札幌医科大学 医学部 薬理学講座



Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y.
Resveratrol decreases oxidative stress by restoring mitophagy and improves the pathophysiology of dystrophin-deficient mdx mice.
Oxid Med Cell Longev. 2018 in press.


Hamada H, Shimoda K, Horio Y, Ono T, Hosoda R, Nakayama N, Urano K.
Pterostilbene and Its Glucoside Induce Type ⅩⅦ Collagen Expression.
Nat Prod Commun. Vol. 12 No. 1, 85-86, 2017

久野 篤史
Resveratrol restores autophagy and improve cardiac dysfunction in a mouse model of Duchenne muscular dystrophy. 「レスベラトロールはジストロフィン欠損マウスの心筋オートファジーを回復させ心障害を軽減する」

細田 隆介
Protective role of SIRT1 in the cardiomyocyte in doxorubicin-induced cardiotoxicity.「ドキソルビシン心筋障害におけるSIRT1の保護的な役割」

Keystone Symposia "Aging and Mechanisms of Aging-Related Disease"
久野 篤史
Role of impaired autophagy caused by aberrant activation of mTORC1 in dystrophic cardiomyopathy.

細田 隆介
Protective role of SIRT1 in the cardiomyocyte in doxorubicin cardiotoxicity in mice.

瀬堀 理生(久野講師が口頭発表)

細田 隆介
SIRT1により負の制御を受ける Prl2c3は老化誘導タンパクである

細田 隆介

瀬堀 理生


Kuno A, Horio Y.
SIRT1: A Novel Target for the Treatment of Muscular Dystrophies.
Oxid Med Cell Longev. 2016.

Hagiwara K, Okura M, Sumikawa Y, Hida T, Kuno A, Horio Y, Yamashita T.
Biochemical effects of the flavanol-rich lychee fruit extract on the melanin biosynthesis and reactive oxygen species.
J Dermatol. 2016.

Klionsky DJ, Abdelmohsen K, Abe A, Kuno A et al.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 2016.

久野 篤史
Impaired autophagy induced by activated mTORC1 underlies development of dystrophic cardiomyopathy.

会場にて 久野篤史 講師

細田 隆介
Ablation of SIRT1 in the cardiomyocyte aggravates doxorubicin cardiotoxicity in mice: Possible role of accumlation of deleted mtDNA.

会場にて 細田隆介 助教

上田 直弘
Regulation of prolactin-like peptide 2c3 by the NAD+-dependent deacetylase SIRT1 in mouse embryonic fibroblasts. 「マウス胚由来線維芽細胞におけるNAD+依存性脱アセチル化酵素SIRT1によるプロラクチン様ペプチド2c3の発現制御」

会場にて MDPhDコース 医学部6年 上田直弘君

細田 隆介
Role of down-regulation of insulin-like growth factor binding protein 5 in cellular senescence of mouse embryonic fibroblasts. 「マウス線維芽細胞での細胞老化におけるIGFBP5の役割」

瀬堀 理生
SIRT1 maintains skeletal muscle function and protects from muscle membrane damage. 「SIRT1は筋機能維持と筋膜保護に働く」


Kuno A, Tanno M, Horio Y.
The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.
Ann N Y Acad Sci. 2015.

Hori YS, Hosoda R, Akiyama Y, Sebori R, Wanibuchi M, Mikami T, Sugino T, Suzuki K, Maruyama M, Tsukamoto M, Mikuni N, Horio Y, Kuno A.
Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells.
J Neurooncol. 122, 11-20, 2015. (Cover capture)

斉藤 慶樹
Role of insulin-like growth factor binding protein 5 (IGFBP5) in regulation of cellular senescence. 「細胞老化におけるインスリン様成長因子結合蛋白5 (IGFBP5) の役割」

久野 篤史
Resveratrol improves cardiomyopathy in the mdx mouse via FoxO transcription faactors. 「レスベラトロールはFoxO転写因子を介してジズトロフィン欠損mdxマウスの心筋症を軽減する」

会場にて MDPhDコース 医学部5年 斉藤 慶樹君


Kunimoto R, Jimbow K, Tanimura A, Sato M, Horimoto K, Hayashi T, Hisahara S, Sugino T, Hirobe T, Yamashita T, Horio Y.
SIRT1 regulates lamellipodium extension and migration of melanoma cells.
J Invest Dermatol. 134(6), 1693-700, 2014.


