X, Shintani T, Urushibara N, Song YW, He MY, Liu MQ, Tang WF, Peng JS, Hu Q, Zhou DJ, Kobayashi N. Molecular epidemiology and genetic evolution of the whole genome of G3P[8] human rotavirus in Wuhan, China, from 2000 through 2013. PLoS ONE, 2014, 9:e88850.
  • ・Paul SK, Ghosh S, Kawaguchiya M, Urushibara N, Hossain MA, Ahmed S, Mahmud MC, Jilani MSA, Haq JA, Ahmed AA, Kobayashi N. Detection and genetic characterization of PVL-positive ST8-MRSA-IVa and exfoliative toxin D-positive European CA-MRSA-like ST1931 (CC80)-MRSA-IVa strains in Bangladesh. Microb Drug Resist, 2014, 20:325-336.
  • ・Luo T, Sumi A, Zhou D, Kobayashi N, Mise K, Yu B, Kong D, Wang J, Duan Q. Seasonality of reported tuberculosis cases from 2006 to 2010 in Wuhan, China. Epidemiol Infect, 2014, 142:2036-2048.

  • 2013年
  • ・Onishi M, Urushibara N, Kawaguchiya M, Ghosh S, Shinagawa M, Watanabe N, Kobayashi N. Prevalence and genetic diversity of arginine catabolic mobile element (ACME) in clinical isolates of coagulase-negative staphylococci: identification of ACME type I variants in Staphylococcus epidermidis. Infect Genet Evol. 2013, 20:381-388.
  • ・Kawaguchiya M, Urushibara N, Ghosh S, Kuwahara O, Morimoto S, Ito M, Kudo K, Kobayashi N. Genetic diversity of emerging PVL/ACME-positive ST8-MRSA-IVa and ACME-positive CC5 (ST5/ST764)-MRSA strains in northern Japan. J Med Microbiol, 2013, 62:1852-1863.
  • ・ Yesmin T, Hossain MA, Paul SK, Mahmud C, Kabir MR, Haque N, Sultana S, Mowla G, Bhuiyan MK, Kobayashi N. Prevalence and Antimicrobial Susceptibility Pattern of ESBL Producing Isolates. Mymensingh Med J, 2013, 22:625-631.
  • ・MR Kabir, MA Hossain, MM Alam, SK Paul, Z Begum, US Parvin, N Haque, N Kobayash. Frequency and antimicrobial susceptibility of diarrheagenic Escherichia coli obtained from patients with acute diarrhea in a tertiary care hospital, Bangladesh. Community Based Medical Journal, 2013, 2(2):46-51.
  • ・Ghosh S, Taniguchi K, Aida S, Ganesh B, Kobayashi N. Whole genomic analysis of equine group A rotaviruses from Japan: evidence for bovine-to-equine interspecies transmisson and reassortment events. Vet Microbiol, 2013, 166:474-485.
  • ・Wan M-T, Lauderdale T-L, Kobayashi N, Urushibara N, Chou C-C. Population deviation of piggery-associated methicillin-resistant Staphylococcus aureus based on mec-associated direct repeat unit analysis. Infect Genet Evol, 2013, 16:349-354.
  • ・Hoque SM, Hossain MA, Paul SK, Mahmud MC, Ahmed S, Mahmud NU, Khan ER, Sakib MAM, Ghosh S, Kobayashi N. Detection of Chlamydia trachomatis by immunological and genetic methods in female sex workers and local female population of reproductive age in Mymensingh, Bangladesh. Jpn J Infect Dis, 2013, 66:256-259.
  • ・Wang YH, Pang BB, Zhou X, Ghosh S, Tang WF, Peng JS, Hu Q, Zhou DJ, Kobayashi N. Complex evolutionary patterns of two rare human G3P[9] rotavirus strains possessing a feline/canine-like H6 genotype on an AU-1-like genotype constellation. Infect Genet Evol, 2013, 16:103-112.
  • ・Isogai N, Urushibara N, Kawaguchiya M, Ghosh S, Suzaki K, Watanabe N, Quiñones D, Kobayashi N. Characterization of Enterococcus faecium with macrolide resistance and reduced susceptibility to quinupristin/dalfopristin in a Japanese hospital : detection of extensive diversity in erm(B)-regulator regions. Microb Drug Resist, 2013, 19:298-307.
  • ・Ghosh S, Urushibara N, Chawla-Sarkar M, Krishnan T, Kobayashi N. Whole genomic analyses of asymptomatic human G1P[6], G2P[6] and G3P[6] rotavirus strains reveal intergenogroup reassortment events and genome segments of artiodactyl origin. Infect Genet Evol, 2013, 16:165-173.
  • ・Sumi A, Rajendran K, Ramamurthy T, Krishnan T, Nair GB, Harigane K, Kobayashi N. Effect of temperature, relative humidity, and rainfall on rotavirus infections in Kolkata, India. Epidemiol Infect, 2013,141:1652-1661.
  • ・Kawaguchiya M, Urushibara N, Yamamoto D, Yamashita T, Shinagawa M, Watanabe N, Kobayashi N. Characterization of PVL/ACME-positive methicillin-resistant Staphylococcus aureus (genotypes ST8-MRSA-IV and ST5-MRSA-II) isolated from a university hospital in Japan. Microb Drug Resist, 2013,19:48-56.
  • ・Sumi A, Luo T, Zhou D, Yu B, Kong D, Kobayashi N. Time series analysis of hepatitis A, B, C and E infections in a large Chinese city: Application to prediction analysis. Epidemiol Infect, 2013, 141:905-915.
  • ・Ghosh S, Urushibara N, Kawaguchiya M, Shintani T, Kobayashi N. The origin of two rare human P[10] rotavirus strains. Infect Genet Evol, 2013, 13:292-300.

