北海道分子生物学研究会（HAMB） | 演題 |
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| 日時 | 2000年11月 2日（木）17：00 〜 18：00 |
| 場所 | 札幌医科大学付属図書館4階セミナー室（基礎研究棟2階・図書館入口よりお入りください） |
Phosphatidylinositol 4,5-bisphosphate (PIP2) is now recognised as being a lipid with a large number of different intracellular functions. In addition to its well-known function as the precursor to the second messengers inositol trisphosphate (IP3), diacylglycerol and phosphatidylinositol 3,4,5-trisphosphate (PIP3), it has been found over the last few years to control many intracellular processes itself. For example, it regulates vesicle secretion, K-ATP channels, vinculin, gelsolin and profilin. PIP2 has also been found within the nucleus, where is has a number of functions not yet fully understood. Because of this multifunctional nature of PIP2, it is not surprising that the family of enzymes that synthesise it, the PIP kinases (PIPkins), are diverse and subject to many complex forms of regulation. One especially surprising aspect of their diversity was recently discovered: the two main groups of PIPkins, Type Is and Type IIs, are in fact synthesising PIP2 by different routes. The Type I enzymes are PI4P 5-kinases (and are therefore the major group responsible for synthesising PI45P2), whereas the Type II enzymes are in fact PI5P 4-kinases. This discovery poses a whole new range of questions about the Type II PIPkins - for example, is their function to synthesise PI45P2 by an alternative route, or is to to remove PI5P, a new inositol lipid which may have its own intracellular functions? For several years we have been studying the Type II PIPkins, of which there are three isoforms, alpha, beta and gamma, and we have been investigating their localisation, regulation and possible functions. My seminar will describe some of what we have discovered recently about these fascinating enzymes.
| 共催 | 北海道分子生物学研究会 日本生化学会北海道支部 |
| 連絡先 | 加納英雄 札幌医科大学生化学第２講座 〒060-8556 札幌市中央区南1条西17丁目 Tel: 011-611-2111（内線2680）； FAX: 011-622-1918 E-mail: kanoh@sapmed.ac.jp |
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