Hosoda R, Kuno A, Hori YS, Ohtani K, Wakamiya N, Oohori A, Hamada H, Horio Y.
Differential cell-protective function of two resveratrol (trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress.
J Pharmacol Exp Ther. 344, 124-132, 2013.

Srisuttee R, Koh SS, Malilas W, Moon J, Cho IR, Jhun BH, Horio Y, Chung YH.
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis.
Biochem Biophys Res Commun. 429, 45-50, 2013.

Hosoda R, Horio Y, Shimoda K, Hamada M, Hamada H.
Regioselective hydroxylation and glucosylation of flavanones with cultured plant cells of Eucalyptus perriniana.
Nat Prod Commun. 8(7), 905-6, 2013.

Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y.
Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 Protein-mediated modulation of p300 Protein.
J Biol Chem. 288(8), 5963-72, 2013.

Hori YS, Kuno A, Hosoda R, Horio Y.
Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress.
PLoS One. 8(9), e73875, 2013.


Srisuttee R, Koh SS, Kim SJ, Malilas W, Boonying W, Cho IR, Jhun BH, Ito M, Horio Y, Seto E, Oh S, Chung YH.
Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase.
Oncol Rep. 28(1), 276-282, 2012.

Cho IR, Koh SS, Malilas W, Srisuttee R, Moon J, Choi YW, Horio Y, Oh S, Chung YH.
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.
Biochem Biophys Res Commun. 423(2), 270-5, 2012.

Tanno M, Kuno A, Horio Y, Miura T.
Emerging beneficial roles of sirtuins in heart failure.
Basic Res Cardiol. 107(4), 273, 2012.


Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
J Cell Biol. 192, 615-629, 2011  

Mariño G, Morselli E, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
Longevity-relevant regulation of autophagy at the level of the acetylproteome.
Autophagy 7, 647-649, 2011  

Horio Y, Hayashi T, Kuno A, Kunimoto R.
Cellular and molecular effects of sirtuins in health and disease.
Clin Sci. 121, 191-203, 2011  

Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K and Horio Y.
Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy.
J Pharmacol Exp. Ther. 338, 784-794, 2011 (Highlighted paper)

Horio Y.
Diabetes: Insulin signal meets SIRT1 at AKT.
Nat Rev Endocrinol. 8, 131-132, 2011


Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K and Horio Y.
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.
J Biol Chem. 285, 8375-8382, 2010.

Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y.
Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells.
FEBS Lett. 584, 2821-2826, 2010.


Iwahara N, Hisahara S, Hayashi T and Horio Y.
Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX.
Biochem Biophys Res Commun. 386, 671-675, 2009


Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y.
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.
Proc Natl Acad Sci USA 105, 15999-15604, 2008 (Cover capture)


Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y.
Nucleo-cytoplasmic shuttling of NAD+-dependent histone deacetylase SIRT1.
J Biol Chem. 282, 6823-6832, 2007


Kobayashi Y, Furukawa-Hibi Y, Chen C, Horio Y, Isobe K, Ikeda K, Motoyama N.
SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress.
Int J Mol Med. 16, 237-243, 2005

Hisahara S, Chiba S, Matsumoto H, Horio Y.
NAD+-dependent histone deacetylase SIRT1 (Sir2α).
J Pharmacol Sci. 98, 200-204, 2005


Sakamoto J, Miura T, Shimamoto K, Horio Y.
Predominant expression of Sir2α, an NAD+-dependent histone deacetylase in the mouse embryonic heart and brain.
FEBS Lett. 556, 281-286, 2004