  • 2012年
  • ・Bhowmick R, Halder UC, Chattopadhyay S, Chanda S, Nandi S, Bagchi P, Nayak MK, Chakrabarti O, Kobayashi N, Chawla-Sarkar M. Rotaviral enterotoxin nonstructural protein 4 targets mitochondria for activation of apoptosis during infection. J Biol Chem, 2012, 287:35004-35020.
  • ・Ganesh B, Banyai K, Kanungo S, Sur D, Malik YS, Kobayashi N. Detection and molecular characterization of porcine picobirnavirus in feces of domestic pigs from Kolkata, India. Indian J Virol, 2012, 23:387-391.
  • ・Mukherjee A, Mullick S, Kobayashi N, Chawla-Sarkar M. The first identification of rare human group A rotavirus strain G3P[10] with severe infantile diarrhea in eastern India. Infect Genet Evol, 2012, 12:1933-1937.
  • ・Pativada M, Nataraju SM, Ganesh B, Rajendran K, Ramamurthy T, Ganguly S, Bhattacharya MK, Ghosh M, Kobayashi N, Krishnan T. Emerging trends in the epidemiology of human astrovirus infection among infants, children and adults hospitalized with acute watery diarrhea in Kolkata, India. Infect Genet Evol, 2012, 12:1685-1693.
  • ・Bagchi P, Nandi S, Chattopadhyay S, Bhowmick R, Halder UC, Nayak MK, Kobayashi N, Chawla-Sarkar M. Identification of common human host genes involved in pathogenesis of different rotavirus strains: an attempt to recognize probable antiviral targets. Virus Res. 2012, 169:144-153.
  • ・Ghosh S, Shintani T, Urushibara N, Taniguchi K, Kobayashi N. Whole genomic analysis of a human G1P[9] rotavirus strain reveals intergenogroup reassortment events. J Gen Virol, 2012, 93:1700-1705.
  • ・Wang YH, Zhou DJ, Zhou X, Yang T, Ghosh S, Pang BB, Peng JS, Liu MQ, Hu Q, Kobayashi N. Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010. Arch Virol, 2012, 157:2417-2424.
  • ・Kabir MR, Hossain MA, PaulSK, Mahmud C, Ahmed S, Mahmud NU, Sultana S, Yesmin T, Hoque SM, Habiba U, Rahman MA, Kobayashi N. Enteropathogens associated with acute diarrhea in a tertiary hospital of Bangladesh. Mymensingh Med J. 2012, 21:618-623.
  • ・Shintani T, Ghosh S, Wang Y-H, Zhou X, Zhou D-J, Kobayashi N. Whole genomic analysis of human G1P[8] rotavirus strains from different age groups in China. Viruses, 2012, 4:1289-1304; doi:10.3390/v4081289
  • ・Urushibara N, Kawaguchiya N, Kobayashi N. Two novel arginine catabolic mobile elements and staphylococcal chromosome cassette mec composite islands in community-acquired methicillin-resistant Staphylococcus aureus genotypes ST5-MRSA-V and ST5-MRSA-II. J Antimicrob Chemother, 2012, 67:1828-1834.
  • ・Ghosh S, Shintani T, Kobayashi N. Evidence for the porcine origin of equine rotavirus strain H-1. Vet Microbiol, 2012, 158:410-414.
  • ・Ganesh B, Bányai K, Martella V, Jakab F, Masachessi G, Kobayashi N. Picobirnavirus infections: viral persistence and zoonotic potential. Rev Med Virol, 2012, 22:245-256.
  • ・Nasreen SA, Hossain MA, Paul SK, Mahmud MC, Ahmed S, Ghosh S, Kobayashi N. PCR-based detection of Leishmania DNA in skin samples of post kala-azar dermal leishmaniasis patients from an endemic area of Bangladesh. Jpn J Infect Dis, 2012, 65:315-317.
  • ・Kabir MR, Hossain MA, Paul SK, Mahmud C, Sultana S, Yesmin T, Haque N, Kobayashi N. Multiplex Polymerase Chain Reaction for Rapid Identification of Diarrheagenic Escherichia coli. Mymensingh Med J. 2012, 21:404-410.
  • ・Sultana S, Hossain MA, Alam MA, Paul SK, Mahmud C, Kabir MR, Haque N, Yesmin T, Kayes MT, Maruf AA, Kobayashi N. Nested polymerase chain reaction for early diagnosis of typhoid Fever. Mymensingh Med J. 2012, 21:21-27.
  • ・Ghosh S, Urushibara N, Taniguchi K, Kobayashi N. Whole genomic analysis reveals the porcine origin of human G9P[19] rotavirus strains Mc323 and Mc345. Infect Genet Evol, 2012, 12:471-477.
  • ・Mukherjee A, Nayak MK, Roy T, Ghosh S, Naik TN, Kobayashi N, Chawla-Sarker M. Detection of human G10 rotavirus strains with similarity to bovine and bovine-like equine strains from untypable samples. Infect Genet Evol, 2012, 12:467-470.
  • ・Sumi A, Kamo K. MEM spectral analysis for predicting influenza epidemics in Japan. Environmental Health and Preventive Medicine, 2012, 17:98-108.
  • ・Hasan MM, Hossain MA, Paul SK, Mahmud C, Khan ER, Rahman MM, Rukunuzzaman M, Hasan MS, Kobayashi N. Evaluation of PCR with culture for the diagnosis of pulmonary tuberculosis. Mymensingh Med J. 2012 Jul;21(3):399-403.
  • ・Rahman A, Hosaain MA, Mahmud C, Paul SK, Sultana S, Haque N, Kabir MR, Kobayashi N. Species distribution of coagulase negative staphylococci isolated from different clinical specimens. Mymensingh Med J. 2012 Apr;21(2):195-9.
  • ・Khan ER, Hossain MA, Paul SK, Mahmud C, Hasan MM, Rahman MM, Nahar K, Kobayashi N. Comparison between ICT and PCR for diagnosis of Chlamydia trachomatis. Mymensingh Med J. 2012 Apr;21(2):190-4.

  • 2011年
  • ・Wang Y-H, Zhou X, Ghosh S, Zhou D-J, Pang B-B, Peng J-S, Hu Q, Kobayashi N. Prevalence of human rotavirus genotypes in Wuhan, China during 2008-2011 : changing trend of predominant genotypes and emergence of strains with P[8]b subtype of VP4 gene. Arch Virol, 2011, 156:2221-2231.
  • ・Aung MS, Urushibara N, Kawaguchiya M, Aung TS, Mya S, San T, Nwe KM, kobayashi N. Virulence factors and genetic characteristics of Methicillin-resistant and -susceptible Staphylococcus aureus isolates in Myanmar. Microbial Drug Resistance, 2011, 17:525-535.
  • ・Ghosh S, Kobayashi N. Whole genomic analysis of rotavirus strains: current status and future prospects. Future Microbiol, 2011, 6:1049-1065.
  • ・Wang F, Wang Y-H, Peng J-S, Zhou X, Tang L, Kobayashi N, Hu Q, Zhou D-J, Huang H-J, Liu M-Q. Genetic characterization of Human astrovirus infection in Wuhan, People’s Republic of China, 2007-2008. Can J Microbiol, 2011, 57:964-968.
  • ・Pativada MS, Chatterjee D, Mariyappa NS, Rajendran K, Bhattacharya MK, Ghosh M, Kobayashi N, Krishnan T. Emergence of unique variants and inter-genotype recombinants of human astroviruses infecting infants, children and adults in Kolkata, India. Int J Mol Epidemiol Genet, 2011, 2:228-235.
  • ・Ghosh S, Adachi N, Gatheru Z, Nyangao J, Yamamoto D, Ishino M, Urushibara N, Kobayashi N. Whole genomic analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains. J Gen Virol, 2011, 92:2201-2208.
  • ・Ghosh S, Paul SK, Yamamoto D, Nagashima S, Kobayashi N. Full Genomic analysis of human rotavirus strains possesing the rare P[8]b VP4 subtype. Infect Genet Evol, 2011, 11:1481-1486.
  • Yamamoto D, Kawaguchiya M, Ghosh S, Ichikawa M, Numazaki K, Kobayashi N. Detection and full genomic analysis of G6P[9] human rotavirus in Japan. Virus Genes, 2011, 43:215-223.
  • Dutta D, Chattopadhyay S, Bagchi P, Halder UC, Nandi S, Mukherjee A, Kobayashi N, Taniguchi K, Chawla-Sarkar M. Active participation of cellular chaperone Hsp90 in regulating the function of Rotavirus nonstructural protein 3 (NSP3). J Biol Chem, 2011, 286:20065-20077.
  • ・Mukherjee A, Ghosh S, Bagchi P, Dutta D, Chattopadhyay S, Kobayashi N, Chawla-Sarkar M. Full genomic analyses of human G4P[4], G4P[6], G9P[19] and G10P[6] strains from North-eastern India: Evidence for interspecies transmission and complex reassortment events. Clin Microbiol Infect, 2011, 17:1343-1346.
  • Nataraju SM, Pativada M, Kumar R, Bhattacharya MK, Bagchi SR, Kobayashi N, Krishnan T. Emergence of novel norovirus recombinants with GII.1/GII.5 NoV RdRp gene and GII.13 NoV capsid gene among children and adults in Kolkata, India. Int J Mol Epidemiol Genet, 2011, 2:130-137.
  • ・Urushibara N, Paul SK, Hossain MA, Kawaguchiya M, Kobayashi N. Analysis of staphylococcal cassette chromosome mec (SCCmec) in Staphylococcus haemolyticus and Staphylococcus sciuri: identification of a novel ccr gene complex with a newly identified ccrA allotype (ccrA7). Microbial Drug Resistance, 2011, 17:291-297.
  • ・Kawaguchiya M, UrushibaraN, Kuwahara O, Ito M, Mise K, Kobayashi N. Molecular characteristics of community-acquired methicillin- resistant Staphylococcus aureus (CA-MRSA) in Hokkaido, northern main island of Japan : identification of ST6 and ST59  PVL-positive CA-MRSA. Microbial Drug Resistance, 2011, 17:241-250.
  • ・Ghosh S, Paul SK, Hossain MA, Alam MM, Ahmed MU, Kobayashi N. Full genomic analyses of two human G2P[4] rotavirus strains isolated in 2005 : Identification of caprine-like VP3 gene. J Gen Virol., 2011, 92:1222-1227.
  • ・Ganesh B, Banyai K, Masachessi G, Mladenova Z, Nagashima S, Ghosh S, Nataraju SM, Pativada M, Kumar R, Kobayashi N. Genogroup I picobirnavirus in diarrhoeic foals: can the horse serve as a natural reservoir for human infection? Vet Res, 2011, 42:52.
  • ・Rajendran K, Sumi A, Bhattachariya MK, Manna B, Sur D, Kobayashi N, Ramamurthy T. Influence of relative humidity in Vibrio cholearae infection : A time series model. Indian J Med Res, 2011, 133:138-145.
  • ・Ganesh B, Nagashima S, Ghosh S, Nataraju SM, Rajendran K, Manna B, Ramamurthy T, Niyogi SK, Kanungo S, Sur D, Kobayashi N, Krishnan T. Detection and molecular characterization of multiple strains of Picobirnavirus causing mixed infection in a diarrhoeic child: Emergence of prototype Genogroup II-like strain in Kolkata, India. Int J Mol Epidemiol Genet, 2011, 2:61-72.
  • ・Yamamoto D, Ghosh S, Kuzuya M, Wang Y-H, Zhou X, Chawla-Sarkar M, Paul SK, Ishino M, Kobayashi N. Whole genomic characterization of human group C rotaviruses: identification of two lineages in VP3 gene. J Gen Virol, 2011, 92:361-369.
  • ・Ribas M, Nagashima S, Calzado A, Acosta G, Tejero Y, Cordero Y, Piedra D, Kobayashi N. Emergence of G9 as a predominant genotype of human rotaviruses in Cuba. J Med Virol, 2011, 83:738-744.
  • ・Ghosh S, Gatheru Z, Nyangao J, Adachi N, Urushibara N, Kobayashi N. Full Genomic analysis of a simian SA11-like G3P[2] Rotavirus strain isolated from an asymptomatic infant : identification of novel VP1, VP6, and NSP4 genotype. Infect Genet Evol, 2011,11:57-63.
  • ・Ghosh S, Gatheru Z, Nyangao J, Adachi N, Urushibara N, Kobayashi N. Full genomic analysis of a G8P[1] Rotavirus strain isolated from an asymptomatic infant in Kenya provides evidence for an artiodactyl-to-human interspecies transmission event. J Med Virol, 2011, 83:367-376.
  • ・Sumi A, Kamo K, Ohtomo N, Mise K, Kobayashi N. Time series analysis of incidence data of influenza in Japan. J Epidemiol, 2011, 21:21-29.
  • ・ Luo T, Sumi A, Zhou D, Kamo K, Yu B, Zhao D, Mise K, Kobayashi N. Study on the effect of measles control programs on periodic structures of the disease eidemics in Wuhan, China. Epidemiol Infect, 2011, 139:257-264.

