業績

2014年以降

  1. Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Miyajima M, Mishina T, Yamada G, Otsuka M, Hasegawa T, Kojima T, Niki T, Watanabe A, Takahashi H, Sakuma Y. Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis. Lab Invest 2017; 97: 232-42.
  2. Sakuma Y, Nishikiori H, Hirai S, Yamaguchi M, Yamada G, Watanabe A, Hasegawa T, Kojima T, Niki T, Takahashi H. Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype. Lab Invest 2016; 96: 391-8.
  3. Hamanaka R, Yokose T, Sakuma Y, Tsuboi M, Ito H, Nakayama H, Yamada K, Masuda R, Iwazaki M. Prognostic impact of vascular invasion and standardization of its evaluation in stage I non-small cell lung cancer. Diagn Pathol 2015; 10: 17.
  4. Nishii Y, Yamaguchi M, Kimura Y, Hasegawa T, Aburatani H, Uchida H, Hirata K, Sakuma Y. A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells. Int J Oncol 2015; 46: 1781-7.
  5. Watanabe H, Saito H, Yokose T, Sakuma Y, Murakami S, Kondo T, Oshita F, Ito H, Nakayama H, Yamada K, Iwazaki M. Relation between thin-section computed tomography and clinical findings of mucinous adenocarcinoma. Ann Thorac Surg 2015; 99: 975-82.
  6. Nagata K, Kawakami T, Kurata Y, Kimura Y, Suzuki Y, Nagata T, Sakuma Y, Miyagi Y, Hirano H. Augmentation of multiple protein kinase activities associated with secondary imatinib resistance in gastrointestinal stromal tumors as revealed by quantitative phosphoproteome analysis. J Proteomics 2014; 115C: 132-42.
  7. Yamaguchi M, Nishii Y, Nakamura K, Aoki H, Hirai S, Uchida H, Sakuma Y, Hamada H. Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells. Biochem Biophys Res Commun 2014; 454: 600-3.
  8. Matsubara D, Kishaba Y, Yoshimoto Y, Sakuma Y, Sakatani T, Tamura T, Endo S, Sugiyama Y, Murakami Y, Niki T. Immunohistochemical analysis of E-cadherin and ZEB1 expressions in non-small cell lung cancer. Pathol Int 2014; 64: 560-8.
  9. Ui T, Morishima K, Saito S, Sakuma Y, Fujii H, Hosoya Y, Ishikawa S, Aburatani H, Fukayama M, Niki T, Yasuda Y. The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway. Oncol Rep 2014; 31: 619-24.

佐久間裕司

主要原著論文(*はCorresponding authorを、X timesは2017年4月1日現在の引用回数を示す)

  1. Yamaguchi M, Hirai S, Tanaka Y, Sumi T, Miyajima M, Mishina T, Yamada G, Otsuka M, Hasegawa T, Kojima T, Niki T, Watanabe A, Takahashi H,*Sakuma Y. Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis. Lab Invest 2017; 97: 232-42.
  2. *Sakuma Y, Nishikiori H, Hirai S, Yamaguchi M, Yamada G, Watanabe A, Hasegawa T, Kojima T, Niki T, Takahashi H. Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype. Lab Invest 2016; 96: 391-8. (3 times)
  3. *Sakuma Y, Matsukuma S, Nakamura Y, Yoshihara M, Koizume S, Sekiguchi H, Saito H, Nakayama H, Kameda Y, Yokose T, Oguni S, Niki T, Miyagi Y. Enhanced autophagy is required for survival in EGFR-independent EGFR-mutant lung adenocarcinoma cells. Lab Invest 2013; 93: 1137-46. (15 times)
  4. *Sakuma Y, Yamazaki Y, Nakamura Y, Yoshihara M, Matsukuma S, Koizume S, Miyagi Y. NF-κB signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells. Biochem Biophys Res Commun 2012; 423: 667-71. (9 times)
  5. *Sakuma Y, Yamazaki Y, Nakamura Y, Yoshihara M, Matsukuma S, Nakayama H, Yokose T, Kameda Y, Koizume S, Miyagi Y. WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. Lab Invest 2012; 92: 371-83. (16 times)
  6. *Sakuma Y, Tsunezumi J, Nakamura Y, Yoshihara M, Matsukuma S, Koizume S, Miyagi Y. ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis. Oncol Rep 2011; 25: 661-7. (10 times)
  7. *Sakuma Y, Takeuchi T, Nakamura Y, Yoshihara M, Matsukuma S, Nakayama H, Ohgane N, Yokose T, Kameda Y, Tsuchiya E, Miyagi Y. Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src. J Pathol 2010; 220: 574-85. (15 times)
  8. *Sakuma Y, Okamoto N, Saito H, Yamada K, Yokose T, Kiyoshima M, Asato Y, Amemiya R, Saitoh H, Matsukuma S, Yoshihara M, Nakamura Y, Oshita F, Ito H, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y. A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2cm or less in size. Lung Cancer 2009; 65: 85-90. (5 times)
  9. Sakuma Y, Matsukuma S, Yoshihara M, Sakurai S, Nishii M, Kishida T, Kubota Y, Nagashima Y, Inayama Y, Sasaki T, Nakamura Y, Miura T, Kameda Y, Tsuchiya E, *Miyagi Y. Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan. Cancer Lett 2008; 259: 119-26. (12 times)
  10. Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Nakayama H, Kameda Y, Tsuchiya E, *Miyagi Y. Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung. Mod Pathol 2007; 20: 967-73. (16 times)
  11. Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Noda K, Nakayama H, Kameda Y, Tsuchiya E, *Miyagi Y. Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: Confirmation of the correlations with histologic subtypes and gene mutations. Am J Clin Pathol 2007; 128:100-8. (85 times)
  12. Kawanowa K, Sakuma Y, *Sakurai S, Hishima T, Iwasaki Y, Saito K, Hosoya Y, Nakajima T, Funata N. High incidence of microscopic gastrointestinal stromal tumors in the stomach. Hum Pathol 2006; 37: 1527-35. (159 times)
  13. Sakuma Y, *Sakurai S, Oguni S, Satoh M, Hironaka M, Saito K. c-kit gene mutations in intracranial germinomas. Cancer Sci 2004; 95: 716-20. (48 times)
  14. Sakuma Y, *Sakurai S, Oguni S, Hironaka M, Saito K. Alterations of the c-kit gene in testicular germ cell tumors. Cancer Sci 2003; 94: 486-91. (75 times)

