Preventive
Effect
of
HUO
MAI
YIN
(extract
of
Chinese
medicine)
on
Restenosis
after
Percutaneous
Transluminal
Renal
Angioplasty
in
Patients
with
Renovascular
Hypertension
Xie
Hui
Fang,
Song
Xin,
Li
Xiao
Dong
Department
of
Cardiology
Chen
Li
Ying
Department
of
Radiology
No.2
Affiliated
Hospital
China
Medical
University
Shenyang,
P.R.
China
Percutaneous
transluminal
angioplasty
(PTA)
is
a
relatively
safe
and
effective
procedure
with
benefits
both
in
hypotensive
effect
and
preserving
renal
function
in
the
treatment
of
renal
vascular
hypertension
(RVH)
which
caused
by
unilateral
or
bilateral
renal
arterial
stenosis.
Unfortunately,
the
recurrent
rate
of
restenosis
of
the
balloon
dilated
segments
of
renal
artery
is
as
high
as
17.3~51.7%
in
all
cases
undervent
a
successful
PTA.
Restenosis
is
therefore
the
main
threat
to
lasting
blood
pressure
(BP)
improvement
and
restored
or
maintained
renal
function
after
a
successful
PTA.
To
assess
the
preventive
effect
of
HUO
MAI
YIN
(HMY)
Which
consists
of
Huang
qi
(astragali),
Danshen
(red
sage
root),
Chuanxion
(Ligustici),
Honghua
(Sufflower),
Chishao
(red
peony
root)
et
al
on
restenosis,
34
consecutive
cases
with
RVH
(12
were
male,
22
were
female,
age
ranged
17~56yvrs)
in
No.2
Hospital
of
China
Medical
University
were
allocated
to
two
groups,
control
(n=17)
treated
with
aspirin
and
dipyridamol,
and
HMY
(n=17)
treated
with
HMY
21g/day
in
combination
with
aspirin
and
dipyridamol
two
weeks
before
and
12
weeks
after
PTA.
There
was
no
significant
difference
between
two
groups
in
the
clinical
status
and
the
degree
or
severity
of
the
stenotic
segments
before
PTA.
PTA
had
been
performed
successfully
in
all
patients
except
for
one
case
in
group
of
HMY.
One
month
after
PTA,
the
average
BP
dropped
dramatically
in
both
group
(from
194.71±28.96/121.76±22.31
to
135.59±31.01/87.65±26.45
mmHg
(control)
vs
from
212.65±30.02/130.00±21.20
to
145.29±31.05/86.35±23.20
(HMY)
with
being
cured
and
improved
rate
of
95.2%
vs
94%.
But
in
control
group,
6
months
after
PTA,
the
average
BP
rose
again
(155.06±29.06/
96.12±16.73),
while
the
average
BP
in
group
of
HMY
continuously
dropped
(135.29±24.52/81.12±13.07),
because
that
9
cases
in
control
group
had
a
recurrent
hypertension
caused
by
restenosis
of
the
balloon
dilated
segments
of
renal
artery
identified
by
a
abdominal
aortogram,
only
one
case
had
restenosis
in
group
of
HMY.
The
results
of
this
study
showed
that
the
recurrent
rate
was
52.94%
in
control
group
and
6.25%
in
group
of
HMY
(P<0.01).
According
to
the
Chinese
pharmacopoeia,
HMY
has
favorable
effects
on
the
healing
of
wound,
the
inhibition
of
platelet
aggregation,
coagulant
activity
of
thrombin,
inflammation
and
proliferation
of
the
injured
blood
vessel
which
undoubtedly
contributed
to
the
reduction
of
the
recurrent
rate
of
restenosis
in
group
of
HMY.
In
conclusion,
HMY
in
combination
with
aspirin
and
dipyridamole
can
significantly
decrease
the
incidence
of
restenosis
after
PTA.
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