  • 2010年
  • ・Aung MS, Aung TS, OoKY, Win N, Ghosh S, Yamamoto D, Kobayashi N. Phylogenetic analysis of human rotavirus in Myanmar: detection of Indian-Bangladeshi G1/G2 lingeages, Chinese G3 lineage and OP354-like P[8]lineage and OP354-like P[8] kineage(P[8]b subtype). Southeast Asian J Trop Med Public Health, 2010, 41:1393-1404.
  • ・Nataraju SM, Ganesh B, Das S, Chowdhury S, Nayak MK, Ghosh M, Chatterjee MK, Sarkar U, Mitra U, Bhattacharya MK, Arora R, Kobayashi N, Krishnan T. Emergence of Noroviruses homologous to strains reported from Djibouti (horn of Africa), Brazil, Italy, Japan and USA among children in Kolkata, India. Eur Rev Med Pharmacol Sci, 2010, 14:789-794.
  • ・Nataraju SM, Pativada M, Chatterjee D, Nayak MK, Ganesh B, Bhattacharya MK, Ramamurthy T, Ganguly S, Saha DR, Rajendran K, Ghosh M, Kobayashi N, Krishnan T. Molecular epidemiology of Norovirus infections among children and adults; sequence analysis of region C indicates genetic diversity of NVGII strains in Kolkata, India. Epidemiology and Infection, 2010, 19:1-9.
  • ・Ghosh S, Alam MM, Ahmed MU, Talukdar RI, Paul SK, Kobayashi N. The complete genome constellation of a caprine group A rotavirus strain reveals common evolution with ruminant and human rotavirus strains. J Gen Virol., 2010, 91:2367-2373.
  • ・Bagchi P, Dutta D, Chattopadhyay S, Mukherjee A, Halder UC, Sarkar S, Kobayashi N, Komoto S, Taniguchi K, Chawla-Sarkar M. Rotavirus non-structural protein-1 supresses virus induced cellular apoptosis to facilitate viral growth by activating the cell-survival pathways during early stages of infection. J Virol, 2010, 84:6834-6845.
  • ・Yamamoto D, Ghosh S, Ganesh B, Krishnan T, Chawla-Sarkar M, Alam MM, Aung TS, Kobayashi N. Analysis on genetic diversity and molecular evolution of human group B rotaviruses based on whole genome segments. J Gen Virol, 2010, 91:1772-1781.
  • ・Hirose M, Kobayashi N, Ghosh S, Paul SK, Shen T, Urushibara N, Kawaguchiya M, Shinagawa M, Watanabe N. Identification of Staphylocoagulase genotypes I-X and discrimination of type IV and V subtypes by multiplex PCR assay for clinical isolates of Staphylococcus aureus. Jpn J Infect Dis, 2010,63:257-263.
  • ・Chattopadhyay S, Bagchi P, Dutta D, Mukherjee A, Kobayashi N, Chawla-Sarkar M. Computational identification of the post-translational modification sites and the functional family prediction reveals possible moonlighting role of rotaviral proteins. Bioinformation, 2010, 4:448-451.
  • ・Nagashima S, Kobayashi N, Paul SK, Ghosh S, Chawla-Sarkar M, Hossain MA, Krishnan T. Identification of P[8]b subtype in OP354-like human rotavirus strains by a modified RT-PCR method. Jpn J Infect Dis, 2010, 63:208-211.
  • ・Ghosh S, Kobayashi N, Nagashima S, Chawla-Sarkar M, Krishnan T, Ganesh B, Naik T. Molecular characterization of VP1, VP2, VP4, VP6, NSP1 and NSP2 genes of bovine group B rotaviruses: Identification of novel VP4 genotype. Arch Virol, 2010, 155:159-167.
  • ・Ganesh B, Nataraju SM, Rajendran K, Ramamurthy T, Kanungo S, Manna B, Nagashima S, Sur D, Kobayashi N, Krishnan T. Detection of closely related Picobirnaviruses among diarrhoeic children in Kolkata: - evidence of zoonoses? Infect Genet Evol, 2010, 10:511-516.
  • ・Llanes R, Soria C, Nagashima S, Kobayashi N, Gala A, Guzman D, Feliciano O, Valdes L, Gutierrez O, Fernandez H, Llop A, Wada A. Phenotypic and genetic characterization of antimicrobial profiles of Helicobacter pylori strains in Cuba. J Health Popul Nutr, 2010, 28:124-129.
  • ・Wang Y-H, Kobayashi N, Nagashima S, Zhou X, Ghosh S, Peng J-S, Hu Q, Zhou D-J, Yang Z-Q. Full genomic analysis of a porcine-bovine reassortant G4P[6] rotavirus strain R479 isolated from an infant in China. J Med Virol, 2010, 82:1094-1102.
  • ・Ghosh S, Kobayashi N, Nagashima S, Chawla-Sarkar M, Krishnan T, Ganesh B, Naik T. Full genomic analysis and possible origin of a porcine G12 rotavirus strain RU172. Virus Genes, 2010, 40:382-388.
  • ・石埜正穂. 2009年特許審査基準の改定に見る医療技術の特許保護 ―類型による審査戦略の限界―. 社団法人日本国際知的財産保護協会月報(AIPPI), 2010, 55:236-253.
  • 石埜正穂、翁雅男. iPS細胞技術の展開と特許争奪競争における現状分析. パテント. 2010;63: 59-71.