山口美樹

特許出願

論文

  1. 山口美樹、濱田洋文
    腫瘍の標的化を目的とした表面抗原の探索とその実用化に向けて
    胆と膵.2011 Vol.32(2):p129-133.
  2. Yamaguchi M, Fujihara M, Wakamoto S, Sakai H, Takeoka S, Tsuchida E, Hamada H, Azuma H, Ikeda H.
    Biocompatibility study of hemoglobin vesicles, cellular-type artificial oxygen carriers, with human umbilical cord hematopoietic stem/progenitor cells using an in vitro expansion system.
    ASAIO J. 2009 May-Jun;55(3):200-5.
  3. Azuma H, Yamaguchi M, Takahashi D, Fujihara M, Sato S, Kato T, Ikeda H.
    Elevated Ca²+ influx-inducing activity toward mast cells in pretransfusion sera from patients who developed transfusion-related adverse reactions.
    Transfusion. 2009 Aug;49(8):1754-61.
  4. Yamaguchi M, Fujihara M, Wakamoto S, Sakai H, Takeoka S, Tsuchida E, Azuma H, Ikeda H.
    Influence of hemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro.
    J Biomed Mater Res A. 2009 Jan;88(1):34-42.
  5. Yamaguchi M, Azuma H, Fujihara M, Hamada H, Ikeda H.
    Generation of a Considerable Number of Functional Mast Cells with a High Basal Level of FcepsilonRI Expression from Cord Blood CD34(+) Cells by Co-culturing Them with Bone Marrow Stromal Cell Line Under Serum-free Conditions.
    Scand J Immunol. 2007 Jun;65(6):581-8.
  6. Kawano Y, Kobune M , Yamaguchi M, Nakanura K, Ito Y, Sasaki K, Takahashi S, Nakamura T, Chiba H, Mathunaga T, Azuma H, Ikabuchi K, Ikeda H, Kato J, Niitsu Y, and Hamada H.
    Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells.
    Blood. 2003 Jan; 101: 532-540
  7. Yamaguchi M, Hirayama F, Wakamoto S, Fujihara M, Murahashi H, Sato N, Ikebuchi K, Sawada K, Koike T, Kuwabara M, Azuma H, Ikeda H
    Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cell expansion.
    Transfusion.2002 Jul; 42(7): 921-7.
  8. Yamaguchi M, Hirayama F, Murahashi H, Azuma H, Sato N, Miyazaki H, Fukazawa K, Sawada K, Koike T, Kuwabara M, Ikeda I, Ikebuchi K
    Ex vivo expansion of human cord blood primitive hematopoietic progenitors and transplantable stem cells using human primary bone marrow stromal cells and human AB serum.
    Cytotherapy.2002  Vol.4(2): 109-18.
  9. Yamaguchi M, Hirayama F, Kanai M, Sato N, Fukazawa K, Yamashita K, Sawada K, Koike T, Kuwabara M, Ikeda H, Ikebuchi K.
    Serum-free coculture system for ex vivo expansion of human cord blood primitive progenitors and SCID mouse-reconstituting cells using human bone marrow primary stromal cells.
    Exp Hematol. 2001 Feb;29(2):174-82.
  10. Yamaguchi M, Ikebuchi K, Hirayama F, Sato N, Sekiguchi S.
    Cell cycle-dependent change of the adhesive character of CD34+ progenitor cells and their VLA-4 expression
    Rinsho Byori. 1999  May;47(5):439-46. Review. Japanese.
  11. Yamaguchi M, Ikebuchi K, Hirayama F, Sato N, Mogi Y, Ohkawara J, Yoshikawa Y, Sawada K, Koike T, Sekiguchi S.
    Different adhesive characteristics and VLA-4 expression of CD34(+) progenitors in G0/G1 versus S+G2/M phases of the cell cycle.
    Blood. 1998 Aug 1;92(3):842-8.
  12. Yamaguchi M, Sawada K, Sato N, Koizumi K, Sekiguchi S, Koike T.
    A rapid nylon-fiber syringe system to deplete CD14+ cells for positive selection of human blood CD34+ cells. Use of immunomagnetic microspheres.
    Bone Marrow Transplant. 1997 Feb;19(4):373-9.