  • 2009年
  • ・Wang Y-H, Kobayashi N, Zhou X, Nagashima S, Zhu Z-R Peng J-S, Liu M-Q, Hu Q, Zhou D-J, Watanabe S, Ishino M. Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China. J Med Virol, 2009, 81:382-389.
  • ・Mise K, Sumi A, Kobayashi N, Torigoe T, Ohtomo N. Spectral analysis of spatial series data of pathogenic tissue: a study on small intestine in ICR mouse. Jpn J Appl Phys, 48:017001-9, 2009.
  • ・ Watanabe S, Kobayashi N, Quinones D, Hayakawa S, Nagashima S, Uehara N, Watanabe N. Genetic diversity of the low-level vancomycin resistance gene vanC-2/vanC-3 and identification of a novel vanC subtype (vanC-4) in Enterococcus casseliflavus. Microb Drug Resist, 2009, 15:1-9.
  • ・Mukherjee A, Dutta D, Ghosh S, Bagchi P, Chattopadhyay S, Nagashima S, Kobayashi N, Dutta P, Krishnan T, Naik TN, Chawla-Sarkar M. Full genomic analysis of a human group A rotavirus G9P[6] strain from Eastern India provides evidence for porcine to human interspecies transmission. Arch Virol, 2009, 154:733-746.
  • ・Quinones D, Marrero D, Llop A, Kobayashi N, del Campo R. Genetic diversity and antibiotic resistance determinants of Enterococcus faecalis isolates causing pediatric infections in Cuba. J Pediatr Infect Dis, 2009, 4: 267-274.
  • ・ Sumi A, Hemila H, Mise K, Kobayashi N. Predicting the incidence of human campylobacteriosis in Finland with time series analysis. APMIS (Acta Pathologica, Microbiologica, et Immunologica Scandinavica) 2009, 117:614-622.
  • ・Watanabe S, Kobayashi N, Quinones D, Nagashima S, Uehara N, Watanabe N. Genetic diversity of enterococci harboring high-level gentamicin resistance genes aac(6’)-Ie-aph(2”)-Ia or aph(2”)-Ie in a Japanese hospital. Microb Drug Resist, 2009, 15: 185-194.
  • ・Ohtomo K, Kobayashi N, Sumi A, Ohtomo N. Relationship of cholera incidences to El Nino and solar activity elucidated by the time-series analysis. Epidemiol Infect, 2009, 19:1-9.
  • ・ Nagashima S, Kobayashi N, Paul SK, Alam MM, Chawla-Sarkar M, Krishnan T. Characterization of full-length VP4 genes of OP354-like P[8] human rotavirus strains detected in Bangladesh which represent a novel P[8] subtype. Arch Virol, 2009, 154:1223-1231.
  • ・Dutta D, Bagchi P, Chatterjee A, Nayak MK, Mukherjee A, Chattopadhyay S, Nagashima S, Kobayashi N, Komoto S, Taniguchi K, Chawla-Sarkar M. The molecular chaperone heat shock protein-90 positively regulates rotavirus infection. Virology, 2009, 391:325-333.
  • ・Aung TS, Kobayashi N, Nagashima S, Ghosh S, Aung MS, Oo KY, Win N. Detection of group B rotavirus in an adult with acute gastroenteritis in Yangon, Myanmar. J Med Virol, 2009, 81:1968-1974.
  • ・Ghosh S, Kobayashi N, Nagashima S, Naik TN. Molecular characterization of full-length genomic segment 2 of a bovine picobirnavirus strain : evidence for high genetic diversity with genogroup I picobirnaviruses. J Gen Virol, 2009, 90:2519-2524.
  • ・Quinones D, Kobayashi N, Nagashima S. Molecular epidemiologic analysis of Enterococcus faecalis isolates in Cuba by multilocus sequence typing. Microb Drug Resist, 2009, 15:287-293.
  • ・ 今野美紀,澤田いずみ,高橋由美子,仲田みぎわ,道信良子,中島そのみ,青木光広,明石浩史,佐藤利夫,三瀬敬治,寺田豊,高橋延昭,相馬仁,當瀬規嗣,丸山知子,今井浩三.地域医療マインドをもつ医療人の育成.札幌医科大学医学部・保健医療学部合同カリキュラム「地域医療合同セミナー」の評価.日本ルーラルナーシング学会誌4:51-57, 2009
  • ・石埜正穂. 大学におけるライフサイエンス研究と特許出願. 産学官連携ジャーナル, 2009, 5:39-41.
  • ・石埜正穂. iPS細胞技術とそれをめぐる特許出願動向についての分析. パテント. 2009, 62:23-32.
  • ・石埜正穂、前直美、梅田慎介. ジャパン・ティッシュ・エンジニアリングの知財戦略. パテント. 2009, 62:42-46.

  • 2008年
  • ・Alam MM, Kobayashi N, Ishino M, Nagashima S, Paul SK, Chawla-Sarkar M, Krishnan T, Naik TN. Identical rearrangement of NSP3 genes found in three independently isolated virus clones derived from mixed infection and multiple passages of rotaviruses. Arch Virol, 2008, 153:555-559.
  • ・Urasawa S, Wu H, Taniguchi K, Liu H, Wang Y, Kobayashi N, Urasawa T. Clinico-epidemiological study of rotavirus diarrhea in Wuhan, China and Muntinlupa, Philippines -Part I Study in Wuhan, China-. 臨床小児医学, 2008, 56:7-23.
  • ・Aung TS, Kobayashi N, Oo KY, Aung MS. Prevalence of human rotavirus in adult diarrheal patients in Myanmar, 2002-2003. Myanmar Journal of Current Medical Practice, 2008, 12:2-5.  
  • ・Kinoshita M, Kobayashi N, Nagashima S, Ishino M, Otokozawa S, Mise K, Sumi A, Tsutsumi H, Uehara N, Watanabe N, Endo M. Diversity of staphylocoagulase and identification of novel variants of staphylocoagulase gene in Staphylococcus aureus. Microbiol Immunol, 2008, 52:334-348.
  • ・Nayak MK, Balasubramanian G, Sahoo GC, Bhattacharya R, Vinje J, Kobayashi N, Sarkar MC, Bhattacharya MK, Krishnan T. Detection of a novel intergenogroup recombinant Norovirus from Kolkata, India. Virology, 2008, 337:117-123.
  • ・Nagashima S, Kobayashi N, Ishino M, Alam MM, Ahmed MU, Paul SK, Ganesh B, Chawla-Sarkar M, Krishnan T, Naik TN, Wang Y-H. Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus. J Med Virol, 2008, 80:2023-2033.
  • ・Afroz S, Kobayashi N, Nagashima S, Alam MM, Hossain ABMB, Rahman A, Islam MR, Lutfor AB, Muazzam N, Khan MAH, Paul SK, Shamsuzzaman AKM, Mahmud MC, Musa AKM, Hossain MA. Genetic characterization of Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in Bangladesh. Jpn J Infect Dis, 2008, 61:393-396.
  • ・Ghosh S, Samajdar S, Sinha M, Kobayashi N, Taniguchi K, Naik TN. Molecular characterization of rare bovine group A rotavirus G15P[11] and G15P[21] strains from eastern India: identification of simian SA11-like VP6 genes in G15P[21] strains. Virus Genes, 2008, 37:241-249.
  • ・Samajdar S, Ghosh S, Chawla-Sarkar M, Mitra U, Dutta P, Kobayashi N, Naik TN. Increase in prevalence of human group A rotavirus G9 strains as an important VP7 genotype among children in eastern India. J Clin Virol, 2008, 43:334-339.
  • ・Samajdar S, Ghosh S, Dutta D, Chawla-Sarkar M, Kobayashi N, Naik TN. Human group A rotavirus P[8] Hun9-like and rare OP354-like strains are circulating among diarrhoeic children in Eastern India. Arch Virol, 2008, 153:1933-1936.
  • ・Paul SK, Kobayashi N, Nagashima S, Ishino M, Watanabe S, Alam MM, Ahmed MU, Hossain MA, Naik TN. Phylogenetic analysis of rotaviruses with genotypes G1, G2, G9 and G12 in Bangladesh : evidence for a close relationship between rotaviruses from children and adults. Arch Virol, 2008, 153:1999-2012.
  • ・Urasawa S, Carlos C, Taniguchi K, Mate R, Kobayashi N, Urasawa T. Clinico-epidemiological study of rotavirus diarrhea in Wuhan, China and Muntinlupa, Philippines ?Part II Study in Muntinlupa, Philippines-臨床小児医学, 2008, 56:63-76.
  • ・Zhou X, Wang Y-H, Kobayashi N, Zhu Z-R, Liu M-Q, Peng J-S, Zhou D-J. Cultivation, identification and significance of 44 strains of human group A rotaviruses detected in Wuhan. Chinese Journal of Zoonoses, 2008, 24: 919-922 (in Chinese).
  • ・Quinones D, Marrero D, Falero B, Tamargo I, Llop A, Kobayashi N. Susceptibilidad antimicrobiana y factores de virulencia en especies de Enterococcus causantes de infecciones pediatricas en Cuba. Rev Cubana Med Trop 2008; 60: 123-129. (in Spanish).
  • ・石埜正穂. 研究のアウトプットの両輪としての論文と特許 --- 論文化と特許化で分岐する研究の道筋. 蛋白質・核酸・酵素2008;53(14) :1905-1911
  • ・石埜正穂. 研究のアウトプットの両輪としての論文と特許 --- 特許に必要とされる実証データの実際. 蛋白質・核酸・酵素2008;53(15): 2007-2012

  • 2007年
  • ・Alam MM, Kobayashi N, Ishino M, Ahmed MS, Ahmed MU, Paul SK, Muzumdar BK, Hussain Z, Wang Y-H, Naik TN. Genetic analysis of an ADRV-N-like rotavirus strain B219 detected in a sporadic case of adult diarrhea in Bangladesh. Arch Virol, 2007, 152:199-208.
  • ・Ghosh S, Varghese V, Samajdar S, Bhattacharya SK, Kobayashi N, Naik TN. Evidence for independent segregation of the VP6 and NSP4 encoding genes in porcine group A rotavirus G6P[13] strains. Arch Virol 2007, 152:423-429.
  • ・ Ghosh S, Varghese V, Sinha M, Kobayashi N, Naik TN. Evidence for interstate transmission and increase in prevalence of bovine group B rotavirus strains with a novel VP7 genotype among diarrhoeic calves in Eastern and Northern states of India. Epidemiol Infect 2007, 135:1324-1330.
  • ・Wang Y-H, Kobayashi N, Zhou D-Z, Yang Z-Q, Zhou X, Peng J-S, Zhu Z-R, Zhao D-F, Liu M-Q, Gong J. Molecular epidemiologic analysis of group A rotaviruses in adults and children with diarrhea in Wuhan city, China, 2000-2006. Arch Virol 2007, 152:669-685.
  • ・Sano H, Ishino M, Kramer H, Shimizu T, Mitsuzawa H, Nishitani C, Kuroki Y. The microtubule binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. J Biol Chem 2007, 282:7973-7981.
  • ・Sumi A, Kamo K, Ohtomo N, Kobayashi N. Study of the effect of vaccination on periodic structures of measles epidemics in Japan. Microbiol Immunol 2007, 51:805-814.
  • ・Ghosh S, Varghese V, Samajdar S, Sinha M, Kobayashi N, Naik TN. Molecular characterization of bovine group A rotavirus G3P[3] strains. Arch Virol 2007, 152:1935-1940.
  • ・Ghosh S, Varghese V, Samajdar S, Sinha M, Naik TN, Kobayashi N. Evidence for bovine origin of VP4 and VP7 genes of human group A rotavirus G6P[14] and G10P[14] strains. J Clin Microbiol 2007, 45:2751-2753.

  • 2006年
  • ・Ishino M, Mise K, Takemura H, Ahmed MU, Alam MM, Naik TN, Kobayashi N. Comparison of NSP4 protein between group A and B human rotaviruses : detection of novel diarrhea-causing sequence in group B NSP4. Arch Virol., 2006, 151:173-182.
  • ・ Iijima Y, Iwamoto T, Nukuzuma S, Ohishi H, Hayashi K, Kobayashi N. An outbreak of rotavirus infection among adults in an institution for rehabilitation: long-term residence in a closed community as a risk factor for rotavirus illness. Scand J Infect Dis, 2006, 38:490-496.
  • ・Varghese V, Ghosh S, Das S, Bhattacharya SK, Krishnan T, Karmakar P, Kobayashi N, Naik TN. Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains. Virus Genes, 2006, 32:241-247.
  • ・Ghosh S, Varghese V, Samajdar S, Bhattacharya SK, Kobayashi N, Naik TN. Molecular characterization of a porcine Group A rotavirus strain with G12 genotype specificity. Arch Virol, 2006, 151:1329-1344.
  • ・Samajdar S, Varghese V, Barman P, Ghosh S, Mitra U, Dutta P, Bhattacharya SK, Narsingham MV, Panda P, Krishnan T, Kobayashi N, Naik TN. Changing pattern of human group A rotaviruses: Emergence of G12 as an important pathogen among children in eastern India. J Clin Virol, 2006, 36:183-188.
  • ・Barman P, Ghosh S, Samajdar S, Mitra U, Dutta P, Bhattacharya SK, Krishnan T, Kobayashi N and Naik TN. RT-PCR based diagnosis revealed importance of human group B rotavirus infection in childhood diarrhoea. J Clin Virol, 2006, 36:222-227.
  • ・Alam MM, Kobayashi N, Ishino M, Naik TN, Taniguchi K. Analysis on genetic factors related to preferential selection of NSP1 gene segment observed in mixed infection and multiple passage of rotaviruses. Arch Virol, 2006, 151:2149-2159.
  • ・Wang Y-H, Zhou X, Kobayashi N, Zhu Z-R, Liu M-Q, Yang Z-Q. Amplification of entire fragment of group C rotavirus genes and the sequence analysis on VP6 and VP7 genes in the field strain Wu-82 isolated in Wuhan area. Chinese Journal of Zoonoses, 2007, 23:1167-1171. (in Chinese).
  • ・石埜正穂、一瀬信敏. 新しい医療技術の普及と知的財産リテラシー教育 −医療技術移転の現場から−. パテント. 2007, 60:48-54.

  • 2005年
  • ・Nishimoto Y, Kobayashi N, Alam MM, Ishino M, Uehara N, Watanabe N. Analysis of the prevalence of tetracycline resistance genes in clinical isolates of Enterococcus faecalis and Enterococcus faecium in a Japanese hospital. Microb Drug Resist, 2005, 11:146-153.
  • ・ Sumi A, Kobayashi N, Ohtomo N. Proportion of sporadic gastroenteritis cases caused by rotavirus, norovirus, adenovirus, and bacteria in Japan from January 2000 to December 2003. Microbiol Immunol, 2005, 49:745-756.
  • ・Alam MM, Kobayashi N, Ishino M, Sumi A, Kobayashi K, Uehara N, Watanabe N. Detection of a novel aph(2”) Allele (aph(2”)-Ie) conferring high-level gentamicin resistance and a spectinomycin resistance gene ant(9)-Ia (aad9) in clinical isolates of enterococci. Microb Drug Resist, 2005, 11:239-247.
  • ・Rahman MT, Kobayashi N, Alam MM, Ishino M. Genetic Anyalysis of mecA Homologues in Staphylococcus sciuri strains derived from mastitis in dairy cattle. Microb Drug Resist, 2005, 11:205-214.
  • ・Higashino F, Aoyagi M, Takahashi A, Ishino M, Taoka M, Isobe T, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M. Adenovirus E4 or f16 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism. J Cell Biol, 2005,170:15-20.
  • ・Sumi A, Ohtomo K, Kobayashi N. Prediction analysis of surveillance data of infectious diseases in Japan. Bull Marine Biomed Inst Sapporo Med Univ (札幌医科大学臨海医学研究所紀要), 2005, 6:1-14.
  • ・石埜正穂. 特許法第35条が大学教員の発明の円滑な活用に与える問題点について. パテント. 2005, 58:44-49.

  • 2004年
  • ・Ahmed MU, Kobayashi N, Wakuda M, Sanekata T, Taniguchi K, Kader A, Naik TN, Ishino M, Alam MM, Kojima K, Mise K, Sumi A. Genetic analysis of group B human rotaviruses detected in Bangladesh in 2000 and 2001. J Med Virol 2004, 72:149-155.
  • ・Das S, Varghese V, Chaudhuri S, Barman P, Kojima K, Dutta P, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Genetic variability of human rotavirus strains isolated from eastern and northern India. J Med Virol 2004, 72:156-161.
  • ・Varghese V, Das S, Singh Ng B, Kojima K, Bhattacharya SK, Krishnan T, Kobayashi N, Naik TN. Molecular characterization of a human rotavirus reveals porcine characteristics in most of the genes including VP6 and NSP4. Arch Virol 2004, 149:155-172.
  • ・Barman P, Ghosh S, Das S, Varghese V, Chaudhuri S, Sarkar S, Krishnan T, Bhattacharya SK, Chakrabarti A, Kobayashi N, Naik TN. Sequencing and sequence analysis of VP7 and NSP5 gene reveal emergence of a new genotype of bovine group B rotaviruses in India. J Clin Microbiol 2004, 42:2816-2818.
  • ・Shiomi H, Urasawa T, Urasawa S, Kobayashi N, Taniguchi K. Isolation and characterization of poliovirus mutants resistant to heating at 50°C for 30 min. J Med Virol 2004, 74:484-491.
  • Yang J-H, Kobayashi N, Wang Y-H, Zhou X, Li Y, Zhou D-J, Hu Z-H, Ishino M, Alam MM, Naik TN, Ahmed MU. Phylogenetic analysis of a human group B rotavirus WH-1 detected in China in 2002. J Med Virol 2004, 74:662-667.
  • Kobayashi N, Alam MM, Ishino M, Mise K. Genomic and structural diversity of antiseptic resistance gene smr encodind multidrug efflux protein in staphylococci. Drug Design Reviews – Online, 2004, 1:303-312.
  • ・石埜正穂.生命科学分野の特許発明に関する試験研究の実施を担保する環境について.知財管理 2004、54:1613-1622.
  • ・ Wang Y-H, Zhou X, Kobayashi N, Shan J-G, Zhou D-J, Diao P, Yan L, Yang Z-Q. Surveillance of rotavirus infection in adult patients with diarrhea and the genotype study of group A rotavirus. Chin. J.Zoonoses. 2004, 20:980-982. (in Chinese).

  • 2003年
  • ・Alam MM, Kobayashi N, Uehara N, Watanabe N. Genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus. Microb Drug Resist, 2003, 9:109-121.
  • ・Sanekata T, Ahmed MU, Kader A, Taniguchi K, Kobayashi N. Human group B rotavirus infections cause severe diarrhea in children and adults in Bangladesh. J Clin Microbiol 2003, 41:2187-2190.
  • ・Das S, Varghese V, Chaudhury S, Barman P, Mahapatra S, Kojima K, Bhattacharya SK, Krishnan T, Ratho RK, Chhotray GP, Phukan AC, Kobayashi N, Naik TN. Emergence of novel group A rotavirus G12 strains in India. J Clin Microbiol 2003, 41:2760-2762.
  • ・Alam MM, Ishino M, Kobayashi N. Analysis on genomic diversity and evolution of low-level antiseptic resistance gene smr in Staphylococcus aureus. Microb Drug Resist 2003, 9 suppl.:1-7.
  • ・Wakuda M, Nagashima S, Kobayashi N, Pongsuwanna Y, Taniguchi K. Serologic and genomic characterization of a G12 human rotavirus in Thailand. J Clin Microbiol, 2003, 41:5764-5769.
  • ・Sumi A, Olsen LF, Ohtomo N, Tanaka Y, Sawamura S. Spectral study of measles epidemics: the dependence of spectral gradient on the population size of the community. Jpn J Appl Phys, 2003, 42:721-733.
  • ・Sumi A, Ohtomo N, Tanaka Y, Sawamura S, Olsen LF, Kobayashi N. Prediction analysis for measles epidemics. Jpn J Appl Phys, 2003, 42:7611-7620.
  • ・Oda S, Wada I, Miura K, Okawa K, Kadoya T, Kato T, Nishihara H, Maeda M, Tanaka S, Nagashima K, Nishitani C, Matsuno K, Ishino M, Machesky LM, Fujita H, Randazzo P. CrkL directs ASAP1 to peripheral focal adhesions. J Biol Chem, 2003, 278:6456-6460.
  • ・Tang S-W, Tang L, Wang B, Kobayashi N, Yang J-H. Structural protein vp7 gene sequence analysis of  human group B rotavirus strain WH-2. Virologica Sinica, 2003, 18:432-436. (in Chinese).
  • ・Li W-L, Tang L, Wang B, Tang S-W, Kobayashi N, Li Y, Duan J-J, Yang J-H. Analysis of non-tructural protein NSP2 gene sequence and protein structure of human group B rotavirus strain WH-1.Chin J Microbiol Immunol, 2003, 23:853-857.(in Chinese).

  • 2002年
  • ・Das S, Sen A, Uma G, Varghese V, Chaudhuri S, Bhattacharia SK, Krishnan T, Dutta P, Dutta D, Bhattacharia MK, Mitra U, Kobayashi N, Naik TN. Genomic diversity of group A rotavirus strains infecting humans in eastern India. J Clin Microbiol 2002, 40:146-149.
  • ・Takeyama K, Kunishima Y, Matsukawa M, Takahashi S, Hirose T, Kobayashi N, Kobayashi I, Tsukamoto  T. Multidrug-resistant Pseudomonas aeruginosa isolated from the urine of patients with urinary tract infection. J Infect Chemother 2002, 8:59-63.
  • ・Pongsuwanna Y, Guntapong R, Chiwakul M, Tacharoenmuang R, Onvimala N, Wakuda M, Kobayashi N, Taniguchi K. Detection of a human rotavirus with G12 and P[9] specificity in Thailand. J Clin Microbiol 2002, 40:1390-1394.

  • 2001年
  • ・Sen A, Kobayashi N, Das S, Krishnan T, Bhattacharya SK, Naik TN. The evolution of human group B rotaviruses. Lancet 2001, 357:198-199.
  • ・ Kobayashi N, Alam MM, Urasawa S. Genomic rearrangement of the mec regulator region mediated by  insertion of IS431 in methicillin resistant staphylococci. Antimicrob Agents Chemother 2001, 45:335-338.
  • ・Kobayashi N, Alam MM, Urasawa S. Analysis on distribution of insertion sequence IS431 in clinical isolates of staphylococci. Diagn Microbiol Infect Dis 2001, 39:61-64.
  • ・Kobayashi N, Alam MM, Nishimoto Y, Urasawa S, Uehara N, Watanabe N. Distribution of aminoglycoside resistance genes in recent clinical isolates of Enterococcus faecalis, Enterococcus faecium and Enterococcus avium. Epidemiol Infect 2001, 126:197-204.
  • ・ Kobayashi N, Naik TN, Kusuhara Y, Krishnan T, Sen A, Bhattacharya SK, Taniguchi K, Alam MM,  Urasawa T, Urasawa S. Sequence analysis of genes encoding structural and nonstructural proteins of a human group B rotavirus detected in Calcutta, India. J Med Virol 2001, 64:583-589.
  • ・ Sasaki J, Kusuhara Y, Maeno Y, Kobayashi N, Yamashita T, Sakae K, Takeda N, Taniguchi K.  Construction of an infectious cDNA clone of Aichi virus(a new member of the family Picornaviridae) and mutational analysis of a stem-loop structure at the 5’ end of the genome. J Virol 2001, 75:8021-8030.
  • 著書・総説他
    2001-2017年
  • ・小林宣道、アーメッド サルマ、鷲見紋子、漆原範子、川口谷充代、アウン メイジソウ.バングラデシュにおける産褥期感染症に関する共同研究.日本衛生学雑誌、2017、72:106-111.
  • ・鷲見紋子, 小林 宣道.中国・インド・フィリピン・北欧との感染症発生動向に関する共同研究.日本衛生学雑誌、2017、72:112-122.
  • ・小林宣道、川口谷充代、漆原範子、メイジ ソウアウン.グローバル感染症と薬剤耐性菌対策の動向.〜最近のMRSA、薬剤耐性肺炎球菌の特徴について〜.産業医学ジャーナル、2017、40:52-57.
  • ・小林宣道. Vaccine Topic-ロタウイルスの分子疫学の意義とワクチン導入後の動向. Vaccine Digest、2016、第11号3-4.
  • ・小林宣道(分担執筆).人獣共通感染症(改訂3版)、IV.細菌性人獣共通感染症 3.腸球菌感染症 p240-244. 医薬ジャーナル社(東京)、2016.
  • ・小林宣道.ロタウイルスの分子疫学 −遺伝子型の世界的動向−.最新医学、2015、70(11月増刊号):2247-2255.
  • ・小林宣道(分担執筆) 南山堂 医学大辞典 第20版、学校感染症(p.380)、感染症法(p.160, 161)、検疫(p.717)、国連合同エイズ計画(p.846)、南山堂(東京)、2015.
  • ・Ganesh B, Banyai K, Kobayashi N. Chapter 3 : Picobirnaviruses. In : Malik YS, Pandey AB, Kataria JM, editors. Trends in Diagnosis of Animal Viral Diseases. AGRI-BIOVET PRESS, New Delhi, India, 2013, 37-50.

  • ・小林宣道(分担執筆). NEW予防医学・公衆衛生学(改訂第3版)、4部 環境と健康、4章 食品保健、E.食中毒 p.291-294、南江堂(東京)、2012.

  • ・小林宣道.全遺伝子配列に基づくヒトロタウイルスの遺伝子型別とその世界的な動向.病原微生物検出情報(月報)(IASR), 2014, 35(No.409):66-67.
  • ・小林宣道.特集:国際感染症の現状と課題.感染性胃腸炎の現状と対策.公衆衛生、2012、76:610-614
  • ・Luo Tongyong, Zhou Dunjin, Ayako Sumi. Time Series Analysis Based By Spectral Power Distribution (PSD) – Maximum Entropy Method (MEM), Chinese Journal of Health Statistics. 2010, 27:477-479, 484. (中国語)
  • ・小林宣道.ロタウイルスの遺伝子型 -最近の世界的な動向について-.病原微生物検出情報(月報)(IASR), 2011, 32(No.373):64-66.
  • Alam MM, Kobayashi N, Ishino M, Ghosh S. Preferential assortment of rearranged NSP3 gene in the genetic background of simian rotavirus SA11. In A. Méndez-Vilas, Editor. Communicating Current Research and Educational Topics and Trends in Applied Microbiology ( Microbiology Book Series no.2 – 2010 Edition) Formatex , Spain , 2010, 773-778.
  • ・小林宣道. 各論(食中毒の臨床)ウイルス性食中毒. 臨床検査. 2009.53:688-692.
  • ・Kobayashi N. Ishino M. Wang Y-H., Chawla-Sarkar M, Krishnan T, Naik T.N. Diversity of G-type and P-type of human and animal rotaviruses and its genetic background. In A. Mendez-Vilas, Editor. Communicating Current Research and Educational Topics and Trends in Applied Microbiology(Microbiology Book Series, No.1, 2007 Edition) Formatex, Spain, 2007. 847-858.
  • ・小林宣道. ロタウイルスワクチンの開発・実用化に関する最近の動向. ウイルス感染症セミナー、2007,9:25-39.
  • ・小林宣道、長嶋茂雄.特集:注目される感染症 診断と治療の進歩 V.病院内感染症 3.ウイルス性感染性腸炎.日本内科学会雑誌, 2007, 96:2476-2483.
  • ・Kobayashi N, editor. Drug Resistance of Enterococci: Epidemiology and Molecular Mechanisms. Trivandrum, India, Research Signpost. 2006.
  • ・ Kobayashi N, Alam M. Prevalence and genetic diversity of aminoglycoside modifying enzymes in enterococci. In: Kobayashi N, editor. Drug Resistance of Enterococci: Epidemiology and Molecular Mechanisms. Trivandrum, India, Research Signpost. 2006, 209-227.
  • ・小林宣道、田中智之.特集-今、感染症は:ノロウイルス感染症. Pharma Medica, 2006, 24:21-25.
  • ・小林宣道、鷲見紋子.ウイルス感染症−研究と臨床の最前線 ウイルス性感染性腸炎.医学のあゆみ、2006, 218:868-876〔別冊医学のあゆみ ウイルス感染症−研究と臨床の最前線、ウイルス性感染性腸炎.2007、52-60〕.
  • ・鷲見紋子、小林宣道、大友詔雄. 日本における感染症発生と病原体発生の季節変動 −感染症サーベイランスデータと病原微生物検出情報の相互利用−北海道公衆衛生学雑誌 2006, 20:42-51.
  • ・大友詔雄、鷲見紋子、大友健太.時系列データ解析に関する一考察. 札幌医科大学臨海医学研究所紀要, 2005, 6:41-48.
  • ・鷲見紋子、三瀬敬治、鳥越俊彦、小林宣道、大友詔雄.上皮組織の空間構造に関する研究スペクトル解析からの展望-. 札幌医科大学臨海医学研究所紀要, 2005, 6:59-66.
  • ・石埜正穂.Far Western法.福井泰久(編).生物化学実験法 49 細胞内シグナル伝達.東京、学会出版センター.2004, 89-93.
  • ・小林宣道、石埜正穂、王遠虹. 臨床微生物学−注目される最近の展開−Uウイルスのジェノタイプ ロタウイルス. 臨床と微生物、2004, 31:155-161.
  • ・Kobayashi N, editor. Genetic diversity and molecular epidemiology of rotaviruses. Trivandrum, India, Research Signpost. 2003.
  • ・Kobayashi N, Alam MM, Kojima K, Ishino M, Sumi A. Genomic diversity and evolution of rotaviruses : an overview. In: Kobayashi N, editor. Genetic diversity and molecular epidemiology of rotaviruses. Trivandrum, India, Research Signpost. 2003, 75-89.
  • ・Kobayashi N, Naik TN, Ahmed MU. Genomic diversity and molecular evolution of group B human rotaviruses. In: Kobayashi N, editor. Genetic diversity and molecular epidemiology of rotaviruses. Trivandrum, India, Research Signpost. 2003, 91-103.
  • ・Sumi A, Kobayashi N. A new development of chaos analysis and a possibility of its application to epidemics of rotavirus infection. In: Kobayashi N, editor. Genetic diversity and molecular epidemiology of rotaviruses. Trivandrum, India, Research Signpost. 2003, 105-117.
  • ・ Sen A, Kobayashi N, Bhattacharya SK, Naik TN. Molecular characterization and epidemiology of group B rotaviruses. In: Raghunath D, Nayak R, editors. Diarrhoeal diseases-current status, research trends and field studies. New Dheli, Tata McGraw-Hill Publishing. 2003, 137-178.
  • ・Kobayashi N, Alam MM, Ishino M. Genomic diversity of antiseptic resistance genes in staphylococci. In: S.G.Pandalai, editor. Recent Research Developments in Antimicrobial Agents & Chemotherapy (Vol.6-2003). Trivandrum, India, Research Signpost. 2003, 53-64.
  • ・鷲見紋子、小林宣道. 感染症のダイナミクス 札幌医学雑誌 2003, 72:23-29.
  • ・小林宣道、石埜正穂. 胃腸炎ウイルス感染と遺伝子診断の進歩. 総合臨床 2002, 51:2937-2943.
  • ・小林宣道、石埜正穂. ロタウイルスによる感染性胃腸炎の病態と予防. 日本医事新報 2002, 4094:12-14.
  • ・小林宣道、浦澤正三. ロタウイルス. ウイルス2001, 50:157-172.

  • 外部研究資金および研究プロジェクト 2001-2017年


    科学研究費補助金によるもの:
  • ・アジア・カリブ開発途上地域における新興薬剤耐性菌の蔓延実態解明と包括的分子疫学(課題番号17H04664)平成29-31年度科学研究費補助金 基盤研究(B)小林宣道(代表)、鷲見紋子、漆原範子、川口谷充代、メイジソウアウン

    ・日本と中国における結核の時間的・空間的な流行動態に関する研究(課題番号16K09061)平成28-30年度科学研究費助成事業(学術研究助成基金助成金)基盤研究(C)鷲見紋子(代表)、小林宣道

    ・新規ワクチン開発に向けた肺炎球菌の血清型、薬剤耐性および表層抗原の分子疫学的研究 (課題番号16K09101)平成28-30年度科学研究費助成事業(学術研究助成基金助成金)基盤研究(C)川口谷充代(代表)、小林宣道、漆原範子

    ・ブドウ球菌の動く遺伝因子「SCC複合体」の新規遺伝子構造と分子疫学的性状解析(課題番号15K08781)平成27-29年度科学研究費助成事業(学術研究助成基金助成金)基盤研究(C)
    漆原範子(代表)、小林宣道

    ・新規遺伝学的手法による肺炎球菌の血清型および薬剤耐性の分子疫学的解析(課題番号26893212)平成26‐27年度科学研究費助成事業(研究活動スタート支援)川口谷充代(代表)

    ・わが国に出現した新規市中感染型MRSAの蔓延状況と分子疫学的性状の解明
    課題番号26460804 平成26-29年度 基盤研究(C)小林宣道(代表)、鷲見紋子、漆原範子、川口谷充代

    ・新規網羅的全ゲノム解析法に基づくアジアのロタウイルスの分子疫学と集団流行動態
    課題番号25305022 平成25-28年度 基盤研究(B) 小林宣道(代表)、鷲見紋子、漆原範子、ゴッシュ ソウビック

    ・中国における結核およびインフルエンザの時間的・空間的な流行動態に関する研究
    課題番号25460769 平成25-27年度 基盤研究(C) 鷲見紋子(代表)、小林宣道、ゴッシュ ソウビック

    ・MRSAの新規SCCmec-ACME複合体の遺伝子構造解析と分子疫学調査への応用
    課題番号24590751 平成24-26年度 基盤研究(C) 漆原範子(代表)、小林宣道

    ・市中感染型MRSA新興クローンの同定と伝播動態に関する分子疫学的解析
    課題番号23590746 平成23-25年度 基盤研究(C) 小林宣道(代表)、漆原範子、鷲見紋子、
    ゴッシュ ソウビック

    ・アジアを席巻する新変異型、新興型ロタウイルス感染症の流行動態と蔓延の分子機序
    課題番号22406017 平成22-24年度 基盤研究(B) 小林宣道(代表)、石埜正穂、鷲見紋子、漆原範子

    ・ライフサイエンスの研究で生まれる価値ある創作物の著作権制度による保護
    課題番号22653013 平成22-23年度 挑戦的萌芽研究 石埜正穂(代表)、飯田香緒里、高林龍

    ・ロタウイルスの遺伝学的多様性と種間伝播に関する研究
    平成20-21年度 特別研究員奨励費 小林宣道、Ghosh S.

    ・新規分子疫学的手法を用いたPVL陽性黄色ブドウ球菌・MRSAの蔓延状況の解明
    課題番号20590608 平成20-22年度 基盤研究(C) 小林宣道(代表)、石埜正穂、鷲見紋子、長嶋茂雄

    ・インフルエンザの時間的および空間的な流行動態に関する研究 課題番号20590609
    平成20-22年度 基盤研究(C) 鷲見紋子(代表)、加茂憲一、小林宣道

    ・アジアで発見された新種ヒトロタウイルスの性状と浸淫状況に関する研究
    課題番号18406018 平成18-20年度 基盤研究(B) 小林宣道(代表)、石埜正穂、鷲見紋子、
    三瀬敬治、谷口孝喜

    ・外来病原因子による下痢発症生理におけるプロテオーム解析 課題番号18659173
    平成18-19年度 萌芽研究 石埜正穂(代表)

    ・腸球菌における消毒剤耐性遺伝子の同定とその浸淫状況の解明 課題番号17590521
    平成17-19年度 基盤研究(C) 小林宣道(代表)、石埜正穂、鷲見紋子

    ・南アジア・東南アジア地域における成人ロタウイルス感染症の実態究明 課題番号15406028
    平成15-17年度 基盤研究(B) 小林宣道(代表)、小島和暢、石埜正穂、三瀬敬治、鷲見紋子、
    谷口孝喜、秋原志穂

    ・ブドウ球菌および腸球菌における薬剤耐性の蔓延に関する分子疫学的研究
    平成15-16年度 特別研究員奨励費 小林宣道、Alam M.M.

    ・本邦におけるペニシリン耐性腸球菌の浸淫状況に関する分子疫学的研究 課題番号14570302
    平成14-16年度 基盤研究(C) 小林宣道(代表)、小島和暢、石埜正穂、三瀬敬治

    ・アジアにおけるB 群ヒトロタウイルスの浸淫状況の解明 課題番号12576011
    平成12-14年度 基盤研究(B) 小林宣道(代表)、小島和暢、石埜正穂、谷口孝喜、實方剛

    厚生労働省科学研究費および国際医療協力研究委託費によるもの:
  • ・網羅的ロタウイルス分子疫学基盤構築とワクチン評価 課題番号H23-新興-一般-005
    平成23-24年度厚生労働科学研究費補助金(新型インフルエンザ等新興・再興感染症研究事業)片山和彦(代表)、岡智一郎、ハンスマン グラント、村上耕介、下池貴志、神谷元、中込治、中込とよ子、小林宣道(分担)、谷口孝喜、辰巳正純

    ・ウイルス感染症の診断、疫学および予防に関する研究
    平成19、20、22、23年度厚生労働科学研究費補助金・社会保障国際協力推進研究事業(日米医学協力計画)倉根一郎(主任研究者)、有川二郎、中込治、西園晃、高島郁夫、井上智、伊藤直人、苅和宏明、小林宣道(分担)、小西英二、森田公一、西條政幸、竹上勉、谷口孝喜、片山和彦

    ・開発途上国の下痢症を中心とする感染性消化器疾患に対する効果的な対策に関する研究
    平成18-20年度 国立国際医療センター 国際医療協力研究委託費  山崎伸二(代表)、土肥多恵子、小林宣道(分担)、西淵光昭、西川喜代孝、泉谷秀昌

    ・広域における食品由来感染症を迅速に探知するために必要な情報に関する研究
    平成18年度厚生労働科学研究費補助金 新興・再興感染症研究事業 寺嶋淳(代表)、武田直和(分担研究者)−
    三瀬敬治、小林宣道(研究協力者)

    民間財団等助成金によるもの:
  • ・バングラデシュ全土における新興リケッチア(リケッチア・フェリス)感染症の蔓延状況の解明.(財)平和中島財団・2016(平成28)年度 アジア地域重点学術研究助成 小林宣道(代表)、漆原範子、Hossain MA、Paul SK, Ahmed S

    ・南・東南アジア地域の医療機関における手術後感染症の原因菌と薬剤耐性に関する分子疫学的解析. (財)平和中島財団・2013(平成25)年度 アジア地域重点学術研究助成
    小林宣道(代表)、漆原範子、ゴッシュソウビック、Paul SK, Thapa B, Nwe KM, Aung MS

    ・バングラデシュ、ミャンマーにおける市中感染型MRSAの蔓延状況に関する分子疫学的解析
    平成22年度 (財)平和中島財団 アジア地域重点学術研究助成小林宣道(代表)、石埜正穂、鷲見紋子、 漆原範子、Hossain MA, Paul SK, Nwe KM, Aung TS.

    ・アジアにおける新出現型ヒトロタウイルスの蔓延に関する分子疫学的研究
    平成20年度日本医師会医学研究助成費 小林宣道

    ・ロタウイルスによる下痢発症生理の解析 
    平成17年度 財団法人湯浅記念会調査研究事業助成金 石埜正穂

    ・インド・バングラデシュにおけるB群ヒトロタウイルスの分布拡大に関する疫学的研究 
    (財)平和中島財団・平成15年度 アジア地域重点学術研究助成 小林宣道(代表)、小島和暢、石埜正穂、T.N.Naik, M.U.Ahmed.

    その他:
  • ・バングラデシュ(マイメンシン市)における小児および成人下痢症由来A群ロタウイルスの分子疫学的解析
    平成20年度 教育研究助成 札幌医科大学学術振興会 長嶋茂雄
    ・スペクトル解析による病理組織画像のパターン分類と病理診断への応用
    平成18年度 教育研究助成 札幌医科大学学術振興会 三瀬敬治(代表)、鷲見紋子、鳥越俊彦
    ・北方圏(北海道・北欧3カ国)におけるインフルエンザ発生変動の時間的変動構造に関する研究
    平成15年度 教育研究助成 札幌医科大学学術振興会 鷲見紋子

    文部科学省 新興・再興感染症研究拠点形成プログラム:
  • (現在協力支援を行っているもの)
    ・感染症研究国際ネットワーク推進プログラム(Japan Initiative for Global Research Network on Infectious Diseases
    「J-GRID」) インド共和国・岡山大学拠点(平成22年度〜)

    日本学術振興会(JSPS)国際交流事業による共同研究の実施:
  • JSPS外国人特別研究員
    1.Dr.Mohammed M. Alam (バングラデシュ農科大学) 平成15-17年
    2.Dr.Souvik Ghosh(インド国立コレラ腸管感染症研究所) 平成20-22年

    JSPS外国人招聘研究者(短期)制度(JSPS short-term fellow)
    1.Dr.Muzahed U. Ahmed (バングラデシュ農科大学教授)(平成16年度)
    2.Dr.Trailokya N. Naik (インド国立コレラ腸管感染症研究所ウイルス部長)(平成18年度)

    論文博士号取得希望者に対する支援事業(論博)
    1.Dr.Shyamal K. Paul (バングラデシュ・マイメンシン医科大学)(平成17-20年度)
    2.Dr.Salma Ahmed (バングラデシュ・マイメンシン医科大学)(平成23-26年度)
    3.Dr.Emily Rahman Khan(バングラデシュ・マイメンシン医科大学)(平成27-29年度)
    4.Dr. Nazia Haque(バングラデシュ マイメンシン医科大学)(平成28-30年度) 

 



札幌医科大学医学部

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